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NANO-MUltIlAYERS WIth hIGh PERPENDICUlAR ANISOtROPY FOR MAGNEtIC RECORDING

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Acta Metallurgica Sinica(English letters) 2003年第4期16卷 261-265页

作者： t.Yang B.h.li DepartmentofMaterialsPhysics UniversityofScienceandTechnologyBeijingBeijing100083China InformationStorageMaterialslaboratory ToyotaTechnologicalInstituteNagoya468-8511JapanManuscriptreceived25November2002

(FePt/Ag)n nano-multilayers were deposited on MgO (100) single crystal with laser ablation and then subjected to annealing. FePt l1o grains with (001) texture and thus a large perpendicular magnetic anisotropy constant Ku of the order of 106 J/m3 were formed. A thick Ag layer is found to be favorable for decreasing the dispersion of the easy axis for magnetization. the measurement of time decay of magnetization gave rise to a small activation volume of the order of 10-25m3, showing the promising of being the recording medium for future high density perpendicular recording.

关键词： recording media perpendicular magnetic anisotropy activation volume

Intermittent fasting boosts antitumor immunity by restricting CD11b^(+)ly6C^(low)ly6G^(low) cell viability through glucose metabolism in murine breast tumor model

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Food Science and human Wellness 2024年第4期13卷 2327-2345页

作者： Chenghao Fu Zhehao liang Zemiao Niu Ning Chen Yuemin li Zhenhua liang Yanwei huo hao Xi Rong Wang Yonghuan Yan Xiaoruo Gan Mengtian Wang Yun huang Yan Zhang Mingming Gao Pin lü Postdoctoral Station for Basic Medicine Cardiovascular Medical Science CenterDepartment of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China hebei Key laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China hebei Food Safety Key laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China laboratory of lipid Metabolism Department of Biochemistry and Molecular BiologyKey Laboratory of Medical Biotechnology of Hebei ProvinceShijiazhuang 050017China

Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or ***,it is still uncertain how to select immunotherapy drugs to combine with intermittent *** we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis,as well as prolonged overall survival in mice bearing 4t1 and 4t07 breast *** this process,both the immunosuppressive monocytic-(M-)and granulocytic-(G-)myeloid-derived suppressor cell(MDSC)decreased,accompanied by an increase in interleukin(Il)7R^(+)and granzyme B^(+)t cells in the tumor ***,we observed that ly6G^(low)G-MDSC sharply decreased after fasting treatment,and the cell surface markers and protein mass spectrometry data showed potential therapeutic *** investigation revealed that glucose metabolism restriction suppressed the splenic granulocytemonocyte progenitor and the generation of colony-stimulating factors and Il-6,which both contributed to the accumulation of *** the other hand,glucose metabolism restriction can directly induce the apoptosis of ly6G^(low)G-MDSC,but not ly6G^(high)*** summary,these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3^(+)t cells,providing potential solutions for enhancing immune-based cancer interventions.

关键词： Intermittent fasting ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction

Sc元素添加对双辊铸轧Al−Cu−li−Mg−Zr基合金热处理的影响

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transactions of Nonferrous Metals Society of China 2024年第6期34卷 1759-1773页

作者： Rostislav KRÁlÍK Barbora KŘIVSKÁ lucia BAJtOŠOVÁ Mykhailo StOlBChENKO Mirko SChAPER Olexandr GRYDIN Miroslav CIESlAR Department of Physics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116PragueCzech Republic Department of Materials Science Faculty of Mechanical EngineeringUniversity of PaderbornWarburger Straße 10033098PaderbornGermany

提出制备含Sc的Al−Cu−li−Mg−Zr基合金带材的工艺方案。即先采用双辊铸轧技术制备近净形状的3 mm厚带材,再对其进行均匀化/固溶处理。研究两种Al−Cu−li−Mg−Zr基双辊铸轧合金,其中一种添加质量分数为0.17%的Sc,另一种未添加Sc。两种合金... 详细信息

提出制备含Sc的Al−Cu−li−Mg−Zr基合金带材的工艺方案。即先采用双辊铸轧技术制备近净形状的3 mm厚带材,再对其进行均匀化/固溶处理。研究两种Al−Cu−li−Mg−Zr基双辊铸轧合金,其中一种添加质量分数为0.17%的Sc,另一种未添加Sc。两种合金均先在300℃下退火30 min,然后在450℃下退火30 min以及530℃下退火30 min,随后进行室温水淬。前两段退火后组织中生成了细小、弥散的Al_(3)Zr/Al_(3)(Sc,Zr)颗粒。最后的退火步骤起到了均匀化/固溶处理的作用。双辊铸轧材料的细小晶粒结构使含有主要合金元素的原始颗粒在较短的退火时间内溶解。缩短保温时间可以限制表面层中li的耗尽和Al_(3)Zr/Al_(3)(Sc,Zr)弥散相的明显粗化。铸态含Sc材料已经具有明显细小的晶粒结构,而经均匀化/固溶处理后生成的Al_(3)(Sc,Zr)弥散相抑制了晶粒在高温下发生粗化。在后续180℃下时效处理后,形成了θʹ(Al_(2)Cu)、t1(Al_(2)Culi)和S'(Al_(2)CuMg)强化相。在峰值时效状态下,屈服强度提高了200 MPa,这一数值与类似直接冷却铸造材料的相当,从而证实了所提方案的合理性。

关键词：显微组织力学性能 Al−Cu−li基合金 Sc合金化双辊铸轧

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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific t-cells regardless of infection history

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Journal of Sport and health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith tiffany M.Zúñiga Forrest l.Baker helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA the University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:the mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific t-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 t-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,t-cell receptor(tCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive t-cells,as well as CD4+central memory t-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific t-cells to blood in an intensity-dependent *** groups mobilized t-cells that reacted to spike protein;however,only the hybrid immunity group mobilized t-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:these data indicate that acute exercise mobilizes SARS-CoV-2 specific t-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 t-Cells Vaccine

A StAtIStICAl INVEStIGAtION OF FAtIGUE CRACK INItIAtION AND GROWth PROCESS BASED UPON A lARGE SAMPlE SIZE EXPERIMENt

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Acta Mechanica Solida Sinica 1996年第1期9卷 1-12页

作者： Min, l Ning, t Yang, QX NORthWEStERN POlYtECh UNIV DEPT AIRCRAFT ENGNXIAN 710072PEOPLES R CHINA

After finishing 102 replicate constant amplitude crack initiation and growth tests on ly12-CZ aluminum alloy plate, a statistical investigation of the fatigue crack initiation and growth process is conducted in this paper. According to the post-mortem fractographic examination by scanning electron microscopy (SEM), some qualitative observations of the spacial correlation among fatigue striations are developed to reveal the statistical nature of material intrinsic inhomogeneity during the crack growth process. From the test data, an engineering division between crack initiation and growth is defined as the upper limit of small crack. the distributions of crack initiation life N-i, growth life N, and the statistical characteristics of crack growth rate da/dN are also investigated. It is hoped that the work will provide a solid test basis for the study of probabilistic fatigue, probabilistic fracture mechanics, fatigue reliability and its engineering applications.

关键词： crack initiation crack growth statistical nature large sample size

兼顾通信效率与效用的自适应高斯差分隐私个性化联邦学习

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计算机学报 2024年第4期47卷 924-946页

作者：李敏肖迪陈律君重庆大学计算机学院重庆400044

近年来,由于联邦学习中的通信参数(或梯度)会给参与方本地敏感数据带来重大的隐私泄露风险,联邦学习隐私保护引起了广泛的关注.然而,梯度交换频繁、数据分布异构、参与方本地硬件资源受限等一系列不可避免的因素给联邦学习隐私保护增加... 详细信息

近年来,由于联邦学习中的通信参数(或梯度)会给参与方本地敏感数据带来重大的隐私泄露风险,联邦学习隐私保护引起了广泛的关注.然而,梯度交换频繁、数据分布异构、参与方本地硬件资源受限等一系列不可避免的因素给联邦学习隐私保护增加了挑战难度.为了以一种统一的方式同时有效地解决数据隐私、模型效用、通信效率以及参与方数据非独立同分布等四个方面的问题,本文提出了一种新的兼顾通信效率与效用的自适应高斯差分隐私个性化联邦学习(Communication-efficient and Utility-aware Adaptive Gaussian Differential Privacy for Personalized Federated learning,CUAG-PFl)方法.具体而言,本文提出一种动态层级压缩模型梯度的方案先为通信模型梯度每一层动态生成特定的压缩率,再根据压缩率构造对应的确定性二进制测量矩阵去除梯度冗余信息.随后,通过同时优化裁剪阈值、敏感度和噪声尺度等隐私相关参数来对压缩的模型梯度执行自适应高斯差分隐私操作.此外,本文对CUAG-PFl进行了严格的隐私分析.为了验证CUAG-PFl在隐私、效用、通信效率以及个性化四个方面的优势,本文在CIFAR-10和CIFAR-100两个真实联邦数据集上进行了大量实验模拟、对比和分析,结果表明CUAG-PFl能够提高参与方本地数据隐私性、通信效率和模型效用,同时解决了数据非独立同分布的问题.特别地,即使在隐私预算仅为0.92且上行通信量减少68.6%时,CUAG-PFl因隐私保护和梯度压缩所引起的模型效用损失仅为1.66%.

关键词：自适应高斯差分隐私隐私-效用权衡动态层级压缩通信高效个性化联邦学习隐私计算

Effect of thermal Refining on Mechanical Properties of Annealed SAE 4130 by Multilayer GtAW

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Journal of Iron and Steel Research International 2012年第7期19卷 71-78页

作者： I K lee C l Chung Y t lee Y t Chien Department of Materials Science and Engineering Da-Yeh University

During the first welding process in manufacturing a precise seam container, the steel material must first undergo a full annealing treatment. Multilayer welding operations are conducted and then applied with refining treatment to obtain the goal by hardening. the influence of thermal refining on mechanical properties of annealed SAE 4130 by multilayer GtAW （gas tungsten arc welding） was discussed. the AW （annealing＋welding） and AWSt （annealing＋welding＋solution＋tempering） occurred with a minimum hardness value at GGhAZ （grain growth heat affected zone） due to coarse grain growth~ the hardness occurred with sudden drops between the multilayer welding, but was still larger than the minimum value at hAZ （heat affected zone）. the welded joint efficiency of the AWSt was 89.9%, with the elongation reduced to 77.2% of ASt （annealing＋solution＋tempering）. the cross section of the tensile samples both appeared with a uniform dimple-shaped structure, and however the necking for ASt was greater than that for AWSt. the impact value for AWSt was 166.5% of ASt. Moreover, from microstructure observations, it was found that AWSt had a greater tendency to ductile failure than ASt. these results can be inferred., the process of steady pressure and the initial position of the precision tube breakage hAZ. however, when stress occurs instantly, hAZ can absorb more energy, therefore the initial damage does not occur.

关键词： thermal refining SAE 4130 multilayer welding GtAW

Formation of β' phase in lPSO structures in an Mg88Co5Y7 alloy

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Journal of Magnesium and Alloys 2022年第1期10卷 175-182页

作者： Q.Q.Jin X.h.Shao Y.t.Zhou B.Zhang S.J.Zheng X.l.Ma Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua Road110016 ShenyangChina Materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China School of Materials Science and Engineering Research Institute for Energy Equipment MaterialsHebei University of TechnologyTianjin 300130China

Formation of β’ phase in long-period stacking ordered(lPSO) structures in an Mg;Co;Y;(at.%) alloy after aging at 200 °C for 24 h or electron beam(EB) irradiation has been studied by high-angle annular dark-field scanning transmission electron microscopy(hAADFStEM). β’ phase was precipitated only in the Mg matrix but not in lPSO structures after aging at 200 °C for 24 h. lPSO structure containing stacking defects transforms into the β’-long phase during EB irradiation, which plays a key role in accelerating solute atoms’ diffusion. New complex β’(lPSO) structures formed in the alloy after EB irradiation, such as β’(12 h) structure with an orthorhombic lattice(Mg;Y, Cmcm,a = 2 _(a0)= 0.642 nm, b=4√3_(a0), c = 6 _(c0)= 3.12 nm).

关键词： Magnesium alloys long-period stacking ordered(lPSO)structure hAADF-StEM β’phase

Plasticity-induced stacking fault behaviors ofγ'precipitates in novel CoNi-based superalloys

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Journal of Materials Science & technology 2021年第31期90卷 20-29页

作者： W.-W.Xu G.h.Yin Z.Y.Xiong Q.Yu t.Q.Gang l.J.Chen School of Aerospace Engineering Xiamen UniversityXiamen 361005China

Implementation of novelγ/γ'Co-based superalloys with higher strength and improved creep durability is a challenging task for *** lack of atomic-level understanding of plastic deformation behavior has seriously limited the exploration of the full capacity of Co-based *** put forward a comprehensive study of generalized stacking fault energies by first principles to explore the effect of Ni and Al/W on the plastic deformation mechanism ofγ'precipitates in Co-based *** is found that alloying Ni and adjusting Al/W obviously change the dislocation glide and twinning nucleation in theγ'precipitates by altering the stable fault energies and the unstable fault energy *** addition of either Ni or W deteriorates the strength even the stability of *** ratio of effective planar fault energy(ΔEp)bridges intrinsic energy barriers and various deformation mechanisms of superalloys at elevated *** for alloying effects,the grain orientation also significantly governs the operation of the plastic deformation of *** theoretical results agree with the available measurements and well capture the observed phenomena in experiments.

关键词： Co-based superalloys Stacking fault energy Creep resistance First-principles method