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Food Bioscience 2022年第3期47卷 91-110页

作者： Sandra Peñaloza Cornelio Delesma Jesús Muñiz lópez-Ortiz A. Instituto de Energías Renovables Universidad Nacional Autónoma de MéxicoPriv.Xochicalco s/nCol.CentroTemixco62580MorelosMexico

This review is intended to cover the works related to the anthocyanin behavior in food that is subjected to *** experimental and theoretical results available in scientific literature are *** increase in anthocyanin concentration has been observed upon thermal ***,a conclusive explanation is still *** accessible studies suggest an increase in concentration during maturations,which could be related to the enzymatic *** possible enzymes involved in such a procedure have also been covered,including their role played in the *** possible activation mechanisms and the related factors such as temperature,pH,oxygen contents and the presence of UV-light irradiation were also ***,the metabolic pathways were also explored including experimental evaluation and theoretical models based on atomistic methodologies such as density functional theory(DFT).This review is aimed to provide a comprehensive overview of the probable mechanisms behind the increase of anthocyanin concentration during drying.

关键词： Anthocyanin Metabolic pathway PAl CHS UFGT HPlC Theoretical model

Optimization of performance of the KM2A full array using the Crab Nebula

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Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.Heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 lHAASO Collaboration Key laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Hebei Normal University Shijiazhuang 050024China Key laboratory of Dark Matter and Space Astronomy&Key laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the large High Altitude Air Shower Observatory(lHAASO)has been in operation since July *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from lHAASO and other experiments.

关键词： γ-ray Crab Nebula significance

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Science Bulletin 2024年第4期69卷 449-457页

作者： lHAASO Collaboration Zhen Cao Chuandong Gao Cong li Ruo-Yu liu Ruizhi Yang 不详 Key laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

Incorporation of dysprosium ions into PbTiO_(3) ferroelectric ceramic system

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Journal of Advanced Dielectrics 2015年第1期5卷 29-33页

作者： A.Pel.iz-Barranco Y.Mendez-González Jinfei Wang Tongqing Yang Facultad de Física-IMRE Universidad de La Habana.San Lázaro y L Vedado.La Habana 10400Cuba Functional Materials Research laboratory College for Materials Science and Engineering Tongji University 4800 CaoanShanghai 201804P.R.China

A structural analysis concerning the incorporation of dysprosium into A-and/or B-sites of the lead titanate is *** two"boundary"refinements are presented,i.e.,Dy^(2+)substitutes for Pb^(2+)(Dy^(3+)substitutes for Ti^(4+))and Dy^(3+)substitutes for Pb^(2+)(Dy^(3+)substitutes for Ti^(4+)).The results offer quantitative information about the incorporation into both crystallographic *** increase of Dy^(3+)fraction into B-site provides the increase of the Ti^(4+)atomic displacement along the[001]direction and the tetragonal distortion.

关键词： lead titanate lanthanides perovskites crystalline structure

Ferroelectric ceramic materials of the Aurivillius family

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Journal of Advanced Dielectrics 2013年第4期3卷 9-19页

作者： A.Pel.iz-Barranco Y.González-Abreu Facultadde Física Facultad de Física Universidad de la Habana.San lázaro y l Vedado.la Habana 10400 Cuba

Ferroelectric ceramics are important materials with a wide range of industrial and commercial *** the discovery of the phenomenon of ferroelectricity,they have been the heart and soul of several multibillion dollar industries,ranging from highdielectric-permittivity capacitors to developments in piezoelectric transducers,pyroelectric sensors,medical diagnostic transducers,electro-optical devices,*** based on barium titanate and lead zirconate titanate have dominated the field throughout their ***,the ferroelectric ceramics from the Aurivillius family receive great attention due to their large remanent polarization,lead-free nature,relatively low processing temperatures,high Curie temperatures and excellent piezoelectric properties,which made them good candidates for multiple *** review presents a general overview of the progress in the studies on the ferroelectric ceramics from the Aurivillius *** progress includes several aspects:(i)structural studies,(ii)dielectric and electric behavior,(iii)piezoelectricity,and(iv)pyroelectricity.

关键词： layered perovskites dielectric relaxation relaxors dielectric permittivity

Development of gluten-free tarhana formulations:Part *** of legume composite flours and baker’s yeast

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Food Bioscience 2022年第3期47卷 802-809页

作者： Hatice Kılıç Keskin Nermin Bilgiçli Elif Yaver Department of Food Engineering Engineering FacultyNecmettin Erbakan UniversityKöyceğiz Campus42090KonyaTurkey

Many gluten-free foods are prepared from starch-rich ingredients with low protein and fiber content,resulting in poor nutritional and functional *** this study,five different composite legume flours which are prepared from different levels of chickpea,lentil,common bean,soybean and lupin flours were used at 75%level in gluten-free tarhana formulations to improve nutritional ***,effect of baker’s yeast(Saccharomyces cerevisiae)at different levels(2.5%and 5.0%)on physicochemical and sensory attributes of the samples containing composite flours was *** inclusion of composite flours(75%)resulted in lower l^(*) and hue values in tarhana than gluten-free sample without composite *** viscosity of tarhana soup containing“25%chickpea+50%lentil”composite flour(F2)was similar to traditional wheat tarhana soup(p>0.05).The utilization of composite flours containing“50%chickpea+25%lentil”(F1),F2,and“25%chickpea+25%lentil+25%common bean”(F3)in tarhana revealed comparable oil absorption capacity to wheat ***,pH and foaming capacity values of the samples containing composite flours were greater than wheat tarhana and gluten-free tarhana without composite *** addition of composite flours elicited markedly higher ash,protein,fat,and mineral *** phytic acid concentration of tarhana enhanced with the incorporation of composite flour,the use of 5.0%yeast considerably decreased phytic acid content and enriched ash,protein,total phenolic content,Ca,Cu,K,Mg,and P concentrations of tarhana in comparison with tarhana containing 2.5%*** inclusion of F1,F2,and F3 elicited acceptable sensory scores in *** was concluded that gluten-free tarhana prepared from legume composite flours(especially F1,F2,and F3)+5.0%yeast could offer a nutritious and acceptable alternative for gluten-free diet with greater protein and mineral *** on the findings,further studies may evaluate the use of hydrocolloids to improve the tec

关键词： Gluten-free legumes Yeast(Saccharomyces cerevisiae) Tarhana Phytic acid Functional properties

Electrocaloric effect and freezing temperature in(Pb_(0.8)Ba_(0.2))[(Zn_(1/3)Nb_(2/3))_(0.7)Ti_(0.3)]O_(3) relaxor ferroelectric ceramic

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Journal of Advanced Dielectrics 2016年第3期6卷 1-4页

作者： A.Pel.iz-Barranco F.Calderón-Piñar Y.Mendez-González Facultadde Física-IMRE Universidad de La Habana.San Lázaro y LVedado.La Habana 10400Cuba

The electrocaloric effect(ECE)is studied in(Pb_(0.8)Ba_(0.2))[(Zn_(1/3)Nb_(2/3))_(0.7)Ti_(0.3)]O_(3) relaxor ferroelectric ceramic by using an“indirect method”.The electric dependence for the polarization(hysteresis loops)has been obtained for several temperatures showing typical relaxor *** temperature change△T,which is associated with the ECE,is calculated by using the temperature dependence for the polarization.A maximum value for△T is observed for temperatures close above the freezing temperature,showing an indirect evidence of that critical *** results are discussed considering the contribution of the polar nanoregions to the polarization.

关键词： Relaxors ferroelectrics electrocaloric effect freezing temperature

Reconstruction of Cherenkov image bymultiple telescopes of lHAASO-WFCTA

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Radiation Detection Technology and Methods 2022年第4期6卷 544-557页

作者： F.Aharonian Q.An Axikegu l.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen liang Chen liang Chen long Chen M.J.Chen M.l.Chen Q.H.Chen S.H.Chen S.Z.Chen T.l.Chen Y.Chen H.l.Cheng N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.D’Ettorre Piazzoli B.Z.Dai H.l.Dai Z.G.Dai Danzengluobu Ddella Volpe K.K.Duan J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng l.Feng S.H.Feng X.T.Feng Y.l.Feng B.Gao C.D.Gao l.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge l.S.Geng G.H.Gong Q.B.Gou M.H.Gu F.l.Guo J.G.Guo X.l.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He S.l.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu Q.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang W.H.Huang X.T.Huang X.Y.Huang Y.Huang Z.C.Huang X.l.Ji H.Y.Jia K.Jia K.Jiang Z.J.Jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.levochkin B.B.li Cheng li Cong li F.li H.B.li H.C.li H.Y.li J.li Jian li Jie li K.li Wlli XRli Xin li Xin li YZli Zhe li Zhuo li E.W.liang Y.F.liang S.J.lin B.liu C.liu D.liu H.liu H.D.liu J.liu J.l.liu J.S.liu J.Y.liu M.Y.liu R.Y.liu S.M.liu W.liu Y.liu Y.N.liu W.J.long R.lu Q.luo H.K.lv B.Q.Ma l.l.Ma X.H.Ma J.R.Mao A.Masood Z.Min W.Mitthumsiri Y.C.Nan Z.W.Ou B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi Y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz C.Y.Shao l.Shao O.Shchegolev X.D.Sheng J.Y.Shi H.C.Song Yu.V.Stenkin V.Stepanov Y.Su Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang l.P.Wang l.Y.Wang R.Wang R.N.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin Y.l.Xin Y.Xing Z.Xiong D.l.Xu R.X.Xu l.Xue D.H.Yan J.Z.Yan C.W.Yang F.F.Yang H.W.Yang J.Y.Yang l.l.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye l.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang F.Zhang H.M.Zhang H.Y.Zhang J.l.Zhang l.X.Zhang li Zhang lu Zhang P.F.Zhang P.P.Zhang R.Zhang S.B.Zhang S.R.Zhang S. Key laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina Key laboratory of Dark Matter and Space Astronomy&Key laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and Astronomy(Zhuhai)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000China School of Physics(Guangzhou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dipartimento di Fisica dell’Universitàdi Napoli“Federico II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Physics and Astronomy Yunnan UniversityKunming 650091YunnanChina Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève

Introduction One of main scientiﬁc goals of the large High Altitude Air Shower Observatory(lHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’*** Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of lHAASO and has 18 telescopes,is built to achieve this *** telescopes are put together and point to connected directions for a larger *** Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 ***,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the *** event building method for Cherenkov images measured by multiple telescopes of WFCTA is *** performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in *** and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method.

关键词： method directions conclusion

Use of agents stimulating erythropoiesis in digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4675-4685页

作者： Rosario Moreno lópez Beatriz Sicilia Aladrén Fernando Gomollón García Department of Nephrology San Juan de Dios Hospital Paseo Colón 14 50006 Zaragoza Spain Department of Medicine Universidad de Zaragoza 50009 Zaragoza Spain Department of Medicine (Gastroenterology) Alcaiz Hospital 44600 Alcaiz (Teruel) Spain Department of Gastroenterology Clinical University Hospital "Lozano Blesa" Department of Medicine University of Zaragoza IACS CIBEREHD 50009 Zaragoza Spain

Anemia is the most common complication of inflammatory bowel disease (IBD). Control and inadequate treatment leads to a worse quality of life and increased morbidity and hospitalization. Blood loss, and to a lesser extent, malabsorption of iron are the main causes of iron def iciency in IBD. There is also a variable component of anemia related to chronic inflammation. The anemia of chronic renal failure has been treated for many years with recombinant human erythropoietin (rHuEPO), which significantly improves quality of life and survival. Subsequently, rHuEPO has been used progressively in other conditions that occur with anemia of chronic processes such as cancer, rheumatoid arthritis or IBD, and anemia associated with the treatment of hepatitis C virus. Erythropoietic agents complete the range of available therapeutic options for treatment of anemia associated with IBD, which begins by treating the basis of the inflammatory disease, along with intravenous iron therapy as f irst choice. In cases of resistance to treatment with iron, combined therapy with erythropoietic agents aims to achieve near-normal levels of hemoglobin/hematocrit (11-12 g/dl). New formulations of intravenous iron (iron carboxymaltose) and the new generation of erythropoietic agents (darbepoetin and continuous erythropoietin receptor activator) will allow better dosing with the same eff icacy and safety.

关键词：人红细胞生成素消化系统疾病慢性肾功能衰竭传染性法氏囊病红细胞生成素受体综合治疗类风湿关节炎丙型肝炎病毒

Galectin-3 and Il-33/ST2 axis roles and interplay in dietinduced steatohepatitis

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World Journal of Gastroenterology 2016年第44期22卷 9706-9717页

作者： Nada Pejnovic Ilija Jeftic Nemanja Jovicic Nebojsa Arsenijevic Miodrag l lukic Center for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac

Immune reactivity and chronic low-grade inflammation(metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease(NAFlD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis(NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death. Experimental models of dietary-induced NAFlD/NASH in mice on different genetic backgrounds or knockout mice with different immune reactivity are used for elucidating the pathogenesis of NASH and liver fibrosis. Galectin-3(Gal-3), a unique chimera-type β-galactoside-binding protein of the galectin family has a regulatory role in immunometabolism and fibrogenesis. Mice deficient in Gal-3 develop pronounced adiposity, hyperglycemia and hepatic steatosis, as well as attenuated liver inflammation and fibrosis when fed an obesogenic high-fat diet. Interleukin(Il)-33, a member of the Il-1 cytokine family, mediates its effects through the ST receptor, which is present on immune and nonimmune cells and participates in immunometabolic and fibrotic disorders. Recent evidence, including our own data, suggests a protective role for the Il-33/Il-33R(ST2) signaling pathway in obesity, adipose tissue inflammation and atherosclerosis, but a profibrotic role in NASH development. The link between Gal-3 and soluble ST2 in myocardial fibrosis and heart failure progression has been demonstrated and we have recently shown that Gal-3 and the Il-33/ST2 pathway interact and both have a profibrotic role in diet-induced NASH. This review discusses the current evidence on th

关键词： Galectin-3 liver fibrosis Interleukin-33 ST2 Nonalcoholic steatohepatitis