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FHl2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China life Sciences 2025年

作者： Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling lü Qian Ren Fei liu Song Chen Fengxia Ma Tao Cheng Hui Cheng State Key laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHl2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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Ten-Year Climatological Features and Air Origin of Midlatitude Double Tropopauses

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Advances in Atmospheric Sciences 2015年第12期32卷 1592-1602页

作者： wu Xue lü Daren Key laboratory for Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of Sciences

The 10-year climatological features related to midlatitude double tropopause events （DTs） are examined using ERA- Interim data from 2003 to 2012. The analysis is based on tropopauses defined by lapse rate. Results show that DTs are permanent or semi-permanent in the midlatitudes, and high DT frequency bands move poleward in winter and equatorward in summer, which is consistent with the seasonal movement of the subtropical jet. Based on our statistics, the second tropopause is found at about 100 hPa in the subtropics and at slightly lower altitudes in sub-polar regions. The thickness between the first and second tropopause is smaller in the subtropics and increases with latitude. Next, the origin of air sandwiched between the first and second tropopause of DTs is studied with a revised version of the UK Universities Global Atmospheric Modelling Programme Offline Trajectory Code （Version 3） diabatic trajectory model. The results show that, in the lower or middle troposphere, air is transported into the DTs from lower latitudes, mainly in the tropics. The dominant source regions are mainly areas of deep convection and steep orography, e.g., the western Pacific and Himalayan Mountains, and they show strong seasonality following the seasonal shift of these strong upwelling regions.

关键词： double tropopause trajectory model stratosphere-troposphere exchange

Substrate concentration effect on gene expression in genetic circuits with additional positive feedback

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Science China(Technological Sciences) 2018年第8期61卷 1175-1183页

作者： wu lulu WANG Pei lü JinHu Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences School of Mathematics and Statistics Henan University School of Automation Science and Electrical Engineering State Key Laboratory of Software Development Environment and Beijing Advanced Innovation Center for Big Data and Brain Machine Intelligence Beihang University

In gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation loops, auto-activation loops are ubiquitous regulatory motifs. This paper aims to investigate a two-component dual-positive feedback genetic circuit, which consists of a double negative feedback circuit and an additional positive feedback loop(APFl). We study effect of substrate concentration on gene expression in the single and the networked systems with APFls, respectively. We find that substrate concentration can tune stochastic switch behavior in the signal system and then we explore relationship of substrate concentration with positive feedback strength in aspect of stochastic switch behavior. Furthermore, we also discuss gene expression and stochastic switch behavior in the networked systems with APFls. Based on analysis in the networked systems, we discover that genes express in some specific cells and do not express in the other cells when the expression achieves its steady state. These results can be used to well explain the character of regionalization in the expression of genes and the phenomenon of gene differentiation.

关键词： substrate concentration additional positive feedback loop stochastic switch behavior gene expression gene differ-entiation

Microstructure and Properties of In Situ Si and Fe-rich Particles Reinforced Al Matrix Composites Assisted with Ultrasonic Vibration

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Acta Metallurgica Sinica(English letters) 2014年第5期27卷 862-868页

作者： Shulin lü Shusen wu Chong lin Ping An State Key laboratory of Materials Processing and Die & Mould Technology Huazhong University of Science and Technology

In this research, the in situ Si and Fe-rich particles reinforced Al matrix composites were fabricated by rheocasting （RC） process assisted with ultrasonic vibration （USV）. After USV treatment, the polygonal primary Si crystals were refined into particles with average diameter of about 15-23 μm, and the fraction of primary Si declined to about 5.4-6.5 vol%. The coarse plate-like δ-Al4（Fe,Mn）Si2 phase was transformed into fine particles with average diameter of about 17-20 μm, and the fraction of particle-like Fe-bearing particles is about 3.6-5.3 vol%. The ultimate tensile strength of the RC composites increases with the increase of Fe content at 350 ℃. The increase of the elevated temperature strength of the composites is mainly attributed to the refinement of δ-Al4（（Fe,Mn）Si2 phase and the increase of the volume fraction of the Fe-bearing compounds. Compared with the composites without USV, the RC composites assisted with USV have thinner mechanical mixing layer in wear test, which corresponds to smaller wear rate.

关键词： Fe-bearing phase Metal matrix composites Microstructure Properties Ultrasound

Effects of high-pressure rheo-squeeze casting on the Fe-rich phases and mechanical properties of Al-17Si-(1,1.5)Fe alloys

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International Journal of Minerals,Metallurgy and Materials 2018年第9期25卷 1018-1026页

作者： Chong lin Shu-sen wu Shu-lin lü Ping An He-bao wu State Key laboratory of Materials Processing and Die & Mould Technology Huazhong University of Science and Technology Hubei Provincial Key laboratory of Chemical Equipment Intensification and Intrinsic Safety Wuhan Institute of Technology

The effects of high pressure rheo-squeeze casting(HPRC) on the Fe-rich phases(FRPs) and mechanical properties of Al-17 Si-(1,1.5)Fe alloys were investigated. The alloy melts were first treated by ultrasonic vibration(UV) and then formed by high-pressure squeeze casting(HPSC). The FRPs in the as-cast HPSC Al-17 Si-1 Fe alloys only contained a long, needle-shaped β-Al5 Fe Si phase at 0 MPa. In addition to the β-Al5 Fe Si phase, the HPSC Al-17 Si-1.5 Fe alloy also contained the plate-shaped δ-Al4 Fe Si2 phase. A fine, block-shaped δ-Al4 Fe Si2 phase was formed in the Al-17 Si-1 Fe alloy treated by UV. The size of FRPs decreased with increasing pressure. After UV treatment, solidification under pressure led to further refinement of the FRPs. Considering alloy samples of the same composition, the ultimate tensile strength(UTS) of the HPRC samples was higher than that of the HPSC samples, and the UTS increased with increasing pressure. The UTS of the Al-17 Si-1 Fe alloy formed by HPSC exceeded that of the Al-17 Si-1.5 Fe alloy formed in the same manner under the same pressure. Conversely, the UTS of the Al-17 Si-1 Fe alloy formed by HPRC decreased to a value lower than that of the Al-17 Si-1.5 Fe alloy formed in the same manner.

关键词： high pressure rheo-squeeze casting Al-17Si-(1,1.5)Fe alloys Fe-rich phases mechanical properties

Neutron Star Magnetic Field as for Nonzero Photon Mass

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Communications in Theoretical Physics 2005年第4期43卷 704-708页

作者： WANGQing-wu lǖXiao-Fu DepartmentofPhysics SichuanUniversityChengdu610064China DepartmentofPhysics SichuanUniversityChengdu610064China／／CCAST（WorldLaboratory）P.O.Box8730Beijing100080China／／InstituteofTheoreticalPhysicsAcademiaSinicaP.O.Box2735Beijing100080China

We investigate the neutron star magnetic field by the relative mean-field theory, where the photon effective mass depending on baryon density of charged particles is nonzero. This field is produced by star itself, whi... 详细信息

关键词： effective photon mass Fermi momentum beta-equilibrium

The Selberg-Delange method in short intervals with some applications

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Science China Mathematics 2019年第3期62卷 447-468页

作者： Zhen Cui Guangshi lü Jie wu Department of Mathematics Shanghai Jiao Tong University School of Mathematics Shandong University School of Mathematics and Statistics Yangtze Normal University InstitutElie Cartan de lorraine Université de Lorraine

In this paper, we establish a quite general mean value result of arithmetic functions over short intervals with the Selberg-Delange method and give some applications. In particular, we generalize Selberg's result on the distribution of integers with a given number of prime factors and Deshouillers-Dress-Tenenbaum's arcsin law on divisors to the short interval case.

关键词： asymptotic results on arithmetic functions Selberg-Delange method arithmetic functions distribution of integers

Retrieval of Vertical Distribution of Tropospheric Refractivity through Ground-Based GPS Observation

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Advances in Atmospheric Sciences 2014年第1期31卷 37-47页

作者： wu Xue WANG Xin l Daren Key laboratory for Atmosphere and Global Environment Observation Institute of Atmospheric Physics Chinese Academy of Sciences University of the Chinese Academy of Sciences

In the present reported study, the vertical distributions of local atmospheric refractivity were retrieved from ground- based GPS observations at low elevation angles. An improved optimization method was implemented at altitudes of 0-10 km to search for a best-fit refractivity profile that resulted in atmospheric delays most similar to the delays calculated from the observations. A ray-tracing model was used to simulate neutral atmospheric delays corresponding to a given refractivity profile. We initially performed a ＂theoretical retrieval＂, in which no observation data were involved, to verify the optimization method. A statistical relative error of this ＂theoretical retrieval＂（-2% to 2%） indicated that such a retrieval is effective. In a practical retrieval, observations were obtained using a dual-frequency GPS receiver, and its initial value was provided by CIRA86aQ_UoG data. The statistical relative errors of the practical retrieval range from -3% to 5% were compared with co-located radiosonde measurements, Results clearly revealed diurnal variations in local refractivity prc,files, The results also suggest that the general vertical distribution of refractivity can be derived with a high temporal resolution. However, further study is needed to describe the vertical refractivity gradient clearly.

关键词： Global Positioning System (GPS) refractivity atmospheric delay ray-tracing exhaustive search

Modified sequential importance resampling filter

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Journal of Systems Engineering and Electronics 2015年第3期26卷 441-449页

作者： Yong wu Jun Wang Xiaoyong l Yunhe Cao National lab of Radar Signal Processing Xidian University

In order to deal with the particle degeneracy and impov- erishment problems existed in particle filters, a modified sequential importance resampling （MSIR） filter is proposed. In this filter, the resampling is translated into an evolutional process just like the biological evolution. A particle generator is constructed, which introduces the current measurement information （CMI） into the resampled particles. In the evolution, new particles are first pro- duced through the particle generator, each of which is essentially an unbiased estimation of the current true state. Then, new and old particles are recombined for the sake of raising the diversity among the particles. Finally, those particles who have low quality are eliminated. Through the evolution, all the particles retained are regarded as the optimal ones, and these particles are utilized to update the current state. By using the proposed resampling approach, not only the CMI is incorporated into each resampled particle, but also the particle degeneracy and the loss of diver- sity among the particles are mitigated, resulting in the improved estimation accuracy. Simulation results show the superiorities of the proposed filter over the standard sequential importance re- sampling （SIR） filter, auxiliary particle filter and unscented Kalman particle filter.

关键词： sequential importance resampling (SIR) evolution,current measurement information (CMI) unbiased estimation.