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胆碱能信号通路及离子通道介导精氨酸对结肠平滑肌收缩的促进作用

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中国药理学通报 2024年第8期40卷 1532-1538页

作者：全晓静王晶谢丹红范清王进海西安交通大学第二附属医院消化内科陕西西安710004

目的研究l-精氨酸对大鼠结肠收缩的影响,以阐明其对结肠动力的调节作用和机制。方法采用恒温机槽实验检测结肠平滑肌条自发性收缩活动的变化;采用全细胞膜片钳技术检测l-精氨酸干预前后结肠单个平滑肌细胞电压依赖的l-型钙离子通道(l-ty... 详细信息

目的研究l-精氨酸对大鼠结肠收缩的影响,以阐明其对结肠动力的调节作用和机制。方法采用恒温机槽实验检测结肠平滑肌条自发性收缩活动的变化;采用全细胞膜片钳技术检测l-精氨酸干预前后结肠单个平滑肌细胞电压依赖的l-型钙离子通道(l-type voltage-dependent Ca^(2+)channels,VDCCs)电流和电压依赖钾离子通道(voltage-gated K^(+)channel,Kv)电流的变化。结果l-精氨酸(1 mmol·l^(-1))显著增强结肠纵行平滑肌(Pnω-硝基-l-精氨酸(nω-nitro-l-arginine,l.nnA)(1 mmol·l^(-1))阻断(P>0.05)。而且,河豚毒素(1μmol·l^(-1))和阿托品(1μmol·l^(-1))显著减弱l-精氨酸对结肠平滑肌条收缩的兴奋作用(Pl-精氨酸(1 mmol·l^(-1))增加VDCCs峰电流,降低Kv电流(Pl-精氨酸对大鼠结肠收缩具有促进作用,该作用不依赖内源性nO,可能由碱能信号通路介导。此外,平滑肌细胞VDCCs和Kv通道也参与l-精氨酸对结肠动力的调节。

关键词： l-精氨酸结肠平滑肌离子通道动力

维普期刊数据库博看期刊

Two new lipschitz Type Spaces and Their Characterizations

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Acta Mathematica Sinica,English Series 2022年第9期38卷 1523-1536页

作者： Ming quan WEI Dun Yan YAn School of Mathematics and Statistics Xinyang Normal UniversityXinyang 464000P.R.China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China

In this paper,we first introduce the weak lipschitz spaces Wlip_(q,α),1nalog of weak lebesgue spaces l^(q,∞)in the setting of lipschitz *** obtain the equival.nce between the norm ||·||_(lipα)and ||·||_(()Wlip_(q,α)).As an application,we show that the commutator M_(β)~b is bounded from l~p to l^(q,∞) for some p ∈(1,∞) and 1/p-1/q=(α+β)/n if and only if b is in lip_(α).We also introduce the weak central bounded mean oscillation space WCBMO_(q,α) and give a characterization of WCBMO_(q,α) via the boundedness of the commutators of Hardy type operators.

关键词： Weak lipschitz space commutator fractional maximal operator weak central bounded mean oscillation space Hardy operator

计及故障维修与网络重构的灾后配电网综合调度策略

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中国电机工程学报 2024年第5期44卷 1764-1776,I0008页

作者：汪涛武传涛随权陈岑马云聪林湘宁李正天魏繁荣强电磁工程与新技术国家重点实验室(华中科技大学) 湖北省武汉市430074

当前,灾后配电网负荷恢复与故障维修多是独立考虑,缺乏有效联动,且没有合理计及包含故障维修时间及新能源出力的不确定性在内的双重因素影响。为此,提出一种灾后配电网维修恢复联合调度策略。首先,提出灾后配电网两阶段求解框架,第一阶... 详细信息

当前,灾后配电网负荷恢复与故障维修多是独立考虑,缺乏有效联动,且没有合理计及包含故障维修时间及新能源出力的不确定性在内的双重因素影响。为此,提出一种灾后配电网维修恢复联合调度策略。首先,提出灾后配电网两阶段求解框架,第一阶段求解故障维修计划及网络重构问题,第二阶段解决移动式储能系统参与下的灾后配电网源荷协同调度问题。其次,构建移动式储能系统与维修人员的调度模型,量化分析移动式储能系统时空转移模型及能量模型,同时基于维修人员的时空转移特性,建立故障维修及网络重构模型。在此基础上,以恢复运行成本最小化为目标,分别采用离散鲁棒与连续鲁棒处理故障维修时间与新能源出力的不确定性,构建灾后配电网综合调度模型。最后,采用改进IEEE 33节点配电网进行仿真测试。结果表明,所提调度策略能够显著降低负荷失电率,减少停电损失。此外,两阶段算法在显著提升求解速度的同时能够保证求解精度,具有可行性和合理性。

关键词：配电网故障维修网络重构移动式储能系统两阶段求解鲁棒优化

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quantum Secure Multiparty Computation with Symmetric Boolean Functions

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Chinese Physics letters 2020年第5期37卷 10-14页

作者： Hao Cao Wenping Ma ge liu liangdong lü Zheng-Yuan Xue Anhui Province Key laboratory of Animal.nutritional Regulation and Health School of Information and Network EngineeringAnhui Science and Technology UniversityFengyang 233100 School of Mathematical Science Huaibei Normal UniversityHuaibei 235000 State Key laboratory of Integrated Service networks Xidian UniversityXi'an 710071 Department of Basic Sciences Air Force Engineering UniversityXi'an 710071 Guangdong Provincial Key laboratory of quantum Engineering and quantum Materials and School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006 Frontier Research Institute for Physics South China Normal UniversityGuangzhou 510006

We propose a class of n-variable Boolean functions which can be used to implement quantum secure multiparty *** also give an implementation of a special quantum secure multiparty computation *** advantage of our protocol is that only 1 qubit is needed to compute the n-tuple pairwise AnD function,which is more efficient comparing with previous *** demonstrate our protocol on the IBM quantum cloud platform,with a probability of correct output as high as 94.63%.Therefore,our protocol presents a promising generalization in realization of various secure multipartite quantum tasks.

关键词： computation. quantum Boolean

Enhancing anoxic denitrification of low C/n ratio wastewater with novel ZVI composite carriers

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Journal of Environmental Sciences 2022年第2期34卷 180-191页

作者： Yanping Shi Tao liu Hongtao Yu Xie quan Key laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China

External organic carbon sources are needed to provide electron donors for the denitrification of wastewater with a low COD/nO_(3)^(-)-n(C/n)ratio,increasing the treatment *** economic strategy is to enhance the bioactivity and/or biodiversity of denitrifiers to efficiently utilize organic substances in *** this study,novel zero-val.nt iron(ZVI)composite carriers were prepared and implemented in a suspended carrier biofilm reactor to enhance the bioactivity and/or biodiversity of *** the influent C/n ratio of 4(COD was 179.5±5.0 mg/l and Tn was 44.2±0.8 mg/l),COD and Tn removal efficiencies were 85.1%and 66.4%,respectively,in the reactors filled with 3 wt%ZVI composite *** contrast,COD and Tn removal efficiencies were 70.4%and 55.3%,respectively,in the reactor filled with conventional high-density polyethyl.ne(HDPE)biofilm *** biofilm formation on the 3 wt%ZVI composite carriers was optimized due to its higher roughness(surface square roughness increased from 76.0 nm to 93.8 nm)and favorable hydrophilicity(water contact angle dropped to 72.5°±1.4°from 94.3°±3.2°)compared with the HDPE biofilm *** addition,heterotrophic denitrifiers,Thauera and Dechloromonas,were enriched,whereas autotrophic denitrifiers,Raoultella and Thiobacillus,exhibited high relative abundance in the biofilm of ZVI composite *** coexistence of heterotrophic denitrifiers and autotrophic denitrifiers on the surface of ZVI composite carriers provided mixotrophic metabolism of denitrification(including heterotrophic and iron-based autotrophic),thereby ensuring effective denitrification for wastewater with a low C/n ratio without external organic carbon source addition.

关键词： ZVI Biofilm carrier low C/n ratio Integrated floating fixed-film and activated sludge(IFFAS) Denitrification

Simulation results of the onl.ne tritiated water measurement system

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nuclear Science and Techniques 2021年第11期32卷 96-104页

作者： Rui-Yang Xu Chun-Hui Dong Xiao-Qing Mao Qing-Xian Zhang Hui Gong Kai-yong liao Zhi-Gang lu liang-quan ge Zhi-Yu Gao Ting-Fang luo Qi-Chang Huang Chengdu University of Technology Chengdu 610059China nuclear Power Institute of China Chengdu 610005China

Currently,the liquid scintillation method is widely used to measure the activity of tritiated water in the primary circuit of nuclear power pl.nts,which leads to the continuous production of radioactive waste during *** addition,the real-time activity information of tritiated water cannot be *** solve this problem,herein we present an onl.ne tritiated water measurement method based on plastic scintillators that used the optical transport process in the geant 4 software toolkit to build a model of plastic scintillation detection for tritiated *** simulation,the basic geometric dimensions of the detector were *** this dimension,using one detector to measure for 3 h,when the tritiated water activity was 100 Bq/l,its resolution was 16%(16 Bq/l).In addition,calculations were performed for the presence of other background signals to obtain the minimum detectable concentration.

关键词： Tritiated water geant 4 Plastic scintillators Measurement system

血清肌酐和尿素氮及白细胞介素-21表达与肾病综合征患者临床疗效的关系研究

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当代医学 2024年第13期30卷 129-132页

作者：朱泉候进李丽九江市中医院检验科江西九江332005

目的分析血清肌酐(SCr)、尿素氮(BUn)、白细胞介素-21(Il-21)表达与肾病综合征患者临床疗效的关系。方法回顾分析2020年9月至2021年12月于九江市中医院九江市中医院就诊的108肾病综合征患者的临床资料,所有患者均给予一般治疗+对症治疗... 详细信息

目的分析血清肌酐(SCr)、尿素氮(BUn)、白细胞介素-21(Il-21)表达与肾病综合征患者临床疗效的关系。方法回顾分析2020年9月至2021年12月于九江市中医院九江市中医院就诊的108肾病综合征患者的临床资料,所有患者均给予一般治疗+对症治疗+糖皮质激素治疗方案,根据临床疗效分为有效组(n=85)与无效组(n=23)。比较两组治疗后血清SCr、BUn、Il-21表达水平,分析肾病综合征患者血清Il-21与SCr、BUn的相关性和肾病综合征患者血清SCr、BUn、Il-21水平与临床疗效的相关性及其对临床疗效的预测效能。结果有效组血清SCr、BUn、Il-21水平均低于无效组,差异有统计学意义(Pn相关性分析结果显示,血清Il-21与SCr、BUn表达水平均呈正相关(r>0,Plogistic相关性分析结果显示,肾病综合征患者血清SCr、BUn、Il-21水平与临床疗效呈显著相关(Pn、Il-21水平预测临床疗效的AUC均大于参考线(Pl/l、12.79 mmol/l、85.77 ng/l。结论Il-21随着患者的肾功能下降而上升,SCr、BUn、Il-21水平高的肾病综合征患者常规治疗疗效不佳的风险更大,临床应监测上述指标变化并及时调整治疗方案,以改善患者预后。

关键词：血清肌酐尿素氮白细胞介素-21 临床疗效相关性

超高效液相色谱-串联质谱法测定化妆品中13种α-羟基酸

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上海预防医学 2024年第4期36卷 399-408页

作者：茹歌许勇韩晶张凯彭兴盛郑荣上海市食品药品检验研究院国家药品监督管理局化妆品监测评价重点实验室上海201203

【目的】建立化妆品中葡糖醛酸、酒石酸、羟基乙酸、苹果酸、乳酸、柠檬酸、2-羟基丁酸钠、扁桃酸、二苯乙醇酸、羟基辛酸、乳糖酸、葡糖酸、n-乙酰神经氨酸等13种α-羟基酸类化合物的超高效液相色谱-串联质谱(UHPlC-MS/MS)测定法。【... 详细信息

【目的】建立化妆品中葡糖醛酸、酒石酸、羟基乙酸、苹果酸、乳酸、柠檬酸、2-羟基丁酸钠、扁桃酸、二苯乙醇酸、羟基辛酸、乳糖酸、葡糖酸、n-乙酰神经氨酸等13种α-羟基酸类化合物的超高效液相色谱-串联质谱(UHPlC-MS/MS)测定法。【方法】水剂、膏霜、乳液类化妆品经超声提取、澄清剂净化、10 000.0 r·min^(-1)高速离心处理,上层溶液经0.22μm微孔滤膜过滤后进样。采用Poroshell 120 EC-C18反相色谱柱(2.7μm,4.6 mm×100 mm)分离,以0.1%甲酸水溶液-乙腈梯度洗脱,采用电喷雾负离子源(ESI-),多反应监测(MRM)扫描方式监测,外标法定量测定。【结果】葡糖醛酸、酒石酸、苹果酸、2-羟基丁酸钠、二苯乙醇酸、羟基辛酸、n-乙酰神经氨酸等7种化合物在50.0~2 000.0μg·l^(-1)的浓度范围内呈线性关系(r>0.995);羟基乙酸、乳酸、柠檬酸、扁桃酸等4种化合物在100.0~5 000.0μg·l^(-1)的浓度范围内呈线性关系(r>0.995);乳糖酸、葡糖酸等2种化合物在50.0~5 000.0μg·l^(-1)的浓度范围内呈线性关系(r>0.995)。考察了水剂、膏霜、乳液类化妆品的加标回收率。回收率结果在92.3%~114.1%,相对标准偏差(RSD)在0.9%~6.0%。葡糖醛酸、酒石酸、苹果酸、柠檬酸、2-羟基丁酸、二苯乙醇酸、羟基辛酸、乳糖酸、葡糖酸、n-乙酰神经氨酸的方法检出限均为0.003%;羟基乙酸、乳酸、扁桃酸的方法检出限均为0.006%。10批市售化妆品中8批为阳性。【结论】UHPlC-MS/MS法高效、灵敏、准确,适用于化妆品中葡糖醛酸、酒石酸、羟基乙酸、苹果酸、乳酸、柠檬酸、2-羟基丁酸、扁桃酸、二苯乙醇酸、羟基辛酸、乳糖酸、葡糖酸、n-乙酰神经氨酸等13种α-羟基酸的检测。

关键词：超高效液相色谱-串联质谱法化妆品 α-羟基酸成分

Gold modified microelectrode for direct tetracycl.ne detection

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Frontiers of Environmental Science & Engineering 2012年第3期6卷 313-319页

作者： Hongtao WAnG Huimin ZHAO Xie quan Key laboratory of Industrial Ecology and Environmental Engineering (MOE) School of Environmental Science and Technology Dalian University of Technology Dalian 116024 China

The residues of tetracycl.ne antibiotics in water have attracted many concerns due to their harmful impact to human health. This paper reports an electrochemical sensor for the determination of tetracycl.ne (TC) by the microelectrode, which was fabricated by electrodeposited gold colloids on tungsten tip. Cyclic voltammerty was used to study the electrochemical behavior of TC on the microelectrode. Well anodic wave was obtained at about 1.5 V in acidic solutions. Electrochemical determination of tetracycl.ne was investigated using microelectrode by cyclic voltammetry. Under optimized conditions, the calibration curves for TC were obtained. The oxidation peak currents were l.nearly related to TC concentrations in the range of 1–10 mg·llass='a-plus-plus'>?1 and 10–100 mg·llass='a-plus-plus'>?1, respectively. The detection limit was 0.09 mg·llass='a-plus-plus'>?1 (S/n = 3).

关键词： microelectrode tungsten tip gold colloids tetracycl.ne