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Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study

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Neural Regeneration Research 2024年第8期19卷 1842-1848页

作者： lu he Qinming Zhou Chaoyang Xiu Yaping Shao Dingding Shen Huanyu Meng Weidong le Sheng Chen Department of Neurology and Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina Center for Translational Research on Neurological Diseases the First Affiliated HospitalDalian Medical UniversityDalianLiaoning ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Institute of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial HospitalChengduSichuan ProvinceChina Department of Neurology Xinrui HospitalWuxiJiangsu ProvinceChina

Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive *** is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke *** this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy *** bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral *** biomarke rs were selected based on functionality and expression *** validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent *** substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,Pher enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value oflting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle ***,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and transl

关键词： amyotrophic lateral sclerosis cathelicidin-related antimicrobial peptide hemoglobin label-free quantitative proteomics multi-protein combined diagnostic panel serum biomarkers talin-1 translationally-controlled tumor protein zyxin

Effect of acacetin on inhibition of apoptosis in helicobacter pyloriinfected gastric epithelial cell line

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3624-3634页

作者： Qi-Xi Yao Zi-Yu li Hou-le Kang Xin he Min Kang Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Orthopaedics The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Emergency Luzhou People’s HospitalLuzhou 646000Sichuan ProvinceChina

BACKGROUND helicobacter pylori(***)infection can cause extensive apoptosis of gastric epithelial cells,serving as a critical catalyst in the progression from chronic gastritis,gastrointestinal metaplasia,and atypical gastric hyperplasia to gastric *** eradication of *** is paramount for ameliorating the pathophysiological conditions associated with chronic inflammation of the gastric mucosa and the primary prevention of gastric ***,which has multifaceted pharmacological activities such as anti-cancer,anti-inflammatory,and antioxidative properties,has been extensively investigated across various ***,the impact and underlying mechanisms of action of acacetin on ***-infected gastric mucosal epithelial cells remain *** To explore the defensive effects of acacetin on apoptosis in ***-infected GES-1 cells and to investigate the underlying *** GES-1 cells were treated with *** and acacetin in *** viability was assessed using the CCK-8 assay,cell mortality rate via lactate dehydrogenase assay,alterations in cell migration and healing capacities through the wound healing assay,rates of apoptosis via flow cytometry and TUNEl staining,and expression levels of apoptosis-associated proteins through western blot *** *** infection led to decreased GES-1 cell viability,increased cell mortality,suppressed cell migration,increased rate of apoptosis,increased expressions of Bax and cle-caspase3,and decreased Bcl-2 ***,acacetin treatment enhanced cell viability,mitigated apoptosis induced by *** infection,and modulated the expression of apoptosis-regulatory proteins by upregulating Bcl-2 and downregulating Bax and cleaved *** Acacetin significantly improved GES-1 cell viability and inhibited apoptosis in ***-infected GES-1 cells,thereby exerting a protective effect on gastric mucosal epithelial cells.

关键词： Gastric epithelial GES-1 cells helicobacter pylori Infection Acacetin Antibiotic resistance Apoptosis

Hybrid electromechanical properties of hetero-doped and homogeneously bonded dual-mode pressure sensor for indoor body area network node

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Science China(Information Sciences) 2024年第1期67卷 240-253页

作者： Junbin YU Shuai XIAN Jinbiao MU Min WANG Yin WANG Xiaojuan HOU le ZHANG Jian he Jiliang MU Xiujian CHOU Science and Technology on Electronic Test and Measurement laboratory North University of China Sichuan Aerospace Fenghuo Servo Control Technology Corporation

Pressure sensors are considerably important for continuous monitoring of human movement and the surrounding environment to construct a caregiving system for the elderly living *** challenge for pressure sensors that still remains is combining self-driven,comfort,and ***,an all-in-one conformal pressure sensor(ACPS) based on a homogeneous integrated triboelectric-piezoelectric hybrid sensor is *** ACPS has dual-mode sensing properties due to coupling triboelectrification and piezoelectric effect ensuring a stable response to various external ***-coated glass microspheres and polyacrylonitrile were uniformly filleted into the silicone rubber substrate using a hetero-doping method to create a stretchable electrode layer with flexible conformal characteristics and a piezoelectric layer with excellent piezoelectric properties,***,the triboelectric layer was fabricated using the same silicone rubber,allowing ACPS to be homogeneously bonded into an all-in-one structure with reliable *** allowed various functional layers to have outstanding interface characteristics and thus improve the electrical transmission *** developed ACPS had outstanding sensitivity(1.04 V/104Pa),high linearity(about 0.984),a wide measurement range(10–700 k Pa),and can accurately and continuously distinguish multiple ***,using a homemade signal processing circuit,ACPSs can be deployed in the human body and the room as indoor body area network *** successfully applied to the remote tracking of daily dynamic home life and the remote operation of small electrical equipment,these ACPSs can achieve real-time caregiving for the elderly living *** an application area desperately needed by society,this study envisions a caregiving system for the elderly living alone without violating personal privacy.

关键词： dual-mode pressure sensor homogeneous bonding all-in-onestructure indoor body area network node elderly caregiving microsystem

Gut microbiota modulating intestinal stem cell differentiation

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World Journal of Stem Cells 2024年第6期16卷 619-622页

作者： lin he Chen Zhu Xiang-Feng Zhou Shu-E Zeng le Zhang Kuan li Department of Alcohol and Drug Dependence Treatment The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina Department of Physical Education Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Department of Geriatric Psychiatry The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina Sleep Medicine Center The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina

Proliferation and differentiation of intestinal stem cell(ISC)to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut ***,when this disordered proliferation continues,it induces the ISC to enter a cancerous *** gut microbiota on the free surface of the gut mucosal barrier is able to interact with ISC on a sustained ***-biota metabolites are able to regulate the proliferation of gut stem and progenitor cells through transcription factors,while in steady state,differentiated colono-cytes are able to break down such metabolites,thereby protecting stem cells at the gut *** the future,the gut flora and its metabolites mediating the regulation of ISC differentiation will be a potential treatment for enteropathies.

关键词： Intestinal stem cells Gut microbiota Gut stem niche Microenvironment Probiotics

Material flow analysis and global warming potential assessment of an industrial insect-based bioconversion plant using housefly larvae

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Journal of Environmental Sciences 2024年第5期139卷 483-495页

作者： Tao lu Fan lü Nanlin liao Honghui Chai Hua Zhang Pinjing he Institute of Waste Treatment and Reclamation Tongji UniversityShanghai 200092China State Key laboratory of Pollution Control and Source Reuse Tongji UniversityShanghai 200092China Zhejiang Qihe Ecological Technology Co. Ltd.Hangzhou 310052China

The significant increase in the demand for biomass waste treatment after garbage classification has led to housefly larvae treatment becoming an attractive treatment *** can provide a source of protein while treating biomass waste,which means that nutrients can be returned to the natural food ***,the performance of this technology in terms of its environmental impacts is still unclear,particularly with regards to global warming potential(GWP).This study used a life cycle assessment(lCA)approach to assess a housefly larvae treatment plant with a treatment capacity of 50 tons of biomass waste per *** lCA results showed that the 95% confidence intervals for the GWP in summer and winter were determined to be 24.46-32.81 kg CO_(2) equivalent(CO_(2)-eq)/ton biomass waste and5.37-10.08 kg CO_(2)-eq/ton biomass waste,*** greater GWP value in summer is due to the longer ventilation time and higher ventilation intensity in summer,which consumes more *** main GWP contributions are from(1)electricity needs(accounting for 78.6% of emissions in summer and 70.2%in winter)and(2)product substitution by mature housefly larvae and compost(both summer and winter accounting for 96.8% of carbon reduction).

关键词： Biomass waste Musca domestica Housefly larvae life cycle assessment Global warming potential

Photoredox catalytic alkylarylation of alkynes with arylsulfonylacetate as bifunctional reagent

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Science China Chemistry 2024年第6期67卷 2022-2028页

作者： Chonglong he Min Wang Yulong Wang lirong Zhao Youkang Zhou Keyuan Zhang Shenyu Shen Yaqiong Su Xin-Hua Duan le liu School of Chemistry Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Key Laboratory of Sustainable Energy Material ChemistryXi’an Jiaotong UniversityXi’an710049China

Difunctionalization of alkynes represents a powerful and straightforward approach to the synthesis of complex ***,the radical difunctionalization of alkynes mediated by bifunctional reagents remains challenging and underexplored,despite significant progress having been made in alkene ***,we report a novel arylsulfonylacetate skeleton in which aryl rings are attached to acetates through SO_(2),serving as a powerful bifunctional reagent for the alkylarylation of alkynes via vinyl-radical intermediate under photoredox *** modular bifunctional reagent enables the simultaneous incorporation of a wide range of functional groups,including(hetero)aryl ring and alkyl carboxylate into alkynes,resulting in synthetically valuable all-carbon tetrasubstituted alkene *** transformation is distinguished by its redox-neutral nature,readily accessible starting materials,compatibility with diverse functional groups and its capacity to facilitate convergent *** utility of this approach was further demonstrated by the late-stage functionalization of complex molecules and the preparation of fluorescent molecules and anti-cancer drugs.

关键词： bifunctional reagent photoredox catalysis Smiles rearrangement alkylarylation tetrasubstituted acyclic all-carbon olefins

Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

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Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su le Chang Guanzhong Jiao Yang Ou Mei Yang Chao Xu Pengtao liu Zejia Wang Zewen Qi Wenwen liu linhua Sun Guangming he Xing Wang Deng Hang he School of Advanced Agriculture Sciences and School of life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain *** reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related *** interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in *** compartment domain(CD)boundaries,the distal interactions were more in hybrids than their *** the hybrids of CURlY leAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower ***-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance *** addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop *** findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

Adaptive neural network control of a 2-DOF helicopter system considering input constraints and global prescribed performance

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Science China(Information Sciences) 2024年第7期67卷 224-239页

作者： Zhijia ZHAO Jiale WU Zhijie lIU We he C.l.Philip CheN School of Mechanical and Electrical Engineering Guangzhou University School of Intelligence Science and Technology and Key laboratory of Intelligent Bionic Unmanned Systems of Ministry of Education University of Science and Technology Beijing School of Computer Science and Engineering South China University of Technology Pazhou lab

In this study, an adaptive neural network(NN) control is proposed for nonlinear two-degree-offreedom(2-DOF) helicopter systems considering the input constraints and global prescribed ***, radial basis function NN(RBFNN) is employed to estimate the unknown dynamics of the helicopter system. Second, a smooth nonaffine function is exploited to approximate and address nonlinear constraint functions. Subsequently, a new prescribed function is proposed, and an original constrained error is transformed into an equivalent unconstrained error using the error transformation and barrier function transformation methods. The analysis of the established lyapunov function proves that the controlled system is globally uniformly bounded. Finally, the simulation and experimental results on a constructed Quanser's test platform verify the rationality and feasibility of the proposed control.

关键词： adaptive NN control 2-DOF helicopter global prescribed performance input constraints

The Influence of limestone Powder and Metakaolin Co-Blending on the Hydration Process and Mechanical Properties of Q-Phase Cement

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1169-1176页

作者： XIONG Xuan he Yongjia lÜlinnü MA Jie WANG Fazhou State Key laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Hubei Key laboratory of Theory and Application of Advanced Materials Mechanics School of ScienceWuhan University of TechnologyWuhan 430070China China Railway Design Corporation Tianjin 300250China

A ternary system comprising Ca_(20)Al_(26)Mg_(3)Si_(3)O_(68)(Q-phase),limestone,and metakaolin is proposed,and its hydration behavior,hydration product phases,microstructure,and mechanical properties are investigated and compared with pure Q-phase *** results indicate that the ternary system exhibits exceptional and sustained compressive strength even under a 40℃environment,significantly outperforming pure *** mechanism lies in that metakaolin effectively inhibits the transformation of metastable ***,the interactions among Q-phase,limestone,and metakaolin further enhance the cementitious *** ternary system effectively addresses potential issues of strength loss in Q-phase cement application,and as a low-carbon cementitious material system,it holds promising potential applications.

关键词： Q-phase limestone metakaolin hydration compressive strength