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Micro RNA expression in hepatitis C virus-related malignancies: A brief review

World Journal of Gastroenterology 2015年第28期21卷 8562-8568页

作者： l.ura gragnani Alessia Piluso Elisa Fognani Anna linda Zignego Center for Systemic Manifestations of Hepatitis Viruses Department of Experimental and Clinical Medicine University of Florence

Not only is chronic hepatitis C virus(HCV) infection a major public health problem,but also it can cause hepatocellular carcinoma and,more rarely,nonHodgkin's *** characteristics mean that HCV is the only virus infecting humans that is able to cause two different *** fine pathogenetic and molecular mechanisms by which HCV induces these two malignancies are not completely *** the last decade,it has been shown that microRNAs(miRNAs),a class of 21-23-nucleotide molecules modulating posttranscriptional gene expression,make an important contribution to the pathogenesis of several cancers and are also considered highly promising ***,we briefly describe the current knowledge about microRNAs' involvement in HCV-related molecular *** decided to focus our attention on studies fully conducted on ex vivo samples with this specific etiology,and on cultured cell lines partially or completely expressing the HCV *** of the results reported in this review are controversial,possibly because of methodological issues,differences in sampling size and features,and ethnicity of *** is certain is that miRNAs play a remarkable role in regulating gene expression during oncogenetic processes and in viral infection.A clear understanding of their effects is fundamental to elucidating the mechanisms underlying virus-induced malignancies.

关键词： MicroRNA Hepatitis C virus Hepatocellularcarcinoma lymphoma

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