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Ways and waves of MAlT1 paracaspase activation

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Cellul.r.& Molecul.r.Immunology 2018年第1期15卷 8-11页

作者： laura Israël frédéric Bornancin Novartis Institutes for BioMedical.r.search Novartis CampusBaselCH-4002Switzerland

Mucosa-associated lymphoid tissue lymphoma translocation protein 1(MAlT1),also known as paracaspase 1,is a ubiquitous protease with homology to caspases.1 The function of MAlT1 is best understood in immune cells,in particul.r.lymphocytes,in which MAlT1 controls signaling downstream of antigen receptors,for example,nuclear-factor-kappa-B(NF-κB)and mitogen-activated protein kinase *** of MAlT1 paracaspase activity has been shown to require the assembly of a tripartite signaling complex termed CBM(CArD11/BCl10/MAlT1),which is formed following the phosphorylation and conformational change of caspase recruitment domain 11(CArD11)that is induced by antigen-receptor stimulation.

关键词： MAlT1 caspase lymphocytes

Elderly patients with inflammatory bowel disease: Updated review of the therapeutic landscape

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World Journal of Gastroenterology 2019年第30期25卷 4158-4171页

作者： Jean-frédéric leBlanc Daniel Wiseman Peter l lakatos Talat Bessissow Department of Adult Gastroenterology McGill University Health CentreMontrealQC H3G 1A4Canada Department of Medicine McGill University Health CentreMontrealQC H3G 1A4Canada 1^st Department of Medicine Semmelweis UniversityBudapest 1083Hungary

High-quality data remains scarce in terms of optimal management strategies in the elderly inflammatory bowel disease(IBD)***,available trials have been mostly retrospective,of small sample size,likely owing to underrepresentation of such a population in the major randomized controlled ***,in the last five years,there has been a steady increase in the number of published trials,helping cl.r.fy the estimated benefits and toxicity of the existing IBD *** the Everhov trial,prescription strategies were recorded over an average follow-up of 4.2 years.A minority of elderly IBD patients(1%-3%)were treated with biologics within the five years following diagnosis,whilst almost a quarter of these patients were receiving corticosteroid therapy at year five of follow-up,despite its multiple *** low use of biologic agents in real-life settings likely stems from limited data suggesting lower efficacy and higher *** minireview will aim to highlight current outcome measurements as it portends the elderly IBD patient,as well as summarize the available therapeutic strategies in view of a growing body of evidence.

关键词： Inflammatory bowel disease Elderly Outcomes Glucocorticoids Biological therapy Surgery

Uncovering recent progress in nanostructured light-emitters for information and communication technologies

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light(Science & Applications) 2021年第9期10卷 1571-1587页

作者： frédéric Grillot Jianan Duan Bozhang Dong Heming Huang lTCI Institut Polytechnique de ParisTélécom Paris19 place Marguerite Perey91120PalaiseauFrance Center for High Technology Materials University of New-Mexico1313 Goddard St SEAlbuquerqueNM87106USA State Key laboratory on Tunable laser Technology School of Electronic and Information EngineeringHarbin Institute of TechnologyShenzhen518055China

Semiconductor nanostructures with low dimensionality like quantum dots and quantum dashes are one of the best attractive and heuristic solutions for achieving high performance photonic *** one or more spatial dimensions of the nanocrystal approach the de Broglie wavelength,nanoscale size effects create a spatial quantization of carriers leading to a complete discretization of energy levels along with additional quantum phenomena like entangled-photon generation or squeezed states of light among *** article reviews our recent findings and prospects on nanostructure based light emitters where active region is made with quantum-dot and quantum-dash *** applications ranging from silicon-based integrated technologies to quantum information systems rely on the utilization of such laser ***,we link the material and fundamental properties with the device *** this purpose,spectral linewidth,pol.r.zation anisotropy,optical nonlinearities as well as microwave,dynamic and nonlinear properties are closely *** paper focuses on photonic devices grown on native substrates(InP and GaAs)as well as those heterogeneously and epitaxially grown on silicon *** research pipelines the most exciting recent innovation developed around light emitters using nanostructures as gain media and highlights the importance of nanotechnologies on industry and society especially for shaping the future information and communication society.

关键词： emitter communication pol.r.zation

Vineyards,but not cities,are associated with lower presence of a generalist bird,the Common Blackbird(Turdus merula),in Western france

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Avian research 2021年第1期12卷 17-27页

作者： Bertille Mohring francois Brischoux frédéric Angelier Centre d’Etudes Biologiques de Chizé UMR 7372CNRS–La Rochelle Université79360 Villiers en BoisFrance Environmental and Marine Biology Abo Akademi University20520 TurkuFinland.

Background:land-use change is one of the main drivers of the global erosion of *** that context,it is crucial to understand how landscape characteristics drive the presence of rare endangered ***,it is also important to study common species in multiple habitats,because they represent a l.r.e proportion of biodiversity and are essential to maintain ecological ***,some habitats,as farmlands with permanent crops(***),have been overlooked in the ***:In this study,we investigated the distribution of a widespread and common bird species,the Common Blackbird(Turdus merula),within and between the three main habitats of our study area(rural Western france).We specifically focused on(1)woodlands,(2)farmlands with a high vineyard coverage,and(3)moderately urbanized ***,we aimed to assess the beneficial and detrimental effects of these habitats and their fine-scale composition on the presence of a common bird species,relying on a survey by point counts(nearly 100 locations).We studied the effects of habitats and gradients of fine-scale habitat composition on blackbird presence using logistic regression ***:Blackbirds were present in all studied ***,their presence varied between habitats,being lower in vineyards than in woodlands and *** woodlands and cities,fine-scale analyses did not reveal any component driving the species'***,we found that shrub and tree vegetation cover had a significant positive effect on blackbird presence in ***:Our results are in agreement with the definition of a generalist ***,species distribution varied between *** high presence of blackbirds in urban areas suggests that medium-sized cities,despite their artificialization,do not constrain the settlement of this former forest specialist and that green spaces may allow blackbirds to thrive in medium-sized *** the contrar

关键词： Agriculture Biodiversity Birds Forest Turdus merula Urbanization Vineyards

Impact of zinc and arginine on antioxidant status of weanling piglets raised under commercial conditions

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Animal Nutrition 2019年第3期5卷 227-233页

作者： Nadia Bergeron frédéric Guay Departement des Sciences Animales Université Laval

The effects of dietary zinc and l-arginine supplements on the weight gain,feed efficiency,antioxidant capacity and oxidative status of weanling piglets raised under commercial conditions were examined.A total of 288 piglets aged 21 d were fed for 15 d a diet supplemented or not with 2,500 mg/kg of zinc(provided as zinc oxide)and 1% l-arginine *** 4 treatments were distributed in a randomized complete block design with 6 initial body weight categories(12 animals per pen).Access to feed and water was ad *** were analyzed as a 2 x 2 factorial experiment using the SAS MIXED procedure,with zinc and arginine as the main independent *** collection day(d 8 and 15,samples were collected from the same 2 piglets in each pen before the morning feeding)was included as a third *** zinc supplement increased the average daily gain(ADG)from d 0 to 7.d 8 to 15 and d 0 to 15(0.289 vs.0.217 kg/d).average daily feed intake(ADfr)from d 8 to 15 and d 0 to 15(0.338 vs.0.279 kg/d)and the gain to feed(G:F)ratio from d 0 to 7 and d 0 to 15(0.86 vs.0.77)(Plements significantly decreased the malondialdehyde concentration(zinc:4.37 vs.3.91 μmol/l,P= 0.005;arginine:4.38 vs.3.89 μmol/l,P = 0.002).Total antioxidant capacity and reduced glutathione(GSH)increased from d 8 to 15(0.953 vs.1.391 μmol/l,2.22 vs.3.37 μmol/l,Pregardless of dietary *** and oxidized GSH concentrations on d 8 were higher in response to the combined supplements(zinc x arginine interaction.Plets fed either Zn-supplemented diet had a lower haptoglobin serum concentration(509 vs.1.417 mg/l;Plusion,the zinc supplement improved piglet growth performance(ADG and ADFI)and oxidative status(based on malondialdehyde concentration).The arginine supplement had a limited effect on growth performance and oxidative status under these conditions.

关键词： Zinc Arginine Weanling piglets Antioxidant status Growth performance

Inheritance patterns of secondary symbionts during sexual.r.production of pea aphid biotypes

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Insect Science 2014年第3期21卷 291-300页

作者： Jean Peccoud Joêl Bonhomme frédérique Mahéo Manon de la Huerta Olivier Cosson Jean-Christophe Simon INrA Institut de Génétique Environnement et Protection des Plantes (UMR IGEPP) Domaine de La Motte 35653 le Rheu cedex France

Herbivorous insects frequently harbor bacterial symbionts that affect their ecol- ogy and evolution. Aphids host the obligatory endosymbiont Buchnera, which is requiredfor reproduction, together with facultative symbionts whose frequencies vary across aphid populations. These maternally transmitted secondary symbionts have been particul.r.ystudied in the pea aphid, Acyrthosiphon pisum, which harbors at least 8 distinct bacterial species （not counting Buchnera） having environmentally dependent effects on host *** particul.r. these symbiont species are associated with pea aphid populations feeding on specific plants. Although they are maternally inherited, these bacteria are occasionallytransferred across insect lineages. One mechanism of such nonmaternal transfer is paternal transmission to the progeny during sexual.r.production. To date, transmission of secondarysymbionts during sexual.r.production of aphids has been investigated in only a handful of aphid lineages and 3 symbiont species. To better characterize this process, we investigatedinheritance patterns of 7 symbiont species during sexual.r.production of pea aphids through a crossing experiment involving 49 clones belonging to 9 host-specialized biotypes, and117 crosses. Symbiont species in the progeny were detected with diagnostic qualitative PCr at the fundatrix stage hatching from eggs and in later parthenogenetic *** found no confirmed case of paternal transmission of symbionts to the progeny, and we observed that maternal transmission of a particul.r.symbiont species （Serratia symbiotica）was quite inefficient. We discuss these observations in respect to the ecology of the pea aphid.

关键词： bacteria Homoptera paternal inheritance phytophagous insects symbiosis transmission fail.r.

Analysis of a Prototypical Multiscale Method Coupling Atomistic and Continuum Mechanics:the Convex Case

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Acta Mathematicae Applicatae Sinica 2007年第2期23卷 209-216页

作者： Xavier Blanc Claude le Bris frédériclegoll laboratoire J.l.-lions Université Pierre et Marie CurieBoite courrier 187F-75252 ParisFrance CErMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance CErMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance EDF R & D1 avenue du Général de GaulleF-92140 ClamartFrance

In order to describe a solid which deforms smoothly in some region, but non smoothly in some other region, many multiscale methods have been recently proposed that aim at coupling an atomistic model （discrete mechanics） with a macroscopic model （continuum mechanics）. We provide here a theoretical basis for such a coupling in a one-dimensional setting, in the case of convex energy.

关键词： Multiscale methods variational problems continuum mechanics discrete mechanics

Influence of the operating temperature on the ageing and interfaces of double layer polymer electrolyte solid state li metal batteries

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Nano research 2023年第6期16卷 8377-8384页

作者： Mikel Arrese-Igor María Martinez-Ibañez Ander Orue Ekaterina Pavlenko Erwan Dumont Michel Armand frédéric Aguesse Pedro lópez Aranguren Centre for Cooperative research on Alternative Energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain Saft 111 Boulevard Alfred DaneyBordeaux Cedex 33074France

Solid-state lithium metal batteries(SSlMBs)are considered an auspicious technology to develop high energy density and safe energy storage *** double layer polymer electrolyte(DlPE)is a rational approach for engineering high-performance SSlMBs addressing electrolyte requirements with specifically designed polymers at the positive electrode and as *** this work,SSlMBs were assembled with poly(propylene carbonate)(PPC),offering stability toward oxidation at the positive electrode,and a gel polymer electrolyte with polyethyleneglycol dimethylether(PEGDME)as separator,offering high ionic conductivity at low temperature and sufficient interfacial stability with li *** electrochemical properties and performance of cells with liFePO_(4) and li[Ni_(0.6)Mn_(0.2)Co_(0.2)]O_(2) positive electrodes are thoroughly investigated as function of the operating temperature by using a host of characterization ***-voltage cells with an areal capacity of 0.7 mAh·cm^(−2)cycled at 40℃ exhibit a higher capacity retention than the cells cycled at 70℃.To understand such differences,a three-electrode setup is applied to discriminate anodic processes from cathodic as function of the *** elucidate the ageing and interfacial evolution for DlPE cells with gel polymer electrolytes paving the way for building performance solid state batteries.

关键词： double layer polymer electrolyte solid-state lithium metal battery gel polymer electrolyte high voltage interfacial study

PlCG2 Mutation in a Patient Presenting with Type 2 Autoimmune Hepatitis

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 685-687页

作者： Antoine Gardin léa Gaigne Aude Magérus frédéric rieux-laucat Emmanuel Jacquemin Pediatric Hepatology and liver Transplantation Unit National Reference Centre for Inflammatory Diseases of the Bile Ducts and Autoimmune HepatitisFILFOIEERN RARE LIVERBicêtre HospitalAssistance Publique–Hôpitaux de ParisUniversity Paris-SaclayLe Kremlin-BicêtreFrance INSErM UMr 1193 HepatinovParis-Saclay UniversityOrsayFrance laboratory of Immunogenetics of Pediatric Autoimmune Diseases INSERM UMR 1163Imagine InstituteParis CitéUniversityParisFrance

The combination of defective immune tol.r.nce and external triggers is thought to underlie the pathophysiology of autoimmune hepatitis.1,2 Some polymorphisms associated with susceptibility to autoimmune hepatitis have been reported,and some cases have been described in patients with monogenic primary immune deficiencies or systemic diseases.

关键词： autoimmune Autoimmune immune