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The value of endoscopic ultrasonography on diagnosis and treatment of esophageal hamartoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 662-666页

作者： guo-qiang XU Feng-ling HU li-hua CHEN guo-dong SHAN Bing-ling ZHANG Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective:To examine the values of endoscopic ultrasonography (EUS) on diagnosis and treatment of esophageal hamartoma. Methods:We compared and analyzed various kinds of imaging examinations such as barium esophagram, con-trast-enhanced computed tomography (CT) and conventional gastroscopy in retrospectively reviewing the clinical data of an esophageal hamartoma patient seen in our clinic in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Having received various imaging examinations, this patient was finally diagnosed with esophageal hamartoma and underwent gastroscopic resection of hamartoma with the diagnostic information obtained from EUS. The patient had been regularly followed up for 13 months after treatment. Results: Barium esophagram, CT and conventional gastroscopy detected the lesion, but were unable to distinguish it from common esophagopolypus and other submucosal lesions, and unable to determine etiopathogenisis. EUS detected the hamartoma and identified its internal structure, echo, exact size, depth of invasion, origin and the relationship between adjacent tissues and organs, differentiating the lesion from other submucosal tumors and clearly defining the diagnosis. EUS-guided fine needle aspiration (FNA) also helped to identify the etiological diagnosis. Conclusion: EUS was superior to other imaging means in diagnosis and treatment of hamartoma.

关键词： Esophageal hamartoma Endoscopic ultrasonography (EUS) Gastroscopic resection

Numerical Study on Welding line Behavior of Deep Drawing TWB Process

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Journal of Iron and Steel Research International 2007年第5期14卷 36-38,46页

作者： WANG li-juan WANG guo-dong liU Xiang-hua WU Ming-tang State Key Laboratory of Rolling Automation and Technology Northeastern University Shenyang 110004 Liaoning China

The FEM technology is used to analyze the welding line movement behavior of deep drawing TWB sheet with different thickness. It is found that high stress fields are concentrated around the welding line and large residual stresses are left. The effect of the welding line movement is like a rigid string and the selected nodes of the thin part near the welding line show the related larger strain.

关键词： welding line behavior deep drawing TWB

Synthesis and Crystal Structure of 5-[(1H-1,2,4-Triazol-1- yl)methyl]-4-(2,3-dimethoxybenzylideneamino)-2-2H-1,2,4-triazole-3(4H)-thione Monohydrate

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Chinese Journal of Structural Chemistry 2006年第6期25卷 673-676页

作者： XU liang-Zhong SHANG Yu-Qing YU Guan-Ping li Kai SI guo-dong College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China

The title compound 5-[（1H-1,2,4-triazol-1-yl）methyl]-4-（2,3-dimethoxy-benzylideneamino）- 2H-1,2,4-triazole-3（4H）-thione monohydrate 4 has been synthesized by the treatment of 4-amino-3-（ 1,2,4-triazol- 1-yl）- 1 H- 1,2,4-triazole-5（4H）-thione 3 with 2,3-dimethoxybenzaldehyde. It crystallizes as a monohydrate in the triclinic system, space group P1^- with a = 8.147（2）, b = 10.820（2）, c = 10.835（2）A, α= 73.770（6）, β = 84.916（7）,γ = 70.679（6）°, C14H17N7O35, Mr = 363.41, V= 865.4（2）A^3, Z= 2, Dc = 1.395 g/cm^3, F（000） = 380, μ = 0.217 mm^-1, the final R = 0.0400 and wR = 0.0975 for 3454 unique reflections. The dihedral angles made by the thione-substituted triazole ring with the other triazole ring and benzene ring are 74.92（3） and 14.81（2）°, respectively. There are some weak hydrogen bonds and C-H..π supramolecular interactions in the lattice, forming a three-dimensional network, which stabilizes the crystal structure.

关键词： 1,2,4-triazole crystal structure synthesis

Synthesis, Crystal Structure and Biological Activities of 2-(4-Fluorophenyl)-2-oxo-1-(1H-1,2,4-triazol-1-yl) ethyl morpholine-4-carbodithioate

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Chemical Research in Chinese Universities 2005年第6期21卷 673-676页

作者： XU liang-zhong ZHU Chong-yi YU Chen-long li Kai SI guo-dong College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

The title compound, 2-（ 4-fluorophenyl ） -2-oxo-1-（ 1H-1, 2,4-triazol-1-yl ） ethyl morpholine-4-carbodithioate, was synthesized and its structure was confirmed by means of IR, MS, 1 H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound possesses some biological activities.

关键词： 1H-1,2,4-Triazole Morpholine Crystal structure Biological activity

Activity and Tissue Expression of Tyrosine Phosphatase PTP-MEG2

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Chemical Research in Chinese Universities 2011年第2期27卷 287-290页

作者： dong Hong-bo li guo-dong WANG Shao-feng FU Xue-qi ZHAO Zhi-zhuang Joe Edmond H. Fischer Signal Transduction Laboratory College of Life Science Jilin University Changchun 130012 P. R. China School of Pharmaceutical Science Jilin University Changchun 130021 P. R. China The Second Hospital of Jilin University. Changchun 130041 P. R. China Department of Pathology University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA

Protein tyrosine phosphatases（PTPs） are crucial regulators of signal transduction. Among them, PTP-MEG2 is an intracellular enzyme of 593 amino acid residues with a putative lipid-binding domain at the N-terminus. In the present study, we cloned the full-length form of the enzyme and expressed it in E. coli cells as a 6xHis-tagged protein. The majority of the expressed enzyme was found in the inclusion body of E. coli cell extracts. Upon extraction with a buffer containing urea, the recombinant enzyme was purified to near homogeneity on a single Ni-NTA-agarose column. This procedure resulted in the production of over 100 mg of purified recombinant PTP-MEG2 from 1 L E. coli cell culture. The purified protein displayed a single polypeptide band with expected molecular size on SDS-polyacrylamide gel electrophoresis under reducing conditions. Isolated under denatured conditions in urea, the purified enzyme was re-natured by dialyzing against a refolding buffer. The re-natured enzyme effectively dephosphorylated the common PTP substrate para-nitrophenylphosphate with a specific activity of 2000 units/mg. Meanwhile, the denatured enzyme was used to immunize a rabbit to produce antibodies. The resulting anti- serum had extremely high sensitivity and specificity. When used for Western blot analysis, the anti-serum revealed a wide expression of PTP-MEG2 in many tissues of mice. Together, we developed a highly effective way to purify a large amount of PTP-MEG2 and generated highly sensitive antibodies that can specifically detect endogenous expression of the enzyme in tissues.

关键词： Protein tyrosine phosphatase Expression Antibody production Enzyme assay Tissue expression

Facile Preparation and Cellular Imaging of Photoluminescent Carbogenic Nanoparticles Derived from Defoliations

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Chemical Research in Chinese Universities 2013年第1期29卷 189-192页

作者： XIU Yang ZHOU Yan GAO Qian CHEN Jie-sheng li guo-dong State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry National Engineering Laboratory for AIDS Vaccine College of Life Science Jilin University Changchun 130012 P. R. China" School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China

In the past two decades, photoluminescent semiconductor quantum dots（QDs） have received intensive attention for a variety of promising properties and applications, especially for their potential application in cellular imagingE. QDs with high quantum yield have been prepared based on cad mium（zinc） selenide（sulfide） and related coreshell compo sites. However, the release of Cd2＋, S2 and Se2 ions in evitably causes serious health and environmental concerns. Therefore, many efforts have been devoted to developing be nign alternatives with enhanced photoluminescence, such as silicon nanoparticles and nanowires. Carbonbased nanomaterials, including carbon nano tubes（CNTs） and carbogenic nanoparticles（CNPs）, represent an exciting new type of alternative to the aforementioned QDs with high quantum yield. CNPs are superior to QDs in chemi cally inertness, biocompatibility and photostability. After the report on the photoluminescence of carbon dots prepared by laser ablation with graphite as carbon sourcetill, several strate gies have been developed for the preparation of luminescent CNPs. For instance, luminescent CNPs were prepared by liu et al.021 with candle soot via oxidative acid treatment, and the resulting CNPs with different emission colors were isolated by means of electrophoretic separation. Hu et al. employed an improved onestep approach for the synthesis of luminescent CNPs by laser irradiating a suspension of carbon materials in organic solvents of diamineterminated oligomeric poly（ethylene glycol）（PEG1500N）. More recently, luminescent carbogenic dots have been obtained by Peng and Travas via surface passivation of carbogenic dots in an aqueous solution with carbohydrates as the starting materials. Carbogenic nano particlesloaded magnesiumaluminophosphate solid phosphors.

关键词： Carbogenic nanoparticle Photoluminescence Cellular imaging

Water source identification in mines combining liF technology and ResNet

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Journal of Mountain Science 2023年第11期20卷 3392-3401页

作者： YAN Peng-cheng ZHAO Yu-ting li guo-dong WANG Jing-bao WANG Wen-chang State Key Laboratory of Deep Coal Mine Exploitation Response and Disaster Prevention Anhui University of Science andTechnologyHuainan 232001China School of Electrical and Information Engineering Anhui University of Science and TechnologyHuainan 232001China Collaborative Innovation Center of Mine Intelligent Equipment and Technology Anhui University of Science&TechnologyHuainan 232001China

The problem of mine water source has always been an important hidden danger in mine safety *** water source under the mine working face may lead to geological disasters,such as mine collapse and water *** research background of mine water source identification involves many fields such as mining production,environmental protection,resource utilization and technological *** is a comprehensive and interdisciplinary subject,which helps to improve the safety and sustainability of mine ***,timely and accurate identification and control of mine water source is very important to ensure mine production ***-Induced Fluorescence(liF)technology,characterized by high sensitivity,specificity,and spatial resolution,overcomes the time-consuming nature of traditional chemical *** this experiment,sandstone water and old air water were collected from the Huainan mining area as original *** types of mixed water samples were prepared by varying their proportions,in addition to the two original water samples,resulting in a total of seven different water samples for *** preprocessing methods,namely,MinMaxScaler,StandardScaler,Standard Normal Variate(SNV)transformation,and Centering Transformation(CT),were applied to preprocess the original spectral data to reduce noise and *** was determined as the optimal preprocessing method based on class discrimination,data distribution,and data *** maintain the original data features while reducing the data dimension,including the original spectral data,five sets of data were subjected to Principal Component Analysis(PCA)and linear Discriminant Analysis(LDA)dimensionality *** comparing the clustering effect and Fisher's ratio of the first three dimensions,PCA was identified as the optimal dimensionality reduction ***,two neural network models,CT+PCA+CNN and CT+PCA+ResNet,were constructed by combining Convolutional Neural Networks(

关键词： Water source identification Mine safety liF technology CT PCA ResNet

Thermodynamics and Phase Equilibrium of Cu－Ce－O，Cu－Ce－S，Cu－Ce－O－S liquid Solutions

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Journal of Iron and Steel Research International 1995年第1期2卷 10-14页

作者： DU Ting li guo dong Central Iron and Steel Research Institute MMI

Thermodynamics of Cu-Ce-O,Cu-Ce-S and Cu-Ce-0-S solutions at 1200℃ were studied by using solid electrolyte cell and chemical equilibrium *** equilibrium constant of deoxidation,desulfurization and deoxysulfurization by Ce,the Gibbs standard reaction free energies of the formation of Ce_2O_3,CeS and Ce_2O_2S in Cu-base solution,activity interaction coefficients of S and Ce,temperature dependence of standard reaction free energy of solution of Ce in Cu,self-interaction coefficients of Ce in liquid Cu have been *** phase precipitation diagram for Cu-CeS-O system has been *** thermodynamic condition of the existence of Ce_2O_3,CeS and Ce_2O_2S in liquid Cu has been *** provides the basis for predicting the sequence and the type of equilibrium inclusions of Ce formed in Cu-base solution.

关键词： Cu liquid Ce O S thermodynamic property phase diagram

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Expression of gastric cancer-associated MG7 antigen in gastric cancer,precancerous lesions and ***-associated gastric diseases

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World Journal of Gastroenterology 2002年第6期8卷 1009-1013页

作者： dong-li guo Ming dong Lan Wang li-Ping Sun Yuan Yuan,Cancer Institute,First Affiliated Hospital,China Medical University,Shenyang,110001,liaoning Province,China Cancer Institute First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China.

AIM: To investigate the relationship between the antigen MG7 antigen expression and gastric cancer as well as precancerous condition; to study the relationship between the MG7 antigen expression and H. pyloriinfection in benign gastric lesions in order to find out the effect of H. pylori infection on the process of gastric cancer ***: The level of MG7 antigen expression was determined by immunohistochemical method in 383 gastric biopsied materials. The intestinal metaplasia was determined by histochemistry method. The H. pyloriinfection was determined by HE stain, PCR and EliSA in 291 specimens, among which only 34 cases of H. pylori-associated gastric lesions were followed ***: The positive rate of MG7 expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric cancer increased gradually in ascending order (P＜0.01). The positive rate of MG7 antigen expression in type Ⅲ intestinal metaplasia of gastric mucosa was higher than that of type Ⅰand Ⅱ intestinal metaplasia, being highly significant (P＜0.05).The positive rate of MG7 antigen expression in superficial gastritis, atrophic gastritis and gastric cancer increased gradually (11.9 %, 64.8 %, 91.2 %, P＜0.01). There was no significant difference between ***-negative and H. pyloripositive intestinal metaplasia, atrophic gastritis and dysplasia of gastric epithelium in the positive rate of MG7 antigen expression. There was no expression of MG7 antigen in H. pylori-negative superficial gastritis. The positive rate of MG7 expression in H. pylori-positive superficial gastritis was 20.5 %, and the difference between them was significant (P＜0.05). During following up, one of the three H. pylori negative cases turned positive again, and its MG7 antigen expression turned to be stronger correspondingly. 3 of 31 H. pyloripositive cases were detected as early gastric cancer, among which one with '+++' MG7 antigen expression was diminished after H. pylori ***: M

关键词：胃癌 MG7抗原基因表达癌前病变幽门螺杆菌相关胃疾病