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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha cação Coimbra Marina Alessandra Pereira leonardo cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-l1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-l1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-l1 status in PT and matched lymph node metastases(lNM)of GC patients and to determine the correlation between the PD-l1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-l1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-l1+PT staged as pN+were also tested for PD-l1 expression in their ***-l1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-l1+PT and 24 of them had pN+.For comparison,44 PD-l1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-l1+PT,54.2%(13/24 cases)were also PD-l1+in the *** PD-l1(-)PT,9.1%(4/44)had PD-l1+in the *** agreement between PT and lNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-l1 positivity in both *** was no statistical difference in overall survival for PT and lNM according to the PD-l1 status(P=0.166 and P=0.837,respectively).CONClUsioN Intra-patient heterogeneity in PD-l1 expression was observed between the PT and matched *** disagreement in PD-l1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1528-1549页

作者： Rosane Mazzarella Karina canon‑Beltran Yulia N.cajas Meriem Hamdi Encina M.Gonzalez Juliano C.da Silveira Claudia l.V.leal D.Rizos Department of Animal Reproduction INIA-CSICMadridSpain Department of Biochemistry and Molecular Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain Department Agrarian Production Technical University of MadridUPMMadridSpain Departamento de Ciencias Biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador Department of Anatomy and Embryology FV-UCMMadridSpain Department of Veterinary Medicine FZEA-USPPirassunungaBrazil

Background Extracellular vesicles(EVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes(lMGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. Bioactive molecules within EVs in maternal reproductive fluids, such as micro RNAs(miRNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated miRNA cargo in OF-EVs from the early luteal phase and UF-EVs from the mid-luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on lMGs and sign-aling pathways crucial for early embryo development. A total of 333 miRNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed miRNAs, 19 up-regulated in UF-EVs(bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) and one(bta-miR-148b) in OF-EVs. These miRNAs were predicted to modulate several pathways such as Wnt, Hippo, MAPK, and lipid metabolism and degradation. Differ-ences in miRNAs found in OF-EVs from the early luteal phase and UF-EVs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, miRNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： Embryo-maternal interaction Epigenetic Exosomes Mammalian Preimplantation Reproductive fluids

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Twenty years of population dynamics in European beech-oak forest at their rear range margin anticipate changes in its structure and composition

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Forest Ecosystems 2024年第3期11卷 358-370页

作者： álvaro Rubio-Cuadrado Iciar Alberdi Isabel.canellas Fernando Montes Jesús Rodríguez-calcerrada Rosana lópez Guillermo G.Gordaliza María Valbuena-carabana Nikos Nanos Ramón Perea luis Gil Departamento de dinamica y gestion forestal Instituto de Ciencias Forestales(ICIFOR-INIA)CSICCtra.La Coruna km 7.528040MadridSpain Departamento de Sistemas y Recursos Naturales Escuela Tecnica Superior de Ingeniería de MontesForestal y del Medio NaturalUniversidad Politecnica de Madrid.Ciudad Universitaria s/n28040MadridSpain School of Forestry and Natural Environment Aristotle University of ThessalonikiUniversity Campus54124ThessalonikiGreece

There is an increasing interest in restoring degraded forests,which occupy half of the forest *** the forms of restoration,passive restoration,which involves the elimination of degrading factors and the free evolution of natural dynamics by applying minimal or no management,is gaining *** dynamics is difficult to predict due to the influence of multiple interacting factors such as climatic and edaphic conditions,composition and abundance of species,and the successional character of these ***,we study the natural dynamics of a mixed forest l.cated in central Spain,which maintained an open forest structure,due to intensive use,until grazing and cutting were banned in the *** most frequent woody species in this forest are Fagus sylvatica,Quercus petraea,Quercus pyrenaica,Ilex aquifolium,Sorbus aucuparia,Sorbus aria and Prunus avium,with contrasting shade and drought *** species are common in temperate European deciduous forest and are found here near their southern distribution limit,except for *** order to analyze forest dynamics and composition,three inventories were carried out in 1994,2005 and *** results show that,despite the Mediterranean influence,the natural dynamics of this forest has been mainly determined by different levels of shade *** the abandonment of grazing and cutting,*** expanded rapidly due to its lower shade tolerance,whereas after canopy closure and forest densification,shade-tolerant species gained ground,particularly ***,despite its lower drought and late-frost *** the current dynamics continue,*** will overtake the rest of the species,which will be relegated to sites with shallow soils and steep ***,all the multi-centennial beech trees,which are undergoing a rapid mortality and decline process,will disappear.

关键词： Forest succession Secondary forest Woodland Mixed forest Competition Recruitment

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Mechanics and physics under supergravity conditions

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Acta Mechanica Sinica 2024年第6期40卷 1-2页

作者： Chaofeng lü Chao Sun Shengqiang cai Faculty of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China New Cornerstone Science laboratory Center for Combustion EnergyDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mechanical and Aerospace Engineering University of CaliforniaSan DiegoLa Jolla CA 92093USA

"Supergravity"refers to the conditions where the effective gravity is greater than that of *** conditions are generally relevant to stellar evolution,geophysical movement,astrophysical flows,and *** also frequently occur in various engineering scenarios involving acceleration,such as the launch of space shuttles,operation of rotor engines,impacts and explosions,chemical separation processes,and overloaded testing *** is already demonstrated in physiological experiments that living organisms of animals or plants could be damaged,either temporarily or permanently,when subjected to *** create supergravity conditions for scientific research on the Earth,centrifugal equipment or rapidly rotating devices are omnipresent in various fields,such as aerospace engineering,geophysical science,chemical and biomedical engineering,nuclear engineering,rotating flows,and physical modeling tests.

关键词： geophysical Earth stellar

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Determination of the standardized ileal digestible calcium requirement of Ross broilers from hatch to day 14 post-hatch

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Animal Nutrition 2024年第1期16卷 122-129页

作者： carrie l.Walk Raffaella Aureli Pauline Jenn DSM Nutritional Products Research Center for Animal Nutrition and Health DSM Nutritional Products

An experiment was conducted to determine the standardized ileal digestible (SID) calcium requirement of fast-growing broilers from hatch to d 14 *** 308 (n=360) male broilers were obtained on day of hatch and all.cated to 1 of 5 treatments in battery *** were 6 birds per cage and 12 pens per *** treatments were formulated to contain 0.60%,0.46%,0.32% or 0.18% SID *** final treatment was formulated using total.ca to meet or exceed all nutrient requirements,including 0.90% total.ca and 0.49% non-phytate P (nPP),using the same *** treatment was the reference diet for comparison and validation of the SID ca *** and feed were weighed at placement and on d *** and ileal contents were obtained on d 14 and excreta was collected per pen and pooled on d *** were analyzed using JMP Pro and requirements were estimated using 3different non-linear regression *** the SID ca content in the diet from 0.18% to 0.60% improved (quadratic,Plity corrected feed conversion ratio (mFCR).The estimated SID ca requirement to optimize gain or m FCR was between 0.39% and 0.52%.Tibia ash percent and weight increased (quadratic,Pca content in the diet increased and the estimated SID ca requirement was between 0.32% and 0.58%.Phosphorus utilization was improved in birds fed diets formulated using SID ca compared with birds fed the reference *** conclusion,the SID ca requirement of fast-growing broilers from hatch to d 14 was estimated between 0.534% and 0.398% when quadratic,straight-broken line,or quadratic-broken line regressions were *** results agree with previously published data evaluating the SID ca requirement of fast-growth broilers from hatch to d 10.

关键词： Apparent ileal digestibility Digestible calcium Requirements Retention Tibia ash

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Model Change Active learning in Graph-Based Semi-supervised learning

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1270-1298页

作者： Kevin S.Miller Andrea l.Bertozzi Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLos AngelesCA 90095USA

Active learning in semi-supervised classification involves introducing additional labels for unlabelled data to improve the accuracy of the underlying classifier.A challenge is to identify which points to label to best improve performance while limiting the number of new labels."Model Change"active learning quantifies the resulting change incurred in the classifier by introducing the additional label(s).We pair this idea with graph-based semi-supervised learning(SSl)methods,that use the spectrum of the graph laplacian matrix,which can be truncated to avoid prohibitively large computational and storage *** consider a family of convex loss functions for which the acquisition function can be efficiently approximated using the laplace approximation of the posterior *** show a variety of multiclass examples that illustrate improved performance over prior state-of-art.

关键词： Active learning Graph-based methods Semi-supervised learning(SSl) Graph laplacian

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Proteomic response of Phaeocystis globosa to nitrogen limitation

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Journal of Oceanology and limnology 2024年第1期42卷 141-149页

作者： Haisu lIU Ruiwang WEI Qiangyong lEI lei CUI Songhui lÜ Key laboratory of Eutrophication and Red Tide Prevention Research Center for Harmful Algae and Marine BiologyJinan UniversityGuangzhou 510632China Southern Marine Science and Engineering Guangdong laboratory Zhuhai 519082China National Engineering laboratory of Electronic and Information Standardization Shenzhen 518057China

Phaeocystis globosa is an important unicellular eukaryotic alga that can also form *** can cause massive harmful algal blooms and plays an important role in the global.carbon or sulfur *** far,the ecophysiology of *** has been investigated by numerous ***,the proteomic response of *** to nitrogen depletion remains largely *** compared four protein preparation methods of *** for two-dimensional electrophoresis(2-DE)(Urea/Triton X-100 with trichloroacetic acid(Tca)/acetone precipitation;Tca/acetone precipitation;Radio Immuno Precipitation Assay(RIPA)with Tca/acetone precipitation;and Tris buffer).Results show that the combination of RIPA with Tca/acetone precipitation had a clear gel background and showed the best protein spot separation effect,based on which the proteomic response to nitrogen depletion was studied using *** addition,we identified six differentially expressed proteins whose relative abundance increased or decreased more than 1.5-fold(Pld not be identified,which might be attributed to the lack of genomic sequences of *** nitrogen limitation,repl.cation protein-like,RNA ligase,and sn-glycerol-3-phosphate dehydrogenase were reduced,which may decrease the DNA repl.cation level and ATP production in *** *** increase of endonucleaseⅢand transcriptional regulator enzyme may affect the metabolic and antioxidant function of *** cells and induce cell *** findings provide a basis for further proteomic study of *** and the optimization of protein preparation methods of marine microalgae.

关键词： Phaeocystis globosa nitrogen limitation proteomic response two-dimensional electrophoresis

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深海环境海洋生态系统监测与修复新技术

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Engineering 2024年第3期34卷 195-211页

作者： Jacopo Aguzzi laurenz Thomsen Sascha Flögel Nathan J.Robinson Giacomo Picardi Damianos Chatzievangelou Nixon Bahamon Sergio Stefanni Jordi Grinyó Emanuela Fanelli Cinzia Corinaldesi Joaquin Del Rio Fernandez Marcello calisti Furu Mienis Elias Chatzidouros Corrado Costa Simona Violino Michael Tangherlini Roberto Danovaro Instituto de Ciencias del Mar(ICM-CSIC) Barcelona 08003Spain Stazione Zoologica Anton Dohrn Naples 80121Italy University of Gothenburg Göteborg 40530Sweden GEOMAR Helmholtz Centre for Ocean Research Kiel 24148Germany Fundación Oceanogràfic de la Comunitat Valenciana Valencia 46013Spain Royal Netherlands Institute for Sea Research(NIOZ) Den Burg Texel 1790 ABNetherlands Polytechnic University of Marche(UNIVPM) Ancona 60131Italy SARTI-MAR of the Universitat Politecnica de catalunya(UPC) Vilanova i la Geltrú08800Spain lincoln Institute for Agri-food Technology University of LincolnLincoln LN22LGUK Engitec Systems International limited Limassol 3083Cyprus Consiglio per la Ricerca in Agricoltura e l’analisi Dell’economia Agraria(CREA) Centro di Ricerca Ingegneria e Trasformazioni AgroalimentariMonterotondo 00015Italy

The United Nations(UN)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural *** ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work ***,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial *** expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

关键词： Ecosystem restoration Robotic manipulation Acoustic tracking Fishery resources Artificial reefs

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Ranking academic institutions based on the productivity,impact,and quality of institutional scholars

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Journal of Data and Information Science 2024年第3期9卷 116-154页

作者： Amir Faghri Theodore l.Bergman Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Mechanical Engineering University of KansasLawrenceKS 66045USA

Purpose:The quantitative rankings of over 55,000 institutions and their institutional programs are based on the individual rankings of approximately 30 million scholars determined by their productivity,impact,and ***/methodology/approach:The institutional ranking process developed here considers all institutions in all countries and regions,thereby including those that are established,as well as those that are emerging in scholarly *** of individual scholars worldwide are first generated using the recently introduced,fully indexed ScholarGPS *** rankings of individual scholars are extended here to determine the lifetime and last-five-year Top 20 rankings of academic institutions over all Fields of scholarly endeavor,in 14 individual Fields,in 177 Disciplines,and in approximately 350,000 unique *** associated with five specific Fields(Medicine,Engineering&Computer Science,life Sciences,Physical Sciences&Mathematics,and Social Sciences),and in two Disciplines(Chemistry,and Electrical&Computer Engineering)are presented as examples,and changes in the rankings over time are ***:For the Fields considered here,the Top 20 institutional rankings in Medicine have undergone the least change(lifetime versus last five years),while the rankings in Engineering&Computer Science have exhibited significant *** evolution of institutional rankings over time is largely attributed to the recent emergence of Chinese academic institutions,although this emergence is shown to be highly Field-and *** implementations:Existing rankings of academic institutions have:(i)often been restricted to pre-selected institutions,clouding the potential discovery of scholarly activity in emerging institutions and countries;(ii)considered only broad areas of research,limiting the ability of university leadership to act on the assessments in a concrete manner,or in contrast;(iii)have considered only a narrow are

关键词： Academic institution ranking Top institutional scholars ScholarGPS

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High-efficiency carbonation Modification Methods of Recycled Coarse Aggregates

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 386-398页

作者：张美香 YANG Xiaolin 丁亚红 SUN Bo ZHANG Xianggang lÜXiuwen Department of Civil Engineering Henan Polytechnic UniversityJiaozuo 454150China College of Architectural Engineering Xinyu UniversityXinyu 336500China

To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put *** carbonation effect of modified recycled coarse aggregate with three different carbonation methods was evaluated,and water absorption,apparent density and crush index of modified recycled coarse aggregate were *** with XRD,SEM,and MIP microscopic analysis,the high-efficiency carbonation strengthening mechanism of modified recycled coarse aggregate was *** experimental results show that,compared with the non-carbonated recycled coarse aggregate,the physical and microscopic properties of carbonated recycled coarse aggregate are *** method of carbonation with nano-sio_(2) pre-soaking can realize the high-efficiency carbonation of recycled coarse aggregate,for modified recycled coarse aggregate with the method,water absorption is reduced by 23.03%,porosity is reduced by 44.06%,and the average pore diameter is 21.82 *** high-efficiency carbonation strengthening mechanism show that the pre-socked nano-sio_(2) is bound to the hydration product ca(OH)_(2) of the old mortar with nano-scale C-S-H,which can improve the CO_(2) absorption rate,accelerate the carbonation reaction,generate more stable caCO_(3) and nano-scale sil.ca gel,and bond to the dense three-dimensional network structure to realize the bidirectional enhancement of nano-materials and pressurized *** is concluded that the method of carbonation with nano-sio_(2) pre-soaking is a novel high-efficiency carbonation modification of recycled coarse aggregate.

关键词： recycled coarse aggregate pressurized carbonation high-efficiency carbonation nano-sio2 strengthening mechanism

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