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Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection

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World Journal of Gastrointestinal Oncology 2017年第7期9卷 300-307页

作者： özgür Akgül Erdinc Cetinkaya Metin Yalaza Sabri özden Mesut Tez General Surgery Department Ankara Numune Training and Research Hospital06100 AnkaraTurkey

AIM To evaluate the prognostic significance of neutrophilto-lymphocyte ratio(NlR), platelet-to-lymphocyte ratio(PlR), lymphocyte-to-monocyte ratio(lMR), and prognostic nutritional index(PNI) and other clinicopathological factors in patients undergoing curative resection of colon ***183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels(CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival(months), NlR, PlR, lMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database. The primary outcome measure was overall *** Regarding overall survival, on univariate analysis the following variables were significantly associated with poor outcome following resection: T-stage(P = 0.037), lymph node invasion(P = 0.037), cancer stage(P = 0.034), CEA(P = 0.042), CA19-9(P = 0.004), and PNI(P = 0.001). To evaluate the independent prognostic value, multivariate Cox proportional hazard analysis to control for other prognostic factors was used. Using cancer-specific death as an end point for NlR, PlR, lMR, PNI and CA19-9 the optimal cut off values were calculated by ROC analysis. Regarding overall survival, on multivariate analysis high CA19-9(hr = 1.001, 95%CI: 1.00-1.002, P = 0.012) and low PNI(hr = 0.938, 95%CI: 0.891-0.987, P = 0.014) were the only variables independently associated with shortened overall survival. Patients with a PNI 35 had a median OS of 66 mo. Patients with a CA 19-9 < 17 had a median OS of 66 mo and in patients with

关键词： Colorectal cancer Prognosis Overall survival Prognostic nutritional index CA19-9

MgO-based adsorbents for CO2 adsorption:Influence of structural and textural properties on the CO_2 adsorption performance

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Journal of Environmental Sciences 2017年第7期29卷 418-428页

作者： Gutiérrez-Bonilla Elvira Granados-Correa Francisco Sánchez-Mendieta Víctor Morales-luckie Raúl Alberto National Institute of Nuclear Research Department of ChemistryA.P.18-1027Col.EscandonMigud Hidalgo DelegationZip Code 1180 Mexico D.F.Mexico Autonomous University of Mexieo State Faculty of ChemistryColon avenueintersection with ride Tollocan s/n TolucaMexicoMexico

A series of MgO-based adsorbents were prepared through solution–combustion synthesis and ball-milling *** prepared MgO-based powders were characterized using X-ray diffraction,scanning electron microscopy,N_2 physisorption measurements,and employed as potential adsorbents for CO_2 *** influence of structural and textural properties of these adsorbents over the CO_2 adsorption behaviour was also *** results showed that MgO-based products prepared by solution–combustion and ball-milling processes,were highly porous,fluffy,nanocrystalline structures in nature,which are unique physico-chemical properties that significantly contribute to enhance their CO_2 *** was found that the MgO synthesized by solution combustion process,using a molar ratio of urea to magnesium nitrate（2：1）,and treated by ball-milling during 2.5 hr（MgO-BM2.5h）,exhibited the maximum CO_2 adsorption capacity of 1.611 mmol/g at 25℃ and 1 atm,mainly via *** CO_2 adsorption behaviour on the MgO-based adsorbents was correlated to their improved specific surface area,total pore volume,pore size distribution and *** reusability of synthesized MgO-BM2.5h was confirmed by five consecutive CO_2adsorption–desorption times,without any significant loss of performance,that supports the potential of MgO-based *** results confirmed that the special features of MgO prepared by solution–combustion and treated by ball-milling during 2.5 hr are favorable to be used as effective MgO-based adsorbent in post-combustion CO_2 capture technologies.

关键词： CO_2 adsorption MgO-based adsorbents Porous materials Solution–combustion synthesis Ball-milling process Textural properties

Active learning of deep surrogates for PDEs:application to metasurface design

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npj Computational Materials 2020年第1期6卷 312-318页

作者： Raphaël Pestourie Youssef Mroueh Thanh V.Nguyen Payel Das Steven G.Johnson Department of Mathematics Massachusetts Institute of Technology77 Massachusetts AveCambridgeMA 02139USA IBM Research AI IBM Thomas J Watson Research CenterYorktown HeightsYorktownNY 10598USA MIT-IBM Watson AI lab CambridgeMA 02139USA Iowa State University AmesIA 50011USA

Surrogate models for partial differential equations are widely used in the design of metamaterials to rapidly evaluate the behavior of composable ***,the training cost of accurate surrogates by machine learning can rapidly increase with the number of *** photonic-device models,we find that this training becomes especially challenging as design regions grow larger than the optical *** present an active-learning algorithm that reduces the number of simulations required by more than an order of magnitude for an NN surrogate model of optical-surface components compared to uniform random *** show that the surrogate evaluation is over two orders of magnitude faster than a direct solve,and we demonstrate how this can be exploited to accelerate large-scale engineering optimization.

关键词： optimization surrogate faster

猪小肠黏膜下层移植修复兔膝关节内侧副韧带缺损

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中国组织工程研究与临床康复 2007年第21期11卷 4089-4092页

作者：陶海荣刘勇章邹剑王立许志兴金文杰丁欢上海交通大学医学院附属第三人民医院上海市201900 上海市第六人民医院上海市200233

目的:观察猪小肠黏膜下层修复兔膝关节内侧副韧带缺损的作用效果。方法:实验于2006-01/08在上海交通大学医学院附属第三人民医院动物房及中心实验室完成。选用新西兰大白兔24只,动物左右两膝分别作为猪小肠黏膜下层移植组及自体韧带移植... 详细信息

目的:观察猪小肠黏膜下层修复兔膝关节内侧副韧带缺损的作用效果。方法:实验于2006-01/08在上海交通大学医学院附属第三人民医院动物房及中心实验室完成。选用新西兰大白兔24只,动物左右两膝分别作为猪小肠黏膜下层移植组及自体韧带移植组,分别制作兔膝关节内侧副韧带缺损模型。猪小肠黏膜下层移植组植入猪小肠黏膜下层,猪小肠黏膜下层作为细胞外基质,无免疫原性;自体韧带移植组植入对侧副韧带。分别于术后2,4,8和12周取白兔膝关节内侧副韧带,行大体形态观察及组织学和力学检查,两组间进行对比观察。结果:24只白兔均进入结果分析,无脱失。①内侧副韧带移植段大体形态观察结果:术后4周,猪小肠黏膜下层移植组有大量的肉芽增生,与周围粘连;自体韧带移植组肉芽组织与周围粘连相对少。术后8周,猪小肠黏膜下层移植组组织梭形增生;自体韧带移植组组织平行增生,直径略小于猪小肠黏膜下层移植组。术后12周,猪小肠黏膜下层移植组增生组织平行于自体韧带,大小一致;自体韧带移植组增生组织直径与猪小肠黏膜下层移植组相一致。②内侧副韧带移植段光镜检查结果:术后2周,猪小肠黏膜下层移植组少量炎性细胞浸润,成纤维细胞数目不多,血管增生明显;自体韧带移植组炎性细胞稀少。术后4周,猪小肠黏膜下层移植组有大量的成纤维细胞,胶原增多;自体韧带移植组成纤维细胞和胶原比猪小肠黏膜下层移植组多。术后8周,猪小肠黏膜下层移植组纤维细胞为主,纤维纵向排列;自体韧带移植组也以成纤维细胞为主。术后12周,两组均有大量的胶原,排列整齐,细胞和纤维密度相一致。③内侧副韧带力学检查结果:术后4周猪小肠黏膜下层移植组白兔内侧副韧带的最大拉伸负荷大于自体韧带移植组[(36.8±8.9,25.3±7.3)N(P0.05)。结论:猪小肠黏膜下层是一种良好的生物材料,可以用来移植修复膝关节内侧副韧带缺损和损伤,移植后期具有与自体韧带相似的替代修复作用。

关键词：肠粘膜/移植内侧副韧带,膝/损伤组织移植

Transcomplementation, but not Physical Association of the CC-NB-ARC and lRR Domains of Tomato R Protein Mi-1.2 is Altered by Mutations in the ARC2 Subdomain

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Molecular Plant 2008年第3期1卷 401-410页

作者： Gerben van Ooijen Gabriele Mayr Mario Albrecht Ben J. C. Cornelissen Frank l.W. Takken Plant Pathology Swammerdam Institute for Life Sciences University of Amsterdam PO Box 94062 1090 GB Amsterdam the Netherlands Max Planck Institute for Informatics Stuhlsatzenhausweg 85 66123 Saarbrücken Germany

Race-specific disease resistance in plants is mediated by Resistance （R） proteins that recognize pathogen at- tack and initiate defence responses. Most R proteins contain a central NB-ARC domain and a C-terminal leucine-rich repeat （lRR） domain. We analyzed the intramolecular interaction of the lRR domain of tomato R protein Mi-1.2 with its N- terminus. We expressed the CC-NB-ARC and lRR parts in trans and analyzed functional transcomplementation and physical interactions. We show that these domains functionally transcomplement when expressed in trans. Known autoactivating lRR domain swaps were found to induce a hypersensitive response （hr） upon co-expression. likewise, autoactivating mutants in the NB subdomain transcomplemented to induce hr. Point mutations in the ARC2 subdomain that induce strong autoactivation in the full-length Mi-1.2 protein, however, fail to induce hr in the transcomplementation assay, These data indicate distinct functions for the NB-ARC subdomains in induction of hr signalling. Furthermore, dissociation of the lRR is not required to release its negative regulation, as in all combinations of CC-NB-ARC and lRR domains tested, a physical interaction was observed.

关键词： RESISTANCE PROTEIN DISEASE RESISTANCE NUClEOTIDE-BINDING CEll-DEATH HYPERSENSITIVE RESPONSE

The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design

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Journal of Sport and Health Science 2021年第4期10卷 499-506页

作者： Kimberley l.Way Angela S.lee Stephen M.Twigg Nathan A.Johnson Faculty of Medicine and Health Discipline of Exercise and Sports ScienceUniversity of SydneyLidcombeNSW 2141Australia Charles Perkins Centre University of SydneyCamperdownNSW 2006Australia Boden Collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia Faculty of Medicine and Health Central Clinical SchoolUniversity of SydneyCamperdownNSW 2006Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia

Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this *** aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with ***,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic ***,the effect of HIIE on the aforementioned outcomes in people with diabetes is not *** purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MICE)in adults with diabetes;and(ii)compare the effects of HIIE and MICE on the aforementioned ***:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over *** participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(hr_(peak)),interspersed with 3 min of active recovery at 60%-70%hr_(peak);(ii)MICE:33 min of continuous cycling at 60%-70%hr_(peak);and(iii)control(CON):lying quietly in a supine position for 30 ***:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MICE or CON *** was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MICE but not for *** all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of

关键词： Augmentation index Central systolic blood pressure Diabetes High-intensity interval exercise

Electromagnetic wave absorbing properties and hyperfine interactions of Fe–Cu–Nb–Si–B nanocomposites

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Chinese Physics B 2014年第8期23卷 50-54页

作者：韩满贵郭韦吴燕辉刘明 Magundappa l. Hadimanic State Key laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Analytical and Testing Center Sichuan University Department of Electrical and Computer Engineering Iowa State University

The Fe-Cu-Nb-Si-B alloy nanocomposite containing two ferromagnetic phases （amorphous phase and nanophase phase） is obtained by properly annealing the as-prepared alloys. High resolution transmission electron microscopy （hr- TEM） images show the coexistence of these two phases. It is found that Fe-Si nanograins are surrounded by the retained amorphous ferromagnetic phase. Mossbauer spectroscopy measurements show that the nanophase is the D03-type Fe- Si phase, which is employed to find the atomic fractions of resonant 57Fe atoms in these two phases. The microwave permittivity and permeability spectra of Fe-Cu-Nb-Si-B nanocomposite are measured in the frequency range of 0.5 GHz- 10 GHz. large relative microwave permeability values are obtained. The results show that the absorber containing the nanocomposite flakes with a volume fraction of 28.59% exhibits good microwave absorption properties. The reflection loss of the absorber is less than -10 dB in a frequency band of 1.93 GHz-3.20 GHz.

关键词： Mossbauer spectroscopy magnetic permeability nanocrystalline alloys

Enhanced acetone sensing performance of nanostructured Sm2O3 doped SnO2 thick films

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Journal of Rare Earths 2017年第8期35卷 813-823页

作者： F.I.Shaikh l.P.Chikhale J.Y.Patil I.S.Mulla S.S.Suryavanshi School of Physical Sciences Solapur University Solapur 413255 (M.S.) lndia Council of Scientific and Industrial Research Pashan Pune 411008 India

In the present work, we synthesized Sm2O3 doped SnO2 in order to prepare a selective acetone sensor with fast response, quick recovery and good repeatability. Pure as well as 2 mol.%, 4 mol.%, 6 mol.% and 8 mol.% Sm2O3 doped SnO2 nanostructured samples were synthesized by using a co-precipitation method. The characterization of the samples was done by thermogravimetric and differential thermo-gravimetric analysis（TG-DTA）, X-ray diffraction（XRD）, field emission gun-scanning electron microscopy（FEG-SEM）, energy dispersive analysis by X-rays（EDAX）, high resolution scanning electron microscopy（hr-TEM）, selected area X-ray diffraction（SAED）, Brunauer-Emmet-Teller（BET） and ultraviolet-visible-near infrared（UV-Vis-NIR） spectroscopy techniques. The gas response studies of liquid petroleum gas, ammonia, ethanol and acetone vapor were carried out. The results showed that Sm doping systematically lowered operating temperature and enhanced the gas response and selectivity for acetone. The response and recovery time for 6 mol.% Sm2O3 doped SnO2 thick film at the operating temperature of 250 °C were 15 and 24 s, respectively.

关键词： tin oxide samarium oxide screen printing thick film acetone sensor rare earths

非亲缘异基因外周血干细胞移植重建白血病幼儿造血功能:1例报告

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中国组织工程研究与临床康复 2007年第3期11卷 530-533页

作者：闫洪敏王恒湘段连宁薛梅朱玲刘静潘世平樊五四丁丽陈惠仁纪树荃全军半相合骨髓移植中心空军总医院血液科骨髓移植病房北京市100036

目的:分析非亲缘异基因外周血干细胞移植治疗幼儿急性非淋巴性白血病的可行性。方法:患儿,男,3岁,于2005-07-18为行造血干细胞移植入本院血液科骨髓移植病房,入院诊断为急性非淋巴细胞性白血病-M5b。经抗肿瘤药物治疗病情获得完全缓解... 详细信息

目的:分析非亲缘异基因外周血干细胞移植治疗幼儿急性非淋巴性白血病的可行性。方法:患儿,男,3岁,于2005-07-18为行造血干细胞移植入本院血液科骨髓移植病房,入院诊断为急性非淋巴细胞性白血病-M5b。经抗肿瘤药物治疗病情获得完全缓解。患儿首先接受清髓性预处理,然后接受同性别非亲缘异基因外周血造血干细胞移植。①移植预处理包括马利兰、阿糖胞苷和环磷酰胺。移植前依次用药为马利兰3.2mg/(kg·d)×4d,口服,于移植前6,7,8,9d给药;阿糖胞苷3.2g/(m2·d)×2d,于移植前4,5d给药;环磷酰胺54mg/(kg·d),于移植前2,3d给药。②急性移植物抗宿主病的预防用药包括环孢菌素A和氨甲蝶呤、抗胸腺细胞球蛋白及吗替麦考酚酯。供者接受粒细胞集落刺激因子动员4d后采集外周血造血干细胞,供、受者间HlA全相合,患者血型A,供者血型B,主次要均不合。结果:①患儿移植后早期获得造血重建,中性粒细胞>0.5×109l-1和血小板>50×109l-1的天数分别是12d和11d。②移植后1个月经DNA短串联重复序列多态性分析证明为供者型完全植入,移植后3个月查骨髓象正常。③移植后3,6个月定期行淋巴细胞亚群检查表明除CD19+,CD4+细胞未恢复外,自然杀伤细胞在移植后3个月恢复正常,T淋巴细胞CD3+与CD8+、体液免疫球蛋白在移植后6个月中均获得重建。④整个移植过程顺利,未出现明显感染和重度急性移植物抗宿主病。移植后96d时出现Ⅰ度皮肤移植物抗宿主病,经加用激素治疗,皮疹消失。移植术后已随访观察12个月,患儿正常生活。结论:如果患儿有HlA完全相合的供者,非亲缘异基因外周血干细胞移植治疗儿童高危白血病是一种有效和安全的方法,对国内独生子女家庭拓宽供者来源有重要的实用价值。

关键词：白血病移植异种造血干细胞移植