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丛书名： The McGraw-Hill/Irwin series: operations and decision sciences

2004年

作者： bruce l. Bowerman Richard T. O'Connell J.B. Orris.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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改进医疗服务质量、确保病人安全的教学方法

中国循证医学杂志 2009年第9期9卷 938-941页

作者： Merrilyn M Walton bruce H Barraclough Samantha A Van Staalduinen Susan l Elliott 段玉蓉(译) 张鸣明(审校) 澳大利亚悉尼大学医学院毕业后医学教育部澳大利亚西悉尼大学医学院澳大利亚墨尔本大学不详

提高医疗服务质量、确保病人安全是当前医学教育及培训面临的巨大挑战。今天的医生及医务工作者应具备良好的沟通能力,掌握如何在临床实践中鉴别、预防和处理不良事件及接近过失事件(nearmisses),如何使用当前获得的证据及相关信息,如... 详细信息

提高医疗服务质量、确保病人安全是当前医学教育及培训面临的巨大挑战。今天的医生及医务工作者应具备良好的沟通能力,掌握如何在临床实践中鉴别、预防和处理不良事件及接近过失事件(nearmisses),如何使用当前获得的证据及相关信息,如何安全有效地在团队中工作,如何在实践中教授和学习病人安全知识,如何根据认可的伦理原则服务公众。

关键词：病人安全医疗服务质量医学教育

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Reducing the oxidative stress mediates the cardioprotection of bicyclol against ischemia-reperfusion injury in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 487-495页

作者： Jie CUI Zhi lI ling-bo QIAN Qin GAO Jue WANG Meng XUE Xiao-e lOU Iain C.bruce Qiang XIA Hui-ping WANG Department of Physiology School of MedicineZhejiang University Department of Physiology Xuzhou Medical College Department of Physiology Zhejiang Medical College

Objective:To investigate the beneficial effect of bicyclol on rat hearts subjected to ischemia-reperfusion(IR) injuries and its possible ***:Male Sprague-Dawley rats were intragastrically administered with bicyclol(25,50 or 100 mg/(kg·d)) for 3 *** IR was produced by occlusion of the coronary artery for 1 h and reperfusion for 3 *** ventricular hemodynamics was continuously *** the end of reperfusion,myocardial infarct was measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining,and serum lactate dehydrogenase(lDH) level and myocardial superoxide dismutase(SOD) activity were determined by *** ventricular myocytes from adult rats were exposed to 60 min anoxia and 30 min reoxygenation to simulate IR *** reperfusion,cell viability was determined with trypan blue;reactive oxygen species(ROS) and mitochondrial membrane potential of the cardiomyocytes were measured with the fluorescent *** mitochondrial permeability transition pore(mPTP) opening induced by Ca2+(200 μmol/l) was measured with the absorbance at 520 nm in the isolated myocardial ***:low dose of bicyclol(25 mg/(kg·d)) had no significant improving effect on all cardiac parameters,whereas pretreatment with high bicyclol markedly reduced the myocardial infarct and improved the left ventricular contractility in the myocardium exposed to IR(Plol(50 mg/(kg·d)) markedly improved the myocardial contractility,left ventricular myocyte viability,and SOD activity,as well decreased infarct size,serum lDH level,ROS production,and mitochondrial membrane potential in rat myocardium exposed to *** reduction of ventricular myocyte viability in IR group was inhibited by pretreatment with 50 and 100 mg/(kg·d) bicyclol(Ply inhibited by medium ***:Bicyclol exerts cardioprotection against IR injur

关键词： Ischemia-reperfusion injury Cardioprotection Oxidative stress Mitochondrial permeability transition pore Bicyclol

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疟疾疫苗的研制及存在的问题

微生物学免疫学进展 1988年第2期 89-91页

作者： bruce-Chwatt l J ,蒋宁园

一九八五年和八六年在研制、试验和临床试用疟疾疫苗方面取得了显著的进展。由于热带地区疟疾地方性流行区控制(更不用说根除)疟疾的方法正日益减少,到本世纪七十年代就明显地需要一种新的疟疾控制方法。由于媒介按蚊对大多数有效的(但... 详细信息

一九八五年和八六年在研制、试验和临床试用疟疾疫苗方面取得了显著的进展。由于热带地区疟疾地方性流行区控制(更不用说根除)疟疾的方法正日益减少,到本世纪七十年代就明显地需要一种新的疟疾控制方法。由于媒介按蚊对大多数有效的(但价格越来越贵的)杀虫剂抗性日益增加,疟原虫

关键词：疟疾疫苗蛋白恶性疟原虫猴疟原虫子孢子抗原

Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population

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World Journal of Gastroenterology 2011年第42期17卷 4682-4688页

作者： Dana l Bruden Michael G bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon Arctic Investigations Program Division of Preparedness and Emerging InfectionsNational Center for Emerging Zoonoses and Infectious DiseasesCenters for Disease Control and Prevention Alaska Native Tribal Health Consortium Anchorage

AIM： TO evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori （H. pylon] infection, H. pyIori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient＇s *** test, 13C urea breath test （UBT）, and immunoglobulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori test by culture or, in case of a negative culture result, by positive histology and a positive rapid urease test.RESUlTS： The sensitivity and specificity of the 13C- UBT were 93% and 88%, respectively, relative to the gold standard. The antibody test had an equivalent sensitivity of 93% with a reduced specificity of 68%. The false positive results for the antibody test were associated with previous treatment for an H. pylorlinfection [relative risk （RR） = 2.8]. High levels of antibodies to H. py/or/were associated with chronic gastritis and male gender, while high scores in the 13C-UBT test were associated with older age and with theH. pylori bacteria load on histological examination （RR = 4.4）. CONClUSION： The 13C-UBT outperformed the antibody test for H. pylori and could be used when a noninvasive test is clinically necessary to document treatment outcome or when monitoring for reinfection.

关键词： Urea breath test Antibody test Sensitivity Specificity

A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABlE POlYGlYCOlIDE AND POlY(GlYCOlIDE-co-lACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION

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Chinese Journal of Polymer Science 2003年第2期21卷 159-167页

作者： bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier Department of Chemistry State University of New York at Stony Brook Stony BrookNY 11794-3400 USA Ethicon Worldwide A Johnson & Johnson Company P. O. Box 151 Somerville. New Jersey 08876-0151 USA

Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PlA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-raydiffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGAfibers were found to have higher degrees of crystallinity than corresponding PGA-co-PlA samples produced under similarconditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain morecrystallinity and higher T_g than PGA-co-PlA samples. The higher crystallinity in PGA fibers resulted in a slower rate ofdegradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretchingstages was released in the post-annealing stage for a1l PGA and PGA-co-PlA samples. During earlier stages of in vitrodegradation, both PGA and PGA-co-PlA samples exhibited the typical cleavage-induced crystallization mechanism. Theheat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PlAsamples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, mostlikely due to relaxation of the cleaved chains.

关键词： Polyglycolide Poly(glycolide-co-lactide) Bioabsorbable Fiber processing in vitro Degradation

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leptosphaeria biglobosa Induced Resistance to *** in Brassica napus Involves Different Signalling Pathways

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Leptosphaeria biglobosa Induced Resistance to *** in Brassic...

嵌入式与实时系统开发使用UMl、对象技术、框架与模式 4

中国植物病理学会2005年学术年会暨植物病理学报创刊50周年纪念会

作者： Akinwunmi O.latunde-Dada Hans Cools bruce D.l.Fitt John.A.lucas Rothamsted Research HarpendenHertfordshire AL5 2JQUK

Effects of pre-treatment of Brassica napus leaves with ascospores of l. biglobosa or chemical defence activators (acibenzolar-S-methyl (ASM) or menadione sodium bisulphate (MSB)) on local and systemic resistance to infection by ascospores of leptosphaeria maculans (phoma stem canker) were studied in controlled environment and field experiments. In controlled environment experiments, pre-treatment of oilseed rape leaves (cv. Madrigal) with l. biglobosa, ASM or MSB delayed appearance of l. maculans phoma leaf spot lesions. These pre-treatments also decreased phoma leaf spot lesion area in both pre-treated (local effect) and untreated (systemic effect) leaves. In winter oilseed rape field experiments in 2002/2003 and 2003/2004 growing seasons, pre-treatment with l. biglobosa or ASM in October/November decreased not only number of phoma leaf spot lesions per leaf caused by l. maculans in autumn/winter, but also severity of phoma stem canker in the subsequent spring/summer. Effects were greater in 2002/2003, when natural l. maculans ascospore release began in September 2002, than in 2003/2004, when ascospore release began in December, following a period of dry weather in August/September 2003.

关键词：

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Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease:a multicentre,randomised,double-blind,parallel-group,phase 3b trial

丛书名：计算机科学丛书

2005年

作者：（美）bruce Powel Douglass 柳翔等译

本书重点介绍了使用统一建模语言进行基于模型的实时系统和嵌入式系统开发以及被称为ROPES的基于风险的迭代开发生命周期。

ISBN: (数字)7111155920

ISBN: (纸本)7111155920

本书重点介绍了使用统一建模语言进行基于模型的实时系统和嵌入式系统开发以及被称为ROPES的基于风险的迭代开发生命周期。

关键词：实时操作系统程序设计

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四川生理科学杂志 2022年第5期44卷 940-940页

作者： bruce E Sands [a]Dr Henry D Janowitz Division of Gastroenterology Icahn School of Medicine at Mount Sinai New York NY USA [b]Department of Gastroenterology Guy's and St Thomas’ NHS Foundation Trust London UK [c]School of Immunology and Microbial Sciences King's College London London UK [d]Immunology Global Medical Affairs Janssen Pharmaceutical Companies of Johnson & Johnson Horsham PA USA [e]Janssen Scientific Affairs Horsham PA USA [f]Gastroenterology Department Hôpital Saint-Louis Assistance Publique-Hôpitaux de Paris (AP-HP) INSERM U1160 Université de Paris Paris France [g]Gastroenterology and Endoscopy IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele Milan Italy [h]Northwestern University Feinberg School of Medicine Chicago IL USA [i]Division of Gastroenterology Department of Medicine University Hospital London ON Canada [j]Division of Epidemiology and Biostatistics Western University London ON Canada [k]Department of Internal Medicine Gastroenterology Diabetology Hemato-Oncology and Palliative Medicine Medius Clinic Nuertingen Nürtingen Germany [l]Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA [m]Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine and Science Rochester MN USA [n]Department of Internal Medicine and Hematology Semmelweis University Budapest Hungary [o]Inflammatory Bowel Disease Unit Division of Gastroenterology and Hepatology University of Calgary Calgary AB Canada [p]Weill Department of Medicine New York Presbyterian Hospital Weill Cornell Medicine New York NY USA [q]Division The City Center for IBD Diagnosis and Treatment Saint Petersburg State Budgetary Health Institution City Clinical Hospital 31 Saint Petersburg Russia [r]Division of Gastroenterology University of California San Diego La Jolla CA USA

Background:Active-comparator trials are important to inform patient and physician *** aimed to evaluate the efficacy and safety of monotherapy with either ustekinumab or adalimumab in biologic-naive patients with mode... 详细信息

关键词： patients centre moderately

Crown Ratio and Relative Spacing Relationships for loblolly Pine Plantations

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Open Journal of Forestry 2012年第3期2卷 101-115页

作者： Dehai Zhao Michael Kane bruce E. Borders Warnell School of Forestry and Natural Resources University of Georgia Athens USA

Two loblolly pine (Pinus taeda l.) culture/density studies were established in 1995-1998 across the lower Coastal Plain and Upper Coastal Plain/Piedmont regions of the southern USA. Each installation contains 12 plots of loblolly pine planted at six levels of density from 741 to 4448 trees/ha in combination with two levels of cultural intensity, operational and intensive. The data from 37 viable installations were used to evaluate the crown ratio and relative spacing relationship of loblolly pine plantations. The effects of planting density, site quality, and cultural intensity on the relationship were investigated with a nonlinear mixed-effects modeling approach. The crown ratio and relative spacing relationship is exceedingly predictable. When loblolly pine plantation stands reached the average live crown ratio of 0.40, a critical point representing a generally acceptable level of tree vigor, the corresponding relative spacing index ranged from 0.11 to 0.20, mainly depending on initial planting density. The information about the crown ratio and relative spacing relationship would be useful for selecting the best intensity and timing of thinning.

关键词： loblolly Pine Intensive Culture Planting Density live Crown Ratio Relative Spacing Index