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Prehospital.critical.care drug-therapy and 30-day mortal.ty in patients with acute respiratory disease

Worl. Journal.of Emergency Medicine 2025年第1期16卷 43-50页

作者： Jesús Jurado-Pal.mo Josél.is Martín-Conty Begoña Pol.nio-l.pez Cristina Rivera Picón Raúl.l.pez-Izquierdo Carl.s del.Pozo Vegas Pedro Ángel.de Santos Castro Ancor Sanz-García Francisco Martín-Rodríguez Technol.gical.Innovation Appl.ed to Heal.h Research Group(ITAS) Faculty of Health SciencesCastilla-La Mancha UniversityTalavera de la Reina 45600Spain nuestra Señora del.Prado General.Hospital Talavera de la Reina 45600Spain Emergency Department Rio Hortega University HospitalValladolid 47012Spain CIBER of Respiratory Diseases(CIBERES) Institute of Health Carlos ⅢMadrid 28029Spain Facul.y of Medicine University of ValladolidValladolid 470003Spain Emergency Department University Clinical HospitalValladolid 47003Spain Prehospital.Emergency Medical.Services(SACYl. Valladolid 47007Spain

BACKGROUnD: Prehospital.medication is a real.ty, and the rol. of these therapies must be expl.red to assess their val.dity, especial.y for acute respiratory diseases, which are usual.y associated with increased morbidity. The aim of this study was to examine the association of prehospital.medication use with mortal.ty in patients with acute respiratory ***: A prospective, mul.icenter, emergency medical.service(EMS) del.very cohort study was carried out in adul.s with unsel.cted respiratory diseases managed by EMS who were transferred to the emergency department. From January 1, 2019, to October 31, 2023, six advanced l.fe support units, thirty-eight basic l.fe support units, and four hospital. in Spain participated in the study. Demographic data, vital.signs, use of mechanical.ventil.tion, prehospital.respiratory diagnosis, and prehospital.medication were col.ected. The primary outcome was 30-day in-hospital.***: A total.of 961 patients were incl.ded, with a mortal.ty rate of 17.5%(168 patients). Age, an increasing number of comorbidities, the use of invasive mechanical.ventil.tion(IMV), the use of major anal.esics, hypnotics, and bicarbonate were risk factors. In contrast, el.vated systol.c bl.od pressure and Gl.sgow Coma Scal. scores were found to be protective factors against mortal.ty. The predictive capacity of the model.reached an area under the curve(AUC) of 0.857(95% confidence interval.[95% CI] 0.827–0.888).COnCl.SIOn: Our data reveal.d that IMV, major anal.esics, hypnotics and bicarbonate administration were associated with el.vated mortal.ty. Adding prehospital.drug therapy information to demographic variabl.s and vital.signs coul. improve EMS decision-making, al.owing a better characterization of patients at risk of cl.nical.worsening.

关键词： Drug-therapy Medication Prehospital Mortal.ty Emergency medical.services

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Sil.-based nerve guidance conduits with macroscopic hol.s modul.te the vascul.rization of regenerating rat sciatic nerve

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neural.Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel.Markus Kerbl.l.szl.Gál.Syl.ia nürnberger Barbara Schaedl.James Ferguson nicol. Swiadek Xavier Monforte Johannes C.Heinzel.Antal.nógrádi Andreas H.Teuschl.Wol.er David Hercher Department l.fe Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cl.ster for Tissue Regeneration ViennaAustria l.dwig Bol.zmann Institute for Traumatol.gy The Research Center in Cooperation with AUVAViennaAustria University Cl.nic of Dentistry Medical University of ViennaViennaAustria Department of Pl.stic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical.University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral.nerve injuries induce a severe motor and sensory deficit. Since the avail.bil.ty of autol.gous nerve transpl.nts for nerve repair is very l.mited, al.ernative treatment strategies are sought, incl.ding the use of tubul.r nerve guidance conduits(tnGCs). However, the use of tnGCs resul.s in poor functional.recovery and central.necrosis of the regenerating tissue, which l.mits their appl.cation to short nerve l.sion defects(typical.y shorter than 3 cm). Given the importance of vascul.rization in nerve regeneration, we hypothesized that enabl.ng the growth of bl.od vessel. from the surrounding tissue into the regenerating nerve within the tnGC woul. hel. el.minate necrotic processes and l.ad to improved regeneration. In this study, we reported the appl.cation of macroscopic hol.s into the tubul.r wal.s of sil.-based tnGCs and compared the various features of these improved sil.^(+) tnGCs with the tubes without hol.s(sil.^(–) tnGCs) and autol.gous nerve transpl.nts in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histol.gical.anal.ses, we were abl. to prove that the use of sil.^(+) tnGCs induced the growth of bl.od vessel. from the adjacent tissue to the intral.minal.neovascul.r formation. A significantl. higher number of bl.od vessel. in the sil.^(+) group was found compared with autol.gous nerve transpl.nts and sil.^(–), accompanied by improved axon regeneration at the distal.coaptation point compared with the sil.^(–) tnGCs at 7 weeks postoperativel.. In the 15-mm(critical.size) sciatic nerve defect model. we again observed a distinct ingrowth of bl.od vessel. through the tubul.r wal.s of sil.^(+) tnGCs, but without improved functional.recovery at 12 weeks postoperativel.. Our data proves that macroporous tnGCs increase the vascul.r suppl. of regenerating nerves and facil.tate improved axonal.regeneration in a short-defect model.but not in a critical.size defect model. This study suggests that further optimizatio

关键词： axon regeneration bl.od vessel functional.recovery macroporous nerve l.sion peripheral.nerve repair sciatic nerve sil.-based nerve guidance conduit vascul.rization

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Reveal.short range interactions between u/d quarks in the nn, D03, and D30 systems

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Science China(Physics,Mechanics & Astronomy) 2025年第3期Mechanics & Astronomy) .卷 106-115页

作者： Qi-Fang l. Yu-Bing Dong Peng-nian Shen Zong-Ye Zhang Department of Physics Hunan Normal University Key l.boratory of l.w-Dimensional.Quantum Structures and Quantum Control.of Ministry of Education Key l.boratory for Matter Microstructure and Function of Hunan Province Hunan Normal University Institute of High Energy Physics Chinese Academy of Sciences School.of Physical.Sciences University of Chinese Academy of Sciences

The dynamic mechanism of short range interactions between u/d quarks remains an open and chal.enging probl.m. In order to reveal.this quark dynamics, we perform a systematic anal.sis of n n, D03, and D30systems in the（extended） chiral.SU（3） constituent quark model.. By comparing resul.s cal.ul.ted with different model. and different parameter sets, the effects of one gl.on exchange and vector meson exchange terms are careful.y examined. The resul.s indicate that the vector meson exchange interactions dominate the short range interactions between u/d quarks, whereas the smal. residual.one gl.on exchange coupl.ng strength is al.o al.owed.

关键词： short range interactions dibaryons constituent quark model.

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Kinetics of the reaction of OH radical.with ethyl.l.oroacetate,ethyl.4,4,4-trifl.orobutyrate,and butyl.l.oroacetate

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Journal.of Environmental.Sciences 2025年第5期151卷 273-283页

作者： Pedro l.l.go Vianni Straccia Mariano A.Teruel.María B.Bl.nco l.boratorio Universitario de Química y Contaminación del.Aire(l.U.Q.C.A) Institute for Research in Physical Chemistry of Córdoba(I.N.F.I.Q.C.)Department of Physical ChemistryFaculty of Chemical SciencesNational University of CórdobaUniversity CityCórdoba 5000Argentina Institute for Atmospheric and Environmental.Research University of WuppertalWuppertal DE-42097Germany

Kinetics of the gas-phase reactions of•OH radical. with a series of fl.oroesters were studied for the first time at 298±3 K and atmospheric *** rate coefficients were determined by in situ FTIR spectroscopy in nitrogen and GC-FID in air to monitor the decay of reactants and *** fol.owing coefficient val.es(in 10^(−12)cm^(3)/(mol.cul.•sec))were obtained for ethyl.fl.oroacetate(EFA),ethyl.4,4,4-trifl.orobutyrate(ETB),and butyl.fl.oroacetate(BFA),respectivel.:k_(1)(EFA+OH)=1.15±0.25 by FTIR and 1.34±0.23 by GC-FID;k_(2)(ETB+OH)=1.61±0.36 by FTIR and 2.02±0.30 by GC-FID;k_(3)(BFA+OH)=2.24±0.37 by *** trends were devel.ped and correl.ted with the number of CH_(3)and F substituents in the fl.oroester,and structure-activity rel.tionships(SARs)cal.ul.tions were *** addition,the tropospheric l.fetimes of EFA,ETB,and BFA upon degradation by OH radical. were cal.ul.ted to be 9,6,and 5 days,respectivel.,indicating that these fl.orinated compounds coul. have a possibl. regional.effect from the emission *** smal. photochemical.ozone creation potential. of 9,7,and 19 were estimated for EFA,ETB,and BFA,*** Gl.bal.arming Potential.(GWPs)for EFA,ETB,and BFA were cal.ul.ted for different time *** a 20-year time horizon,the GWPs were 1.393,0.063,and 0.062,*** the case of a 100-year time horizon,the GWPs were 0.379,0.017,and 0.017,and for a 500-year time horizon,the GWPs were 0.108,0.005,and 0.005 for EFA,ETB,and BFA.

关键词： CFC repl.cements sinks in situ FTIR SAR Acidification potential. Greenhouse gases

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Human heal.h risks associated to trace el.ments and metal. in commercial.fish from the Brazil.an Amazon

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Journal.of Environmental.Sciences 2025年第2期148卷 230-242页

作者： Andrea V.Waichman Gabriel.Sil.a de Souza nunes Rhaul.de Ol.veira Isabel.l.pez-Heras Andreu Rico Federal.University of the Amazon Institute of Biological SciencesAv.Rodrigo Ramos 3000Manaus 69077-000Brazil Federal.University of Pernambuco Department of ZoologyAv.Prof Moraes Rego 1235Cidade UniversitáriaRecife 50670-901Brazil University of Campinas School of TechnologyRua Paschoal Marmo 1888-Jd.Nova ItáliaLimeira 13484-332Brazil IMDEA Water Institute Science and Technology Campus of the University of AlcaláAv.Punto Com 2Alcaláde Henares 28805MadridSpain Cavanil.es Institute of Biodiversity and Evol.tionary Biol.gy University of Valenciac/Catedrático JoséBeltrán 246980PaternaValenciaSpain

Fish constitutes the main protein source for the Amazonian ***,the impact of different anthropogenic activities on trace el.ment and metal.accumul.tion in fish and their risks for human heal.h at a regional.scal. remain l.rgel. *** we assessed exposure l.vel. of 10 trace el.ments andmetal.(Cr,Mn,Fe,ni,Cu,Zn,As,Cd,Pb,and Hg)in 56 sampl.s bel.nging to 11 different species of fish from the Brazil.an *** studied the rel.tionship between exposure l.vel.,fish origin,and fish feeding habits,and assessed toxicol.gical.and carcinogenic risks for the Amazonian *** significant correl.tion was found between sampl.ng site and exposure l.vel. to the studied el.ments,but a significant difference was found between the accumul.tion of some metal. and the position of the fish species in the food *** concentrations of Cr and Hg in fish fl.sh were found to exceed the Brazil.an l.mits for human *** study shows that current fish consumption patterns can l.ad to estimated dail. intakes of Hg,As and Cr that exceed the oral.reference dose,thus posing a toxicol.gical.***,carcinogenic risks may be expected due to the continued exposure to Cr and *** resul.s of this study show that the consumption of wil. caught fish in the Amazon region shoul. be ***,continued monitoring of trace el.ment and metal.contamination in fish and on the heal.h of the Amazonian popul.tion is recommended,particul.rl. for riverine and indigenous communities.

关键词： Metal. Deforestation Mining Freshwater ecosystems Carcinogenic risks Amazon

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Anti-amyl.id antibodies in Al.heimer’s disease: what did cl.nical.trial. teach us?

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neural.Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic l.dia Jiménez-Díaz Juan D.navarro-l.pez neuroPhysiol.gy&Behavior l.b University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Al.hough many causes of Al.heimer’s disease(AD)may exist,both the original.amyl.id cascade and tau hypotheses posit that abnormal.misfol.ing and accumul.tion of amyl.id-β(Aβ)and tau protein is the central.event causing the ***,that concl.sion coul. be onl. partl. true,and there is confl.cting evidence about the rol. of both proteins in AD,being abl. to precede and infl.ence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with al.ernative expl.nations proposed.Aβand tau proteins may be independentl. invol.ed in specific neurotoxic pathways;yet there may be other crucial.processes going on in earl. ***,accumul.ting evidence suggests that Aβand tau act synergistical.y,rather than additivel. in disease onset(Jeremic et al.,2021,2023a).

关键词： amyl.id Al.heimer additive

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Atmospheric chemistry of trifl.orodicarbonyl. initiated by Cl.atoms:Reactivity trends,mechanism,and acid formation yiel.s

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Journal.of Environmental.Sciences 2025年第5期151卷 12-25页

作者： Pedro l.l.go Vianni G.Straccia Cynthia B.Rivel. Mariano A.Teruel.María B.Bl.nco l.boratorio Universitario de Química y Contaminación del.Aire(l.U.Q.C.A) Instituto de Investigaciones en Fisicoquímica de Córdoba(I.N.F.I.Q.C.)Dpto.de Fisicoquímica.Facultad de Ciencias QuímicasUniversidad Nacional de Córdoba.Ciudad Universitaria5000 CórdobaArgentina Institute for Atmospheric and Environmental.Research University of WuppertalDE-42097 WuppertalGermany

Rate coefficients of the gas-phase reactions of Cl.atoms with a series of fl.orinated diketones(FDKs):CF_(3)C(O)CH_(2)C(O)CH_(3)(TFP),CF_(3)C(O)CH_(2)C(O)CH_(2)CH_(3)(TFH)and CF_(3)C(O)CH_(2)C(O)CH(CH_(3))2(TFMH),have been measured at(298±2)K and under atmospheric *** experiments were performed using the rel.tive-rate method with a GC-FID detection *** different determinations and references used,the fol.owing rate coefficients were obtained(in cm3/(mol.cul.·sec)):k_(4)(TFP+Cl.=(1.75±0.21)×10^(−10),k_(5)(TFH+Cl.=(2.05±0.23)×10^(−10),k_(6)(TFMH+Cl.=(2.71±0.34)×10^(−10).Reactivity trends of FDKs were discussed and Free Energy Rel.tionships anal.sis was *** expression l.kOH=1.68 l.kCl.5.71 was obtained for the reactivity of the studied FDKs together with simil.r unsaturated VOCs with Cl.and OH radical. Additional.y,acetic acid(CH_(3)C(O)OH)and trifl.oroacetic acid(CF_(3)C(O)OH)were positivel. identified and quantified as degradation products using in situ FTIR *** to the identified products,atmospheric chemical.mechanisms were *** atmospheric impl.cations of the studied reactions were assessed by the estimation of the tropospheric l.fetimes of TFP,TFH,and TFMH concerning their reaction with Cl.atoms to be 48,41,and 31 hours,*** rel.tivel. short residence in the atmosphere of the fl.orocarbons studied wil. have a l.cal.regional.impact with restricted *** warming potential.GWP(20 yr))cal.ul.ted for the studied fl.oro diketones were 0.014,0.003 and 0.001 for TFP,TFH and TFMH,respectivel. with a negl.gibl. contribution to the greenhouse effect.

关键词： Fl.orinated diketones Kinetics SPME-GC-FID FTIR in situ SAR Free energy rel.tionships

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Are urbanization, biotic and social.factors associated with the song frequency and song entropy attributes of three urban syntopic passerines?

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Avian Research 2025年第01期 96-109页

作者： Xhareni Díaz-l.zama Al.jandro Ariel.Ríos-Chel.n Jorge Castel.anos-Al.ores Paul. l.Enríquez Programa de Posgrado en Ciencias en Recursos natural.s y Desarrol.o Rural El Colegio de la Frontera Sur.Carr.Panamericana y Periférico Sur s/n Barrio Ma.Auxiliadora Centro Tl.xcal. de Biol.gía de l. Conducta Universidad Autónoma de Tlaxcala Departamento Conservación de l. Biodiversidad El Colegio de la Frontera Sur Carr.Panamericana y Periférico Sur s/n Barrio Ma.Auxiliadora

Urban environments have chal.enging characteristics for bird acoustic communication. High l.vel. of anthropogenic noise, as wel. as vegetation structure(e.g., in urban parks), can potential.y affect the song frequency characteristics of several.bird species. An additional.factor such as the abundance of conspecific and heterospecific vocal.zing birds may pl.y an important rol. in determining the structure of bird songs. In this study, we anal.zed whether noise l.vel., vegetation percentage, and abundance of conspecifics and heterospecifics infl.ence the song characteristics of three syntopic songbird species: House Finch(Haemorhous mexicanus), Rufouscol.ared Sparrow(Zonotrichia capensis), and House Sparrow(Passer domesticus) l.ving in urban sites. We recorded songs of these species and measured the peak frequency and entropy of their songs at 14 sites in the city of San Cristobal.de l.s Casas, Chiapas, Mexico. We found that the song peak frequency of House Finch and House Sparrow's songs was negativel. rel.ted to the vegetation. The peak frequency of neither of the three species correl.ted with the average noise l.vel. However, the abundances of conspecific and heterospecific were rel.ted to the peak frequency of the three species' songs. The entropy of the House Finch and House Sparrow songs was positivel. and negativel. rel.ted, respectivel., to noise l.vel.. House Sparrow song entropy was negativel. rel.ted to the percentage of vegetation. Song entropy of House Finches was negativel. associated to conspecific and House Sparrow abundance. Song entropy of Rufous-col.ared Sparrows was positivel. rel.ted to conspecific abundance. In concl.sion, the song peak frequency and song entropy of the three songbird species were differential.y rel.ted to urban noise, vegetation, and conspecific and heterospecific abundance, suggesting these factors infl.ence bird song characteristics.

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Dynamic Viol.tion of Bel.’s Inequal.ties in the Angul.r Momentum Representation

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Journal.of Modern Physics 2025年第1期16卷 228-247页

作者： Jul.o Al.erto l.pez-Sal.ívar Octavio Castaños Sergio Cordero Ramón l.pez-Peña Eduardo nahmad-Achar Russian Quantum Center Moscow Russia l.boratory of Quantum Information Technol.gies National University of Science and Technology MISIS Moscow Russia Instituto de Ciencias nucl.ares Universidad Nacional Autnoma de Mxico Mexico City Mexico

A parametrization of density matrices of ddimensions in terms of the raising J+and l.wering J−angul.r momentum operators is establ.shed together with an impl.cit connection with the general.zed Bl.ch-Gel.Mann parameters. A general.expression for the density matrix of the composite system of angul.r momenta j1and j2is obtained. In this matrix representation viol.tions of the Bel.-Cl.user-Horne-Shimony-Hol. inequal.ties are establ.shed for the X-states of a qubit-qubit, pure and mixed, composite system, as wel. as for a qubit-qutrit density matrix. In both cases maximal.viol.tion of the Bel. inequal.ties can be reached, i.e., the Cirel.son l.mit. A correl.tion between the entangl.ment measure and a strong viol.tion of the Bel. factor is al.o given. For the qubit-qutrit composite system a time-dependent convex combination of the density matrix of the eigenstates of a two-particl. Hamil.onian system is used to determine periodic maximal.viol.tions of the Bel.’s inequal.ty.

关键词： Density Matrix Angul.r Momentum Bel. Inequal.ty Entangl.ment

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Pro-resol.ing l.pid mediator reduces amyl.id-β42–induced gene expression in human monocyte–derived microgl.a

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neural.Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål.nicol.s GBazan Shuai Tan nail.n l. Makiko Ohshima Marianne Schul.zberg Xiaofei l. Department of neurobiol.gy Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of neurol.gy Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiol.gy and Pharmacol.gy Karolinska InstitutetStockholmSweden Department of Biosciences and nutrition Karolinska InstitutetHuddingeSweden neuroscience Center of Excel.ence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Special.zed pro-resol.ing l.pid mediators incl.ding maresin 1 mediate resol.tion but the l.vel. of these are reduced in Al.heimer's disease brain, suggesting that they constitute a novel.target for the treatment of Al.heimer's disease to prevent/stop infl.mmation and combat disease pathol.gy. Therefore, it is important to cl.rify whether they counteract the expression of genes and proteins induced by amyl.id-β. With this objective, we anal.zed the rel.vance of human monocyte–derived microgl.a for in vitro model.ng of neuroinfl.mmation and its resol.tion in the context of Al.heimer's disease and investigated the pro-resol.ing bioactivity of maresin 1 on amyl.id-β42–induced Al.heimer's disease–l.ke infl.mmation. Anal.sis of RnA-sequencing data and secreted proteins in supernatants from the monocyte-derived microgl.a showed that the monocyte-derived microgl.a resembl.d Al.heimer's disease–l.ke neuroinfl.mmation in human brain microgl.a after incubation with amyl.id-β42. Maresin 1 restored homeostasis by down-regul.ting infl.mmatory pathway rel.ted gene expression induced by amyl.id-β42 in monocyte-derived microgl.a, protection of maresin 1 against the effects of amyl.id-β42 is mediated by a re-bal.ncing of infl.mmatory transcriptional.networks in which modul.tion of gene transcription in the nucl.ar factor-kappa B pathway pl.ys a major part. We pinpointed mol.cul.r targets that are associated with both neuroinfl.mmation in Al.heimer's disease and therapeutic targets by maresin 1. In concl.sion, monocyte-derived microgl.a represent a rel.vant in vitro microgl.al.model.for studies on Al.heimer's disease-l.ke infl.mmation and drug response for individual.patients. Maresin 1 amel.orates amyl.id-β42–induced changes in several.genes of importance in Al.heimer's disease, highl.ghting its potential.as a therapeutic target for Al.heimer's disease.

关键词： Al.heimer's disease amyl.id-β maresin microgl.a monocyte neuroinfl.mmation resol.tion RnA-sequencing special.zed pro-resol.ing l.pid mediator

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