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Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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The Innovation 2024年第2期5卷 107-114页

作者： Johan Gustafsson fariba Roshanzamir Anders Hagnestål sagar M.Patel oseeyi I.Daudu Donald f.Becker Jonathan l.Robinson Jens Nielsen Department of life sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

special Properties of Morita Contexts

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Algebra Colloquium 2024年第2期31卷 309-322页

作者： Kamal Paykan l.A.Bokut Department of Mathematics Tafresh UniversityTafreshIran 不详

In this paper we continue the study of various ring theoretic properties of Morita *** and sufficient conditions are obtained for a general Morita context or a trivial Morita context or a formal triangular matrix ring to satisfy a certain ring property which is among being Kasch,completely primary,quasi-duo,2-primal,NI,semiprimitive,projective-free,*** also characterize when a general Morita context is weakly principally quasi-Baer or strongly right mininjective.

关键词： Morita context formal triangular matrix ring Kasch quasi-duo Köthe's conjecture weakly principally quasi-Baer

Electron kinetic effects in back-stimulated Raman scattering bursts driven by broadband laser pulses

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： Q.K.liu l.Deng Q.Wang X.Zhang f.Q.Meng Y.P.Wang Y.Q.Gao H.B.Cai s.P.Zhu Graduate school China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Physics and Computational Mathematics Beijing 100094China school of Nuclear science and Technology University of Science and Technology of ChinaHefei 230026China shanghai Institute of laser Plasma Shanghai 201800China HEDPs Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China school of Physics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(BsRs)bursts using particle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity spikes and generating large numbers of hot ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate the interference of the broadband laser’s random intensity *** the simplified model,we isolate and characterize the spectrum of electron plasma *** spectrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asymmetry in the spectrum is *** asymmetry is amplified and transferred to electron phase space by high-intensity broadband laser pulses,leading to violent vortex-merging and generation of hot *** proportion of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects profoundly influence the BsRs evolution driven by broadband lasers.

关键词： scattering kinetic simplified

Generation of polarized electron beams through self-injection in the interaction of a laser with a pre-polarized plasma

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High Power laser science and Engineering 2024年第3期12卷 62-68页

作者： l.R.Yin X.f.li Y.J.Gu N.Cao Q.Kong M.Büscher s.M.Weng M.Chen Z.M.sheng Key laboratory of Nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghaiChina state Key laboratory of High field laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina sANKEN(Institute of scientific and Industrial Research) Osaka UniversityOsakaJapan sichuan Research Institute Shanghai Jiao Tong UniversityChengduChina Peter Grünberg Institut(PGI-6) Forschungszentrum JülichJülichGermany Institut für laser-und Plasmaphysik Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany Key laboratory for laser Plasmas(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IfsA Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao lee Institute Shanghai Jiao Tong UniversityShanghaiChina

Polarized electron beam production via laser wakefield acceleration in pre-polarized plasma is investigated by particlein-cell *** evolution of the electron beam polarization is studied based on the Thomas±Bargmann±Michel±Telegdi equation for the transverse and longitudinal self-injection,and the depolarization process is found to be influenced by the injection *** the case of transverse self-injection,as found typically in the bubble regime,the spin precession of the accelerated electrons is mainly influenced by the ***,in the case of longitudinal injection in the quasi-1D regime(for example,*** et al.,***.110,135002(2013)),the direction of electron spin oscillates in the laser *** the electrons move around the laser axis,the net influence of the laser field is nearly zero and the contribution of the wakefield can be ***,an ultra-short electron beam with polarization of 99%can be obtained using longitudinal self-injection.

关键词： laser wakefield acceleration longitudinal self-injection particle-in-cell simulation polarized electron beam

Complex-frequency waves:beat loss and win sensitivity

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light(science & Applications) 2024年第2期13卷 181-183页

作者： Qingqing Cheng Tao l school of optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Respiratory Diseases and Critical Medicine Quzhou Hospital Affiliated to Wenzhou Medical UniversityQuzhou324000China National laboratory of solid state Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China

Recent experiments have demonstrated that synthesized complex-frequency waves can impart a virtual gain to molecule sensing systems,which can effectively restore information lost due to intrinsic molecular *** enhancement notably amplifies the signal of trace molecular vibrational fingerprints,thereby substantially improving the upper limit of sensitivity.

关键词： thereby Complex limit

sANC Monte Carlo programs for small-angle Bhabha scattering

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Chinese Physics C 2024年第4期48卷 14-19页

作者： A.B.Arbuzov s.G.Bondarenko I.R.Boyko l.V.Kalinovskaya A.A.Kampf R.R.sadykov V.l.Yermolchyk Bogoliubov laboratory of Theoretical Physics JINRDubna141980 Russia Dzhelepov laboratory of Nuclear Problems JINRDubna141980 Russia Dubna state University Dubna141982 Russia

luminosity monitoring at e^(+)e^(−)colliders was investigated using sANC Monte Carlo event generator RenesANCe and integrator MCsANC for simulation of Bhabha scattering at low *** are presented for center-of-mass energies of the Z boson resonance and at 240 GeV for the conditions of typical luminosity *** is shown that bremsstrahlung events with extremely low electron scattering angles are relevant to match the precision tags of future electron-positron colliders.

关键词： luminosity Bhabha scattering QED Monte Carlo simulation

Corrosion testing of X52 and X80 steels immersed in stimulated emulsions using a real petroleum sample

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Petroleum Research 2024年第2期9卷 304-316页

作者： l.M.Quej-Ake J.l.Alamilla A.Contreras Instituto Mexicano del Petróleo Eje Central Lázaro CárdenasNorte 152San Bartolo AtepehuacanGustavo A.MaderoCiudad de MéxicoC.P.07730México

The aim of this study is to evaluate the internal corrosion process on X52 and X80 steels/real petroleum interfaces containing condensed hydrocarbon plus oilfield-produced water,which were subjected to stimulated emulsions using 50/50 vol ratio mixtures at 45℃,different hydrodynamic conditions,1 h,and 24 h.A washing process by using deionized water was proposed to simulate and identify the corrosiveness of the hydrocarbon phase after 24 h of exposure *** characterization by electrochemical impedance spectroscopy and the monitoring of the polarization curves indicated that X80 steel/oilfield-produced water interfaces were more susceptible to corrosion than X52 steel exposed to oilfield-produced *** combined speed rotation of 600 rpm using a magnetic stirrer+600 rpm using a rotating disk electrode decreased the corrosion rate on X52 *** stimulated emulsions made of hydrocarbon+oilfield-produced water and hydrocarbon+deionized water at 24 h increased the corrosion rate on X80 steel(0.34 mm/year and 0.43 mm/year,respectively),promoting the formation of erosion and pitting *** types of corrosion depended mainly on the physicochemical properties of the hydrocarbon,oilfield-produced water,exposure times,and hydrodynamic systems in which the hydrocarbon was studied.

关键词： Corrosion Emulsions X52 steel X80 steel

Assessment of portable fTIR and Raman spectroscopy for the detection of 2,3-dimethyl-2,3-dinitrobutane(DMDNB)in plastic explosives

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Defence Technology（防务技术） 2024年第4期34卷 11-18页

作者： Jacky Cailes Robert Dunsmore Kathryn l.linge ChemCentre PO Box 1250PerthAustralia

The Marplex Convention was established to prevent the manufacture of unmarked plastic explosives and stipulates that a volatile detection agent must be added at the time of ***,to-date,laboratory testing remains the internationally accepted practice for identifying and quantifying the taggants stipulated in the *** this project,portable fTIR and Raman instruments were tested for their ability to detect 2,3-dimethyl-2,3-dinitrobutane(DMDNB),the chemical marker incorporated in plastic explosives that are manufactured within *** both fTIR and Raman instruments detected solid DMDNB(98%purity),field analysis of plastic explosives at an Australian Defence establishment showed that both fTIR and Raman spectra were matched the relevant explosive(RDX or PETN),rather than the DMDNB *** all three plastic explosives tested,the concentration of DMDNB was measured by sPME-GC-Ms to be between 1.8 and 2%,greater than the minimum 1%concentration stipulated by the Marplex *** testing with a plastic explosive analogue confirmed that the minor absorption peaks that would characterize low concentrations of DMDNB were masked by absorption bands from other compounds within the ***,while both fTIR and Raman spectroscopy are suitable for detection of plastic explosives,neither rely on the presence of DMDNB for *** is likely that similar results would be found for other taggants stipulated by the Marplex Convention,given they are also present in concentrations less than 1%.

关键词： Explosive ICAo taggants 2,3-Dimethyl-2,3-dinitrobutane(DMDNB) fourier transform infrared(fTIR) Raman

Nonaqueous potassium-ion full-cells:Mapping the progress and identifying missing puzzle pieces

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Journal of Energy Chemistry 2024年第6期93卷 384-399,I0010页

作者： Badre larhrib louiza larbi lénaïc Madec Universite de Pau et des Pays de l’Adour E2S UPPACNRSIPREMPauFrance Universitéde Haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde strasbourg F-67081 StrasbourgFrance Réseau sur le stockage Electrochimique de l’Energie CNRS FR3459AmiensFrance Institut des Matériaux Jean Rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion full-cells(KIfCs)in view of the transition from potassium-ion half-cells(KIHCs)toward commercial K-ion batteries(KIBs).It focuses on the key parameters of KIfCs such as the electrode/electrolyte interfaces challenge,major barriers,and recent advancements in *** strategies for enhancing KIfC performance,including interfaces co ntrol,electrolyte optimization,electrodes capacity ratio,electrode material screening and electrode design,are *** review highlights the need to evaluate KIBs in full-cell configurations as half-cell results are strongly impacted by the K metal *** also emphasizes the importance of understanding solid electrolyte interphase(sEI)formation in KIfCs and explores promising nonaqueous as well as quasiand all-solid-state electrolytes *** review thus paves the way for practical,cost-effective,and scalable KIBs as energy storage systems by offering insights and guidance for future research.

关键词： K-ion full-cells Potassium-ion batteries Cross-talk solid-state batteries Potassium reactivity Electrolyte design Electrode design