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Disparate outcomes in Hispanic patients with metabolic dysfunctionassociated steatotic liver disease/steatohepatitis and type 2 diabetes: large cohort study

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World Journal of Diabetes 2024年第5期15卷 886-897页

作者： Joseph Matthew Gosnell George Golovko esteban Arroyave Akshata Moghe Michael l Kueht Omar AbdulSaldarriaga Kevin H McKinney Heather l Stevenson Monique R Ferguson Department of Pathology University of Texas Medical BranchGalvestonTX 77555United States Department of Pharmacology&Toxicology University of Texas Medical BranchGalvestonTX 77555United States Department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States Department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASlD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient ***,these conditions seem to have disparate rates and outcomes between different ethnic *** combination of MASlD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South *** To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic *** This cohort analysis was conducted with data obtained from TriNetX,llC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations *** cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast *** This study findings revealed Hispanics/latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/latino *** mortality in Hispanics/latinos was lower within the United States group and not statistically elevated in the UTMB *** This would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.

关键词： Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Hispanic Diabetes mellitus TriNetX Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Steatotic liver disease Hepatocellular carcinoma

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Photosynthetic Gas Exchange and Nitrogen Assimilation in Green Bean Plants Supplied with Two Sources of Silicon

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 963-980页

作者： Julio C.Anchondo-Páez esteban Sánchez Carlos A.Ramírez-Estrada Alondra Salcido-Martínez Erick H.Ochoa-Chaparro Department of Plant Physiology Centro de Investigación en Alimentación y DesarrolloCiudad Delicias33089México

Beans contain a wide range of vitamins,proteins,calcium,and zinc which make them an important food source for many *** meet the demand for bean production worldwide,large amounts of fertilizers and pesticides are ***,the cost of production and environmental impact *** produce food sustainably,the use of beneficial nutrients such as silicon as a biostimulant has been ***,information about the effect of different sources of silicon on the metabolism of bean plants is *** plants *** were grown in pots for 60 days and the effect of foliar application of silicon nanoparticles and the silicon-based biostimulant Codasilat 4 concentrations(0,1,2,and 4 mM)on total biomass,yield,photosynthetic pigment concentration,photosynthetic activity,stomatal conductance,transpiration rate,chlorophyll fluorescence,and nitrogen assimilation were *** results obtained showed that the supply of silicon at a dose of 1 mM functioned as a biostimulant,favoring gas exchange and nitrogen assimilation within the plant,which stimulated growth and *** results of this research work allowed a better comprehension of the effects of silicon application through silicon nanoparticles and the biostimulant Codasilon the physiology of green bean plants.

关键词： Nanoparticles silicon Phaseolus vulgaris l.

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A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： Pedro lopez-Gomez Javier Buezo Marina Urra Alfonso Cornejo Raquel esteban Jorge Fernandez de los Reyes Estibaliz urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel Marino Victor Martinez-Merino Jose F.Moran Institute for Multidisciplinary Research in Applied Biology(IMAB) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced Materials and Mathematics(INAMAT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

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Intersections between innate immune response and gastric cancer development

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World Journal of Gastroenterology 2023年第15期29卷 2222-2240页

作者： Franz Villarroel-Espindola Troy Ejsmentewicz Roxana gonzal.z-Stegmaier Roddy A Jorquera esteban Salinas Translational Medicine Unit Instituto Oncologico Fundacion Arturo Lopez PerezSantiago 7500000Metropolitan regionChile

Worldwide,gastric cancer(GC)is the fifth most commonly diagnosed *** has a reduced prevalence but has maintained its poor prognosis being the fourth leading cause of deaths related to *** highest mortality rates occur in Asian and latin American countries,where cases are usually diagnosed at advanced ***,GC is viewed as the consequence of a multifactorial process,involving the virulence of the Helicobacter pylori(***)strains,as well as some environmental factors,dietary habits,and host intrinsic *** tumor microenvironment in GC appears to be chronically inflamed which promotes tumor progression and reduces the therapeutic *** has been suggested that inflammation assessment needs to be measured qualitatively and quantitatively,considering cell-infiltration types,availability of receptors to detect damage and pathogens,and presence or absence of aggressive *** *** epithelial cells express several Toll-like receptors and determine the first defensive line against pathogens,and have been also described as mediators of ***,other molecules,such as cytokines related to inflammation and innate immunity,including immune checkpoint molecules,interferon-gamma pathway and NETosis have been associated with an increased risk of ***,this review will explore innate immune activation in the context of premalignant lesions of the gastric epithelium and established gastric tumors.

关键词： Gastric cancer Toll-like receptor Helicobacter pylori Nuclear factor kappa B Neutrophils

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Effects of Chemical Products on Fire Blight Suppression,and Fruit Production and Quality in Apple(Malus domestica Borkh.)*** Glory

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Phyton-International Journal of Experimental Botany 2022年第7期91卷 1341-1351页

作者： Álvaro Rodríguez-Peña Ana C.gonzal.z-Franco Jared Hernández-Huerta Nora A.Salas-Salazar Dámaris l.Ojeda-Barrios esteban Sánchez loreto Robles-Hernández Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaPascual OrozcoChihuahua31350México Centro de Investigación y Desarrollo A.C. DeliciasChihuahua33089México

Antibiotics are widely used in fire blight management programs,yet there are no studies that demonstrate the evaluation of their efficacy in ***,the present study was conducted to investigate the effects of the active ingredients in five commercial products(Kasumin■2l,Agrygent Plus■,Agricul.ural Terramycin■,Agrimicin100,and Actigard■)on fire blight suppression,and fruit yield and quality of apple(Malus domestica Borkh.)*** *** experiment was conducted in a commercial orchard using a completely randomized block design,with six treatments:(1)Oxytetracycline[Ox],110 mg l^(−1);(2)Kasugamycin[Kas],4.7 ml l^(−1);(3)Oxytetracycline+Gentamicin[Ox+Gen],48 mg l^(−1)+12 mg l^(−1);(4)Streptomycin+Oxytetracycline[Str+Ox],90 mg l^(−1)+9 mg l^(−1);(5)Acibenzolar-S-methyl[ASM],70 mg l^(−1);and(6)Control,only water,with four replications,and three 11-year-old trees as an experimental *** of infection including flowers,shoots and fruits,yield and fruit quality were *** treatments suppressed infection in flowers,shoots,and *** provided the highest levels of reduction of flower and shoot infection,while Kas had the least effect on the reduction of infection in these *** Ox+Gen treatment had the greatest suppression of fruit infection,and the best results on fruit yield and quality,followed by Ox and *** is the first study conducted to evaluate the efficacy of the active ingredients of five commercial products used for the management of fire blight in apple trees in Mexico.

关键词： Erwinia amylovora oxytetracycline gentamicin kasugamycin streptomycin Acibenzolar-S-methyl

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Differential responses to artificial selection on oviposition site preferences in Drosophila melanogaster and D. simulans

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Insect Science 2015年第6期22卷 821-828页

作者： Eduardo M. Soto Maria I. l. Betti Juan Hurtado esteban Hasson Departamento de Ecologia Genetica y Evolucion IEGEBA (CONICET-UBA) Facultad de Ciencias Exactas y Naturales Universidad deBuenos Aires Buenos Aires Argentina

The preference-performance relationship in plant-insect interactions is a cen- tral theme in evolutionary ecology. Among many insects, eggs are vulnerable and larvae have limited mobility, making the choice of an appropriate oviposition site one of the most important decisions for a female. We investigated the evolution of oviposition preferences in Drosophila melanogaster Meigen and Drosophila simulans Sturtevant by artificially selecting for the preference for 2 natural resources, grape and quince. The main finding of our study is the differential responses of D. melanogaster and D. simulans. Although preferences evolved in the experimental populations of D. melanogaster, responses were not consistent with the selection regimes applied. In contrast, responses in D. simulans were consistent with expectations, demonstrating that this species has selectable genetic variation for the trait. Furthermore, crosses between D. simulans divergent lines showed that the genetic factors involved in grape preference appear to be largely recessive. In summary, our artificial selection study suggests that D. melanogaster and D. simulans possess different genetic architectures for this trait.

关键词： artificial selection behavior Drosophila genetic variation naturalresources oviposition preference

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Quality indicators in subtropical soils of Formosa,Argentina:Changes for agriculturization process

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International Soil and Water Conservation Research 2014年第4期2卷 13-24页

作者： Juan esteban Baridón Roberto Raúl Casas Universidad Nacional de la Plata Buenos AiresArgentina laboratorio de Suelos Aguas y Forrajes.Centro de Validación de Tecnologías Agropecuarias IbarretaIbarreta(CP 3624)FormosaArgentina Centro de Investigación de Recursos Naturales.Instituto Nacional de Tecnología Agropecuaria:Dr.Nicolás Repetto(ex las Cabañas)y los Reseros Castelar(CP1712)Buenos AiresArgentina

The agriculturization process has been defined as the advance of annual crops in different environments,in competition with traditional land uses such as agriculture rotations with *** Argentina and other countries agriculturization has different degrees of impact on natural *** the northeast region of the province of Formosa,Argentina,agriculturization includes deforestation(clear cutting,slash burning and plowing),technological improvements and changes in land *** of these alterations,it is necessary to define the state of the soil to evaluate its *** can be done by means of indicators,which are not universal;they differ according to the use,management and type of soils,weather conditions and *** objectives of this paper are:(1)To identify quality indicators for subtropical Argiudolls and Hapludolls;(2)To determine which indicators related to organic matter are most affected during *** changes produced in the Typic Hapludolls and Typic Argiudolls after 25 years of continuously using native forests,agriculture,fruit plantations and pastures were *** changes were in pH,electrical conductivity,total organic carbon,particulate organic carbon,total nitrogen,structural stability,hydraulic conductivity,respiration and dehydrogenase and urease and enzyme *** with significant differences between diverse uses were evaluated by multivariate methods,Principal Component Analysis,and Correlation *** results of this study showed that total organic carbon,particulate organic carbon,structural stability and dehydrogenase activity are the quality indicators most affected by *** are related to organic matter.

关键词： Hapludolls Argiudolls Soil quality Soil use

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Breeding for drought tolerance in perennial ryegrass(lolium perenne l.)and tall fescue(lolium arundinaceum[Schreb.]Darbysh.)by exploring genotype by environment by management interactions

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Grassland Research 2023年第1期2卷 22-36页

作者： Claudio C.Fernandes Filho Mario H.Murad leite Andrade Jose A.Rodrigues Nunes Joseph Wipff Debra l.Hignight esteban F.Rios Kevin Kenworthy Kenneth Hignight Biology Department Institute of Natural SciencesUniversidade Federal de LavrasLavrasBrazil Agronomy Department University of FloridaGainesvilleFloridaUSA NexGen Plant Science Center LLCAlbanyOregonUSA NexGen Turf Research LLCAlbanyOregonUSA

Background:Drought‐tolerant turfgrass cultivars are becoming more important each year as landscape irrigation practices are becoming more ***:In this study,we quantified the level of drought tolerance(DT)in perennial ryegrass and tall fescue genotypes across years under different mowing(MH)and fertility(Fl)rates.A total of 48 ryegrass and 38 tall fescue genotypes were planted in 2011 at NexGen,Albany,*** trial was divided into three subtrials:(i)DT;(ii)MH and DT;and(iii)Fl and ***:The results showed that there was significant genetic variance for most of the traits in both *** genotype×year interaction was predominantly simple,indicating small changes in genotype ranking for both *** MH improved DT in perennial ryegrass,whereas higher MH resulted in greater DT in tall *** both species,higher MH improved the population mean for turf *** Fl inputs led to higher turf quality for both species,but it did not affect the DT ***:Using a selection index,six genotypes for perennial ryegrass and four for tall fescue were selected.

关键词： drought stress ryegrass tall fescue turf quality turfgrass breeding

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Influence of temperature and salinity on hydrodynamic forces

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Journal of Ocean Engineering and Science 2016年第4期1卷 325-336页

作者： A.Escobar V.Negro J.S.lópez-Gutiérrez M.D.esteban Technical University of Madrid C/Profesor Aranguren S/N28040 MadridSpain

The purpose of this study is to introduce an innovative approach to offshore engineering so as to take variations in sea temperature and salinity into account in the calculation of hydrodynamic *** this in mind,a thorough critical analysis of the influence of sea temperature and salinity on hydrodynamic forces on piles like those used nowadays in offshore wind farms will be carried *** influence on hydrodynamic forces occurs through a change in water density and viscosity due to temperature and salinity ***,the aim here is to observe whether models currently used to estimate wave forces on piles are valid for different ranges of sea temperature and salinity apart from observing the limit when diffraction or nonlinear effects arise combining both effects with the magnitude of the pile ***,specific software has been developed to simulate equations in fluid mechanics taking into account nonlinear and diffraction *** software enables wave produced forces on a cylinder supported on the sea bed to be *** study includes observations on the calculation model’s sensitivity as to a variation in the cylinder’s diameter,on the one hand and,on the other,as to temperature and salinity *** software will enable an iterative calculation to be made for finding out the shape the pressure wave caused when a wave passes over will have for different pile diameters and water with different temperature and salinity.

关键词： Sea temperature Salinity Hydrodynamic forces Wave action Offshore wind farms

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Frozen ground and periglacial processes relationship in temperate high mountains: a case study at Monte Perdido-Tucarroya area(The Pyrenees, Spain)

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Journal of Mountain Science 2020年第5期17卷 1013-1031页

作者： SERRANO Enrique lóPEZ-MORENO Juan Ignacio GóMEZ-lENDE Manuel PISABARRO Alfonso MARTíN-MORENO Raúl RICO Ibai AlONSO-GONZálEZ esteban Dept of GeographyUniversity of ValladolidValladolid 47011Spain Dept of Geoenvironmental Processes and Global ChangePyrenean Institute of EcologyZaragoza 50.080Spain Dept.Specific Didactics.Autonom University of Madrid.Madrid 28049Spain Dept of GeographyPrehistory and ArcheologyUniversity of the Basque CountryVitoria 01006Spain

Seasonally frozen ground,mountain permafrost and cryogenic geomorphological processes are important components of the Pyrenean high *** work presents the results of a study on the distribution of frozen ground in a marginal and paraglacial environment of temperate *** inventory was made of landforms and indicators of frozen ground,and frozen ground was mapped *** 2014 and 2016 ground temperatures and thermal regimes were monitored,basal temperatures of snow-cover(BTS)were measured and a thermal map was *** thermal behaviours were detected among different elevations and slope *** processes are the most widespread,in which frost weathering and nivation,together with gelifluction and cryoturbation,are the most efficient processes;the latter two are generally linked to the presence of frozen *** fall in air and ground temperatures with altitude,slope orientations,and snowpack thickness and evolution determine ground thermal *** the study area,three types of thermal regimes were established:climate-controlled,snowcover-controlled,and frozen *** frozen ground occurs across a broad range of elevation between 2650 and 3075 m asl,whereas possible permafrost only occurs above 2750 m asl.

关键词： Geomorphology Periglacial Seasonally frozen ground Mountain permafrost Pyrenees

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