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Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis

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Neural Regeneration Research 2024年第3期19卷 642-649页

作者： Xiuling Tang Tao Yan Saiying Wang Qingqing liu Qi Yang Yongqiang Zhang Yujiao li Yumei Wu Shuibing liu Yulong ma le Yang Precision Pharmacy&Drug Development Center Department of PharmacyTangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Clinical Pharmacy Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu ProvinceChina Department of Pharmacology School of PharmacyAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Anatomy Histology and Embryology and K.K.Leung Brain Research CentreAir Force Medical UniversityXi’anShaanxi ProvinceChina

β-Sitosterol is a type of phytosterol that occurs naturally in *** studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic *** we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced *** investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic *** addition,β-sitosterol showed high affinity for NPC1l1,a key transporter of cholesterol,and antagonized its *** conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.

关键词： apoptosis blood-brain barrier β-sitosterol cerebral ischemia/reperfusion injury cholesterol overload cholesterol transport endoplasmic reticulum stress ischemic stroke molecular docking NPC1l1

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A fluorescence-enhanced inverse opal sensing film for multi-sources detection of formaldehyde

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Food Science and Human Wellness 2024年

作者： Xiaokang lu Bo Han Deyilei Wei Mingzhu Chu Haojie ma Ran li Xueyan Hou Yuqi Zhang JiJiang Wang Key laboratory of New Energy & New Functional materials Shaanxi Key laboratory of Chemical Reaction Engineering College of Chemistry and Chemical Engineering Yan’an University

The SiO2inverse opal photonic crystals (PC) with a three-dimensional macroporous structure were fabricated by the sacrificial template method， followed by infiltration of a pyrene derivative， 1-(pyren-8-yl)but-3-en-1-amine (PEA)， to achieve a formaldehyde-sensitive and fluorescence-enhanced sensing film. Utilizing the specific Aza-Cope rearrangement reaction of al.yl.mine of PEA and formaldehyde (FA) to generate a strong fluorescent product emitted at ～480 nm， we chose a PC whose blue band edge of stopband overlapped with the fluorescence emission wavelength. In virtue of the fluorescence enhancement property derived from slow photon effect of PC， FA was detected highly selectively and sensitively. The limit of detection (loD) was calculated to be 1.38 nmol/l. Furthermore， the fast detection of FA (within 1 min) is realized due to the interconnected three-dimensional macroporous structure of the inverse opal PC and its high specific surface area. The prepared sensing film can be used for the detection of FA in air， aquatic products and living cells. The very close FA content in indoor air to the result from FA detector， the recovery rate of 101.5% for detecting FA in aquatic products and fast fluorescence imaging in 2 min for living cells demonstrate the reliability and accuracy of our method in practical applications.

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尼拉帕利所致获得性纯巨核细胞性血小板减少性紫癜1例

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肿瘤预防与治疗 2024年第3期37卷 264-270页

作者：郭灵王钇力宋艳芳衷敬华翟聪聪赣南医科大学第一附属医院肿瘤内科江西赣州341000 赣南医科大学第一临床医学院江西赣州341000 赣州市病毒感染相关恶性肿瘤技术创新中心江西赣州341000

尼拉帕利(niraparib)是卵巢癌患者维持治疗中极具代表性的新型聚腺苷二磷酸核糖聚合酶(polyADP-ri-bosepoly-merase,PARP)抑制剂,其罕见不良反应亟需引起临床重视,目前尚无研究表明尼拉帕利在临床治疗过程中导致获得性纯巨核细胞性血小... 详细信息

尼拉帕利(niraparib)是卵巢癌患者维持治疗中极具代表性的新型聚腺苷二磷酸核糖聚合酶(polyADP-ri-bosepoly-merase,PARP)抑制剂,其罕见不良反应亟需引起临床重视,目前尚无研究表明尼拉帕利在临床治疗过程中导致获得性纯巨核细胞性血小板减少性紫癜(acquired amegakaryocytic thrombocytopenic purpura,AATP)。本文通过报道1例因接受尼拉帕利治疗出现AATP的卵巢癌病例,以期提高肿瘤学领域对尼拉帕利罕见不良反应的了解与认识,并为尼拉帕利血液系统不良反应的临床管理提供有效策略。

关键词：尼拉帕利 PARP抑制剂获得性纯巨核细胞性血小板减少性紫癜卵巢癌维持治疗

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吉马酮抑制JAK2/STAT3信号通路对食管癌细胞增殖、凋亡和侵袭的影响

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实用肿瘤杂志 2024年第3期39卷 228-235页

作者：马骏刘倩王孝彬空军军医大学第二附属医院/唐都医院胸腔外科陕西西安710038

目的探讨吉马酮抑制蛋白酪氨酸激酶2(Janus kinase 2,JAK2)/信号转导子与激活子3(signal transducer and activator of transcription 3,STAT3)信号通路对食管癌细胞增殖、凋亡和侵袭的影响。方法甲基噻唑蓝(methyl thiazolyl tetrazolium,MTT)法检测不同浓度(0、10、20、40、80、160和320μmol/l)的吉马酮分别处理人食管癌细胞Eca109和KYSE450以及人食管上皮细胞Het-1A后的细胞存活率。将Eca109细胞分为对照组(常规培养)、吉马酮低剂量组(40μmol/l吉马酮干预24 h)、吉马酮中剂量组(80μmol/l吉马酮干预24 h)、吉马酮高剂量组(160μmol/l吉马酮干预24 h)、Coumermycin A1组(10μmol/l JAK2激活剂coumermycin A1+160μmol/l吉马酮干预24 h)和AG490组(50μmol/l JAK2抑制剂AG490+160μmol/l吉马酮干预24 h)。Transwell检测细胞迁移和侵袭能力。平板克隆实验检测细胞克隆能力。流式细胞术检测细胞凋亡和周期。Western blot检测JAK2、磷酸化JAK2(phos-JAK2,p-JAK2)、STAT3、p-STAT3、Ki-67、Bax、Bcl-2和p53表达情况。结果与0μmol/l比较,10、20、40、80、160和320μmol/l的吉马酮处理下,Eca109和KYSE450细胞存活率均呈浓度依赖性降低(均Plf-inhibitory concentration,IC_(50))分别为(98.18±2.12)μmol/l和(154.77±2.32)μmol/l,而Het-1A细胞存活率差异无统计学意义(均P>0.05)。由于吉马酮对Eca109细胞效果更明显,后续选择Eca109细胞并采用40、80和160μmol/l吉马酮浓度进行作用机制研究。与对照组比较,吉马酮低、中和高剂量组Eca109细胞迁移、侵袭、克隆个数以及p-JAK2、p-STAT3、Ki-67和Bcl-2蛋白表达均降低(均Pl-2蛋白表达均增加,Eca109细胞G_(0)/G_(1)期比例、早期凋亡率和总凋亡率以及Bax和p53表达均降低(均Pl-2表达均降低,Eca109细胞G_(0)/G_(1)期比例、早期凋亡率和总凋亡率以及Bax和p53表达均升高(均P<0.05)。结论吉马酮可通过抑制JAK2/STAT3通路抑制食管癌细胞的增殖和侵袭能力,并促进细胞凋亡。

关键词：食管癌吉马酮 JAK2/STAT3通路细胞增殖细胞凋亡细胞侵袭

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Electrochemical Behaviour of Cu underneath Thin Electrolyte Film in Atmosphere

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Journal of materials Science & Technology 1998年第6期14卷 547-550页

作者： Zhang, XY Du, yl Chinese Acad Sci Inst Corros & Protect Met State Key Lab Corros & Protect Shenyang 110015 Peoples R China

An electrochemical cell was devised to investigate corrosion electrochemical behavior of metal underneath thin electrolyte film in atmosphere. The Piontelli's type of luggin-Haber capillary was inserted from the backward of working electrode. The results show that. cathodic process on Cu is mainly affected by the thickness of the electrolyte film of 0.5 mol/l HCl+1 mol/lNa2SO4 aqueous solution and its anodic dissolution changed from Tafel region to limiting diffusion current. Moreover, the corrosion potential of Cu in due media will increase with decrease of the thickness of the film.

关键词： Atmospheric corrosion

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Specialist predator in a multi-species prey community:boreal voles and weasels

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Integrative Zoology 2008年第1期3卷 51-63页

作者： Janne SUNDEll Hannu ylÖNEN Metapopulation Research Group Department of Biological and Environmental SciencesUniversity of HelsinkiHelsinkiFinland Konnevesi Research Station Department of Biological and Environmental ScienceUniversity of JyväskyläJyväskyläFinland

Dissimilar vulnerabilities of different prey types and preferences of predators are factors likely to contribute to community *** may happen via differential individual properties of prey animals(***,escape)or via habitat effects making hunting by a predator easier and more rewarding in some habitats,or ***,community dynamics may be influenced by predator mediated apparent competition,in which an increase in one prey type has negative effects on another prey type indirectly via the shared *** summarize the current knowledge from the field in a model predator–prey system consisting of sympatric boreal vole species and their common specialist predator and review field studies using predator manipulation and studies on the responses of individuals in the laboratory and in outdoor *** vole species studied represent different prey types that are thought to have different *** observations on the main resident specialist predator,the least weasel(Mustela nivalis nivalis l.),show that it hunts according to prey availability and suitability of the hunting *** voles respond to the presence of the predator behaviorally in various ways to avoid *** conclude that even if the least weasel is a specialized predator of small rodents it acts like a generalist predator within the small rodent guild and may facilitate the coexistence of prey species via predator *** may lead to interspecific synchrony between prey populations,which has often been *** suggest that the processes determining the community impact of predator–prey interactions are driven by the behavioral arms race between the predator and the prey,together with the habitat-dependent density of prey and net gain for the predator.

关键词： apparent competition predator–prey interaction prey choice vole cycle

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Unusual hexa-nuclear cadmium cluster functionalized phosphomolybdate as effective photoelectrochemical sensor for trace Cr(Ⅵ)detection

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Chinese Chemical letters 2022年第9期33卷 4400-4404页

作者： Wenting An Xiujuan Zhang Jiaqi Niu Yuanyuan ma Zhangang Han Hebei Key laboratory of Organic Functional Molecules National Demonstration Center for Experimental Chemistry EducationCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China

Photo-assisted electrochemical technique provides a promising approach towards carcinogen chromium(Ⅵ)detection,which requires reasonable catalyst ***,an unusual hexa-nuclear cadmium cluster functionalized reductive phosphomolybdate hybrid as photo-electrochemical sensor was designed and synthesized with formula of{[Cd(H_(2)O)_(2)]_(2)[Cd(btmbp)]_(2)}{Cd(P_(4)Mo_(6)O_(31)H_(7))_(2)}·20H_(2)O(1)(btmbp=4,4′-bis((^(1)H-1,2,4-triazol-1-yl)methyl)biphenyl),in which the photoactive hexa-nuclear{Cd_(6)}clusters cooperated with reductive phosphomolybdate[P_(4)Mo_(6)O_(31)]^(12)−endow the material with wide light absorption and remarkable redox activity,thus achieving efficient photo-assisted electrochemical Cr(Ⅵ)detection *** visible-light assistance,the detection limit(lOD)and sensitivity of Cr(Ⅵ)is 4.17 nmol/l(0.225 ppb)and 226.32μA l/μmol,which is apparently superior to the performance without photo-assistance(6.25 nmol/l and 106.95μA l/μmol)and far satisfies the demands of world health organization(WHO)for potable water(50 ppb).Moreover,compound 1 showed prominent Cr(Ⅵ)detection performance in practical water samples together with remarkable anti-interference capacity and good electrochemical *** work provides an important guidance for designing efficient polyoxometalate-based crystalline sensors for Cr(Ⅵ)detection.

关键词： Phosphomolybdate Cadmium cluster Photoelectrocatalysis Electrochemical detection Hexavalent chromium

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Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction

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Chinese Medical Journal 2014年第4期127卷 627-632页

作者： Wu NQ Guo yl li Xl liu J Qing P Xu RX Zhu CG Jia Y J liu G Dong Q Jiang lX li J J ma Fl Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology First Hospital of Hohhot Hohhot Inner Mongolia 010030 China

Backround N-terminal pro-brain natriuretic peptide （NT-proBNP） is a reliable predictor in acute coronary artery disease （CAD）. little is known about patients with stable CAD, especially Chinese patients with CAD. The aim of the present study was to investigate the association of NT-proBNP levels with the severity of CAD in patients with normal left ventricular ejection fraction. Methods A total of 658 consecutive patients were divided into two groups based on angiograms： CAD group （n=484） and angiographic normal control group （n=174）. The severity of CAD was evaluated by modified Gensini score, and its relationship with NT-proBNP was analyzed. Results The prevalence of risk factors such as age, male gender, diabetes mellitus （DM）, dyslipidemia, smoking, and family history of CAD in the CAD group were higher than that in the control group. In multivariate regression model analysis, age, gender, and DM were determinants of the presence of CAD. NT-pro BNP was found to be an independent predictor for CAD （OR：1.66 （95% CI： 1.06-2.61）, P 〈0.05）. In a receiver operating characteristic （ROC）curve analysis, an NT-proBNP value of 641.15 pmol/l was identified as a cut-off value in the diagnosis or exclusion of CAD （area under curve （AUC）=0.56, 95% CI： 0.51-0.61）. Furthermore, NT-proBNP was positively correlated with Gensini score （r=0.14, P 〈0.001） in patients with CAD. Conclusion NT-proBNP was an independent predictor for Chinese patients with CAD, suggesting that the NT-proBNP level might be associated with the presence and the severity of CAD.

关键词： N-terminal pro-brain natriuretic peptide coronary artery disease risk factors modified Gensini score

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Analysis of Chlorogenic Acid in Herbal Medicines by Capillary Electrophoresis

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Chinese Chemical letters 1998年第10期9卷 941-944页

作者： long, H Yang, JJ liu, HW Wang, TS Huang, AJ Sun, yl Peking Univ Dept Chem Beijing 100871 Peoples R China

A simple, rapid and accurate capillary zone electrophoresis method was developed for the determination of chlorogenic acid as a marker in traditional Chinese medicines. The buffer solution comprised of 10 mmol/l sodium phosphate and 20 mmol/l boric acid containing 5% ethanol with the pH value adjusted to 7.00. The contents of chlorogenic acid in Flos lonicerae and Flos lonicerae containing herbal preparations were determined within 15 min.

关键词： chlorogenic acid quantitation herbal medicines capillary zone electrophoresis

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新型含(卤代)烷氧基类双酰胺化合物的合成、杀虫活性及构效关系研究

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有机化学 2024年第5期44卷 1584-1591页

作者：刘吉永吴明慧相君成庞怀林李斌吕亮沈阳农业大学植物保护学院沈阳110866 南通泰禾化工股份有限公司江苏南通226407 上海晓明检测技术服务有限公司上海200335

为了发现结构新颖、活性优异、环境友好的新型杀虫剂,以环丙氟虫胺为先导化合物,在其苯胺部分引入(卤代)烷氧基单元,设计合成了一系列未见文献报道的新型含(卤代)烷氧基类双酰胺化合物,其结构经过^(1)H NMR、^(13)C NMR和HRMS确证.初步... 详细信息

为了发现结构新颖、活性优异、环境友好的新型杀虫剂,以环丙氟虫胺为先导化合物,在其苯胺部分引入(卤代)烷氧基单元,设计合成了一系列未见文献报道的新型含(卤代)烷氧基类双酰胺化合物,其结构经过^(1)H NMR、^(13)C NMR和HRMS确证.初步的生物活性测试结果表明,大部分化合物对小菜蛾表现出优异的杀虫活性,其中N-[2-溴-4-(全氟丙烷-2-基)-6-(二氟甲氧基)苯基]-3-[N-(环丙甲基)苯甲酰胺基]-4-氟苯甲酰胺(4a)、N-[2-溴-4-(全氟丙烷-2-基)-6-(三氟甲氧基)苯基]-3-[N-(环丙甲基)苯甲酰胺基]-4-氟苯甲酰胺(4b)、N-(2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)-3-(N-(环丙基甲基)苯甲酰胺基)-2-氟苯甲酰胺(4h)、N-[2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基]-3-[4-氰基-N-(环丙基甲基)苯甲酰胺]-2-氟苯甲酰胺(4j)~N-(3-((2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)氨基甲酰基)-2-氟苯基)-N-(环丙基甲基)异烟酰胺(4o)、N-(3-((2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)氨基甲酰基)-2-氟苯基)-N-(环丙基甲基)-2,4-二氟苯甲酰胺(4q)和N-(3-((2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)氨基甲酰基)-2-氟苯基)-N-(环丙基甲基)-2-氟异烟酰胺(4t)在1mg/l浓度下显示出100%的杀虫活性.同时,化合物4a不仅对小菜蛾和二化螟的杀虫活性接近于环丙氟虫胺,而且对苜蓿蚜和朱砂叶螨的杀虫活性也较高,表现出比环丙氟虫胺更广的杀虫谱,其田间试验正在进行中.

关键词：双酰胺化合物合成杀虫活性构效关系

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