检索结果-南通市图书馆

spatial analysis of Dengue through the reproduction numbers relating to socioeconomic features:Case studies on two Brazilian urban centers

引用

Infectious Disease Modelling 2024年第1期9卷 142-157页

作者： Ana T.C.silva rejane C.Dorn l.via r.tomás leonardo B.l.santos lacita M.skalinski suani T.r.Pinho Departamento de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil Centro Nacional de Monitoramento e Alertas de Desastres Naturais(CEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Estadual de santa Cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de saúde Coletiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional de Ciência e Tecnologia-sistemas Complexos Virtual InstitutionBrazil

The study of the propagation of infectious diseases in urban centers finds a close connection with their population's social characteristics and *** work performs a spatial analysis of dengue cases in urban centers based on the basic reproduction numbers,r0,and incidence by planning areas(PAs),as well as their correlations with the Human Development Index(HDI)and the number of *** analyzed dengue epidemics in 2002 at two Brazilian urban centers,Belo Horizonte(BH)and rio de Janeiro(rJ),using PAs as spatial *** results reveal heterogeneous spatial scenarios for both cities,with very weak correlations between r0 and both the number of trips and the HDI;in BH,the values of r0 show a less spatial heterogeneous pattern than in *** BH,there are moderate correlations between incidence and both the number of trips and the HDI;meanwhile,they weakly correlate for ***,the absence of strong correlations between the considered measures indicates that the transmission process should be treated considering the city as a whole.

关键词： Dengue Mathematical mode lBasic reproduction number Urban mobility Urban indices

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Porphyrinic Acceptors forFullerene-Free MolecularPhotovoltaics

引用

CCs Chemistry 2024年第2期6卷 276-296页

作者： Jorge labella Juan laforga-Martin tomás Torres Department of Organic Chemistry Universidad Aut´onoma de Madrid28049 Madrid Institute for Advanced research in Chemical sciences Universidad Aut´onoma de MadridMadrid IMDEA—Nanociencia 28049 Madrid

Over the past few years,the development of nonfullerene acceptors(NFAs)has become a prominent focus in both organic and perovskite solar cell(OsCs and PsCs,respectively)research *** this context,porphyrinoids,compounds structurally related to porphyrins,have emerged as promising solar cell *** contrast to the widely used fullerene acceptors,porphyrinoids exhibit strong,broad absorption properties across the UV–vis/NIr spectrum,which can be easily tuned through chemical ***,they can be prepared and derivatized using cost-effective and straightforward methodologies,allowing for convenient adjustments in thin-film morphology,processability,supramolecular organization,and energy ***,these compounds offer higher thermal and photochemical stability,resulting in longer device lifetimes compared to their fullerene-based *** this review,we outline the utilization of porphyrinoids as NFAs in OsCs and PsCs,discussing essential aspects such as design guidelines,molecular properties,and device *** goal is to inspire and further promote the development of n-type porphyrinoids,which have not yet fully unleashed their potential.

关键词： fullerene-free molecular photovoltaics nonfullerene acceptors porphyrinic acceptors n-type porphyrinoids organic and perovskite solar cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomass gasification,catalytic technologies and energy integration for production of circular methanol:New horizons for industry decarbonisation

引用

Journal of Environmental sciences 2024年第6期140卷 306-318页

作者： luis F.Bobadilla lola Azancot Miriam González-Castañ Estela ruíz-lópez laura Pastor-Pérez Francisco J.Durán-Olivencia runping Ye Katie Chong Paula HBlanco-sánchez Zenthao Wu tomás r.reina JoséA.Odriozola Departamento de Química Inorgánica e Instituto de Ciencia de Materiales de sevilla Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departamento de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key laboratory of Jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts research Institute(EBrI) Aston UniversityBirminghamB47ETUnited Kingdom Department of Chemical and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernmental Panel on Climate Change(IPCC)recognises the pivotal role of renewable energies in the future energy system and the achievement of the zero-emission *** implementation of renewables should provide major opportunities and enable a more secure and decentralised energy supply *** fuels provide long-term solutions for the transport sector,particularly for applications where fuels with high energy density are *** addition,it helps reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential for scaling-up gasification from the laboratory to *** review deals with the transformation biogenic residues into a valuable bioenergy carrier like biomethanol as the liquid sunshine based on the combination of modified mature technologies such as gasification with other innovative solutions such as membranes and microchannel *** abatement is a critical process in product gas upgrading since tars compromise downstream processes and equipment,for this,membrane technology for upgrading syngas quality is discussed in this *** reactor technology with the design of state-of-the-art multifunctional catalysts provides a path to develop decentralised biomethanol synthesis from biogenic ***,the development of a process chain for the production of(i)methanol as an intermediate energy carrier,(ii)electricity and(iii)heat for decentralised applications based on biomass feedstock flexible gasification,gas upgrading and methanol synthesis is analysed.

关键词： Biogenic residues Gasification Biomethanol Circular Economy Microreactors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

引用

Neural regeneration research 2025年第2期20卷 394-401页

作者： Josep tomàs Víctor Cilleros-Mañé laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk laura Nadal Marta tomàs Carolina silvera-simón Manel M.santafé Maria A.lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTr pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through l-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

引用

Journal of sport and Health science 2024年第3期13卷 398-408页

作者： Pedro l.Valenzuela Alfredo santalla lidia B.Alejo Andrea Merlo Asuncion Bustos laura Castellote-Belles roser Ferrer-Costa Nicola A.Maffiuletti David Barranco-Gil tomas Pinos Alejandro lucia Physical Activity and Health research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of systems Biology University of AlcalaMadrid 28871Spain Department of sport and Computer science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPrED research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of sport sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance lab Schulthess ClinicZurich 8008Switzerland Biomedical research Networking Center on rare Disorders(CIBErEr) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/l).results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all pred endurance exercise capacity(-51%ventilatory threshold and55%peak power output,both pregardless of the CHO dose(pr both doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis Nutrition supplement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

引用

Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin lei Daniël C.de Groot Marij J.P.Welters tom de Wit Ellen schrama Hans van Eenennaam saskia J.santegoets Timo Oosenbrug Annemarthe van der Veen Joris l.Vos Charlotte l.Zuur Noel F.C.C.de Miranda Heinz Jacobs sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOs B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTl)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the sTING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTl anticancer *** cooperation with CD40 ligand(l),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTl response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTls locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTl priming Tumor control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket

引用

synthetic and systems Biotechnology 2024年第2期9卷 380-387页

作者： Xinye Wang Yiyi Huang Weiyan Zhang Kangjie lv Xiaoying li Zhixin Wang li Zhang tom Hsiang lixin Zhang liming Ouyang Xueting liu state Key laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Department of Chemistry Boston UniversityBostonMAUSA school of Environmental sciences University of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada

Fungal bifunctional terpene synthases(BFTss)catalyze the formation of numerous di-/sester-/tri-terpenes ***,the mechanism in controlling the cyclization pattern of terpene scaffolds is rarely deciphered for further application of tuning the catalytic promiscuity of terpene synthases for expanding the chemical *** this study,we expanded the catalytic promiscuity of Fusarium oxysporum fusoxypene synthase(FoFs)by a single mutation at l89,leading to the production of three new *** computational analysis revealed that the reconstitution of the hydrogen-bond(H-bond)network of second-shell residues around the active site of FoFs influences the orientation of the aromatic residue W69 within the first-shell catalytic ***,the dynamic orientation of W69 alters the carbocation transport,leading to the production of diverse ring system *** findings enhance our knowledge on understanding the molecular mechanisms,which could be applied on protein engineering terpene synthases on regulating the terpene skeletons.

关键词： Bifunctional terpene synthase sesterterpene Carbocation transportation Density functional theory calculations Molecular dynamics simulations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

引用

Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： shi-Qi Wang Xun Zhao li-Jun Zhang Yue-Mei Zhao lei Chen Jin-lin Zhang Bao-Cheng Wang sheng Tang tom Yuan Yaozuo Yuan Mei Zhang Hian Kee lee Hai-Wei shi Jiangsu Institute for Food and Drug Control Nanjing210019China school of Pharmacy China Pharmaceutical UniversityNanjing211112China school of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China school of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(Ps20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of Ps20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPlC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPlC-Q-TOF-Ms)with an identical gradient as the HPlC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in Ps20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-Ms identified 1329 to 1511 compounds in 4 batches of Ps20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPlC-Q-TOF-Ms results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Importance of the Development of Veterinary Toxicology in Argentina

引用

Biomedical and Environmental sciences 1989年第1期2卷 7-16页

作者： tomás A.lóPEZ Instituto

The different types of toxic substances that affect farm animals in Argentina are described. These substances include (a) toxic plants, such as solanum glaucophyllum. Baccharis coridifolia, Festuca arundinacea; (b) mycotoxins, such as zearalenone, tremorgenic mycotoxins, and ergoalkaloid; (c) trace elements, such as fluorine, copper, molybdenum, and arsenic; and (d) others, such as toxic algae and pesticides. The direct and indirect economic loss of farm animals associated with these toxic substances in Argentina is roughly estimated at 50 million dollars a year. A number of recommendations are made to ameliorate the situation. 1989 Academic Press, Inc.

关键词： In Importance of the Development of Veterinary Toxicology in Argentina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

sex-specific sterility caused by extreme temperatures is likely to create cryptic changes to the operational sex ratio in Drosophila virilis

引用

Current Zoology 2021年第3期67卷 341-343页

作者： Benjamin s.Walsh Natasha l.M.Manimion tom A.r.Price steven r.Parratt Institute of Integrative Biology University of LiverpoolCrown StreetLiverpoolL697ZBUK

Climate change is increasing the frequency and severity of short-term heat shocks that threaten the persistence of natural ***,most work addressing the evolutionary consequences of anthropogenic environmental change has focused on natural selection,with less attention paid to the impacts on sexual *** conditions under which sexual selection operates is a topic of debate,but a generally observed pattern is that the oper-ational sex ratio(Osr)of a population is key to determining both the extent of competition for fertilizations and the scope for mate choice(Weir et al.2011)

关键词： climate change reproduction sexual selection fertility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：