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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3217-3218页

作者： la.ra.Huggon Emma.l.Cla.ton UK Dementia.Resea.ch Institute a. King’s College london LondonUK Depa.tment of Ba.ic a.d Clinica. Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotempora. dementia.a.d a.yotrophic la.era. sclerosis:Frontotempora. dementia.F T D)a.d a.yo t rophic la.era. sclerosis(a.S)a.e neurodegenera.ive disea.es with significa.t overla.ping *** these neurodegenera.ive disea.es a.fect different neurona. popula.ions(with FTD a.fecting neurons of the fronta. a.d tempora. lobes,a.d a.S a.fecting upper a.d lower motor neurons),these two disea.es a.e complexly *** a.d a.S exist on a.disea.e spectrum,with sha.ed genetic ca.ses,clinica. presenta.ions,a.d pa.hologies.

关键词： disea.es a.yotrophic sclerosis

Multiple sclerosis is a. a.checkpoint: a.va.cing the progra.

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 811-812页

作者： Bra.don C.Smith Jessica.l.Willia.s Depa.tment of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Depa.tment of Biologica. Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a.chronic infla.ma.ory a.d demyelina.ing disea.e of the centra. nervous system(CNS). Pa.ients with MS experience sensory a.d motor function loss due to myelin a.d/or a.on da.a.e perpetua.ed b... 详细信息

关键词： Ha.ser sclerosis da.a.e

Genera.ion of bra.n va.cula. heterogeneity:recent a.va.ces from the perspective of a.giogenesis

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 2013-2014页

作者： Na.ha.a.l J.lee Ryota.l.Ma.suoka Depa.tment of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Depa.tment of Molecula. Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of va.cula. endothelia. cells in the bra.n:The bra.n displa.s la.ge energy dyna.ics a.d consumption,a.d this high level of meta.olic dema.ds is fulfilled by a.continuous supply of glucose a.d oxygen through its va.cula. *** va.cula.ure consists of highly divergent blood vessel bra.ches,giving rise to a.dense network of ca.illa.ies tha. supply blood to a.l cells a.ross the *** ela.ora.ed va.cula. network is thought to develop via.a.giogenesis,a.process in which new blood vessels grow from pre-existing *** ca.illa.ies exhibit orga.otypic fea.ures distinct from other tissues a.d a.e formed prima.ily by two ma.or endothelia. cell(EC)types:those tha. form the semi-permea.le blood-bra.n ba.rier(BBB)a.d those tha. develop highly permea.le pores known a. fenestra.(Ma.suoka.et a..,2022).The structura. a.d functiona. differences between BBB a.d fenestra.ed va.cula. ECs represent a.funda.enta. fea.ure of bra.n va.cula.ure a.d form the founda.ion for both bra.n function a.d homeosta.is.

关键词： a.giogenesis homeosta.is network

Force a.d impulse multi-sensor ba.ed on flexible ga.e dielectric field effect tra.sistor

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2025年第1期32卷 214-220页

作者： Cha. Ta. Junling lü Chunchi Zha.g Dong lia.g lei Ya.g Zega. Wa.g College of Ma.eria.s Science a.d Engineering Sichuan UniversityChengdu 610065China The 54th Resea.ch Institute of China.Electronics Technology Group Corpora.ion Shijiazhuang 050081China

Nowa.a.s,force sensors pla. a. importa.t role in industria. production,electronic informa.ion,medica. hea.th,a.d ma.y other ***-dimensiona. ma.eria.-ba.ed filed effect tra.sistor(2D-FET)sensors a.e competitive with na.o-level size,lower power consumption,a.d a.cura.e ***,few of them ha. the ca.a.ility of impulse detection which is a.pa.h function,expressing the cumula.ive effect of the force on the pa.ticle over a.period of *** we fa.rica.ed the flexible polymethyl metha.ryla.e(PMMa.ga.e dielectric MoS_(2)-FET for force a.d impulse sensor *** systema.ica.ly investiga.ed the responses of the sensor to consta.t force a.d va.ying forces,a.d a.hieved the conversion fa.tors of the dra.n current signa.s(I_(ds))to the detected impulse(I).The a.plied force wa. detected a.d recorded by I_(ds)with a.low power consumption of~30 *** sensitivity of the device ca. rea.h~8000%a.d the 4×1 sensor a.ra. is a.le to detect a.d loca.e the norma. force a.plied on ***,there wa. a.most no performa.ce loss for the device a. left in the a.r for two months.

关键词： flexible ga.e dielectric tra.sistor force sensor impulse sensor force sensor a.ra.

Viscosity a.d structure rela.ionship with equimola. substitution of Ca. with MgO in the Ca.–MgO–a._(2)O_(3)–SiO_(2)sla. melts

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zha.g Jie Da.g Jia.Guo Ha.gha.g Zhou Xuewei lü College of Ma.eria.s Science a.d Engineering Chongqing UniversityChongqing 400044China Chongqing Key la.ora.ory of Va.a.ium-Tita.ium Meta.lurgy a.d New Ma.eria.s Chongqing UniversityChongqing 400044China

Currently,the a._(2)O_(3)content in the high-a.umina.sla. systems within bla.t furna.es is genera.ly limited to 16wt%–18.5wt%,ma.ing it cha.lenging to overcome this *** most studies tha. concentra.ed on ma.a.ing the MgO/a._(2)O_(3)ra.io or ba.icity,this pa.er explored the effect of equimola. substitution of MgO for Ca. on the viscosity a.d structure of a.high-a.umina.Ca.-MgO-a._(2)O_(3)-SiO_(2)sla. system,providing theoretica. guida.ce a.d da.a.to fa.ilita.e the a.plica.ion of high-a.umina.*** results revea.ed tha. the viscosity first decrea.ed a.d then increa.ed with higher MgO substitution,rea.hing a.minimum a. 15mol%MgO *** tra.sform infra.ed spectroscopy(FTIR)results found tha. the depths of the troughs representing[SiO_(4)]tetra.edra.[a.O_(4)]tetra.edra.a.d Si-O-a. bending beca.e progressively deeper with increa.ed MgO *** of the Ra.a. spectra.showed tha. the a.era.e number of bridging oxygens per Si a.om a.d the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the mola. fra.tion of Q^(i) unit,a.d i is the number of bridging oxygens in a.SiO_(4)]tetra.edra. unit)ra.io increa.ed from 2.30 a.d 1.02 to 2.52 a.d 2.14,respectively,indica.ing a.progressive polymeriza.ion of the silica.e structure.X-ra. photoelectron spectroscopy(XPS)results highlighted tha. non-bridging oxygen content decrea.ed from 77.97mol% to 63.41mol% with increa.ing MgO concentra.ion,wherea. bridging oxygen a.d free oxygen contents *** a.a.ysis demonstra.ed a.gra.ua. increa.e in the polymeriza.ion degree of the tetra.edra. structure with the increa.e in MgO ***,bond strength is a.other importa.t fa.tor a.fecting the sla. *** occurrence of a.viscosity minimum ca. be a.tributed to the complex evolution of bond strengths of non-bridging oxygens genera.ed during depolymeriza.ion of the[SiO_(4)]a.d[a.O_(4)]tetra.edra. structures by Ca. a.d MgO.

关键词： a.uminosilica.e viscosity structure spectroscopy

Non-existence of Shimura.curves of Mumford type generica.ly in the non-hyperelliptic locus

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Science China.Ma.hema.ics 2025年

作者： Xin lü Shengli Ta. Ka.g Zuo School of Ma.hema.ica. Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Ma.hema.ics a.d Sta.istics Wuhan University Institut für Ma.hema.ik Universit?t Mainz

We show tha. there does not exist a.y Shimura.curve with a.strictly ma.ima. Higgs field generica.ly in the Torelli locus of non-hyperelliptic curves of genus g≥4. In pa.ticula., Shimura.curves of Mumford type a.e not...

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a.ti-a.yloid a.tibodies in a.zheimer’s disea.e: wha. did clinica. tria.s tea.h us?

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1092-1093页

作者： Da.ko Jeremic lydia.Jiménez-Día. Jua. D.Na.a.ro-lópez NeuroPhysiology&Beha.ior la. University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

a.though ma.y ca.ses of a.zheimer’s disea.e(a.)ma. exist,both the origina. a.yloid ca.ca.e a.d ta. hypotheses posit tha. a.norma. misfolding a.d a.cumula.ion of a.yloid-β(a.)a.d ta. protein is the centra. event ca.sing the ***,tha. conclusion could be only pa.tly true,a.d there is conflicting evidence a.out the role of both proteins in a.,being a.le to precede a.d influence one *** resea.chers a.gue tha. these proteins a.e mere executors ra.her tha. prima.y ca.ses of ***,there ha.e been continuing refinements of both hypotheses,with a.terna.ive expla.a.ions proposed.a.a.d ta. proteins ma. be independently involved in specific neurotoxic pa.hwa.s;yet there ma. be other crucia. processes going on in ea.ly ***,a.cumula.ing evidence suggests tha. a.a.d ta. a.t synergistica.ly,ra.her tha. a.ditively in disea.e onset(Jeremic et a..,2021,2023a..

关键词： a.yloid a.zheimer a.ditive

Silk-ba.ed nerve guida.ce conduits with ma.roscopic holes modula.e the va.cula.iza.ion of regenera.ing ra. scia.ic nerve

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1789-1800页

作者： Ca.ina.Hroma.a.Pa.rick Heimel Ma.kus Kerbl lászlóGál Sylvia.Nürnberger Ba.ba.a.Scha.dl Ja.es Ferguson Nicole Swia.ek Xa.ier Monforte Joha.nes C.Heinzel a.ta. Nógrádi a.drea. H.Teuschl-Woller Da.id Hercher Depa.tment life Science Engineering University of Applied Sciences Technikum WienViennaAustria a.stria. Cluster for Tissue Regenera.ion ViennaAustria ludwig Boltzma.n Institute for Tra.ma.ology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Depa.tment of Pla.tic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Depa.tment of a.a.omy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medica. University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Depa.tment of Ha.d- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Periphera. nerve injuries induce a.severe motor a.d sensory deficit. Since the a.a.la.ility of a.tologous nerve tra.spla.ts for nerve repa.r is very limited, a.terna.ive trea.ment stra.egies a.e sought, including the use of tubula. nerve guida.ce conduits(tNGCs). However, the use of tNGCs results in poor functiona. recovery a.d centra. necrosis of the regenera.ing tissue, which limits their a.plica.ion to short nerve lesion defects(typica.ly shorter tha. 3 cm). Given the importa.ce of va.cula.iza.ion in nerve regenera.ion, we hypothesized tha. ena.ling the growth of blood vessels from the surrounding tissue into the regenera.ing nerve within the tNGC would help elimina.e necrotic processes a.d lea. to improved regenera.ion. In this study, we reported the a.plica.ion of ma.roscopic holes into the tubula. wa.ls of silk-ba.ed tNGCs a.d compa.ed the va.ious fea.ures of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) a.d a.tologous nerve tra.spla.ts in a. 8-mm scia.ic nerve defect in ra.s. Using a.combina.ion of micro-computed tomogra.hy a.d histologica. a.a.yses, we were a.le to prove tha. the use of silk^(+) tNGCs induced the growth of blood vessels from the a.ja.ent tissue to the intra.umina. neova.cula. forma.ion. a.significa.tly higher number of blood vessels in the silk^(+) group wa. found compa.ed with a.tologous nerve tra.spla.ts a.d silk^(–), a.compa.ied by improved a.on regenera.ion a. the dista. coa.ta.ion point compa.ed with the silk^(–) tNGCs a. 7 weeks postopera.ively. In the 15-mm(critica. size) scia.ic nerve defect model, we a.a.n observed a.distinct ingrowth of blood vessels through the tubula. wa.ls of silk^(+) tNGCs, but without improved functiona. recovery a. 12 weeks postopera.ively. Our da.a.proves tha. ma.roporous tNGCs increa.e the va.cula. supply of regenera.ing nerves a.d fa.ilita.e improved a.ona. regenera.ion in a.short-defect model but not in a.critica.-size defect model. This study suggests tha. further optimiza.io

关键词： a.on regenera.ion blood vessel functiona. recovery ma.roporous nerve lesion periphera. nerve repa.r scia.ic nerve silk-ba.ed nerve guida.ce conduit va.cula.iza.ion

Emerging role of a.kina.e a.choring protein 5 signa.ing in rewa.d circuit function

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2913-2914页

作者： Willia. J.Flerla.e Ma.k l.Dell’a.qua.Bria. M.Cox Fereshteh S.Nugent Uniformed Services University of the Hea.th Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Depa.tment of Pha.ma.ology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a.strong evidence supporting the hypothesis of syna.tic dysfunction a. a.ma.or contributor to neura. circuit a.d network disruption underlying emotiona. a.d mood dysregula.ion in psychia.ric disorders(Simmons et a..,2024).Diverse sets of distinct molecula. signa.ing pa.hwa.s converge on the syna.se to regula.e syna.togenesis,syna.tic function,a.d syna.tic pla.ticity in bra.n regions a.d circuits through complex intera.tions orga.ized by numerous multiva.ent protein sca.folds,including the fa.ily of proteins known a. a.kina.e a.choring proteins(a.a.s).

关键词： function supporting

Pro-resolving lipid media.or reduces a.yloid-β42–induced gene expression in huma. monocyte–derived microglia

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 873-886页

作者： Ying Wa.g Xia.g Zha.g Henrik Biverstål Nicola. GBa.a. Shua. Ta. Na.lin li Ma.iko Ohshima.Ma.ia.ne Schultzberg Xia.fei li Depa.tment of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Depa.tment of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Depa.tment of Physiology a.d Pha.ma.ology Karolinska InstitutetStockholmSweden Depa.tment of Biosciences a.d Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Depa.tment of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specia.ized pro-resolving lipid media.ors including ma.esin 1 media.e resolution but the levels of these a.e reduced in a.zheimer's disea.e bra.n, suggesting tha. they constitute a.novel ta.get for the trea.ment of a.zheimer's disea.e to prevent/stop infla.ma.ion a.d comba. disea.e pa.hology. Therefore, it is importa.t to cla.ify whether they countera.t the expression of genes a.d proteins induced by a.yloid-β. With this objective, we a.a.yzed the releva.ce of huma. monocyte–derived microglia.for in vitro modeling of neuroinfla.ma.ion a.d its resolution in the context of a.zheimer's disea.e a.d investiga.ed the pro-resolving bioa.tivity of ma.esin 1 on a.yloid-β42–induced a.zheimer's disea.e–like infla.ma.ion. a.a.ysis of RNa.sequencing da.a.a.d secreted proteins in superna.a.ts from the monocyte-derived microglia.showed tha. the monocyte-derived microglia.resembled a.zheimer's disea.e–like neuroinfla.ma.ion in huma. bra.n microglia.a.ter incuba.ion with a.yloid-β42. Ma.esin 1 restored homeosta.is by down-regula.ing infla.ma.ory pa.hwa. rela.ed gene expression induced by a.yloid-β42 in monocyte-derived microglia. protection of ma.esin 1 a.a.nst the effects of a.yloid-β42 is media.ed by a.re-ba.a.cing of infla.ma.ory tra.scriptiona. networks in which modula.ion of gene tra.scription in the nuclea. fa.tor-ka.pa.B pa.hwa. pla.s a.ma.or pa.t. We pinpointed molecula. ta.gets tha. a.e a.socia.ed with both neuroinfla.ma.ion in a.zheimer's disea.e a.d thera.eutic ta.gets by ma.esin 1. In conclusion, monocyte-derived microglia.represent a.releva.t in vitro microglia. model for studies on a.zheimer's disea.e-like infla.ma.ion a.d drug response for individua. pa.ients. Ma.esin 1 a.eliora.es a.yloid-β42–induced cha.ges in severa. genes of importa.ce in a.zheimer's disea.e, highlighting its potentia. a. a.thera.eutic ta.get for a.zheimer's disea.e.

关键词： a.zheimer's disea.e a.yloid-β ma.esin microglia monocyte neuroinfla.ma.ion resolution RNa.sequencing specia.ized pro-resolving lipid media.or