检索结果-南通市图书馆

Sil.-based nerve guidance conduits with macroscopic hol.s modul.te the vascul.rization of regenerating rat sciatic nerve

在线全文

学校读者我要写书评

暂无评论

neural.Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel.Markus Kerbl.l.szl.Gál.Syl.ia nürnberger Barbara Schaedl.James Ferguson nicol. Swiadek Xavier Monforte Johannes C.Heinzel.Antal.nógrádi Andreas H.Teuschl.Wol.er David Hercher Department l.fe Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cl.ster for Tissue Regeneration ViennaAustria l.dwig Bol.zmann Institute for Traumatol.gy The Research Center in Cooperation with AUVAViennaAustria University Cl.nic of Dentistry Medical University of ViennaViennaAustria Department of Pl.stic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical.University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral.nerve injuries induce a severe motor and sensory deficit. Since the avail.bil.ty of autol.gous nerve transpl.nts for nerve repair is very l.mited, al.ernative treatment strategies are sought, incl.ding the use of tubul.r nerve guidance conduits(tnGCs). However, the use of tnGCs resul.s in poor functional.recovery and central.necrosis of the regenerating tissue, which l.mits their appl.cation to short nerve l.sion defects(typical.y shorter than 3 cm). Given the importance of vascul.rization in nerve regeneration, we hypothesized that enabl.ng the growth of bl.od vessel. from the surrounding tissue into the regenerating nerve within the tnGC woul. hel. el.minate necrotic processes and l.ad to improved regeneration. In this study, we reported the appl.cation of macroscopic hol.s into the tubul.r wal.s of sil.-based tnGCs and compared the various features of these improved sil.^(+) tnGCs with the tubes without hol.s(sil.^(–) tnGCs) and autol.gous nerve transpl.nts in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histol.gical.anal.ses, we were abl. to prove that the use of sil.^(+) tnGCs induced the growth of bl.od vessel. from the adjacent tissue to the intral.minal.neovascul.r formation. A significantl. higher number of bl.od vessel. in the sil.^(+) group was found compared with autol.gous nerve transpl.nts and sil.^(–), accompanied by improved axon regeneration at the distal.coaptation point compared with the sil.^(–) tnGCs at 7 weeks postoperativel.. In the 15-mm(critical.size) sciatic nerve defect model. we again observed a distinct ingrowth of bl.od vessel. through the tubul.r wal.s of sil.^(+) tnGCs, but without improved functional.recovery at 12 weeks postoperativel.. Our data proves that macroporous tnGCs increase the vascul.r suppl. of regenerating nerves and facil.tate improved axonal.regeneration in a short-defect model.but not in a critical.size defect model. This study suggests that further optimizatio

关键词： axon regeneration bl.od vessel functional.recovery macroporous nerve l.sion peripheral.nerve repair sciatic nerve sil.-based nerve guidance conduit vascul.rization

Anti-amyl.id antibodies in Al.heimer’s disease: what did cl.nical.trial. teach us?

在线全文

学校读者我要写书评

暂无评论

neural.Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic l.dia Jiménez-Díaz Juan D.navarro-l.pez neuroPhysiol.gy&Behavior l.b University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Al.hough many causes of Al.heimer’s disease(AD)may exist,both the original.amyl.id cascade and tau hypotheses posit that abnormal.misfol.ing and accumul.tion of amyl.id-β(Aβ)and tau protein is the central.event causing the ***,that concl.sion coul. be onl. partl. true,and there is confl.cting evidence about the rol. of both proteins in AD,being abl. to precede and infl.ence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with al.ernative expl.nations proposed.Aβand tau proteins may be independentl. invol.ed in specific neurotoxic pathways;yet there may be other crucial.processes going on in earl. ***,accumul.ting evidence suggests that Aβand tau act synergistical.y,rather than additivel. in disease onset(Jeremic et al.,2021,2023a).

关键词： amyl.id Al.heimer additive

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramol.cul.r frameworks by reaction time for D2/H2 separation

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang nan Qing l. Xiufang l. Zi-Xiu l. l.nzhe l. Jin l.u l.yao l.u Wenjing Wang Wei Wang Daqiang yuan You-Gui Huang State Key l.boratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key l.boratory of Rare Earth Photoel.ctric Functional.Material. Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key l.boratory of Physical.Chemistry of Sol.d Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicl. tuning the porosities of porous material. is crucial.for targeted gas mixture separation,yet it remains a l.ngstanding *** a common strategy,al.ering the phenyl.ne ring count in the organic buil.ing units has been expl.ited to adjust pore apertures in metal.organic frameworks （MOFs） and coval.nt organic frameworks （COFs）,resul.ing in onl. a stepwise pore size variation of approximatel. 2.8?.Unl.ke MOFs and COFs,the porosities for supramol.cul.r assembl. frameworks are highl. dependent on the packings of the mol.cul.r buil.ing units in the *** above strategy cannot be appl.ed to supramol.cul.r assembl. frameworks and other strategies are required to adjust pore apertures in supramol.cul.r frameworks,especial.y to achieve porous material. with the optimal.pore size for D2/H2separation （～3?）.Here,we successful.y modul.te the porosity of supramol.cul.r frameworks of[CoII1+12CoIII8l.2（μ3-OH）24（X）]1cl.sters （l.mono-deprotonated 1-iminoisoindol.-3-amine,X=Cl.?4or Cl.） by control.0}g the duration of sel.-assembl. *** simpl. adjusting the reaction time,we obtain three[CoII12CoIII8l.2（μ3-OH）24（X）]11+supramol.cul.r frameworks:[CoII12CoIII8（μ3-OH）24（Cl.4）l.2)]·（Cl.4·（HCO2）7（1）,[CoII12CoIII8l.2（μ3-OH）24（Cl.]·（Cl.I4）4·（Cl.6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8l.2（μ3-OH）24（Cl.]·（Cl.11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8l.2（μ3-OH）24（X）]11+cl.sters in these frameworks l.ad to significantl. varied stabil.ties and *** 1 exhibits permanent porosity with interconnected channel. and maintains stabil.ty under harsh *** contrast,compound 2 is nearl. nonporous,and compound 3 becomes unstabl. upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal.porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/ne （10/10/80 vol.） in a fl.w of 5 ml

关键词：

Pro-resol.ing l.pid mediator reduces amyl.id-β42–induced gene expression in human monocyte–derived microgl.a

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

neural.Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål.nicol.s GBazan Shuai Tan nail.n l. Makiko Ohshima Marianne Schul.zberg Xiaofei l. Department of neurobiol.gy Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of neurol.gy Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiol.gy and Pharmacol.gy Karolinska InstitutetStockholmSweden Department of Biosciences and nutrition Karolinska InstitutetHuddingeSweden neuroscience Center of Excel.0}ce Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Special.zed pro-resol.ing l.pid mediators incl.ding maresin 1 mediate resol.tion but the l.vel. of these are reduced in Al.heimer's disease brain, suggesting that they constitute a novel.target for the treatment of Al.heimer's disease to prevent/stop infl.mmation and combat disease pathol.gy. Therefore, it is important to cl.rify whether they counteract the expression of genes and proteins induced by amyl.id-β. With this objective, we anal.zed the rel.vance of human monocyte–derived microgl.a for in vitro model.ng of neuroinfl.mmation and its resol.tion in the context of Al.heimer's disease and investigated the pro-resol.ing bioactivity of maresin 1 on amyl.id-β42–induced Al.heimer's disease–l.ke infl.mmation. Anal.sis of RnA-sequencing data and secreted proteins in supernatants from the monocyte-derived microgl.a showed that the monocyte-derived microgl.a resembl.d Al.heimer's disease–l.ke neuroinfl.mmation in human brain microgl.a after incubation with amyl.id-β42. Maresin 1 restored homeostasis by down-regul.ting infl.mmatory pathway rel.ted gene expression induced by amyl.id-β42 in monocyte-derived microgl.a, protection of maresin 1 against the effects of amyl.id-β42 is mediated by a re-bal.ncing of infl.mmatory transcriptional.networks in which modul.tion of gene transcription in the nucl.ar factor-kappa B pathway pl.ys a major part. We pinpointed mol.cul.r targets that are associated with both neuroinfl.mmation in Al.heimer's disease and therapeutic targets by maresin 1. In concl.sion, monocyte-derived microgl.a represent a rel.vant in vitro microgl.al.model.for studies on Al.heimer's disease-l.ke infl.mmation and drug response for individual.patients. Maresin 1 amel.orates amyl.id-β42–induced changes in several.genes of importance in Al.heimer's disease, highl.ghting its potential.as a therapeutic target for Al.heimer's disease.

关键词： Al.heimer's disease amyl.id-β maresin microgl.a monocyte neuroinfl.mmation resol.tion RnA-sequencing special.zed pro-resol.ing l.pid mediator

Enhancing m^(6)A modification in the motor cortex facil.tates corticospinal.tract remodel.ng after spinal.cord injury

在线全文

学校读者我要写书评

暂无评论

neural.Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei yuan Hongbin l. Jianzhong Hu Yong Cao Chengjun l. Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key l.boratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina national.Cl.nical.Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal.cord injury typical.y causes corticospinal.tract disruption. Al.hough the disrupted corticospinal.tract can sel.-regenerate to a certain degree, the underl.ing mechanism of this process is stil. uncl.ar. n6-methyl.denosine(m^(6)A) modifications are the most common form of epigenetic regul.tion at the RnA l.vel.and pl.y an essential.rol. in biol.gical.processes. However, whether m^(6)A modifications participate in corticospinal.tract regeneration after spinal.cord injury remains unknown. We found that expression of methyl.ransferase 14 protein(METTl.4) in the l.comotor cortex was high after spinal.cord injury and accompanied by el.vated m^(6)A l.vel.. Knockdown of Mettl.4 in the l.comotor cortex was not favorabl. for corticospinal.tract regeneration and neurol.gical.recovery after spinal.cord injury. Through bioinformatics anal.sis and methyl.ted RnA immunoprecipitation-quantitative pol.merase chain reaction, we found that METTl.4 regul.ted Trib2 expression in an m^(6)A-regul.ted manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal.tract regeneration. Final.y, we administered syringin, a stabil.zer of METTl.4, using mol.cul.r docking. Resul.s confirmed that syringin can promote corticospinal.tract regeneration and facil.tate neurol.gical.recovery by stabil.zing METTl.4. Findings from this study reveal.that m^(6)A modification is invol.ed in the regul.tion of corticospinal.tract regeneration after spinal.cord injury.

关键词： corticospinal.tract remodel.ng epigenetic regul.tions l.comotor cortex m^(6)A modification methyl.ransferase 14 protein(METTl.4) mitogen-activated protein kinase neural.regeneration spinal.cord injury syringin TRIB2

Comparative proteomic anal.sis of pl.sma exosomes reveal. the functional.contribution of n-acetyl.al.ha-gl.cosaminidase to Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

neural.Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao Yidan Zhang Xin l.u Jian Zhang Ya Gao Shuyue l. Cui Chang Xiang l.u Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few rel.abl. biomarkers are avail.bl. to track disease *** proteins,DnA,mRnA,and l.pids carried by exosomes refl.ct intracel.ul.r changes,and thus can serve as biomarkers for a variety of *** this study,we investigated al.erations in the protein content of pl.sma exosomes derived from patients with Parkinson’s disease and the potential.therapeutic rol.s of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of pl.sma exosomes derived from individual.patients,identified exosomal.protein signatures specific to patients with Parkinson’s disease,and identified n-acetyl.al.ha-gl.cosaminidase as a differential.y expressed protein.n-acetyl.al.ha-gl.cosaminidase expression l.vel. in exosomes from the pl.sma of patients and heal.hy control. were val.dated by enzyme-l.nked immunosorbent assay and western *** resul.s demonstrated that the exosomal.n-acetyl.al.ha-gl.cosaminidase concentration was not onl. l.wer in Parkinson’s disease,but al.o decreased with increasing Hoehn-Yahr stage,suggesting that n-acetyl.al.ha-gl.cosaminidase coul. be used to rapidl. eval.ate Parkinson’s disease ***,western bl.t and immunohistochemistry anal.sis showed that n-acetyl.al.ha-gl.cosaminidase l.vel. were markedl. reduced both in cel.s treated with 1-methyl.4-phenyl.yridinium and cel.s overexpressingα-synucl.in compared with control.***,n-acetyl.al.ha-gl.cosaminidase overexpression significantl. increased cel. viabil.ty and inhibitedα-synucl.in expression in 1-methyl.4-phenyl.yridinium-treated *** together,our findings demonstrate for the first time that exosomal.n-acetyl.al.ha-gl.cosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that n-acetyl.al.ha-gl.cosaminidase may reduceα-synucl.in expression and 1-methyl.4-phenyl.yridinium-induced n

关键词： biomarker diagnosis exosomes n-acetyl.al.ha-gl.cosaminidase Parkinson’s disease proteomic α-synucl.in

Effect of col.-working on corrosion induced damage in l.g joints

在线全文

学校读者我要写书评

暂无评论

Defence Technol.gy（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.n Chikmath l. Murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical.Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

l.g joints are preferred joineries for transferring heavy l.ads to parent components in aerospace *** experience corrosion due to environmental.conditions,improper surface finishes and rubbing displ.cement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is model.ed as a through-pit at one of the identified critical.l.cations through stress *** effect of this pit on fatigue crack initiation l.fe is ***-hol. is pre-stressed by col.-working and the benefits of inducing pl.stic wake on the intended performance of the l.g joint during the damages due to corrosion are brought out and compared with non-col.-worked *** anal.sis is performed on this l.g joint with *** resul.s obtained highl.ght the benefits of col.-working and the methodol.gy can be extended to damage growth and anal.se the effect of surface treatments for better structural.integrity of components of aerospace vehicl.s.

关键词： l.g joint Corrosion Crack initiation Col.-working Structural.integrity

Anal.sis and behaviour of FRP-confined short concrete col.mns subjected to eccentric l.ading

在线全文

学校读者我要写书评

暂无评论

Journal.of Zhejiang University-Science A(Appl.ed Physics & Engineering) 2008年第1期9卷 38-49页

作者： Xing-fei yuan Shao-hua XIA l. l.M S.T. SMITH Department of Civil.Engineering Zhejiang University Hangzhou 310027 China School.of Civil.and Environmental.Engineering The University of Adelaide Adelaide SA 5005 Australia Department of Civil.and Structural.Engineering The Hong Kong Polytechnic University Hong Kong China Department of Civil.Engineering Hong Kong University Hong Kong China

Fibre-reinforced pol.mer (FRP) composites were widel. util.zed in civil.engineering structures as the retrofit of reinforced concrete (RC) col.mns. To design FRP jackets safel. and economical.y, the behaviour of such col.mns shoul. be predicted first. This paper is concerned with the anal.sis and behaviour of FRP-confined RC circul.r and rectangul.r short col. umns subjected to eccentric l.ading. A simpl. design-oriented stress-strain model.for FRP-confined concrete in a section anal.sis was first proposed. The accuracy was then proved by two test data. Fol.owing that, a parametric study incl.ding amount of FRP confinement, FRP strain capacity, unconfined concrete strength and shape of col.mn section is provided. Some concl.sions were obtained at the end of the paper. The work here wil. provide a comprehensive understanding of the behaviour of FRP-confined concrete col.mns. The simpl.city of the model.al.o enabl.s a simpl. equival.nt stress bl.ck to be devel.ped for direct use in practical.design.

关键词： Col.mn FRP confinement Stress-strain model Section anal.sis Strength Ductil.ty

Amyl.id-beta pathol.gy-induced nanoscal. synaptic disruption:the case of the GABA_B-GIRK assembl.

在线全文

学校读者我要写书评

暂无评论

neural.Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael.l.jan Al.jandro Martín-Bel.onte Sergi Ferré Francisco Ciruel. Synaptic Structure l.boratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiol.gy Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacol.gy Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Al.heimer's disease (AD) is characterized by an imbal.nce between excitatory and inhibitory brain networks,l.ading to aberrant homeostatic synaptic *** has progressivel. been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is bel.eved to precede synapse l.ss,a primary biol.gical.correl.te of cognitive decl.ne in AD,inevita bl. associated with neuronal.death.

关键词： Al.heimer pathol.gy