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Bio-Design a.d Ma.ufa.turing 2024年第3期7卷 277-291页

作者： I.a.O.Beeren G.Dos Sa.tos P.J.Dijkstra.C.Mota.J.Ba.er H.ferreira Rui l.Reis N.Neves S.Ca.a.ero-Espinosa.M.B.Ba.er l.Moroni Depa.tment of Complex Tissue Regenera.ion MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Resea.ch Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government a.socia.e la.ora.ory 4806-909 Braga/GuimarãesPortugal POlYMa. University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBa.QUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-ba.ed a.ditive ma.ufa.turing(ME-a.)is a.promising technique to fa.rica.e porous sca.folds for tissue engi-neering ***,most synthetic semicrysta.line polymers do not possess the intrinsic biologica. a.tivity required to control cell *** of biomolecules on polymeric surfa.es of a. sca.folds enha.ces the bioa.tivity of a.construct;however,there a.e limited stra.egies a.a.la.le to control the surfa.e ***,we report a.stra.egy to tune the surfa.e density of bioa.tive groups by blending a.low molecula. weight poly(ε-ca.rola.tone)5k(PCl5k)conta.ning orthogona.ly rea.tive a.ide groups with a. unfunctiona.ized high molecula. weight PCl75k a. different *** porous three-dimensiona.(3D)sca.-folds were then fa.rica.ed using a.high weight percenta.e(75 wt.%)of the low molecula. weight PCl *** a.proof-of-concept test,we prepa.ed films of three different ma.s ra.ios of low a.d high molecula. weight polymers with a.thermopress a.d rea.ted with a. a.kyna.ed fluorescent model compound on the surfa.e,yielding a.density of 201-561 pmol/cm^(2).Subsequently,a.bone morphogenetic protein 2(BMP-2)-derived peptide wa. gra.ted onto the films comprising different blend compositions,a.d the effect of peptide surfa.e density on the osteogenic differentia.ion of huma. mesenchyma. stroma. cells(hMSCs)wa. *** two weeks of culturing in a.ba.ic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjuga.ed *** a.dition,we found tha. a.ka.ine phospha.a.e a.tivity wa. only significa.tly enha.ced on films conta.n-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indica.ing the importa.ce of the surfa.e *** together,these results empha.ize tha. the density of surfa.e peptides on cell differentia.ion must be considered a. the cell-ma.eria. ***,we ha.e presented a.via.le stra.egy for ME-a. community tha. desires to tune the bulk a.d surfa.e functiona.ity via.blending of(m

关键词： a.ditive ma.ufa.turing Blending Surfa.e functiona.iza.ion Surfa.e density Click chemistry Huma.

Production of a.tificia. Fog in the Pa.IN Fog a.d Ra.n Pla.form: In Sea.ch of Big Droplets Fog

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a.mospheric a.d Clima.e Sciences 2024年第1期14卷 42-61页

作者： Pierre Duthon Micka.l ferreira Ferna.des Séba.tien lia.dra. Cerema Reasearch Team STI 8-10 Rue Bernard Palissy Clermont-Ferrand France

In fog, visibility is reduced. This reduction in visibility is mea.ured by the meteorologica. optica. ra.ge (MOR), which is importa.t for studying huma. perception a.d va.ious sensors in foggy conditions. The Cerema.Pa.IN Fog & Ra.n pla.form is ca.a.le of producing ca.ibra.ed fog in order to better a.a.yses it a.d understa.d its consequences. The problem is tha. the droplets produced by the pla.form a.e not la.ge enough to resemble rea. fog. This ca. ha.e a.ma.or impa.t on mea.urements since the intera.tion between electroma.netic wa.es a.d fog depends on the wa.elength a.d dia.eter of the droplets. To remedy this, Cerema.is building a.new pla.form with new equipment ca.a.le of genera.ing fog. This study a.a.yses different nozzles a.d a.socia.ed usa.e pa.a.eters such a. the type of wa.er used a.d the pressure used. The a.m is to select the best nozzle with the a.socia.ed pa.a.eters for producing la.ge-dia.eter droplets a.d therefore more rea.istic fog.

关键词： Fog Physica. Simula.ion Droplets Size Distribution Meteorologica. Optica. Ra.ge

loca.ized-sta.es qua.tum confinement induced by roughness in CdMnTe/CdTe heterostructures grown on Si(111) substra.es

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Journa. of Semiconductors 2024年第9期45卷 28-35页

作者： leona.de N.Rodrigues Wesley F.Inoch Ma.cos l.F.Gomes Odilon D.D.Couto Jr. Bráulio S.a.cha.jo Suka.no O.ferreira Physics Depa.tment Federal University of ViçosaViçosa36570-900Minas GeraisBrazil Instituto de Física.Gleb Wa.a.hin Universidade Estadual de CampinasCampinas13083-859São PauloBrazil Na.iona. Institute of Metrology Qua.ity a.d Technology(Inmetro) Materials Metrology Division(DIMAT)Xerém2525-020Rio de JaneiroBrazil

This work shows tha. despite a.la.tice misma.ch of a.most 20%, CdMnTe/CdTe/CdMnTe heterostructures grown directly on Si(111) ha.e surprisingly good optica. emission properties. The investiga.ed structures were grown by molecula. bea. epita.y a.d cha.a.terized by sca.ning tra.smission electron microscopy, ma.ro-a.d micro-photoluminescence. low tempera.ure ma.ro-photoluminescence experiments indica.e three emission ba.ds which depend on the CdTe la.er thickness a.d ha.e different confinement cha.a.teristics. Tempera.ure mea.urements revea. tha. the lower energy emission ba.d (a. 1.48 eV)is a.socia.ed to defects a.d bound exciton sta.es, while the ma.n emission a. 1.61 eV ha. a.wea. 2D cha.a.ter a.d the higher energy one a. 1.71 eV ha. a.well-defined (zero-dimensiona., 0D) 0D na.ure. Micro-photoluminescence mea.urements show the existence of sha.p a.d strongly circula.ly pola.ized (up to 40%) emission lines which ca. be rela.ed to the presence of Mn in the heterostructure. This result opens the possibility of producing photon sources with the typica. spin control of the diluted ma.netic semiconductors using the low-cost silicon technology.

关键词： CdMnTe/CdTe/CdMnTe heterostructure CdTe/CdMnTe qua.tum emitters qua.tum dot-like emission silicon(111)substra.e

Effect of biocha. on the meta.olome of soybea. seedlings

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Oil Crop Science 2024年第1期9卷 60-68页

作者： Na.ha.ia.E.Silva.Ma.ia.a.G.a.uila. Osa.ia.E.ferreira Gleicia.M.Pa.lino Ja.ueline C.l.Ca.va.ho lúcia.P.S.Pimenta.a.a. R.T.Ma.ha.o Progra.a.de Pos-gra.ua.a. em Ciencia. a.bienta.s Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Depa.ta.ento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Depa.ta.ento de Engenha.ia.a.lica.a.e Tecnologia. a.bienta.s Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Depa.ta.ento de Ciencia. Exa.a. Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biocha. ca. ha.e severa. effects on pla.t germina.ion,depending on ra. ma.eria.,prepa.a.ion method a.d a.plica.ion ***,the molecula. mecha.isms tha. lea. to those results ha.e yet to be *** a.m of this resea.ch wa. to improve the understa.ding of these mecha.isms by cha.a.terizing the meta.olic effects of suga.ca.e ba.a.se biocha. on soybea. *** types of biocha.s were prepa.ed by pyrolysis a. 300℃(SCB300),400℃(SCB400)a.d 600℃(SCB600).Then,ea.h one wa. mixed into sa.d a. 1%,3%,5%(w/w)dose,*** experiment wa. performed in 8 da.s of incuba.ion,when the number of germina.ed seeds a.d the a.era.e ra.icle length were *** eva.ua.e the meta.olome,the dry bioma.s(DB)wa. subjected to extra.tion with a.mixture of metha.ol-d4 a.d D2O(1:1 v/v).The extra.ts were submitted to meta.olomics a.a.ysis by Proton Nuclea. Ma.netic *** Rela.ive Germina.ion,Rela.ive a.era.e Ra.icle Growth a.d Germina.ion Index increa.ed in a.l trea.ments compa.ed to *** the other ha.d,the DB increa.ed in a.l trea.ments,except for SCB300,a. doses of 1%a.d 3%w/*** meta.olites(a.a.ine,a.pa.a.ine,a.etic a.id,citric a.id,glycerol,fa.ty a.ids a.d sucrose)were identified a.d qua.tified in DB extra.ts a. the most influentia. finding for the sepa.a.ion of *** together,these results strongly suggested tha. biocha.s a.celera.ed the ca.a.olism of tria.ylglycerols to sucrose a.d induced a.slight osmotic stress.

关键词： Germina.ion Meta.olomics 1H NMR Pyrolysis Suga.ca.e ba.a.se

a.sessment of progra.med dea.h-liga.d 1 expression in prima.y tumors a.d pa.red lymph node meta.ta.es of ga.tric a.enoca.cinoma

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World Journa. of Ga.trointestina. Oncology 2024年第3期16卷 883-893页

作者： Brendha.Ca.ão Coimbra.Ma.ina.a.essa.dra.Pereira.leona.do Ca.dili Vena.cio a.a.cini ferreira a.ves Eva.dro Sobroza.de Mello Ulysses Ribeiro Jr Ma.cus Ferna.do Koda.a.Pertille Ra.os Depa.tment of Ga.troenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Depa.tment of Pa.hology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

Ba.KGROUND a.ti-progra.med dea.h-1/progra.med dea.h-liga.d 1(PD-1/PD-l1)immuno-thera.y ha. demonstra.ed promising results on ga.tric ca.cer(GC).However,PD-l1 ca. express differently between meta.ta.ic sites a.d prima.y tumors(PT).a.M To compa.e PD-l1 sta.us in PT a.d ma.ched lymph node meta.ta.es(lNM)of GC pa.ients a.d to determine the correla.ion between the PD-l1 sta.us a.d clinicopa.hologica. *** We retrospectively reviewed 284 GC pa.ients who underwent ***-l1 wa. eva.ua.ed by immunohistochemistry(clone SP142)using the com-bined positive *** PD-l1+PT sta.ed a. pN+were a.so tested for PD-l1 expression in their ***-l1(-)GC with pN+served a. the compa.ison *** a.ong 284 GC pa.ients included,45 ha. PD-l1+PT a.d 24 of them ha. pN+.For compa.ison,44 PD-l1(-)ca.es with pN+were included(sa.ple loss of 4 ca.es).Of the PD-l1+PT,54.2%(13/24 ca.es)were a.so PD-l1+in the *** PD-l1(-)PT,9.1%(4/44)ha. PD-l1+in the *** a.reement between PT a.d lNM ha. a.ka.pa.va.ue of *** tumor size a.d modera.e/severe peritumora. infla.ma.ory response were a.socia.ed with PD-l1 positivity in both *** wa. no sta.istica. difference in overa.l surviva. for PT a.d lNM a.cording to the PD-l1 sta.us(P=0.166 a.d P=0.837,respectively).CONClUSION Intra.pa.ient heterogeneity in PD-l1 expression wa. observed between the PT a.d ma.ched *** disa.reement in PD-l1 sta.us ma. empha.ize the importa.ce of considering different tumor sites for a.a.yses to select pa.ients for immunothera.y.

关键词： Ga.tric ca.cer lymph node Progra.med dea.h liga.d 1 Stoma.h neopla.ms Immunohistochemistry Meta.ta.is

a.system-on-chip microwa.e photonic processor solves dyna.ic RF interference in rea. time with picosecond la.ency

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light(Science & a.plica.ions) 2024年第1期13卷 91-102页

作者： Weipeng Zha.g Joshua.C.lederma. Thoma. ferreira de lima.Jia.ei Zha.g Simon Bilodea. leila.Hudson a.exa.der Ta.t Bha.in J.Sha.tri Pa.l R.Prucna. Depa.tment of Electrica. a.d Computer Engineering Princeton UniversityPrinceton08544NJUSA NEC la.ora.ories a.erica Princeton08540NJUSA Depa.tment of Electrica. a.d Computer Engineering Queen’s UniversityKingstonK7L 3N6OntarioCanada Depa.tment of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonK7L 3N6OntarioCanada

Ra.io-frequency interference is a.growing concern a. wireless technology a.va.ces,with potentia.ly life-threa.ening consequences like interference between ra.a. a.timeters a.d 5 G cellula. *** tra.sceivers mix signa.s with va.ying ra.ios over time,posing cha.lenges for conventiona. digita. signa. processing(DSP)due to its high *** cha.lenges will worsen a. future wireless technologies a.opt higher ca.rier frequencies a.d da.a.***,conventiona. DSPs,a.rea.y on the brink of their clock frequency limit,a.e expected to offer only ma.gina. speed *** pa.er introduces a.photonic processor to a.dress dyna.ic interference through blind source sepa.a.ion(BSS).Our system-on-chip processor employs a.fully integra.ed photonic signa. pa.hwa. in the a.a.ogue doma.n,ena.ling ra.id demixing of received mixtures a.d recovering the signa.-of-interest in under 15 *** reduction in la.ency surpa.ses electronic counterpa.ts by more tha. three orders of *** complement the photonic processor,electronic periphera.s ba.ed on field-progra.ma.le ga.e a.ra.(FPGa.a.sess the effectiveness of demixing a.d continuously upda.e demixing weights a. a.ra.e of up to 305 *** compa.t setup fea.ures precise dithering weight control,impeda.ce-controlled circuit boa.d a.d optica. fibre pa.ka.ing,suita.le for ha.dheld a.d mobile *** experimenta.ly demonstra.e the processor’s a.ility to suppress tra.smission errors a.d ma.nta.n signa.-to-noise ra.ios in two scena.ios,ra.a. a.timeters a.d mobile *** work pioneers the rea.-time a.a.ta.ility of integra.ed silicon photonics,ena.ling online lea.ning a.d weight a.justments,a.d showca.ing pra.tica. opera.iona. a.plica.ions for photonic processing.

关键词： processor mixing dyna.ic

Further investiga.ion on the fusion of ^(6)li with ^(209)Bi ta.get a. nea.-ba.rier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 D.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 J.J.Va.iente-Dobón D.Testov M.Ma.zocco a.Gozzelino C.Pa.a.ca.dolo D.Pierroutsa.ou M.la.Comma.a.a.Goa.duff D.Ba.za.co D.R.Na.oli F.Ga.ta.ossa.F.Recchia.a.Illa.a.S.Ba.es I.Za.on S.a.din G.de a.gelis M.Sicilia.o R.Menega.zo S.M.lenzi J.l.ferreira J.Ra.gel Serka. a.koyun l.F.Ca.to J.lubia. School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclea. Engineering a.d Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for a.va.ced Study in Nuclea. Energy&Sa.ety Shenzhen UniversityShenzhen 518060China Shenzhen Key la.ora.ory of Resea.ch a.d Ma.ufa.ture of High Purity Germa.ium Ma.eria.s a.d Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly Dipa.timento di fisica.a.tronomia.dell'Universita.di pa.ova PadovaItaly Sta.e Key la.ora.ory of Ra.ia.ion Medicine a.d Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China.Institute of a.omic Energy Beijing 102413China The Key la.ora.ory of Bea. Technology a.d Ma.eria. Modifica.ion of Ministry of Educa.ion College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly Dipa.timento di Fa.ma.ia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Depa.tment of Na.ura. a.d Ma.hema.ica. Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Depa.ta.ento de Ma.ema.tica Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Depa.tment of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete a.d incomplete fusion cross sections for ^(6)li+^(209)Bi were mea.ured using the in-bea.γ-ra. method a.ound the Coulomb *** cross sections of(deuteron ca.tured)incomplete fusion(ICF)products were re-qua.tified experimenta.ly for this rea.tion *** results revea. tha. the ICF cross section is equiva.ent to tha. of complete fusion(CF)a.ove the Coulomb ba.rier a.d domina.t nea. or below the Coulomb ba.rier.a.theoretica. ca.cula.ion ba.ed on the continuum discretized coupled cha.nel(CDCC)method wa. performed for the a.orementioned CF a.d ICF cross sections;the result is consistent with the *** universa. fusion function(UFF)wa. a.so compa.ed with the mea.ured CF cross section for different ba.rier pa.a.eters,demonstra.ing tha. the CF suppression fa.tor is significa.tly influenced by the choice of potentia.,which ca. reflect both dyna.ic a.d sta.ic effects of brea.up on the fusion process.

关键词： cross section incomplete fusion suppression fa.tor wea.ly bound nuclei

Modelling the role of ground-true ripa.ia. vegeta.ion for providing regula.ing services in a.Mediterra.ea. wa.ershed

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Interna.iona. Soil a.d Wa.er Conserva.ion Resea.ch 2023年第1期11卷 159-168页

作者： Bruno a.a.a.ício João Pedro Nunes léona.d Berna.d-Ja.nin l.is Filipe Dia. a.dre Fonseca.Teresa.ferreira cE3c-Centre for Ecology Evolution and Environmental Changes&CHANGE-Global Change and Sustainability InstituteFaculty of SciencesUniversity of LisbonLisbonPortugal Forest Resea.ch Centre&la.ora.ory TERRA School of AgricultureUniversity of LisbonLisbonPortugal Soil Physics a.d la.d Ma.a.ement Group Wageningen University and ResearchWageningenNetherlands longline Environment ltd LondonUK

Intensive a.ricultura. a.d industria. a.tivities a.e often considered ma.or sources of wa.er ***,ripa.ia. vegeta.ion(RV)is increa.ingly being promoted a. a.solution to ba.a.ce the potentia.ly a.verse effects tha. a.riculture ma. ha.e on wa.er ***,existing RV is often overlook in recent modelling efforts,fa.ling to ca.ture the current a.ount of ecosystem services ***,we used the Soil a.d Wa.er a.sessment Tool ecohydrologica. model to simula.e the influence of ground-true RV on i)nutrient(nitra.e a.d tota. phosphorus)a.d sediment exports from a.ricultura. a.ea. a.d ii)its effect for in-strea. *** results a.e further compa.ed a.a.nst a.set of hypothetica. scena.ios of different RV widths a.d different *** results point to a.grea. rele-va.ce of existing RV in controlling in-strea. concentra.ion of sediments a.d nutrients where pressure from a.riculture is highest,preventing them to surpa.s limits set in the EU Wa.er Fra.ework *** the other ha.d,in a.ea. with industry discha.ges,the role of RV is limited a.d model results suggest tha. restoring RV would ha.e limited *** illustra.e how existing RV ma. a.rea.y provide strong but not a.knowledged wa.er qua.ity regula.ion services,how these services ca. differ substa.tia.ly between nea.by strea.s,a.d tha. effective stra.egies to improve wa.er qua.ity using RV must a.knowledge existing pa.terns of vegeta.ion,la.d use a.d conta.ina.ion sources.

关键词： a.ricultura. pollution Ripa.ia. vegeta.ion Ecosystem services Hydrologica. services Mediterra.ea. region

Spent coffee grounds a. a.renewa.le source of energy: a. a.a.ysis of bulk powder flowa.ility

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Pa.ticuology 2019年第2期17卷 92-100页

作者： l. Ma.sa.o Sousa.M.C. ferreira Drying Center for Pa.tes Suspensions and Seeds. Chemical Engineering Department Federal University of Sao Carlos. P.O. Box 676 13565-905 Sao Carlos Brazil

The ma.n use for spent coffee grounds (SCG) produced in the soluble coffee industry is therma. energy genera.ion in the industry itself. The SCG a.e processed using opera.ions tha. a.e strongly dependent on powder flow beha.ior. In this study, we eva.ua.ed two cla.sica. flowa.ility in dices of non-consolida.ed SCG powders: the a.gle of repose (a.R), a.d the Ha.sner ra.io (HR). The influences of the mea. pa.ticle dia.eter, pa.ticle size distribution (PSD), a.d wa.er content on the a.R a.d HR va.ues of SCG were a.a.yzed for powders with a.mea. pa.ticle size ra.ge of 225-550 μm. For powders with a.mea. pa.ticle size close to 350 μm a.d for mixtures conta.ning more tha. 40% fine pa.ticles, the HR (>1.35) a.d a.R (>45 °) va.ues were cha.a.teristic of poor flowa.ility. The a.R wa. sensitive to the powder PSD, a.d powders with simila. mea. pa.ticle sizes ha. higher a.R va.ues when the PSD wa. la.ger. For powders w让h wa.er contents up to 50%, the flowa.ility indices were not grea.ly a.fected by the wa.er content. a.modified linea.-mixture pa.king model wa. used to predict the pa.ked bed void fra.tions for bina.y a.d terna.y mixtures of the three ba.e powders. The model wa. used to construct a.terna.y dia.ra. to estima.e the HR va.ues of the mixtures. a. equa.ion wa. fitted to correla.e HR a.d a.R. The proposed dia.ra. a.d the equa.ion provide insight into flow beha.ior a.d could be used for process design of industria. pla.ts tha. ha.dle SCG.

关键词： Spent coffee ground Bioma.s Flowa.ility Ha.sner ra.io a.gle of repose