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ECNU Review of Education 2024年第2期7卷 283-307页

作者：曾成 l.nda fisher 184 Hills Road Cambridge CB28PQUK

Purpose:Mobile-assisted language learning(MAll)apps such as Duolingo have great potential for promoting learners'motivation to learn a second language(l2).However,little research has investigated how this motivational impact takes ***,despite the flexibility of mobile learning,most existing studies are conducted in classroom settings,with less attention paid to out-of-school technology ***/Approach/Methods:To address these gaps,we present a model based on self-determination theory and propose the idea of“motivational transfer”to explain the psychological mechanism underpinning the impact of *** examine the model,we conducted a case study with 20 Year 8 Chinese junior school students who used Duolingo to learn English as a foreign language(EFl)after school for 6 ***:Questionnaire and group interview data support our hypothesized mechanism:learners'activity-specific intrinsic motivation(IM)for using Duolingo and their underlying psychological need for autonomy and competence can be transferred to a more general level,thereby enhancing learners'global ***:The proposed theoretical model expands our understanding of how digital technology stimulates learners'l2 motivation;it can help l2 educators design better technological affordances to promote learners'motivation both in and outside the classroom.

关键词： Digital game-based learning l2 motivation MAll self-determination theory

Dermatofibrosarcoma protuberans: from translocation to targeted therapy

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Cancer Biology & Medicine 2015年第4期12卷 375-384页

作者： Jonathan Noujaim Khin Thway Cyril fisher Robin l.Jones Sarcoma Unit Royal Marsden NHS Foundation Trust

Dermatofibrosarcoma protuberans(DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity for metastasis. Wide surgical resection or Mohs micrographic surgery(MMS) are the preferred approaches for localized disease, while radiation therapy is warranted for inoperable disease or for cases with positive margins where re-excision is not possible. DFSP is generally regarded as refractory to conventional chemotherapy. Treatment options for systemic disease were limited until the discovery of a unique translocation, t(17;22)(q22;q13)(COl1A1;PDGFB) found in a majority of cases. In recent years, imatinib, a PDGFβR, ABl and KIT inhibitor, has revolutionized systemic therapy in DFSP. In this review, we summarize the epidemiological, clinical, histological and genetic characteristics of DFSP and update the readers on its current management.

关键词： Dermatofibrosarcoma protuberans(DFSP) imatinib Mohs micrographic surgery(MMS) translocation targeted therapy

Microenvironmental influences on T cell immunity in cancer and inflammation

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Cellular & Molecular Immunology 2022年第3期19卷 316-326页

作者： Darren R.Heintzman Emilie l.fisher Jeffrey C.Rathmell Department of Pathology Microbiologyand ImmunologyVanderbilt University Medical CenterNashvilleTN37205USA Vanderbilt Center for Immunobiology Vanderbilt University Medical CenterNashvilleTN37205USA

T cell metabolism is dynamic and highly *** the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns,the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways.T cells must function in a wide variety of tissue settings,and how T cells interpret these signals to maintain an appropriate metabolic program for their demands or if metabolic mechanisms of immune suppression restrain immunity is an area of growing *** in inflamed and cancer tissues,a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape *** include fever and increased temperatures,depletion of critical micro and macro-nutrients,and accumulation of inhibitory waste *** we review several of these factors and how the tissue microenvironment both shapes and constrains immunity.

关键词： immunometabolism T cell microenvironment cancer inflammation

Photodynamic therapy in the treatment of intracranial gliomas:A review of current practice and considerations for future clinical directions

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 40-59页

作者： Carl J.fisher lothar lilge Department of Medical Biophysics University of Toronto Princess Margaret Cancer Centre 101 College StRm.15-710 TorontoON M5G 1L7 University Health Network Princess Margaret Cancer Centre 101 College St Rm.15-310TorontoON M5G 1L7

Invasive grade III and IV maliguant gliomas remain difficult to treat with a typical survival time post-diagnosis hovering around 16 months with only minor extension thereof seen in the past decade,whereas some improvements have been obtained towards five-year survival rates for which completeness of resection is a *** techniques such as fluorescence guided resection(FGR)and photodynamic therapy(PDT)are promising adjuvant techniques to in-crease the tumor volume reduction *** has been used in combination with surgical resection or alternatively as standalone treat ment strategy with some sucoess in extending the median survival time of patients compared to surgery alone and the current standard of *** document reviews the outcome of past clinical trials and highlights the general shift in PDT therapeutic *** also looks at the current approaches for interstitial PDT and research options into increasing PDT's glioma treatment fficacy through exploiting both physical and biological based approaches to maximize PDT selectivity and therapeutic index,particularly in brain adjacent to tumor(BAT).Potential reasons for failing to demonstrate a significant survival advantage in prior PDT clinical trials will become evident in light of the improved understanding of glioma biology and PDT dosimetry.

关键词： Oncology brain tumour photodynamic dose therapeutic index photofin aminolu-velinic acid

Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report

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World Journal of Gastroenterology 2006年第35期12卷 5729-5732页

作者： louis Rivera Huan Giap William Miller Jonathan fisher Donald J Hillebrand Christopher Marsh Randolph l Schaffer Naval Medical Center San Diego San Diego CA 92134 United States Department of Radiation Oncology Scripps Clinic/ Green Hospital La Jolla CA 92037 United States Department of Hematology/Oncology Scripps Clinic/Green Hospital La Jolla CA 92037 United States Scripps Center for Organ and Cell Transplantation Scripps Clinic/Green Hospital La Jolla CA 92037 United States

Hepatocellular carcinoma （HCC） recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemoembolization （TACE）, radiofrequency ablation （RFA）, ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres （SIR-Spheres, Sirtex Medical Inc., lake Forest, Il, USA）. Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein （AFP） level. There were no adverse consequences of initial treatment.

关键词： Recurrent hepatocellular carcinoma Yttrium-90 microspheres liver transplantation

CRISPR-mediated genome editing and human diseases

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Genes & Diseases 2016年第4期3卷 244-251页

作者： liquan Cai Alfred l.fisher Haochu Huang Zijian Xie Marshal l Institute for Interdisciplinary Research(MIIR) Marshall UniversityWeisberg Engineering ComplexMarshall University1628 Third AvenueHuntingtonWV 25703USA University of Texas Health Science Center at San Antonio Department of MedicineDivision of GeriatricsGerontologyand Palliative MedicineSan AntonioTX 78229USA GRECC South Texas VA Healthcare SystemSan AntonioTX 78229USA Committee on Immunology Section of RheumatologyDepartment of MedicineKnapp Center for Lupus and Immunology ResearchUniversity of ChicagoChicagoIL 60637USA

CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats)technology has emerged as a powerful technology for genome editing and is now widely used in basic biomedical research to explore gene *** recently,this technology has been increasingly applied to the study or treatment of human diseases,including Barth syndrome effects on the heart,Duchenne muscular dystrophy,hemophilia,b-Thalassemia,and cystic ***/Cas9(CRISPR-associated protein 9)genome editing has been used to correct diseasecausing DNA mutations ranging from a single base pair to large deletions in model systems ranging from cells in vitro to animals in *** addition to genetic diseases,CRISPR/Cas9 gene editing has also been applied in immunology-focused applications such as the targeting of C-C chemokine receptor type 5,the programmed death 1 gene,or the creation of chimeric antigen receptors in T cells for purposes such as the treatment of the acquired immune deficiency syndrome(AIDS)or promoting anti-tumor ***,this technology has been applied to the genetic manipulation of domesticated animals with the goal of producing biologic medical materials,including molecules,cells or organs,on a large ***,CRISPR/Cas9 has been teamed with induced pluripotent stem(iPS)cells to perform multiple tissue engineering tasks including the creation of disease models or the preparation of donor-specific tissues for *** review will explore the ways in which the use of CRISPR/Cas9 is opening new doors to the treatment of human diseases.

关键词： CRISPR DNA double-stranded break Genome editing Human diseases iPS cells

Gender and managerial competence:a comparison of male and female first-line nurse managers in Indonesia

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Frontiers of Nursing 2021年第1期8卷 49-58页

作者： Joko Gunawan Yupin Aungsuroch Mary l.fisher Anna M.McDaniel Faculty of Nursing Chulalongkorn University BangkokBangkok 10330Thailand College of Nursing University of FloridaGainesvilleFlorida 32610USA School of Nursing Indiana UniversityIndianapolisIndiana 46202USA

Objective:First-line nurse managers are more likely to work according to gender beliefs and stereotypes,which may affect their managerial *** study is aimed at comparing managerial competence of male and female first-line nurse managers in public hospitals in ***:This study employed a descriptive comparative approach with a cross-sectional survey with a total of 256 participants selected from 18 public *** measure managerial competence,the managerial competence scale for Indonesian first-line nurse managers was *** were analyzed using descriptive analyses using mean,standard deviation,and Independent ***:Managerial competence of male and female first-line nurse managers was not significantly different(P=0.555).Female nurse managers descriptively reported/received higher ranking in facilitating spiritual nursing care,managing self,staffing and professional development,utilizing informatics,and applying quality care *** nurse managers repor ted higher in leadership and financial ***:Female and male first-line nurse managers should be treated equally for leadership and managerial development.

关键词： nurse administrators male female managerial competence Indonesia

Using multilayer network analysis to explore the temporal dynamics of collective behavior

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Current Zoology 2021年第1期67卷 71-80页

作者： David N.fisher Noa PINTER-WOllMAN Department of Psychology Neuroscience&BehaviourMcMaster UniversityHamiltonON L8S 4K1Canada School of Biological Sciences University of AberdeenAberdeenAB243FXUK Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCAUSA

Social organisms often show collective behaviors such as group foraging or *** behaviors can emerge from interactions between group members and may depend on the behavior of key *** social interactions change over time,collective behaviors may change because these behaviors emerge from interactions among *** the importance of,and growing interest in,the temporal dynamics of social interactions,it is not clear how to quantify changes in interactions over time or measure their ***,the temporal scale at which we should observe changes in social networks to detect biologically meaningful changes is not always *** we use multilayer network analysis to quantify temporal dynamics of social networks of the social spider Stegodyphus dumicola and determine how these dynamics relate to individual and group *** found that social interactions changed over time at a constant *** in both network structure and the identity of a keystone individual was not related to the mean or variance of the collective prey attack *** that maintained a large and stable number of connections,despite changes in network structure,were the boldest individuals in the ***,social interactions and boldness are linked across time,but group collective behavior is not influenced by the stability of the social *** work demonstrates that dynamic social networks can be modeled in a multilayer *** approach may reveal biologically important temporal changes to social structure in other systems.

关键词： collective behavior dynamic network multilayer network multiplex social stability Stegodyphus

Beyond the Pediatric end-stage liver disease system: Solutions for infants with biliary atresia requiring liver transplant

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World Journal of Gastroenterology 2014年第32期20卷 11062-11068页

作者： Mary Elizabeth M Tessier Sanjiv Harpavat Ross W Shepherd Girish S Hiremath Mary l Brandt Amy fisher John A Goss Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Houston Department of Surgery Baylor College of Medicine and Texas Children’s HospitalHouston

Biliary atresia(BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant, with up to one half of BA children needing a transplant by age two. In the current pediatric end-stage liver disease system, children with BA face the risk of not receiving a liver in a safe and timely manner. In this review, we discuss a number of possible solutions to help these children. We focus on two general approaches:(1) preventing/delaying need for transplantation, by optimizing the success of the Kasai operation; and(2) expediting transplantation when needed, by performing techniques other than the standard deceased-donor, whole, ABO-matched organ transplant.

关键词： Biliary atresia liver transplantation Pediatric liver disease Pediatric end-stage liver disease Kasai operation Newborn screening Surgical outcomes living-related donor transplantation Split liver transplantation ABO-incompatible liver transplantation

Pancreatic cancer: Advances in treatment

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World Journal of Gastroenterology 2014年第28期20卷 9354-9360页

作者： Somala Mohammed George Van Buren Ⅱ William E fisher The Elkins Pancreas Center Michael E DeBakey Department of Surgeryand Dan L Duncan Cancer CenterBaylor College of Medicine

Pancreatic cancer is a leading cause of cancer mortality and the incidence of this disease is expected to continue *** patients with pancreatic cancer have traditionally faced a dismal prognosis,over the past several years various advances in diagnosis and treatment have begun to positively impact this *** of effective combinations of existing chemotherapeutic agents,such as the FOlFIRINOX and the gemcitabine+nab-paclitaxel regimen,has improved survival for selected patients although concerns regarding their toxicity profiles remain.A better understanding of pancreatic carcinogenesis has identified several pre-malignant precursor lesions,such as pancreatic intraepithelial neoplasias,intraductal papillary mucinous neoplasms,and cystic *** technology has also evolved dramatically so as to allow early detection of these lesions and thereby facilitate earlier *** remains a cornerstone of treatment for patients with resectable pancreatic tumors,and advances in surgical technique have allowed patients to undergo resection with decreasing perioperative morbidity and *** has also become feasible in selected patients with borderline resectable tumors as a result of neoadjuvant ***,pancreatectomy involving vascular reconstruction and pancreatectomy with minimally invasive techniques have demonstrated safety without significantly compromising oncologic ***,a deeper understanding of molecular aberrations contributing to the development of pancreatic cancer shows promise for future development of more targeted and safe therapeutic agents.

关键词： Pancreatic cancer Pancreaticoduodenectomy Treatment advances Pancreatic oncology Chemotherapy FOlFIRINOX Pancreatic resection