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liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

World Journal of Hepatology 2024年第6期16卷 920-931页

作者： De-liang Huang Qin-xian cai Guang-De Zhou Hong Yu Zhi-Bin Zhu Jing-Han Peng Jun Chen Department of liver Diseases The Third People’s Hospital of ShenzhenShenzhen 510000Guangdong ProvinceChina Department of Pathology Beijing Youan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology National Clinical Research Centre for Infectious DiseaseThe Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously *** To assess the liver histological changes in the indeterminate phase CHB patients using liver *** The clinical and laboratory data of 1532 untreated CHB patients were collected,and all patients had least once liver biopsy from January 2015 to December *** significant differences among different phases of CHB infection were compared with t-test,and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression *** Among 1532 untreated CHB patients,814(53.13%)patients were in the indeterminate *** liver histological changes(defined as biopsy score≥G2 and/or≥S2)were found in 488/814(59.95%)CHB patients in the indete-rminate *** liver histological changes were significant differences among different age,platelets(PlTs),and alanine aminotransferase(AlT)subgroup in indeterminate *** logistic regression analysis indicated that age≥40 years old[adjust odd risk(aOR),1.44;95%confidence interval(CI):1.06-1.97;P=0.02],PlTs≤150×10^(9)/l(aOR,2.99;95%CI:1.85-4.83;PlT≥upper limits of normal(aOR,1.48;95%CI:1.08,2.05,P=0.0163)were independent risk factors for significant liver histological changes in CHB patients in the indeterminate *** Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase,and additional strategies are urgently required for the management of these patients.

关键词： Chronic hepatitis B Indeterminate phase Gray-zone liver biopsy Pathological histology Risk factors

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A study on wildfire impacts on greenhouse gas emissions and regional air quality in South of Orléans,France

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Journal of Environmental Sciences 2024年第1期135卷 521-533页

作者： Chaoyang xue Gisèle Krysztofiak Yangang Ren Min cai Patrick Mercier Frédéric le Fur Corinne Robin Benoit Grosselin Véronique Daele Max RMcGillen Yujing Mu Valéry Catoire Abdelwahid Mellouki laboratoire de Physique et Chimie de l’Environnement et de l’Espace(lPC2E) CNRS–UniversitéOrléans–CNES(UMR 7328)Orléans Cedex 245071France Institut de Combustion AérothermiqueRéactivitéEnvironnement(ICARE)CNRSOrléans Cedex 245071France Research Centre for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China lig’Air-Association de surveillance de la qualitéde l’air en région Centre-Val de loire Saint-Cyr-en-Val 45590France Mohammed V University RabatMorocco

Wildfire events are increasing globally which may be partly associated with climate change,resulting in significant adverse impacts on local,regional air quality and global *** September 2020,a small wildfire(burned area:36.3 ha)event occurred in Souesmes(loiret-Cher,Sologne,France),and its plume spread out over 200 km on the following day as observed by the MODIS *** on measurements at a suburban site(~50 km northwest of the fire location)in Orléans and backward trajectory analysis,young wildfire plumes were *** increases in gaseous pollutants(CO,CH_(4),N_(2)O,VOCs,etc.)and particles(including black carbon)were found within the wildfire plumes,leading to a reduced air *** factors,defined as EF(x)=Δx/ΔCO(where,x represents the target species),of various trace gases and black carbon within the young wildfire plumes were determined accordingly and compared with previous *** in the ambient ions(such as ammonium,sulfate,nitrate,chloride,and nitrite in the particle-and gasphase)and aerosol properties(e.g.,aerosol water content,aerosol p H)were also quantified and ***,we estimated the total carbon and climate-related species(e.g.,CO_(2),CH_(4),N_(2)O,and BC)emissions and compared them with fire emission *** biomass burning emission inventories have uncertainties in estimating small fire burned areas and *** instance,we found that the Global Fire Assimilation System(GFAS)may underestimate emissions(e.g.,CO)of this small wildfire while other inventories(GFED and FINN)showed significant *** that it is the first time to record wildfire plumes in this region,related atmospheric implications are presented and discussed.

关键词： Wildfire Air quality Emission factor Emission inventory VOlTAIRE supersite

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High critical current density in li_(6.4)la_(3)Zr_(1.4)Ta_(0.6)O_(12) electrolyte via interfacial engineering with complex hydride

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Rare Metals 2024年第2期43卷 692-701页

作者： Ying-Tong lv Teng-Fei Zhang Zhao-Tong Hu Guang-lin xia Ze-Ya Huang Zhen-Hua liu li-Hua Que cai-Ting Yuan Fang-Qin Guo Takayuki Ichikawa xue-Bin Yu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China Centre for Hydrogenergy College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing210016China Department of Materials Science Fudan UniversityShanghai200433China Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-Hiroshima739-8527Japan

Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and ***,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical ***,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which li_(6.4)la_(3)Zr_(1.4)Ta_(0.6)O_(12)(llZTO)was simply coated with complex hydride(li_(4)(BH_(4))_(3)I(3l1l))in various mass ratios n(li_(4)(BH_(4))_(3)I)-(100−n)llZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable li/llZTO interface,which would promote the development of solid-state batteries.

关键词： Hydrides li_(6.4)la_(3)Zr_(1.4)Ta_(0.6)O_(12)(llZTO) Critical current density Solid-state electrolytes(SSEs) lithium-sulfur batteries

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Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2554-2566页

作者： Jingyi Tan Jiayu Zhang Cheng Hu Gongwei Wang Qianyao Ren Chaoqun Wang Jia Dan Zexin Zeng Jun Hu Wenbo Zhu Jiankai liang Jing cai Ying liu Guangmei Yan Yuan lin Department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510655China Department of Urology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Advanced Medical Technology Center the First Affiliated Hospital-Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key laboratory of Human Microbiome and Elderly Chronic Diseases Ministry of EducationGuangzhou 510655China Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer *** traditional drugs composed of non-replicating compounds or biomolecules,the replicative nature of viruses confer unique pharmacokinetic properties that require further *** some pharmacokinetics studies of OVs,mechanistic insights into the connection between OV pharmacokinetics and antitumor efficacy remain ***,we characterized the pharmacokinetic profile of oncolytic virus M1(OVM)in immunocompetent mouse tumor models and identified the JAK-STAT pathway as a key modulator of OVM *** suppressing the JAK-STAT pathway,early OVM pharmacokinetics are ameliorated,leading to enhanced tumor-specific viral accumulation,increased AUC and Cmax,and improved antitumor *** than compromising antitumor immunity after JAK-STAT inhibition,the improved pharmacokinetics of OVM promotes T cell recruitment and activation in the tumor microenvironment,providing an optimal opportunity for the therapeutic outcome of immune checkpoint blockade,such as *** together,this study advances our understanding of the pharmacokinetic-pharmacodynamic relationship in OV therapy.

关键词： Pharmacokinetics Oncolytic virus JAK-STAT Anticancer

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Clinical efficacy of gamma-oryzanol combined with Femoston for perimenopausal syndrome

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World Journal of Clinical Cases 2024年第22期12卷 4992-4998页

作者： Yang-Yang Kuang Min-Qi xiong Jin-xia cai Women's Health Management Center Jiujiang Maternal and Child Health HospitalJiujiang 332000Jiangxi ProvinceChina

BACKGROUND Perimenopausal syndrome(PMS)is a chronic disease associated with estrogen *** of the unsatisfactory outcomes of current conventional treatments for this condition,its treatment must be continuously explored and *** To assess the clinical effectiveness ofγ-oryzanol in combination with Femoston for *** A total of 119 patients with PMS were selected from June 2023 to December 2023,which included 59 and 60 patients in the control and observation group,*** control and observation groups were treated with Femoston andγ-oryzanol+Femoston,*** analyses were performed in terms of clinical effectiveness,safety(dizziness and headache,nausea and vomiting,and breast tenderness),sex hormones[estradiol(E2),luteinizing hormone(lH),and follicle-stimulating hormone(FSH)],lumbar spine(l1-4)and bilateral femoral bone mineral density(BMD),and sleep quality(sleeping time and frequency of awakenings from sleep).RESUlTS Compared with the control group,the observation group had statistically higher total effective rates of treatment;lower overall incidence of adverse events;higher post-treatment E2 levels and l1-4 and bilateral femoral BMD;and lower lH and FSH levels,sleeping time,and frequency of awakenings from sleep after *** Therefore,for the treatment of PMS,γ-oryzanol combined with Femoston is significantly better than Femoston alone in terms of clinical effectiveness,exhibiting more pronounced clinical advantages in improving safety,sex hormone levels,BMD,and sleep quality.

关键词： γ-oryzanol Femoston Perimenopausal syndrome Clinical effectiveness Adverse reactions

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厚松散层矿区开采沉陷拉伸区域土体内部变形演化规律研究——以淮北孙疃煤矿为例

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煤炭科学技术 2024年第8期52卷 36-49页

作者：蔡毅沈华章黄厚旭严家平蔡国军蔡永祥杨博孙斌杨安徽建筑大学土木工程学院安徽合肥230601 安徽建筑大学安徽省智能地下探测技术研究院安徽合肥230601 安徽理工大学空间信息与测绘工程学院安徽淮南232001 安徽理工大学地球与环境学院安徽淮南232001

为了研究厚松散层矿区开采沉陷拉伸区域相应土体内部变形演化规律,针对淮北孙疃煤矿10111,沿垂直于工作面推进方向,于拟采空区地表投影区域外侧(拉伸区域)以60 m间隔由近及远布设1~3号竖向钻孔;采煤沉陷过程中基于光纤(1号钻孔)、测斜仪... 详细信息

为了研究厚松散层矿区开采沉陷拉伸区域相应土体内部变形演化规律,针对淮北孙疃煤矿10111,沿垂直于工作面推进方向,于拟采空区地表投影区域外侧(拉伸区域)以60 m间隔由近及远布设1~3号竖向钻孔;采煤沉陷过程中基于光纤(1号钻孔)、测斜仪(2~3号钻孔)技术开展钻孔变形监测;将煤炭开采引发移动的上覆岩层与松散层所占区域视为变形区,并引入任意厚度地层移动角的概念,分析开采沉陷拉伸区域相应松散层变形演化特征。结果表明:1号钻孔发生应变的最大孔深约157 m,且钻孔深部较浅部先达到活跃期;2、3号钻孔孔口最终累计水平位移量分别为129.8 mm和99.4 mm,最大位移深度分别约为108 m和75 m;2、3号钻孔监测范围内地层从下至上均可分为稳定段、变形区下段、中段与上段;2、3号钻孔从下至上水平位移量总体分布较均匀,每米深钻孔的平均水平位移量分别约为1.2 mm和1.3 mm;2、3号钻孔变形区下段均先于上段达到活跃期,且变形区下段稳定后上段仍有微弱变形;松散层内一定厚度地层,其地层移动角随地层深度的增加而增加,松散层变形区下边界的深度h随着与工作面水平距离l的增加而减小,h与l满足指数函数关系。

关键词：厚松散层矿区拉伸区域土体内部变形光纤监测钻孔测斜

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Morphology Control and Optical Absorption Properties of Ag Nanoparticles by Ion Implantation

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Journal of Materials Science & Technology 2009年第5期25卷 669-672页

作者： G.x. cai F. Ren x.H. xiao l.x. Fan x.D. Zhou C.Z. Jiang Key laboratory of Acoustic and Photonie Materials and Devices of Ministry of Education Wuhan University Wuhan 430072 China

Ion implantation is a powerful method for fabricating nanoparticles in dielectric. For the actual application of nanoparticle composites, a careful control of nanoparticles has to be achieved. In this letter, the size, distribution and morphology of Ag nanoparticles are controlled by controlling the ion current density, ion implantation sequence and ion irradiation dose. Single layer Ag nanoparticles are formed by Ag^＋ ion implantation at current density of 2.5 μ^A/cm2. By Ag and Cu ions sequential implantation, the size of single layer Ag nanoparticles increases. While, by Cu and Ag ions sequential implantation, uniform Ag nanoparticles with wide distribution are formed. The morphology of Ag nanoparticles changes to hollow and sandwiched nanoparticles by Cu^＋ ion irradiation to doses of 3×10^16 and 5×10^16 ions/cm^2. The optical absorption properties of Ag nanoparticles are also tailored by these ways.

关键词： Nanoparticles Ion implantation Transmission electron microscopy

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基于改进YOlOv5l的田间水稻稻穗识别

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华南农业大学学报 2024年第1期45卷 108-115页

作者：蔡竹轩蔡雨霖曾凡国岳学军华南农业大学电子工程学院/人工智能学院广东广州510642

【目的】引入YOlOv5l算法模型并对其进行改进,以实现大田环境下水稻稻穗的精准、高效、无损检测。【方法】以田间水稻为研究对象,通过数码单镜反光相机采集水稻图像样本,人工标注后对原始图像进行离线数据增强扩充,构建田间水稻图像数据... 详细信息

【目的】引入YOlOv5l算法模型并对其进行改进,以实现大田环境下水稻稻穗的精准、高效、无损检测。【方法】以田间水稻为研究对象,通过数码单镜反光相机采集水稻图像样本,人工标注后对原始图像进行离线数据增强扩充,构建田间水稻图像数据集;对YOlOv5l算法进行适应性改进,在空间金字塔池化(Spatial pyramid pooling,SPP)层前以及Cross-stage-sartial-connections(CSP)层中置入有效通道注意力(Efficient channel attention,ECA)机制,并进行对比试验。选取最优算法作为基准模型进行注意力机制和数据增强消融试验,并测试得到性能最优模型。将改进YOlOv5l与YOlOv5l、YOlOv5x、SSD和Faster R-CNN进行对比试验。【结果】在改进YOlOv5l的水稻识别框架中,将ECA置入网络SPP层前有更出色的性能。利用测试集图像检验模型,识别结果的平均精确率为93.63%,平均召回率为90.94%,总体平均精度可达95.05%。与未融合YOlOv5l算法相比,改进的YOlOv5l算法平均精度高3.03个百分点,图像的检测速率快8.20帧/ms;与YOlOv5x算法相比,改进的YOlOv5l算法平均精度提高0.62个百分点,图像的检测速率快5.41帧/ms,内存占用减少74.1MB,在田间水稻稻穗检测方面,改进YOlOv5l算法的综合性能优于其他算法。【结论】将改进后的YOlOv5l算法引入大田环境下的水稻稻穗检测是可行的,具有较高的精确率、较快的检测速度和较小的内存占用,能够避免传统人工检测的主观性,对稻穗检测和水稻的无损估产具有重要意义。

关键词：水稻估产稻穗检测 YOlOv5l ECA 注意力机制

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Effect of rolling ratios on the microstructural evolution and corrosion performance of an as-rolled Mg-8wt.%li alloy

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Journal of Magnesium and Alloys 2021年第2期9卷 560-568页

作者： B.J.Wang D.K.xu x.cai Y.x.Qiao l.Y.Sheng School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Key laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiangChina Peking University Shenzhen InstituteShenzhen Key Lab Human Tissue Regenerate&RepairShenzhen 518057China

In this work,the influence of rolling ratios on microstructural changes and corrosion behavior of an as-rolled Mg-8 wt.%li alloy in0.1 mol/l Na Cl solution has been *** revealed that with the rolling ratio being increased from 3 to 10,theα-Mg phases were elongated and fragmented,whilst the area fraction of exposedβ-li phases ***,the corrosion performance of the alloy decreased with the increased rolling *** all the samples,their corrosion processes were quite similar and can have two *** the initial stage with the samples being immersed for less than 6 h,the corrosion mainly occurred inβ-li *** the samples were immersed for longer than 6 h,the corrosion attack transferred toα-Mg phases and the hydrogen evolution rate was accelerated.

关键词： Mg-li alloys Wrought Microstructure Corrosion performance

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基于理性扩展热力学的l-S热声弹性理论框架

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吉林大学学报(地球科学版) 2024年第2期54卷 655-687页

作者：李元燮刘财吉林大学地球探测科学与技术学院

本文基于连续介质力学和理性扩展热力学分析流程,将l-S(lord and Shulman)热弹性理论与声弹性理论相结合,建立l-S热声弹性理论的基本框架,包括运动学、力学与热力学、本构方程与演化方程、基本场方程四部分。在运动学部分,区分了lagrang... 详细信息

本文基于连续介质力学和理性扩展热力学分析流程,将l-S(lord and Shulman)热弹性理论与声弹性理论相结合,建立l-S热声弹性理论的基本框架,包括运动学、力学与热力学、本构方程与演化方程、基本场方程四部分。在运动学部分,区分了lagrange描述和Euler描述,以及3种不同的状态和构形,同时针对热声弹性情况定义了两类从自然状态到初始状态的转变过程;在力学与热力学部分,给出了质量守恒定律、动量守恒定律、角动量守恒定律、能量守恒定律以及熵产不等式,从而引出经典不可逆热力学的局限性;在本构方程与演化方程部分,介绍了扩展不可逆热力学原理,并基于理性扩展热力学流程,推导了从自然状态到初始状态、从初始状态到最终状态的热声弹性本构方程与演化方程,将热流作为本构自变量并考虑了热流与应变和温度的相关性;在最后一部分给出了基本场方程的运动方程形式和适用于数值模拟的一阶速度-应力-热流-温度微分方程。

关键词： l-S理论热弹性声弹性连续介质力学理性扩展热力学

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