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Chinese Journal of Chemical Engineering 2021年第4期34卷 360-367页

作者： Muralikrishna Boni S.Srinivasa rao G.Naga Srinivasulu Department of Mechanical Engineering National Institute of Technology WarangalWarangalTelanganaIndia

Passive Direct methanol fuel cells(DMFC)are more suitable for charging small capacity electronic *** passive DMFC,the fuel and oxidant are supplied by diffusion and natural convection process on the anode and cathode sides *** collectors(CC)play a vital importance in fuel cell *** paper presents the combined impact of perforated and wire mesh current collectors(WMCC)on passive DMFC *** types of open ratios of perforated current collectors(PCC),such as 45.40%,55.40%and 63.40%and two types of wire mesh current collectors with open ratios of 38.70%and 45.40%were chosen for the experimental work.A combination of Taguchil9 rule is considered.A combination of three PCC and two WMCC on both anode and cathode was *** concentration was varied from 1 mol·l^(-1)-5 mol·l^(-1)for nine combinations of PCC and *** the experimental results,it is noticed that the combination of PCC and WMCC with an open ratio of 55.40%and 38.70%incorporated passive DMFC produced peak power density at 5 mol·l^(-1)of methanol *** passive DMFC performance was evaluated in terms of maximum power density and maximum current *** combined current collectors of PCC and WMCC open ratios of 55.40%+38.70%have more stable voltage than single PCC of open ratio 63.40%at 4 mol·l^(-1)of methanol concentration.

关键词： Passive DMFC Perforated current collector Wire mesh current collector Methanol concentration Fuel cell performance

血清25-羟维生素D水平预测乌司奴单克隆抗体治疗肛瘘型克罗恩病疗效的临床价值

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中华消化杂志 2024年第6期44卷 385-390页

作者：张顶力吴昊曹曙光肖慧盈饶舜禹蒋益温州医科大学附属第二医院消化内科温州325000

目的评估血清25-羟维生素D[25(OH)D]水平对乌司奴单克隆抗体(UST)治疗肛瘘型克罗恩病(PFCD)患者肛瘘临床应答和影像学应答的预测价值。方法回顾性收集2021年10月1日至2023年6月30日在温州医科大学附属第二医院就诊的80例接受UST治疗的... 详细信息

目的评估血清25-羟维生素D[25(OH)D]水平对乌司奴单克隆抗体(UST)治疗肛瘘型克罗恩病(PFCD)患者肛瘘临床应答和影像学应答的预测价值。方法回顾性收集2021年10月1日至2023年6月30日在温州医科大学附属第二医院就诊的80例接受UST治疗的活动期PFCD患者。采用哈维-布拉德肖指数(HBI)评估PFCD的临床活动度,以肛周疾病活动指数(PDAI)评估肛瘘临床结局,盆腔磁共振成像评估肛瘘的影像学结局。UST治疗第0、8、16和24周均检测PFCD患者的血清25(OH)D水平。采用二元logistic回归模型分析基线血清25(OH)D水平与PFCD患者临床病理特征的关系,并分析血清25(OH)D水平与UST治疗第8周时肛瘘临床应答,以及第24周时肛瘘临床应答和肛瘘影像学应答的关系。采用R软件绘制列线图,并计算C指数。统计学比较采用独立样本t检验、卡方检验。结果多因素二元logistic回归分析发现,PFCD患者的基线血清25(OH)D水平与基线HBI和基线PDAI呈独立相关[OR=1.45,95%置信区间(95%CI)1.08~1.95,P=0.014;OR=1.39,95%CI 1.01~1.92,P=0.042]。UST治疗第8周时,肛瘘临床应答患者血清25(OH)D水平高于临床无应答患者[(21.77±6.17)μg/l比(16.72±6.39)μg/l],而基线PDAI低于临床无应答患者[(6.88±2.15)分比(8.06±2.14)分],既往生物制剂治疗失败和复杂性肛瘘患者比例均低于临床无应答患者[42.4%(14/33)比66.0%(31/47)、57.6%(19/33)比78.7%(37/47)],差异均有统计学意义(t=3.53、2.43,χ^(2)=4.36、4.13;P=0.002、0.022、0.039、0.045)。UST治疗第24周时,影像学应答患者血清25(OH)D水平高于影像学无应答患者[(22.48±5.81)μg/l比(16.66±6.34)μg/l],既往生物制剂治疗失败和复杂性肛瘘患者比例低于影像学无应答患者[40.0%(20/50)比12/15、60.0%(30/50)比14/15],差异均有统计学意义(t=3.33,χ^(2)=7.39、5.86;P=0.004、0.011、0.038)。多因素二元logistic回归分析显示,血清25(OH)D水平和既往生物制剂治疗失败是UST治疗第8周时肛瘘临床应答的2个独立影响因素(OR=1.11,95%CI 1.02~1.21,P=0.012;OR=0.34,95%CI 0.12~0.97,P=0.043),亦是第24周时肛瘘临床应答(OR=1.14,95%CI 1.05~1.24,P=0.002;OR=0.30,95%CI 0.11~0.89,P=0.029)和影像学应答(OR=1.20,95%CI 1.05~1.36,P=0.006;OR=0.11,95%CI 0.02~0.58,P=0.009)的2个独立影响因素。列线图显示第8周和第24周肛瘘临床应答的C指数分别为0.78(95%CI 0.68~0.89)和0.76(95%CI 0.64~0.87),第24周影像学应答的C指数为0.85(95%CI 0.76~0.95)。结论接受UST治疗的PFCD患者中,血清25(OH)D水平和既往生物制剂治疗失败可能独立影响UST治疗第8周和第24周的肛瘘临床应答,以及第24周的肛瘘影像学应答。

关键词：肛瘘型克罗恩病血清25(OH)D水平乌司奴单克隆抗体肛瘘临床应答肛瘘影像学应答

Optimization of green sand mould system using Taguchi based grey relational analysis

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China Foundry 2018年第2期15卷 152-159页

作者： Srinivasa rao Pulivarti Anil Kumar Birru Mechanical Engineering Department National Institute of Technology

The strength of the mould cavity in sand casting is very much significant to attain high-quality castings. Optimization of green sand process parameters plays a vital role in minimizing casting defects. In the present research work, the effect of process parameters such as AFS grain fineness number, water, molasses, bentonite, fly ash, and ramming, and their levels on the resultant mould properties were investigated and optimized using Taguchi based grey relational analysis. The Taguchi l18 orthogonal array and analysis of variance(ANOVA) were used. The quality characteristics viz., green compression strength, permeability, bulk density, mould hardness and shatter index of green sand mould were optimized using grey relational grade, based on the experiments designed using Taguchi's Design of Experiments. ANOVA analysis indicated that water content is the most influential parameter followed by bentonite, and degree of ramming that contributes to the quality characteristics. The results are confirmed by calculating confidence intervals, which lies within the interval limits. Finally, microstructure observations and X-ray diffraction analysis have been performed for the optimal sand parametric combination. Results show that presence of maximum amount of SiO_2, which might be the reason for enhancement of the physical properties of the sand.

关键词： green sand bentonite fly ash molasses Taguchi based grey relational analysis grain fineness number

The impact of dysfunctional tear films and optical aberrations on chronic migraine

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Eye and Vision 2017年第1期4卷 18-21页

作者： Rohit Shetty Kalyani Deshpande Chaitra Jayadev Kareeshma Wadia Pooja Mehta Rushad Shroff Harsha l.rao Department of Ophthalmology Narayana Nethralaya Eye Institute121/CChord Road1“R”BlockRajajinagarBangalore 560010KarnatakaIndia

Background:Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms,including ocular *** eye disease and dysfunction of ocular somatosensory pathways have been implicated in the *** current study investigates the association between a dysfunctional tear film and ocular aberrations with ***:Sixty eyes of 30 patients with migraine and 60 eyes of 30 controls were *** eye evaluation included Schirmer’s test,tear film break-up time,corneal esthesiometry and lipid layer analysis using lipiview^(®)*** aberrations were measured using Optical Path Difference before performing the dry eye *** intraocular light scatter was quantified using the objective scatter index(OSI)of the optical quality analysis *** parameters were compared between the migraine and the control group using independent sample *** analysis was performed using commercial software.A p value of≤0.05 was considered statistically ***:There were 19 females and 11 males in each *** significant difference was found between the two groups with respect to total aberrations(p=0.049),higher order aberrations(p=0.009),coma(p=0.03),spherical aberrations(p=0.018),lipiview interferometric coloric units(pl(p=0.26)and TBUT(p=0.398)were not significantly different between both ***:Ocular aberrations are higher in patients with migraine as compared with *** film abnormalities add to the aberrations in otherwise asymptomatic patients and may also be associated with migraineous *** the ocular surface to obtain a healthy tear film might introduce a potential modifiable factor in the prevention of migraneous attacks.

关键词： Migraine Dry eye Aberrations

Ethnobotanical Study towards Conservation of Medicinal and Aromatic Plants in Upper Catchments of Dhauli Ganga in the Central Himalaya

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Journal of Mountain Science 2012年第2期9卷 286-296页

作者： l.S.KANDARI P.C.PHONDANI K.C.PAYAl K.S.rao R.K.MAIKHURI School of Natural Resources Management and Environmental Sciences College of Agriculture and Environmental SciencesHaramaya University G.B.Pant Institute of Himalayan Environment&Development Department of Botany University of Delhi

The present study broadly focused on medicinal plant species collected from wild by the villagers for different purposes in the upper catchment of Dhauli Ganga in Nanda Devi Biosphere Reserve(NDBR),in the central Himalaya.A schedule based survey was conducted during the years 2003-2005 in 15 villages of Chamoli district part of the *** was collected from collectors, vaidya(medicine man)and those deal.ng with domestication and marketing of the medicinal plants. The aim of the study was to understand the prioritiesed medicinal plants,their mode of collection and document their ethnobotanical uses by the Bhotiya tribal communities,in this world heritage site. During the survey,50 medicinal plants bel.nging to 31 families and 44 genera were *** of these,70% were harvested from the wild,22% were cultivated and 8% were cultivated as well as wild *** the cultivated species,8% were found growing in the kitchen gardens and 14%in the agricultural ***,42%of the plants had their roots and rhizomes used followed by leaves (26%),seeds(10%),seed and leaf(8%),bark and whole plant(6%)and flower(1%).Most plants were reported to be used for rheumatism(16),followed by stomach disorder(14),cold and cough(11),and jaundice(9).Thirty three plants species were reported to have more than one therapeutic uses,while 17 species were reported to be used against single *** distance of villages from road head was one of the factors contributing to the decline in the medicinal plant population in their natural habitats. The availability of medicinal plants increased with increase in distance from road head and also the peoples'dependence on *** of the traditional knowledge will help in conservation of knowledge and also opportunity for using it for future training and *** result of this study will help in promoting sustainable cultivation and implementation in conservation protocol of those species,which are in the verge of exti

关键词： Conservation strategy Ethnobotany Medicinal plants Traditional communities Central Himalaya

Microbial Populations,Activity and Gene Abundance in Tropical Vertisols Under Intensive Chemical Farming

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Pedosphere 2016年第5期26卷 725-732页

作者： Kopparapu APARNA Desiraju lakshmi Narsimha rao Dananjeyan BAlACHANDAR Indian Institute of Soil Science Nabi BaghBhopal 462038(India) Tamilnadu Agricultural University Coirnbatore 641003(India)

There are increasing concerns on the environmental impacts of intensive chemical agriculture. The effect of high agrochemical inputs used in intensive chemical farming was assessed on soil microbiological, molecular and biochemical properties in tropical Vertisols in India. Farm field sites under normal cultivation of arable crops using high inputs of fertilizers and pesticides in chili （Capsicum annum l., 5.0× dose for fertilizers and 1.5× dose for pesticides over normal inputs） and black gram （Vigna mungo l. Hepper, 2.2× dose for fertilizers and 2.3× dose for pesticides over normal inputs） were compared with adjacent sites using normal recommended doses. Organic carbon and basal respiration showed no response to high inputs of fertilizers and pesticides in soils of both crops. labile carbon decreased by 10% in chili soils and increased by 24% in black gram soils under high input farming system. The proportion of soil labile carbon as a fraction of soil organic carbon was unaffected by high inputs. The labile carbon mineralization coefficient （qMlc） increased by 50.0% in chili soils, indicating that the soil microorganisms were under stress due to high agochemical inputs, whereas qMlc decreased by 36.4% in black gram soils. Copiotrophs increased due to high inputs in soils of both chili （63.1%） and black gram （47.1%）. Oligotrophs increased by 10.8% in black gram soils but not in chili soils. The abundance of amoA gene reduced by 39.3% in chili soils due to high inputs and increased significantly by 110.8% in black gram soils. β-Glucosidase also increased by 27.2% and 325.0%, respectively. Acid phosphatase activity reduced by 29.2% due to high inputs in chili soils and increased by 105.0% in black gram soils. The use of high agrochemical inputs thus had adverse consequences on biological health in chili but not in black gram soils. In soils cultivated with black gram, the moderating effect of cultivating legumes and their beneficial effect on soil health were eviden

关键词： amoA gene copiotrophs high agrochemical input legumes oligotrophs soil enzymes

6-姜烯酚通过调控微小RNA-26a-5p/DAPK1减轻脑缺血/再灌注损伤的机制研究

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中华危重病急救医学 2024年第6期36卷 616-623页

作者：李世欣饶欧阳朱宁周航向陶浚泠李叶红刘颖贵州医科大学贵阳550004 贵州医科大学附属医院重症医学科贵阳550004

目的探讨6-姜烯酚(6-SH)是否通过促进微小RNA-26a-5p(miR-26a-5p)表达并抑制死亡相关蛋白激酶1(DAPK1),减轻氧糖剥夺/复氧(OGD/R)神经细胞自噬及神经细胞钙超载,并探究其潜在机制。方法取体外培养的对数生长期小鼠海马神经元HT22细胞,... 详细信息

目的探讨6-姜烯酚(6-SH)是否通过促进微小RNA-26a-5p(miR-26a-5p)表达并抑制死亡相关蛋白激酶1(DAPK1),减轻氧糖剥夺/复氧(OGD/R)神经细胞自噬及神经细胞钙超载,并探究其潜在机制。方法取体外培养的对数生长期小鼠海马神经元HT22细胞,用细胞增殖与毒性检测试剂盒(CCK-8)检测细胞活性,寻找Na2S2O4的最佳制模浓度。将HT22细胞分为空白对照组(NC组)、OGD/R组(无糖培养基+10 mmol/l Na2S2O4处理1.5 h后换正常培养基培养4 h)、6-SH干预组(OGD后用10μmol/l 6-SH培养4 h)、阴性对照抑制剂预处理组(阴性对照抑制剂转染48 h后行OGD,再用6-SH培养4 h)、miR-26a-5p抑制剂预处理组(miR-26a-5p抑制剂转染48 h后行OGD,再用6-SH培养4 h)。采用CCK-8法检测各组细胞活性;透射电镜下观察细胞超微结构;实时荧光定量聚合酶链反应(RT-qPCR)检测DAPK1、miR-26a-5p基因表达;分子对接验证6-SH与miR-26a-5p的相互作用;双荧光素酶验证DAPK1与miR-26a-5p的靶向关系;流式细胞仪测定细胞内Ca2+水平;蛋白质免疫印迹试验(Western blotting)检测磷酸化谷氨酸受体2B(p-NMDAR2B)Ser1303、DAPK1、自噬相关蛋白Beclin1、微管相关蛋白1轻链3(lC3)、p-DAPK1 Ser308蛋白表达;免疫荧光法检测lC3和Beclin1的表达。结果CCK-8法检测结果显示,6-SH干预组细胞活性较OGD/R组明显升高,miR-26a-5p抑制剂预处理组细胞活性较6-SH干预组明显降低。透射电镜下显示,6-SH干预组自噬小体较OGD/R组明显减少,miR-26a-5p抑制剂预处理组自噬小体较6-SH干预组明显增多。RT-qPCR检测结果显示,与OGD/R组比较,6-SH干预组miR-26a-5p表达明显上调,DAPK1 mRNA表达明显下调;与6-SH干预组比较,miR-26a-5p抑制剂预处理组miR-26a-5p表达明显下调,DAPK1 mRNA表达明显上调。分子对接验证6-SH与miR-26a-5p可互相作用。双荧光素酶报告基因检测显示,与阴性对照组比较,mmu-miR-26a-5p显著下调m-DAPK1-3UTR-WT的荧光素酶表达,说明两者之间存在结合作用。流式细胞仪检测结果显示,与OGD/R组比较,6-SH干预组细胞内Ca2+水平明显降低;与6-SH干预组比较,miR-26a-5p抑制剂预处理组Ca2+水平明显升高。Western blotting检测结果显示,与OGD/R组比较,6-SH干预组p-NMDAR2B Ser1303、DAPK1、Beclin1、lC3蛋白表达均明显降低(p-NMDAR2B Ser1303/β-actin:2.34±0.27比4.78±0.39,DAPK1/β-actin:1.40±0.13比2.37±0.21,Beclin1/β-actin:2.61±0.32比4.32±0.29,lC3/β-actin:2.52±0.45比5.09±0.18,均Plin1、lC3蛋白表达明显升高(p-NMDAR2B Ser1303/β-actin:4.08±0.14比2.34±0.27,DAPK1/β-actin:1.96±0.15比1.40±0.13,Beclin1/β-actin:3.92±0.31比2.61±0.32,lC3/β-actin:4.33±0.33比2.52±0.45,均PlC3、Beclin1荧光强度明显降低;与6-SH干预组比较,miR-26a-5p抑制剂预处理组lC3、Beclin1荧光强度明显升高。结论6-SH可通过调控miR-26a-5p/DAPK1减轻细胞自噬及钙超载,从而减轻神经细胞损伤。

关键词：自噬脑缺血/再灌注损伤钙超载 6-姜烯酚微小RNA-26a-5p/死亡相关蛋白激酶1

Dielectric dispersion,linear and nonlinear optical properties of li_(2)O-WO_(3)-B_(2)O_(3):V_(2)O_(5)glasses

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Journal of Advanced Dielectrics 2020年第3期10卷 64-71页

作者： l.nganaboina Srinivasa rao Chinthakuntla Thirmal Parchuri Raghavendra rao Centre for Nanoscience and Technology Department of Physics(Humanities&Sciences)VNR Vignana Jyothi Institute of Engineering and Technology Bachupally Nizampet(S.O)Hyderabad-500090TelanganaIndia Department of Physics Malla Reddy Engineering College for Women Maisamma Guda Dhulapally(PO)Secundrabad-500100TelanganaIndia

40 li_(2)O–5WO_(3)–(55-x)B_(2)O_(3):xV_(2)O_(5)(mol%)for 0.0≤x≤0.8 glasses were prepared by *** polarization was described in terms of the dielectric constant("0)and loss(tanδ).Mixed conduction phenomenon was explained by redox pairs V^(4+)↔V^(5+)and W^(5+)↔W^(6+) at high *** polarizability(αe)was determined over a range of frequencies(100 Hz–100 kHz)and temperatures(30–280℃).The change of boron coordination in the glass network was explained with the aid of temperature coefficient of polarizability(φ).Nonlinear susceptibility(χ^((3)))and optical band gap(E°)were studied as a function of concentration of V_(2)O_(5).The highest values ofαe andχ^((3))were obtained at x=0.6 mol%.These glasses may find potential practical applications in the fields of solid-state ionics and nonlinear optics.

关键词： Dielectric properties electronic polarizability third-order nonlinear optical susceptibility optical band gap

多酶级联反应催化γ-丁内酯生成1,4-丁二醇

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应用与环境生物学报 2024年第1期30卷 167-175页

作者：郭艺鸣姜君逸潘学玮张显徐美娟杨套伟饶志明江南大学生物工程学院工业生物技术教育部重点实验室无锡214122

1,4-丁二醇是一种重要的化学品中间体,已被列入NICNAS高价值量工业化学品清单(HVICl).随着1,4-丁二醇的全球市场需求量不断增加,利用微生物法合成1,4-丁二醇已成为关注热点.基于多酶级联催化构建了一条以γ-丁内酯为底物合成1,4-丁二醇... 详细信息

1,4-丁二醇是一种重要的化学品中间体,已被列入NICNAS高价值量工业化学品清单(HVICl).随着1,4-丁二醇的全球市场需求量不断增加,利用微生物法合成1,4-丁二醇已成为关注热点.基于多酶级联催化构建了一条以γ-丁内酯为底物合成1,4-丁二醇的路径,首先通过己内酯水解酶(ChnC)将γ-丁内酯水解为4-羟基丁酸,接着在羧酸还原酶(Car)的作用下,将4-羟基丁酸还原成4-羟基丁醛,随后,利用醇脱氢酶(YqhD)将4-羟基丁醛进一步还原生成1,4-丁二醇;同时通过引入了甲酸脱氢酶(FDH)构建了NADH/NAD+辅酶循环再生系统.最后对底物添加浓度、催化温度、pH和多酶添加比例进行了优化.综合3种酶的最适反应条件优化之后,在30℃、pH 7.0、酶活力添加比例为1:3:2的优化条件下,以5 g/lγ-丁内酯为底物,1,4-丁二醇产量达到2.41 g/l,摩尔转化率为46.1%,与优化前相比分别提高了375.46%和374.79%.最后,通过底物补加试验,1,4-丁二醇的合成量最高达到6.31 g/l,摩尔转化率最高达到67.3%.本研究基于新设计的1,4-丁二醇多酶级联催化路径,实现了1,4-丁二醇酶法合成,结果有望为酶催化合成1,4-丁二醇及其高附加值衍生的产品提供一种新的思路.(图12表2参41)

关键词：多酶级联转化辅酶循环再生 γ-丁内酯 1,4-丁二醇

MCP-1-induced protein-1,an immune regulator

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Protein & Cell 2012年第12期3卷 903-910页

作者： Jiwei Xu Sheng Fu Wei Peng Zihe rao National laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

MCP-1-induced protein-1(MCPIP1)is a newly identified protein that is crucial to immune *** lack-ing MCPIP1 gene suffer from severe immune disorders,and most of them cannot survive l.nger than 12 *** progress has been made in reveal.ng the mechanism underlying the immune regulatory function of ***1 can act as an RNase to promote the mRNA degradation of some inflammatory cytokines,such as Il-6 and ***-microRNAs are also confirmed to be the substrate of MCPIP1 *** structure of MCPIP1 N-terminal conserved domain shows a PilT N-terminus-like RNase structure,further supporting the notion that MCPIP1 has RNase ***1 can also deubiquitinate TNF receptor-associated factor family proteins,which are known to mediate immune and inflammatory *** this review,we summarize recent progress on the immune regulatory role of MCPIP1 and discuss the mechanisms underlying its function.

关键词： MCPIP1 immune regulation RNase deubiquitinating enzyme crystal structure