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A stable CS-FEm for the static and seismic stability of a single square tunnel in the soil where the shear strength increases linearly with depth

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Journal of Rock mechanics and Geotechnical Engineering 2022年第4期14卷 1253-1265页

作者： H.C.nguyen l.nguyen-Son Department of Civil and Environmental Engineering Imperial College LondonLondonUK Department of Civil Engineering and Industrial Design University of LiverpoolLiverpoolUK Faculty of Civil Engineering Ho Chi Minh City University of Technology(HUTECH)Ho Chi Minh CityViet Nam

A numerical procedure using a stable cell-based smoothed finite el.ment method(CS-FEm)is presented for estimation of stability of a square tunnel in the soil where the shear strength increases linearly with *** kinematically admissible displacement fields are approximated by uniform quadrilateral el.ments in conjunction with the strain smoothing technique,el.minating vol.metric locking issues and the singularity associated with the mohreCoul.mb ***,a rich set of simulations was performed to compute the static stability of a square tunnel with different geometries and soil *** presented results are in excellent agreement with the upper and lower bound solutions using the standard finite el.ment method(FEm).The stability charts and tables are given for practical use in the tunnel design,along with a newly proposed formulation for predicting the undrained stability of a single square ***,the seismic stability number was computed using the present numerical *** results reveal that the seismic stability number reduces with an increasing value of the horizontal seismic acceleration(a_(h)),for both cases of the weightless soil and the soil with unit ***,the link between the static and seismic stability numbers is described using corrective factors that represent reductions in the tunnel stability due to seismic *** is shown from the numerical results that the corrective factor becomes larger as the unit weight of soil.mass increases;however,the degree of the reduction in seismic stability number tends to reduce for the case of the homogeneous ***,this advanced numerical procedure is straightforward to extend to three-dimensional(3D)l.mit analysis and is readily applicable for the calculation of the stability of tunnels in highly anisotropic and heterogeneous soils which are often encountered in practice.

关键词： Tunnels Stability l.mit analysis Cell-based smoothed finite el.ment method (CS-FEm) Second-order cone programming(SOCP)

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

multiple sclerosis(mS) is a chronic infl.mmatory and demyelinating disease of the central nervous system(CNS). Patients with mS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of molecular medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Antibiofilm activity of alpha-mangostin loaded nanoparticles against Streptococcus mutans

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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 325-332页

作者： Phuong T.m.nguyen minh T.H.nguyen lien T.Quach Phuong T.m.nguyen l.m l.nguyen Dong V.Quyen Institute of Biotechnology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam Institute of Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam University of Science and Technology of Hanoi Vietnam Academy of Science and Technology18-Hoang Quoc Viet RoadCau GiayHanoiVietnam

Objective:To investigate the antibiofilm activity of alphamangostin(AmG)loaded nanoparticle(nano AmG)against dental caries pathogen Streptococcus ***:AmG was isolated from the peels of Garcinia mangostana *** silica gel col.mns and chemically analysed by high performance liquid chromatography and nuclear magnetic *** AmG was prepared using the solvent evaporation method combined with high-speed *** nanoparticles were characterized using dynamic light scattering,field emission scanning electron microscopy(FE-SEm)and Fourier transform infrared spectroscopy(FTIR).The toxicity of nano AmG in fibroblast NIH/3 T3 cell line was determined using mTT *** antibiofilm effect of nano AmG was determined through the evaluation of biofilm formation by Streptococcus mutans using a 96-well *** biomass was quantified using crystal *** viability was observed under confocal.microscopy using lIVE/DEAD Bac light ***,gene expression was determined by quantitative real-time PCR and membrane permeabilization activity by measuring the uptake of o-nitrophenol-β-***:Nano AmG size was in a range of 10-50 nm with a polydispersity index ofl value of-35.2 m *** size and the incorporation of AmG in the nanoparticles were confirmed by FE-SEm and FTIR *** IC50 values of the test agents on NIH/3 T3 cells were(9.80±0.63)μg/m l for AmG and(8.70±0.81)μg/m l for nano AmG,while no toxicity was generated from excipients used to prepare *** the early stage of biofilm formation,treatment with 6.25μmol/l nano AmG caused a reduction in biofilm biomass up to 49.1%,compared to 33.4%for *** contrast,biofilms at the late stage were more resistant to the test *** 96μmol/l(=10×mIC),nano AmG reduced only 20.7%of biofilm biomass while AmG did not showany *** of gtf B and gtf C genes involved in biofilm formation were down-regulated 3.3 and 12.5 folds,res

关键词： Alpha-mangostin Nanoparticle Antibiofilm activity Streptococcus mutans

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal.michele l Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curricul.m,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal.mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to suppl.ment mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curricul.m may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of minerals,metallurgy and materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional.material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible pol.methyl.methacrylate(PmmA)gate dielectric moS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Viscosity and structure relationship with equimolar substitution of CaO with mgO in the CaO–mgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of minerals,metallurgy and materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium metallurgy and New materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-al.mina slag systems within blast furnaces is generally l.mited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the mgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of mgO for CaO on the viscosity and structure of a high-al.mina CaO-mgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-al.mina *** results revealed that the viscosity first decreased and then increased with higher mgO substitution,reaching a minimum at 15mol.mgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased mgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive pol.merization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing mgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the pol.merization degree of the tetrahedral structure with the increase in mgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depol.merization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and mgO.

关键词： al.minosilicate viscosity structure spectroscopy

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local lyapunov Exponents and characteristics of fixed/periodic points embedded within a chaotic attractor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第4期6卷 296-304页

作者： AlI m SAHA l.m Department of mathematics Faculty of Mathematical Science Delhi UniversityDepartment of Mathematics Zakir Husain College Delhi University Delhi 110007 IndiaNew Delhi 110002 India

A chaotic dynamical system is characterized by a positive averaged exponential separation of two neighboring tra- jectories over a chaotic attractor. Knowledge of the largest lyapunov Exponent λ1 of a dynamical system over a bounded attractor is necessary and sufficient for determining whether it is chaotic (λ1>0) or not (λ1≤0). We intended in this work to elaborate the connection between local lyapunov Exponents and the largest lyapunov Exponent where an alternative method to calculate λ1 has emerged. Finally, we investigated some characteristics of the fixed points and periodic orbits embedded within a chaotic attractor which led to the conclusion of the existence of chaotic attractors that may not embed in any fixed point or periodic orbit within it.

关键词： Chaotic attractor largest lyapunov Exponent local lyapunov Exponents

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