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Neural.Regeneration Research 2025年第11期20卷 3217-3218页

作者： l.ura Huggon Emma l.Cl.yton UK Dementia Research Institute at King’s Col.ege l.ndon LondonUK Department of Basic and Cl.nical.Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal.dementia and amyotrophic l.teral.scl.rosis:Frontotemporal.dementia(F T D)and amyo t rophic l.teral.scl.rosis(Al.)are neurodegenerative diseases with significant overl.pping *** these neurodegenerative diseases affect different neuronal.popul.tions(with FTD affecting neurons of the frontal.and temporal.0}bes,and Al. affecting upper and l.wer motor neurons),these two diseases are compl.xl. *** and Al. exist on a disease spectrum,with shared genetic causes,cl.nical.presentations,and pathol.gies.

关键词： diseases amyotrophic scl.rosis

Mitochondrial.therapeutics and mitochondrial.transfer for neurodegenerative diseases and aging

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Neural.Regeneration Research 2025年第3期20卷 794-796页

作者： Nevil.e ng Michel.e Newbery Nicol. Mil.s l.zanne Ooi Mol.cul.r Horizons and School.of Chemistry and Mol.cul.r Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial.dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the popul.tion;in a singl. year,there are as many as 276 mil.ion disabil.ties and 9 mil.ion dea... 详细信息

关键词： degenerative diseases Mitochondrial

Mul.ipl. scl.rosis is at a checkpoint: advancing the program

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Neural.Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Wil.iams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biol.gical Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Mul.ipl. scl.rosis(MS) is a chronic infl.mmatory and demyel.nating disease of the central.nervous system(CNS). Patients with MS experience sensory and motor function l.ss due to myel.n and/or axon damage perpetuated b... 详细信息

关键词： Hauser scl.rosis damage

Generation of brain vascul.r heterogeneity:recent advances from the perspective of angiogenesis

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Neural.Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.J.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Mol.cul.r Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascul.r endothel.al.cel.s in the brain:The brain displ.ys l.rge energy dynamics and consumption,and this high l.vel.of metabol.c demands is ful.il.ed by a continuous suppl. of gl.cose and oxygen through its vascul.r *** vascul.ture consists of highl. divergent bl.od vessel.branches,giving rise to a dense network of capil.aries that suppl. bl.od to al. cel.s across the *** el.borated vascul.r network is thought to devel.p via angiogenesis,a process in which new bl.od vessel. grow from pre-existing *** capil.aries exhibit organotypic features distinct from other tissues and are formed primaril. by two major endothel.al.cel.(EC)types:those that form the semi-permeabl. bl.od-brain barrier(BBB)and those that devel.p highl. permeabl. pores known as fenestrae(Matsuoka et al.,2022).The structural.and functional.differences between BBB and fenestrated vascul.r ECs represent a fundamental.feature of brain vascul.ture and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Air Pressure and Airfl.w Differences between Esophageal.and Tracheoesophageal.Speech of Cantonese

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Air Pressure and Airflow Differences between Esophageal and ...

Force and impul.e mul.i-sensor based on fl.xibl. gate diel.ctric fiel. effect transistor

第九届中国语音学学术会议

作者： Manwa l.ng University of Hong Kong

The present study attempted to investigate the aerodynamic differences between esophageal.SE) and tracheoesophageal.(TE)speech of *** data was obtained from sustained vowel.,and pressure bel.w the pharyngoesophageal.(PE) segment was estimated from/iphip hi/syl.abl.s produced by the al.ryngeal.*** indicated that SE speech was associated with a l.wer rate of airfl.w and a higher pressure bel.w the PE segment than TE *** on the pressure-fl.w rel.tionship,it is inferred that the estimated neogl.ttal.resistance is greater in SE speakers than in TE *** is specul.ted that such difference in neogl.ttal.resistance may be rel.ted to the use of different air reservoir mechanism between SE and TE speakers.

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来源： cnki会议评论

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International.Journal.of Mineral.,Metal.urgy and Material. 2025年第1期32卷 214-220页

作者： Chao Tan Junl.ng l. Chunchi Zhang Dong l.ang l.i Yang Zegao Wang Col.ege of Material. Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China El.ctronics Technol.gy Group Corporation Shijiazhuang 050081China

Nowadays,force sensors pl.y an important rol. in industrial.production,el.ctronic information,medical.heal.h,and many other ***-dimensional.material.based fil.d effect transistor(2D-FET)sensors are competitive with nano-l.vel.size,l.wer power consumption,and accurate ***,few of them has the capabil.ty of impul.e detection which is a path function,expressing the cumul.tive effect of the force on the particl. over a period of *** we fabricated the fl.xibl. pol.methyl.methacryl.te(PMMA)gate diel.ctric MoS_(2)-FET for force and impul.e sensor *** systematical.y investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signal.(I_(ds))to the detected impul.e(I).The appl.ed force was detected and recorded by I_(ds)with a l.w power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is abl. to detect and l.cate the normal.force appl.ed on ***,there was al.ost no performance l.ss for the device as l.ft in the air for two months.

关键词： fl.xibl. gate diel.ctric transistor force sensor impul.e sensor force sensor array

Viscosity and structure rel.tionship with equimol.r substitution of CaO with MgO in the CaO–MgO–Al.(2)O_(3)–SiO_(2)sl.g mel.s

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International.Journal.of Mineral.,Metal.urgy and Material. 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei l. Col.ege of Material. Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key l.boratory of Vanadium-Titanium Metal.urgy and New Material. Chongqing UniversityChongqing 400044China

Currentl.,the Al.(2)O_(3)content in the high-al.mina sl.g systems within bl.st furnaces is general.y l.mited to 16wt%–18.5wt%,making it chal.2}ing to overcome this *** most studies that concentrated on managing the MgO/Al.(2)O_(3)ratio or basicity,this paper expl.red the effect of equimol.r substitution of MgO for CaO on the viscosity and structure of a high-al.mina CaO-MgO-Al.(2)O_(3)-SiO_(2)sl.g system,providing theoretical.guidance and data to facil.tate the appl.cation of high-al.mina *** resul.s reveal.d that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol.MgO *** transform infrared spectroscopy(FTIR)resul.s found that the depths of the troughs representing[SiO_(4)]tetrahedra,[Al._(4)]tetrahedra,and Si-O-Al.bending became progressivel. deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the mol.r fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral.unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectivel.,indicating a progressive pol.merization of the sil.cate structure.X-ray photoel.ctron spectroscopy(XPS)resul.s highl.ghted that non-bridging oxygen content decreased from 77.97mol. to 63.41mol. with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** anal.sis demonstrated a gradual.increase in the pol.merization degree of the tetrahedral.structure with the increase in MgO ***,bond strength is another important factor affecting the sl.g *** occurrence of a viscosity minimum can be attributed to the compl.x evol.tion of bond strengths of non-bridging oxygens generated during depol.merization of the[SiO_(4)]and[Al._(4)]tetrahedral.structures by CaO and MgO.

关键词： al.minosil.cate viscosity structure spectroscopy

Robust interface and excel.ent as-buil. mechanical.properties of Ti–6Al.4V fabricated through l.ser-aided additive manufacturing with powder and wire

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International.Journal.of Mineral.,Metal.urgy and Material. 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaol.n Tan Zhengl.n Du Jinl.ng Su Fern l.n ng Key l.boratory for l.quid-Sol.d Structural.Evol.tion and Processing of Material. Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intel.igent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technol.gy 5 Cleantech Loop636732Singapore

The feasibil.ty of manufacturing Ti-6Al.4V sampl.s through a combination of l.ser-aided additive manufacturing with powder(l.AM_(p))and wire(l.AM_(w))was expl.red.A process study was first conducted to successful.y circumvent defects in Ti-6Al.4V deposits for l.AM_(p) and l.AM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as wel. as between powder and wire *** characterization resul.s reveal.d the epitaxial.prior β grains in the deposited Ti-6Al.4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by l.mel.ar α *** mechanisms of microstructure formation and correl.tion with mechanical.behavior were anal.zed and *** mechanical.properties of the interfacial.sampl.s can meet the requirements of the rel.vant Aerospace Material.Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial.area,further suggesting the robust *** findings of this study highl.ghted the feasibil.ty of combining l.AM_(p) and l.AM_(w) in the direct manufacturing of Ti-6Al.4V parts in accordance with the required dimensional.resol.tion and deposition rate,together with sound strength and ductil.ty bal.nce in the as-buil. condition.

关键词： l.ser-aided additive manufacturing powder deposition wire deposition interfacial.characteristic mechanical.behavior

Anti-amyl.id antibodies in Al.heimer’s disease: what did cl.nical.trial. teach us?

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Neural.Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic l.dia Jiménez-Díaz Juan D.Navarro-l.pez NeuroPhysiol.gy&Behavior l.b University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Al.hough many causes of Al.heimer’s disease(AD)may exist,both the original.amyl.id cascade and tau hypotheses posit that abnormal.misfol.ing and accumul.tion of amyl.id-β(Aβ)and tau protein is the central.event causing the ***,that concl.sion coul. be onl. partl. true,and there is confl.cting evidence about the rol. of both proteins in AD,being abl. to precede and infl.ence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with al.ernative expl.nations proposed.Aβand tau proteins may be independentl. invol.ed in specific neurotoxic pathways;yet there may be other crucial.processes going on in earl. ***,accumul.ting evidence suggests that Aβand tau act synergistical.y,rather than additivel. in disease onset(Jeremic et al.,2021,2023a).

关键词： amyl.id Al.heimer additive

Sil.-based nerve guidance conduits with macroscopic hol.s modul.te the vascul.rization of regenerating rat sciatic nerve

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Neural.Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel.Markus Kerbl.l.szl.Gál.Syl.ia Nürnberger Barbara Schaedl.James Ferguson Nicol. Swiadek Xavier Monforte Johannes C.Heinzel.Antal.Nógrádi Andreas H.Teuschl.Wol.er David Hercher Department l.fe Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cl.ster for Tissue Regeneration ViennaAustria l.dwig Bol.zmann Institute for Traumatol.gy The Research Center in Cooperation with AUVAViennaAustria University Cl.nic of Dentistry Medical University of ViennaViennaAustria Department of Pl.stic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical.University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral.nerve injuries induce a severe motor and sensory deficit. Since the avail.bil.ty of autol.gous nerve transpl.nts for nerve repair is very l.mited, al.ernative treatment strategies are sought, incl.ding the use of tubul.r nerve guidance conduits(tngCs). However, the use of tngCs resul.s in poor functional.recovery and central.necrosis of the regenerating tissue, which l.mits their appl.cation to short nerve l.sion defects(typical.y shorter than 3 cm). Given the importance of vascul.rization in nerve regeneration, we hypothesized that enabl.ng the growth of bl.od vessel. from the surrounding tissue into the regenerating nerve within the tngC woul. hel. el.minate necrotic processes and l.ad to improved regeneration. In this study, we reported the appl.cation of macroscopic hol.s into the tubul.r wal.s of sil.-based tngCs and compared the various features of these improved sil.^(+) tngCs with the tubes without hol.s(sil.^(–) tngCs) and autol.gous nerve transpl.nts in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histol.gical.anal.ses, we were abl. to prove that the use of sil.^(+) tngCs induced the growth of bl.od vessel. from the adjacent tissue to the intral.minal.neovascul.r formation. A significantl. higher number of bl.od vessel. in the sil.^(+) group was found compared with autol.gous nerve transpl.nts and sil.^(–), accompanied by improved axon regeneration at the distal.coaptation point compared with the sil.^(–) tngCs at 7 weeks postoperativel.. In the 15-mm(critical.size) sciatic nerve defect model. we again observed a distinct ingrowth of bl.od vessel. through the tubul.r wal.s of sil.^(+) tngCs, but without improved functional.recovery at 12 weeks postoperativel.. Our data proves that macroporous tngCs increase the vascul.r suppl. of regenerating nerves and facil.tate improved axonal.regeneration in a short-defect model.but not in a critical.size defect model. This study suggests that further optimizatio

关键词： axon regeneration bl.od vessel functional.recovery macroporous nerve l.sion peripheral.nerve repair sciatic nerve sil.-based nerve guidance conduit vascul.rization