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long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort

World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 193-205页

作者： Anna Fábián Renáta Bor Béla Vasas Mónika Szűcs Tibor Tóth Zsófia Bősze Kata Judit Szántó Péter Bacsur Anita Bálint Bernadett Farkas Klaudia Farkas Ágnes Milassin Mariann Rutka Tamás Resál Tamás Molnár Zoltán Szepes Department of Internal Medicine University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Pathology University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Medical Physics and Medical Informatics University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6720Hungary USZ Translational Colorectal Research Group Hungarian Centre of Excellence for Molecular MedicineSzeged 6725Hungary

BACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is *** To evaluate long-term outcomes after endoscopic removal of malignant colorectal *** A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and *** disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were *** rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and fisher’s exact test and Mann-Whitney test were *** risk factors of adverse outcomes were RESUlTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were *** proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,*** differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,*** tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical *** analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance *** outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance *** Reporting of histological featur

关键词： Malignant colorectal polyps T1 tumor Endoscopic removal Outcomes long-term Surveillance

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HYDROGEN DISPlACEMENT OF CHEMISORBED CO FROM THE Ni(100) SURFACE

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分子催化 1990年第S1期4卷 49-60页

作者： Shen Shikong(lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, lanzhou 730000. China)John l. Gland (Corporate Research, Exxon R. & E. Co., Annandale, NJ 08801)Dan A. fisher (NSlS-Brookhaven National lab., Upton, NY 11973)Francisco Zaera (Chemistry Dept., University of California/ Riverside, CA 92521)

We report the first observation of hydrogen induced displacement of chemisorbed CO from the Ni（100） surface. This displacement is unexpected since the heat of adsorption for CO is 126 kJ/mole, about 30 kJ/mole larger than the 96 kJ/mole heat of adsorption for hydrogen, Rates of displacement were measured by Fluorescence Yield Near Edge Spectroscopy （FYNES） and Temperature Programmed Desorption （TPD）. Excellent agreement is observed between both methods. Hydrogen pressures in the 10-4 to 10-1 Torr range cause displacement of chemisorbed CO in the 270 to 330 K temperature range in a matter of minutes. The displacement reaction is clearly positive order in CO coverage. The CO coverage data suggested two first order reaction regions with a decrease in rate with decreasing coverage. Displacement is about half order in hydrogen pressure. The activation energy for the high coverage displacement rate is approximately 29±4 kJ/mole while the activation energy for the low coverage displacement rate about

关键词： coverage SURFACE unexpected minutes adsorbed instead decreasing clearly collision desorption

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BMC Family Practice论文摘要汇编——基层医疗机构慢性病患者自我管理支持研究：患者自我管理问题的频率、自我管理事项优先级排序及其与医疗团队成员为其设定的行为目标的一致性

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中国全科医学 2019年第32期22卷 3989-3989页

作者： HESSlER D M fisher l BOWYER V 本刊编辑部

背景为了提供高质量的以患者为中心的诊疗服务,在初级保健卫生系统中融入适当的资源以支持患者发现自我管理中存在的问题以及自我管理事项的优先安排是否合理,有必要研制出实用的系统的评估患者自我管理需求及管理事项优先安排是否合理... 详细信息

背景为了提供高质量的以患者为中心的诊疗服务,在初级保健卫生系统中融入适当的资源以支持患者发现自我管理中存在的问题以及自我管理事项的优先安排是否合理,有必要研制出实用的系统的评估患者自我管理需求及管理事项优先安排是否合理的方法。本研究对Connection to Health(CTH)数据库里的资料进行分析,分析患者报告自我管理中问题出现的频率以及管理事项安排的优先排序,并探究患者自我管理事项的优先排序与患者诊疗小组成员为其设定的最终行为目标是否一致。

关键词：基层医疗机构慢性病患者初级保健卫生系统医疗团队优先排序优先级排序诊疗服务

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维生素D对内皮功能的影响:一项随机、双盲、安慰剂对照试验

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中华高血压杂志 2017年第10期25卷 998-998页

作者： Borgi l McMullan C Wohlhueter A Curhan GC fisher ND Forman JP 陈云叶鹏

在非高血压人群中，低水平的25羟基维生素D[25-hydroxyvitamin D，25（OH）D]已证实与高血压风险增加有关，且维生素D缺乏与内皮功能障碍相关。然而，非高血压人群补充维生素D对内皮细胞功能的影响尚未得到验证。方法：

关键词：维生素D缺乏内皮功能障碍对照试验安慰剂非高血压人群随机双盲内皮细胞功能

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重塑DEll的灵魂

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21世纪商业评论 2006年第1期 92-95页

作者： lawrence M.fisher 余旭辉

2000年末，DEll公司遭受重创。从l984年创立时起，DEll公司就一直是个人电脑用户的宠儿，1988年DEll公司公开上市之后，也备受投资者的追捧。作为供应链管理的专家，DEll公司可以为各种不同需求的客户提供定制的个人电脑。就是这样一家... 详细信息

2000年末，DEll公司遭受重创。从l984年创立时起，DEll公司就一直是个人电脑用户的宠儿，1988年DEll公司公开上市之后，也备受投资者的追捧。作为供应链管理的专家，DEll公司可以为各种不同需求的客户提供定制的个人电脑。就是这样一家优秀的公司，在网络泡沫破灭之后，也一样没能摆脱业务增长停滞的阴影。DEll公司宣布了他的首次裁员消息，但是仍然连续五个月未能达到华尔街的预期，甚至也没能达到公司内部制定的业务收入目标。公司的股价一落千丈，从50多美元迅速跌至17美元。

关键词： DEll公司业务范围经营模式市场竞争价值观念客户需求

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Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice

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life Metabolism 2023年第2期2卷 23-34页

作者： Patrick J.Ferrara Marisa J.lang Jordan M.Johnson Shinya Watanabe Kelsey l.Mclaughlin John Alan Maschek Anthony R.P.Verkerke Piyarat Siripoksup Amandine Chaix James E.Cox Kelsey H.fisher-Wellman Katsuhiko Funai Diabetes&Metabolism Research Center University of UtahSalt Lake CityUtah 84112United States Department of Nutrition&Integrative Physiology University of UtahSalt Lake CityUtah 84112United States East Carolina Diabetes&Obesity Institute East Carolina UniversityGreenvilleNorth Carolina 27834United States Department of Physiology East Carolina UniversityGreenvilleNorth Carolina 27834United States Metabolomics Core Research Facility University of UtahSalt Lake CityUtah 84112United States Molecular Medicine Program University of UtahSalt Lake CityUtah 84112United States Department of Biochemistry University of UtahSalt Lake CityUtah 84112United States

Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight *** suggests that this energetic mismatch originates from lean *** this phenomenon is well documented,the mechanisms have remained *** hypothesized that increased mitochondrial energy efficiency in skeletal muscle is associated with reduced expenditure under weight ***(WT)male C57Bl6/N mice were fed with high-fat diet for 10 weeks,followed by a subset of mice that were maintained on the obesogenic diet(OB)or switched to standard chow to promote weight loss(Wl)for additional 6 *** energy efficiency was evaluated using high-resolution respirometry and *** spectrometric analyses were employed to describe the mitochondrial proteome and *** loss promoted~50%increase in the efficiency of oxidative phosphorylation(ATP produced per O_(2) consumed,or P/O)in skeletal ***,Weight loss did not appear to induce significant changes in mitochondrial proteome,nor any changes in respiratory supercomplex ***,it accelerated the remodeling of mitochondrial cardiolipin(Cl)acyl-chains to increase tetralinoleoyl Cl(TlCl)content,a species of lipids thought to be functionally critical for the respiratory *** further show that lowering TlCl by deleting the Cl transacylase tafazzin was sufficient to reduce skeletal muscle P/O and protect mice from diet-induced weight *** findings implicate skeletal muscle mitochondrial efficiency as a novel mechanism by which weight loss reduces energy expenditure in obesity.

关键词： energy efficiency energy expenditure mitochondria oxidative phosphorylation phospholipids weight loss

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Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

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World Journal of Gastroenterology 2017年第33期23卷 6137-6146页

作者： Morten l Halling Jens Kjeldsen Torben Knudsen Jan Nielsen lars Koch Hansen Department of Gast-roenterology and Hepatology Hospital of Southwest Jutland Department of Medical Gastroenterology S Odense University Hospital Center for Clinical Epidemiology Odense Uni-versity Hospital

AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P lues were estimated using fisher's exact *** There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P ll significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P lerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P liary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P leritis. Restricted to women with UC(P l arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P lUSION Immune mediated diseases were si

关键词： Immune mediated diseases Ulcerative colitis Risk Prevalence Registry Chronic inflammatory diseases Autoimmune diseases Inflammatory bowel disease Crohn’s disease extraintestinal manifestations

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多发性硬化症患者的视网膜神经纤维层厚度与视觉功能之间的关系

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 55-56页

作者： fisher J. B. JacobsD. A. Markowitz C. E. l.J. Balcer 王文军(译) 不详 3 East Gates Building 3400 Spruce Street Philadelphia PA 19104 United States

Purpose: To examine the relation of visual function to retinal nerve fiber layer (RNFl) thickness as a structural biomarker for axonal loss in multiple sclerosis (MS),and to compare RNFl thickness among MS eyes with a history of acute optic neuritis (MS ON eyes),MS eyes without an optic neuritis history (MS non-ON eyes),and disease-free control eyes. Design: Cross-sectional study. Participants: Patients with MS (n=90; 180 eyes) and disease-free controls (n =36; 72 eyes). Methods: Retinal never fiber layer thickness was measured using optical coherence tomography (OCT; fast RNFl thickness software protocol). Vision testing was performed for each eye and binocularly before OCT scanning using measures previously shown to capture dysfunction in MS patients: (1) low-contrast letter acuity (Sloan charts,2.5% and 1.25% contrast levels at 2 m) and (2) contrast sensitivity (Pelli-Robson chart at 1 m). Visual acuity (retroilluminated Early Treatment Diabetic Retinopathy charts at 3.2 m) was also measured,and protocol refractions were performed. Main Outcome Measures: Retinal nerve fiber layer thickness measured by OCT,and visual function test results. Results: Although median Snellen acuity equivalents were better than 20/20 in both groups,RNFl thickness was reduced significantly among eyes of MS patients (92 μ m) versus controls (105 μ m) (P larly was reduced in MS ON eyes (85 μ m; P lations). lower visual function scores were associated with reduced average overall RNFl thickness in MS eyes; for every 1-line decrease in low-contrast letter acuity or contrast sensitivity score,the mean RNFl thickness decreased by 4 μ m. Conclusions: Scores for low-contrast letter acuity and contrast sensitivity correlate well with RNFl thickness as a structural biomarker,supporting validity for these visual function tests as secondary clinical outcome measures for MS trials. These results also sugg

关键词：视网膜神经纤维层厚度多发性硬化症患者视觉功能急性视神经炎 NFl厚度 Snellen视力双眼视功能正常对照组糖尿病视网膜病变

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Convenient model of hard tissue simulation for dental radiographic research and instruction

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World Journal of Methodology 2024年第1期14卷 80-86页

作者： Etiene Andrade Munhoz Claudio Roberto Gaiao Xavier Roberto Ponce Salles Ana lúcia Alvares Capelozza Augusto Vanni Bodanezi Department of Dentistry Health Science CentreFederal University of Santa CatarinaFlorianopolis 88040-379Brazil Department of Stomatology Radiology and Oral SurgerySchool of DentistryUniversity of São PauloBauru 17012-901Brazil

BACKGROUND The authors describe a technique for building an alternative jawbone phantom using dental gypsum and rice for research and dental radiology *** To investigate the potential of an alternative phantom to simulate the trabecular bone aspect of the human maxilla in periapical *** Half-maxillary phantoms built from gypsum-ground rice were exposed to X-rays,and the resulting images(experimental group)were compared to standardized radiographic images produced from dry human maxillary bone(control group)(n=7).The images were blindly assessed according to strict criteria by three examiners for the usual trabecular aspects of the surrounding bone,and significant differences between groups and in assessment reliability were compared using fisher’s exact and kappa tests(α=0.05).RESUlTS The differences in the trabecular aspects between groups were not statistically *** addition,interobserver agreement among observers was 0.43 and 0.51 for the control and experimental groups,respectively,whereas intraobserver agreement was 0.71 and 0.73,*** The tested phantom seemed to demonstrate potential for trabecular bone image Munhoz EA et *** of hard tissue simulation for dental radiography WJM https://*** 2 March 20,2024 Volume 14 Issue 1 simulation on maxillary periapical radiographs.

关键词： Phantom Radiology Education Endodontic treatment Bone trabecular

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Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny l. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda l. Hall lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya lophatananon Sarah l. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril fisher Charles Jameson Colin S. Cooper Dallas R. English John l. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, lMTK2 and KlK2/3. The MSMB and KlK2/3 genes may be useful for PCa screening, and the lMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

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