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glutathione Reductase, liver Transaminases and Atypical lymphocytes Count as Early Predictive Biomarkers in Diagnosis of Thrombocytopenia in Dengue Viral Infection

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Journal of Biosciences and Medicines 2021年第1期9卷 119-130页

作者： Samantha Bandara l.l.g. chandrasena Hemantha Peiris Visula Abesuriya Arjuna De Silva Chandima De Mel Sanjay De Mel Suranjith l. Seneviratne Department of Medical laboratory Sciences Faculty of Allied Health Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Nawaloka Hospitals Research and Education Foundation Nawaloka Hospitals PLC Colombo Sri Lanka Department of Biochemistry Faculty of Medical Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Department of Medicine Faculty of Medicine University of Kelaniya Ragama Sri Lanka Department of Haematology-Oncology National University Cancer Institute National University Health System Singapore Institute of Immunity and Transplantation Royal Free Hospital and University College London UK

Objective: The aim of the study is to identify whether Atypical lymphocyte (Al), liver transaminases, and glutathione Reductase (gR) can be used as potential biomarkers in the assessment of severity and thrombocytopen... 详细信息

g>Objective: g>The aim of the study is to identify whether Atypical lymphocyte (Al), liver transaminases, and glutathione Reductase (gR) can be used as potential biomarkers in the assessment of severity and thrombocytopenia in dengue. g>Methods:g> A cross-sectional analytical study was carried out on diagnosed dengue patients admitted to Nawaloka Hospital, Sri lanka. Blood samples were taken from patients (n = 50) on the day of admission, 3rd and 5th day from admission for analysis of gR, aspartate transaminase, alanine transaminase, platelets, white blood cells, and Atypical lymphocytes (Al). g>Results:g> gR level of all three measured stages had a higher area under the curve (>88%), high sensitivity and specificity compared to liver transaminases. A significant regression model represents on admission gR and Al levels as predictive variables to platelet levels in day 03 from admission (Day 3 Platelet level = 127155.3 - 383 * gR - 0.431 * Al). g>Conclusion:g> liver transaminases, gR, and Al% can be considered as a profile of predictive biomarkers in early diagnosis of severity of dengue infection. The degree of thrombocytopenia can be predicted using on admission gR and Al% level in acute dengue viral infection.

关键词： Dengue liver Transaminases glutathione Reductase Atypical lymphocytes

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