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Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-galán Cristina Jiménez-luna Isabel Rodriguez Elisabeth Maza Carlos García-Col.a.o Antonio Rodríguez-Fernández Javier luis lópez-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nucl.a. Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal.a.enocarcinoma(PDAC)is a lethal malignancy with dispiriting survival data.Immunotherapy is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor microenvironment.We describe a case of metastatic PDAC effectively treated with pembrolizumab.CASE SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus capecitabine.At nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung biopsy.Systemic immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor types.The patient showed a complete metabolic response that was maintained throughout the treatment.The patient continues to be disease-free at 5.6 years since the start of immunotherapy.CONClUSION These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic PDAC.To our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative surgery.Further studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal.a.enocarcinoma lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

Semiotics and political discourse in the post-truth era

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language and Semiotic Studies 2024年第1期10卷 65-82页

作者： Betül.a.akpınar Murat Kalelioğlu V.doğan Günay Istinye University IstanbulTürkiye School of Foreign languages T C Mardin Artuklu UniversityMardinTürkiye Faculty of literature Department of LinguisticsDokuz Eylül UniversityIzmirTürkiye

The concept of post-truth has been on the world’s agenda since 2016.Perhaps this concept,which is frequently encountered in political life,provides the speaker with a freer speaking platform.Politicians,instead of presenting the reality to their constituents as it is,want to reshape this reality according to their own ideology and present it to the recipient.Politicians have certain objectives in creating such a virtual reality.These aims can be listed as keeping the voters,increasing the voting potential.a.d attracting undecided voters to their favor.The common result of all these aims is to gain political power or to remain in the existing power.Post-truth reality is constructed relatively more easily in social media environments.The construction of reality can be through beliefs or emotions.In such ways,the recipient is tried to be persuaded,and thus behavioral change is achieved.One of the most necessary subjects for this artificial reality atmosphere is the anti-subject.The idea that the anti-subject does not know the truth that we(you and I)know and believe and is trying to destroy it is the main theme of post-truth discourse.Politicians try to persuade the voters to believe in their own truth by expressing this idea to them.There are many examples of this around the world.In this study,firstly,the concept of post-truth is examined and its various definitions are discussed.The distinctions between the concepts of real.a.d truth are analyzed and then it is explained how and for what purposes the concept of post-truth is used in politics.Following the comparison of post-truth and fake news,the concept is discussed within the framework of sender-receiver interaction in terms of communication.The concept is tried to be elucidated with the modalities such as/convincing/,/believing/,/being/,/appearing/.Besides,using the semiotic square,the study also tries to reveal the different purposes and forms of use of the concept of post-truth.As a result,it has been observed that the concept of post-truth is effective in

关键词： semiotics discourse politics post-truth fake news

Exploration of Green Alternatives to 6PPD (P-Phenylenediamine) Used as Antiozonant and Antioxidant in the Rubber Industry

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Materials Sciences and Applications 2024年第4期15卷 87-100页

作者： Emine Demir Husnu Gerengi Kerem Savcı Gasim Altundal Canan Yüksel doğaç Çağıl Anlas Tyre Company R&D Center D&#252zce T&#252rkiye Department of Mechanical Engineering Faculty of Engineering D&#252zce University D&#252zce T&#252rkiye The Koc High School &#304stanbul T&#252rkiye

Antiozonants and antioxidants are additives commonly used in the rubber industry to enhance the durability and performance of rubber products. Ozone, present in the atmosphere, can cause rubber to degrade over time through a process known as ozone cracking. These rubber additives are added to rubber compounds to protect against this degradation. They work by reacting with ozone, preventing it from attacking and breaking the molecular chains in the rubber, helping to maintain the structural integrity of the rubber product. It is now well known that 6PPD contributes to the extension of the service life of rubber products. However, recent studies have shown that 6PPD can be harmful to the environment, especially when end-of-life tyres (ElTs) are contaminated with the water. With the effect of ozone, 6PPD is converted to 6PPD quinone, which is toxic enough to kill some sensitive fish species such as Coho Salmon (Oncorhynchus kisutch). This study drew attention to new chemical compounds and natural products that can be used as antiozonants and antioxidants in the rubber industry instead of 6PPD. Although the scientific studies are promising, the fact that 6PPD is still used in production shows that more scientific studies and social.a.areness need to be developed in this area.

关键词： 6PPD Coho Salmon Antiozonant Antioxidant

Wedelolactone from Eclipta prostrata(l)l.suppresses inflammation and improves insulin resistance

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 253-258页

作者： Trinh Tat Cuong Duong Duc Thien Hoang Hai Yen Nguyen Anh Duc Trinh Quang Nam do Viet Khanh Key laboratory for Enzyme and Protein Technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:To eval.a.e the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(l)l.,on inflammation and insulin resistance.Methods:Wedelolactone was extracted from the l.a.es of Vietnamese Eclipta prostrata(l.)l.with methanol by Soxhlet.The effects of wedelolactone on lipopolysaccharide(lPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ElISA),specific immunofluorescent dyes and luminometric analysis,respectively.In addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GlUT4)were examined in 3T3-l1 cells by immunofluorescent dyes and Western blot.Results:Wedelolactone at 30μg/ml significantly inhibited lPS-induced production of tumor necrosis factor-α,interleukin(Il)-6,and Il-8(Ple effects on Il-10 level.It also reduced ROS generation and NADPH oxidase activities in lPS-stimulated Raw 264.7 cells(Plolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GlUT4 in 3T3-l1 cells(Plusions:Wedelolactone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GlUT4

Effect of radiative loss mechanisms on FIR thermometric parameters of Nd3+-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257页

作者： C.Y.Morassuti A.P.l Sil.a.l.a.O.Nunes S.M.lima l.H.C.Andrade Optical.a.d Photothermal Spectroscopy Group (GEOF) Center for Studies in Natural Resources (CERNA)State University of Mato Grosso do Sul(UEMS) Renato Archer Information Technology Center Institute of Physics of Sao Carlos University of S?o Paulo

Nd3+-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio（FIR） technique.Nevertheless,at high Nd3+concentrations,energy transfer（ET） processes such as optical reabsorption and cross-relaxation can affect the Nd3+emission,which has been little explored in the literature.Therefore,the present work investigated the use of Nd3+-doped tellurite glass(samples doped with Nd3+at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%) in fluorescence thermometers,in the temperature range from 299 to 371 K.The results indicate a strong dependence of the FIR parameters on the Nd3+concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd3+emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio4F5/2→4I9/2/4F3/2→4I9/2is observed for samples doped with higher amounts of Nd3+.The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd3+ions.

关键词： Fluorescence intensity ratio Judd-Ofelt Nd3+-doped tellurite glass Optical thermometry Rare earths

Polymer donors with hydrophilic side-chains enabling efficient and thermally-stable polymer solar cells by non-halogenated solvent processing

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Nano Research Energy 2024年第1期3卷 19-29页

作者： Soodeok Seo Jun-Young Park Jin Su Park Seungjin lee do-Yeong Choi Yun-Hi Kim Bumjoon J.Kim Department of Chemical.a.d Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Materials Engineering and Convergence Technology and ERI Gyeongsang National UniversityJinju 52828Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea Department of Chemistry and ERI Gyeongsang National UniversityJinju 52828Republic of Korea

Polymer solar cells(PSCs)with high power conversion efficiency(PCE)and environment-friendly fabrication are the main requirements enabling their production in industrial scale.While the use of non-halogenated solvent processing is inevitable for the PSC fabrication,it significantly reduces the processability of polymer donors(PDS)and small-molecule acceptors(SMAs).This often results in unoptimized blend morphology and limits the device performance.To address this issue,hydrophilic oligoethylene glycol(OEG)side-chains are introduced into a PD(2EG)to enhance the molecular compatibility between the PD and l8-BO SMA.The 2EG PD induces higher crystallinity and alleviates phase separation with the SMA compared to the reference PD(PM7)with hydrocarbon side-chains.Consequently,the 2EG-based PSCs exhibit a higher PCE(15.8%)than the PM7-based PSCs(PCE=14.4%)in the ortho-xylene based processing.Importantly,benefitted from the reduced phase separation and increased crystallinity of 2EG PDS,the 2EG-based PSCs show enhanced thermal stability(84%of initial PCE after 120 h heating)compared to that of the PM7-based PSCs(60%of initial PCE after 120 h heating).This study demonstrates the potential of OEG side-chain-incorporated materials in developing efficient,stable,and eco-friendly PSCs.

关键词： polymer solar cell polymer donor OEG side-chain non-halogenated solvent process side-chain engineering

Tomographic reconstruction of the Earth’s magnetosheath from multiple spacecraft:a theoretical study

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Earth and Planetary Physics 2024年第1期8卷 204-214页

作者： A.M.Jorgensen TianRan Sun Y.Huang l.li R.Xu l.Dai Chi Wang New Mexico Institute of Mining and Technology SocorroNMUSA National Space Science Center Chinese Academy of SciencesBeijing 100190China Tsinghua University Beijing 100084China

Following our earlier work on tomographic reconstruction of the magnetosheath soft X-ray emissions with superposed epoch analysis of many images recorded from a single spacecraft we now explore the instantaneous reconstruction of the magnetosheath and magnetopause using a few images recorded simul.a.eously from a few spacecraft.This work is motivated by the prospect of possibly having two or three soft X-ray imagers in space in the coming years,and that many phenomena which occur at the magnetopause boundary,such as reconnection events and pressure pulse responses,do not lend themselves as well to superposed epoch analysis.If the reconstruction is successful-which we demonstrate in this paper that it can be-this collection of imagers can be used to reconstruct the magnetosheath and magnetopause from a single image from each spacecraft,allowing for high time resolution reconstructions.In this paper we explore the reconstruction using,two,three,and four spacecraft.We show that the location of the subsolar point of the magnetopause can be determined with just two satellites,and that volume emissions of soft X-rays,and the shape of the boundary,can be reconstructed using three or more satellites.

关键词： magnetosheath tomography soft X-ray imaging SMIlE

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中国苦苣苔科一新记录属——四轮苣苔属

广西植物 2024年第5期44卷 998-1002页

作者：熊驰陈彬李政隆赵琼 do Van Truong 温放广西喀斯特植物保育与恢复生态学重点实验室广西壮族自治区中国科学院广西植物研究所中国广西桂林541006 广西植物研究所国家苦苣苔科种质资源库中国野生植物保护协会苦苣苔专委会中国苦苣苔科植物保育中心中国科学院桂林植物园中国广西桂林541006 华东野生濒危资源植物保育中心上海辰山植物园中国上海201602 安徽大学资源与环境工程学院中国安徽合肥230601 越南国家自然博物馆越南科学技术研究院越南河内10072

该文报道了中国苦苣苔科(Gesneriaceae)一新记录属——四轮苣苔属(Tetraphyllum Griff.ex C.B.Clarke)。该新记录属,即四轮苣苔属仅有3种,其中密花四轮苣苔[T.confertiflorum(Drake)B.l.Burtt]在我国首次记录。该研究提供了该属的形态... 详细信息

该文报道了中国苦苣苔科(Gesneriaceae)一新记录属——四轮苣苔属(Tetraphyllum Griff.ex C.B.Clarke)。该新记录属,即四轮苣苔属仅有3种,其中密花四轮苣苔[T.confertiflorum(Drake)B.l.Burtt]在我国首次记录。该研究提供了该属的形态描述和分种区别特征,并提供了该种的详细形态描述及彩色照片。凭证标本馆藏于广西植物研究所标本馆(IBK)和上海辰山植物标本馆(CSH)。

关键词：密花四轮苣苔苦苣苔科新记录属广西中国

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Spark Plasma Sintering of Mg-based Alloys:Microstructure,Mechanical Properties,Corrosion Behavior,and Tribological Performance

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Journal of Magnesium and Alloys 2024年第2期12卷 405-442页

作者： Alessandro M.Ralls Mohammadreza Daroonparvar Pradeep l.Menezes Department of Mechanical Engineering University of Nevada RenoRenoNV89557United States

Within the past ten years,spark plasma sintering(SPS)has become an increasingly popular process for Mg manufacturing.In the SPS process,interparticle diffusion of compressed particles is rapidly achieved due to the concept of Joule heating.Compared to traditional.a.d additive manufacturing(AM)techniques,SPS gives unique control of the structural.a.d microstructural features of Mg components.By doing so,their mechanical,tribological.a.d corrosion properties can be tailored.Although great advancements in this field have been made,these pieces of knowledge are scattered and have not been contextualized into a single work.The motivation of this work is to address this scientific gap and to provide a groundwork for understanding the basics of SPS manufacturing for Mg.To do so,the existing body of SPS Mg literature was first surveyed,with a focus on their structural formation and degradation mechanisms.It was found that successful Mg SPS fabrication highly depended on the processing temperature,particle size,and particle crystallinity.The addition of metal.a.d ceramic composites also affected their microstructural features due to the Zener pinning effect.In degradative environments,their performance depends on their structural features and whether they have secondary phased composites.In industrial.a.plications,SPS'd Mg was found to have great potential in biomedical,hydrogen storage,battery,automotive,and recycling sectors.The prospects to advance the field include using Mg as a doping agent for crystallite size refinement and using bulk metallic Mg-based glass powders for amorphous SPS components.Despite these findings,the interactions of multi-composites on the processing-structure-property relationships of SPS Mg is not well understood.In total,this work will provide a useful direction in the SPS field and serve as a milestone for future Mg-based SPS manufacturing.

关键词： Spark plasma sintering Magnesium alloys Nanocrystalline Tribology Mechanical properties Corrosion

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