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Treatment with acetyl-l-carnitine exerts a neuroprotective effect in the sciatic nerve following loose ligation:a functional and microanatomical study

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Neural Regeneration Research 2018年第4期13卷 692-698页

作者： Daniele Tomassoni l.renzo di cesare mannel.i Vincenzo Bramanti Carla Ghelardini Francesco Amenta Alessandra Pacini School of Bioscience and Veterinary Medicine University of Camerino Department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Pharmacology and Toxicology SectionUniversity of Florence Department of Biomedical and Biotechnological Sciences University of Catania Section of Human Anatomy School of Medicinal and Health Products SciencesUniversity of Camerino Department of Experimental and Clinical Medicine-DMSC-Section of Anatomy and Histology University of Florence

Peripheral neuropathies are chronic painful syndromes characterized by allodynia,hyperalgesia and altered nerve *** tissue degeneration represents the microanatomical correlate of peripheral *** to improve the therapeutic possibilities,this study investigated the hypersensitivity and the neuromorphological alterations related to the loose ligation of the sciatic nerve in *** elicited by treatment with acetyl-l-carnitine（AlCAR） in comparison to gabapentin were *** injury,reduction of myelin deposition and accumulation of inflammatory cells were detected in damaged nerve.A decrease of phosphorylated 200-k Da neurofilament（NFP） immunoreactivity and a redistribution in small clusters of myelin basic like-protein（MBP） were observed in ipsilateral *** with AlCAR（100 mg/kg intraperitoneally-i.p.） and gabapentin（70 mg/kg i.p.） administered bis in die for 14 days induced a significant pain relieving ***,but not gabapentin,significantly countered neuromorphological changes and increased axonal NFP *** findings indicate that both AlCAR and gabapentin significantly decreased the hypersensitivity related to neuropathic *** observation of the positive AlCAR effect on axonal and myelin sheath alterations in damaged nerve supports its use as neurorestorative agent against neuropathies through mechanism（s） consistent to those focused in this study.

关键词： peripheral nerve chronic constriction injury neurorestoration morphology neurofilament myelin basic protein neural regeneration

Molecular regulations of circadian rhythm and implications for physiology and diseases

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Signal Transduction and Targeted Therapy 2022年第3期7卷 666-685页

作者： Francesca Fagiani Daniele di Marino Alice Romagnoli Cristina Travelli Davide Voltan l.renzo di cesare mannel.i Marco Racchi Stefano Govoni Cristina lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Department of life and Environmental Sciences Polytechnic University of Marchevia Brecce Blanche60131 AnconaItaly New York-Marche Structural Biology Center(NY-MaSBiC) Polytechnic University of Marchevia Brecce Bianche60131 AnconaItaly NEUROFARBA Department University of FlorenceFlorenceItaly

The term"circadian rhythms"describes endogenous oscillations with ca.24-h period associated with the earth’s daily rotation and light/dark *** rhythms reflect the existence of an intrinsic circadian clock that tempor... 详细信息

关键词： rotation earth Molecular

diCE:An open-source MATlAB application for quantification and parametrization of digital outcrop model-based fracture datasets

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第5期15卷 1090-1110页

作者： Niccolò Menegoni Daniele Giordan Riccardo inama cesare Perotti Department of Earth and Environmental Sciences University of PaviaPavia27100Italy National Research Council of italy Research Institute for Geo-Hydrological Protection(CNR-IRPI)Torino10135Italy Signal S.r.l. Via Fratelli Cuzio 42Pavia27100Italy

An open-source MATlAB application(app)named discontinuity intensity Calculator and Estimator(diCE)was developed in order to quantitatively characterize the fractures,or in more general,discontinuities within a rocky outcrop in three-dimensional(3D)digital data,such as digital outcrop model(DOM).The workflow proposed for the parametrization of the discontinuities consists of the following steps:(1)Analysis and mapping of the fractures detected within the 3D DOMs;(2)Calculation of the orientation,position and dimensions of discontinuities that are represented by best-fit circular planes;(3)Determining the discontinuity parameters(dimension,distribution,spacing and intensity)by the diCE algorithm using different 3D oriented sampling techniques(3D oriented scanline,3D oriented circular scan window and spherical scan volume).different sampling methods were bench tested with a synthetic,as well as a natural case study,and compared in order to understand the advantages and limitations of each *** 3D oriented circular scan window appears to be the most effective method for fracture intensity estimation with high accuracy(error 0.4%)and stability with variations in scan radius.

关键词： Fracture parameter discontinuity Fault Fracture intensity linear fracture intensity(P10) Areal fracture intensity(P21) Volumetric fracture intensity(P32)

dimethyl ether as circular hydrogen carrier:Catalytic aspects of hydrogenation/dehydrogenation steps

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Journal of Energy Chemistry 2021年第7期30卷 55-77页

作者： Enrico Catizzone cesare Freda Giacobbe Braccio Francesco Frusteri Giuseppe Bonura ENEA–italian Agency for New Technologies Department of Energetic TechnologiesLaboratory of Thermochemical Processes for Waste and Biomass ValorisationRotondellaItaly CNR-iTAE–Consiglio Nazionale delle Ricerche Istituto di Tecnologie Avanzate per l’Energia‘‘Nicola Giordano”Via S.Lucia Sopra Contesse 5I-98126 MessinaItaly

The intermittent nature of renewable resources requires for most applications the development of efficient and cost-effective technologies for steady supply of electrical *** storage of energy in the form of hydrogen chemically bound within organic molecules(rather than physically as compressed gas or cooled liquid)represents an alternative approach that is attracting great research *** to other liquid organic hydrogen carriers(lOHCs),dimethyl ether(DME)appears to have the largest potential impact on society,especially if inserted in technological chains of CO_(2) sequestration and utilization,so to determine an effective mitigation of environmental issues,without any net effect on the carbon ***,the steps of H2 storage and H2 release can take place in two coupled chemical processes,constituted by the exothermic synthesis of DME via CO_(2) hydrogenation and the endothermic steam reforming of DME,***,the latest advances in the development of heterogeneous bifunctional and hybrid catalysts for the direct hydrogenation of CO_(2) to DME are thoroughly reviewed,with special emphasis on thermodynamics,catalyst design and process *** many aspects behind the mechanism of DME synthesis from H2-CO_(2) streams are still to be uncovered,the recent progress in the research on H2 release by DME steam reforming is increasing the interest for effectively closing this binary H2 loop,in view of future green deals and sustainable research developments.

关键词： DME CO_(2)hydrogenation Steam Reforming Hybrid catalysts Hydrogen carrier

Desmosterol, the main sterol in rabbit semen： distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility

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Asian Journal of Andrology 2010年第6期12卷 862-870页

作者： Evangelia Mourvaki Raffaella Cardinali Rita Roberti Alessandro Dal Bosco cesare Castellini Department of Applied Biology Section of Animal Science University of Perugia Perugia 06100 Italy Department of internal Medicine Section of Biochemistry University of Perugia Perugia 06122 Italy

Sterols are essential components of the cell membrane lipid bilayer that include molecules such as cholesterol and desmosterol, which are significantly found in the spermatozoa of several animal species. However, the presence of desmosterol in rabbit semen has never been investigated. The aims of this study were to characterize the sterol composition of subfractions of ejaculated rabbit semen and evaluate the in vitro effects of sterol on the spermatozoa acrosome reaction and motility. Two sterols, occurring prevalently in the free form （94.3%）, were identified in whole semen collected from 10 fertile New Zealand White rabbits, specifically desmosterol （58.5% of total sterols） and cholesterol （35.9% of total sterols）. Desmosterol was the predominant sterol found in all subfractions of rabbit semen, varying from 56.7% （in the prostatic secretory granules, PSGs） to 63.8% （in the seminal plasma）. Spermatozoa contained an intermediate proportion of desmosterol （59.8%）, which was asymmetrically distributed between the heads （52.0% of the total content of sterols） and the tails （81.8%）. Results showed that both desmosterol and cholesterol can be transferred from the PSGs to the spermatozoa and are equally effective in inhibiting in vitro spermatozoa capacitation at a concentration higher than 1 mg l^-1. in contrast, neither desmosterol nor cholesterol had a significant effect on spermatozoa motility. Thus, it was concluded that, the various fractions of rabbit seminal fluid differ from each other in sterol composition and quantity, probably due to their different functional properties, and these fractions may undergo significant sterol changes depending on the stage of spermatozoa capacitation.

关键词： acrosome reaction cholesterol desmosterol motility prostatic secretory granules rabbit seminal plasma spermatozoa head spermatozoa tail

Singing on the wings! Male wing fanning performances affect female willingness to copulate in the aphid parasitoid lysiphlebus testaceipes （Hymenoptera： Braconidae： Aphidiinae）

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insect Science 2016年第4期23卷 603-611页

作者： Giovanni Benelli Nickolas G. Kavallieratos Elisa Donati Giulia Giunti cesare Stefanini Angelo Canale insect Behavior Group Department of Agriculture Food and Environment University of Pisa Pisa Italy laboratory of Agricultural Entomology Department of Entomology and Agricultural Zoology Benaki Phytopathological Institute Kifissia Attica Greece The BioRobotics institute Sant'Anna School of Advanced Studies Pontedera Pisa Italy

lysiphlebus testaceipes （Hymenoptera： Braconidae： Aphidiinae） is a generalist endoparasitoid attacking more than 100 aphid species. in l. testaceipes, wing fanning is a main male courtship display evoked by a female-borne sex pheromone. However, no information is available on the characteristics and behavioral role of male fanning during courtship in this parasitoid. Here, the courtship behavior of a wild strain ofl. testaceipes was quantified and the male wing fanning performances were analyzed through high-speed video recordings and examined in relation to mating success. Courtship sequence of wild l. testaceipes did not substantially differ from that previously reported for other populations mass reared on aphids. We observed that the male courtship duration did not affect mating success. However, video analysis revealed that the males producing high-frequency fanning signals achieved higher mating success over those that display low-frequency fanning. Wing fanning before successful and unsuccessful courtship differed in amplitude of wing movements and alignment toward the mate, highlighting that frontal courtship positively influence the female mating decisions. This study increases knowledge on sexual behavior in a key parasitoid of aphids, highlighting the importance of wing fanning among the range of sensory modalities used in the sexual communication ofl. testaceipes. From a practical point of view, this information is useful in l. testaceipes-based biocontrol strategies, since it can help to establish parameters for quality checking of mass-reared wasps over time.

关键词： biocontrol agent courtship mating success parasitic wasp sensory ecology sexual communication

Feeding broiler chickens with arginine above recommended levels:effects on growth performance,metabolism,and intestinal microbiota

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1528-1541页

作者： Giorgio Brugaletta Marco Zampiga luca laghi Valentina indio Chiara Oliveri Alessandra De cesare Federico Sirri Department of Agricultural and Food Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Veterinary Medical Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Physics and Astronomy Alma Mater Studiorum-University of Bologna40127 BolognaItaly

Background Arginine is an essential amino acid for chickens and feeding diets with arginine beyond the recommended levels has been shown to influence the growth performance of broiler chickens in a positive ***,further research is required to understand how arginine supplementation above the widely adopted dosages affects metabolism and intestinal health of ***,this study was designed to assess the effects of arginine supplementation(i.e.,total arginine to total lysine ratio of 1.20 instead of 1.06-1.08 recommended by the breeding company) on growth performance of broiler chickens and to explore its impacts on the hepatic and blood metabolic profiles,as well as on the intestinal *** this purpose,630 one-day-old male Ross 308 broiler chicks were assigned to 2 treatments(7 replicates each) fed a control diet or a crystalline l-arginine-supplemented diet for 49 *** Compared to control birds,those supplemented with arginine performed significantly better exhibiting greater final body weight at D49(3778 vs.3937 g;P igher growth rate(76.15 vs.79.46 g of body weight gained daily;P lower cumulative feed conversion ratio(1.808 vs.1.732;P lasma concentrations of arginine,betaine,histidine,and creatine were greater in supplemented birds than in their control counterparts,as were those of creatine,leucine and other essential amino acids at the hepatic *** contrast,leucine concentration was lower in the caecal content of supplemented *** alpha diversity and relative abundance of Firmicutes and Proteobacteria(specifically Escherichia coli),as well as increased abundance of Bacteroidetes and lactobacillus salivarius were found in the caecal content of supplemented *** The improvement in growth performance corroborates the advantages of supplementing arginine in broiler *** can be hypothesized that the performance enhancement found in this study is associated with the i

关键词： Arginine Broiler chicken Growth performance Metabolism Microbiota

Evanescent waveguide lab-on-chip for optical biosensing in food quality control

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Photonics Research 2022年第6期10卷 1453-1461页

作者： AlESSiO BUZZiN RiTA ASQUiNi DOMENiCO CAPUTO GiAMPiERO DE cesare Department of information Engineering Electronics and TelecommunicationsSapienza University of Rome00184 RomeItaly

Optical biosensing systems are commonly developed assembling a source,a light–sample interaction area,and a detector as distinct stand-alone *** present a compact,inexpensive,and easy-to-use glass chip that monolithically integrates both the interaction and detection elements in a 1 cm^(2)overall *** device working principle is based on evanescent wavelight interaction with the complex refractive index of a liquid mixture,being the index influenced by the mixture’s physical and chemical *** describe the manufacture of a prototype able to perform investigations on food quality and subsequent tests on the detection of fat content in *** investigations are reported as well as measurements performed on samples in the green spectrum.A sensitivity of about 139 fA/(g/d l)and a limit of detection of 14 ppm have been achieved,better than those of current commercial devices.

关键词： waveguide optical interaction

Control of embryonic stem cell metastability by l-proline catabolism

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分子细胞生物学报:英文版 2011年第2期3卷 108-122页

作者： laura Casalino Stefania Comes Giuseppina lambazzi Benedetta De Stefano Stefania Filosa Sandro De Falco Dario De cesare Gabriella Minchiotti Eduardo Jorge Patriarca Stem Cell Fate laboratory Institute of Genetics and Biophysics“A.Buzzati-Traverso”CNRNaplesItaly

The molecular mechanisms controlling mouse embryonic stem cell(ESC)metastability,*** capacity to fluctuate between different states of pluripotency,are not fully *** developed and used a novel automation platform,the Cellmaker,to screen a library of metabolites on two ESC-based phenotypic assays(*** and colony phenotype)and identified two metabolically related amino acids,namely l-proline(l-Pro)and l-ornithine(l-Orn),as key regulators of ESC *** compounds,but mainly l-Pro,force ESCs toward a novel epiblast stem cell(EpiSC)-like state,in a dose-and time-dependent *** EpiSCs,l-Pro-induced cells(PiCs)contribute to chimeric embryos and rely on leukemia inhibitor factor(liF)to ***,PiCs revert to ESCs or differentiate randomly upon removal of either l-Pro or liF,***,PiC generation depends on both l-Pro metabolism(uptake and oxidation)and Fgf5 induction,and is strongly counteracted by antioxidants,mainly l-ascorbic acid(vitamin C,Vc).ESCs↔PiCs phenotypic transition thus represents a previously undefined dynamic equilibrium between pluripotent states,which can be unbalanced either toward an EpiSC-like or an ESC phenotype by l-Pro/l-Orn or Vc treatments,*** together,our data provide evidence that ESC metastability can be regulated at a metabolic level.

关键词： embryonic stem cells l-proline vitamin C colony phenotype pluripotent states metastability