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Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： lUO zhi-yi TIAN Qi CHENG Niang-mei lIU Wen-han YANG Ye CHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan CHEN Ming-sheng ZHUANG Qiu-yu ZHAO Bi-xing lIU Cong-sheng lIU Xiao-long lI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and Hl-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/ml) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/ml for SK-Hep-1 cells and 330 μg/ml for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μl per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(Plysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,Ple,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

Synthesis,Crystal Structure and Thermoanalysis of Complex of Zn(II) with Aminomethanesulfonic Acid-5-bromosalicylaldelyde Schiff Base

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Chinese Journal of Structural Chemistry 2006年第8期25卷 919-922页

作者： DENG Yi-Fang KUANG Dai-zhi ZHANG Chun-Hua CHEN Man-sheng PENG Yun-lin YANG Ying-Qun lI Wei Department of Chemistry and Material Science Hengyang Normal University Hengyang 421008 China

The title complex [Zn（l）（phen）（CH3OH）] （l = C8H6BrO4NS, aminomethanesulfonic acid 5-bromo-salicylaldelyde schiff base; phen = 1,10-phenanthroline） has been synthesized and characterized by X-ray diffraction method. The crystal belongs to monoclinic, space group P21/c with a = 1.8712（3）, b = 1.38008（19）, c = 0.83685（12） nm, β = 97.791 （2）°, Mr = 569.72, V = 2.1411 （5） nm^3, Z= 4, Dc = 1.767 g/cm^3,μ = 3.151 mm^-1, F（000） = 1144, the final R = 0.0402 and wR = 0.0885. The central Zn（Ⅱ） is six-coordinated by one nitrogen and two oxygen atoms from the Schiff base, two nitrogen atoms from 1,10-phenanthroline and one oxygen from methanol to form a distorted octahedral coordination geometry.

关键词： zinc complex aminomethanesulfonic acid 5-bromo-salicylalddyde schiff base crystal structure thermal analysis

Preparation,Characterization and Thermal Decomposition Kinetics of the Complexes [Dy(p-NBA)_3Phen]_2·3H_2O and [Dy(m-NBA)_3Phen]_2·4H_2O

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Chemical Research in Chinese Universities 2009年第5期25卷 719-725页

作者： XU Su-ling ZHU zhi-jia Ren Ning lIU Hong-mei ZHANG Jian-jun TIAN liang HU Rui-sheng Experimental Center Hebei Normal University Shoiazhuang 050016 P R. China Department of Engineering Shijiazhuang Foreign Economy and Trade Vocational College Shijiazhuang 050061 P. R. China College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 13. R. China Department of Chemistry Handan College Handan 056005 P R. China College of Chemistry and Pharmacy Engineering Hebei University of Science and Technology Shijiazhuang 050018 P R. China School of Chemical Engineering Sho＇iazhuang College Shoiazhuang 050035 P. R. China

The title complexes [Dy（p-NBA）3Phen]2-3H2O（Ⅰ） and [Dy（m-NBA）3Phen]2·4H2O（Ⅱ） were synthesized, in the two molecular formulas of which NBA is nitrobenzoate and Phen is 1,10-phenanthroline. The characterizations of the complexes were carried out by means of elemental analysis, UV, IR, XRD and molar conductivity. The thermal decomposition of the two complexes were studied under the non-isothermal condition by DSC, TG-DTG and IR methods in detail. The kinetic parameters of the dehydration process were also obtained by the analysis of DSC curves of the two complexes with Popescu and Vyazovkin methods, respectively.

关键词： Dysprosium(Ⅲ) complex Nitrobenzoate Non-isothermal kinetics 1,10-Phenanthroline Thermal decomposition

Simultaneous broadband generation of second and third harmonics from chirped nonlinear photonic crystals

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light(Science & Applications) 2014年第1期3卷 135-140页

作者： Bao-Qin Chen Ming-liang Ren Rong-Juan liu Chao Zhang Yan sheng Bo-Qin Ma zhi-Yuan li laboratory of Optical Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China laser Physics Center Research School of Physics and EngineeringAustralian National UniversityCanberraACT 0200Australia College of Sciences Communication University of ChinaBeijing 100024China

Ultrabroadband laser sources are highly desirable in a wide variety of modern science disciplines ranging from physics,chemistry and materials science to information communications and *** we present the design and fabrication of a chirped periodically poled lithium niobate(CPPlN)nonlinear photonic crystal that supports multiple orders of quasiphase matching with finite bandwidth and allows for the simultaneous broadband generation of second and third harmonics with high conversion ***,the chirp rate has a significant influence on the conversion efficiency and *** CPPlN scheme offers a promising approach for the construction of short-wavelength laser sources and enables the generation of the three primary colors—red,green and blue—from a single crystal,which may have potential applications in large-screen laser displays.

关键词： chirped periodically poled lithium niobate quasiphase matching second-harmonic generation third-harmonic generation

Growth-Defense Tradeoffs in Plants： A Balancing Act to Optimize Fitness

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Molecular Plant 2014年第8期7卷 1267-1287页

作者： Bethany Huot Jian Yao Beronda l. Montgomery' sheng Yang He Department of Energy Plant Research laboratory Michigan State University MI 48824 USA Cell and Molecular Biology Program Michigan State University MI 48824 USA Department of Biochemistry and Molecular Biology Michigan State University MI 48824 USA Department of Plant Biology Michigan State University MI 48824 USA Howard Hughes Medical Institute-Gordon and Betty Moore Foundation Michigan State University MI 48933 USA

Growth-defense tradeoffs are thought to occur in plants due to resource restrictions, which demand prior- itization towards either growth or defense, depending on external and internal factors. These tradeoffs have profound implications in agriculture and natural ecosystems, as both processes are vital for plant survival, reproduction, and, ulti- mately, plant fitness. While many of the molecular mechanisms underlying growth and defense tradeoffs remain to be elucidated, hormone crosstalk has emerged as a major player in regulating tradeoffs needed to achieve a balance. In this review, we cover recent advances in understanding growth-defense tradeoffs in plants as well as what is known regard- ing the underlying molecular mechanisms. Specifically, we address evidence supporting the growth-defense tradeoff concept, as well as known interactions between defense signaling and growth signaling. Understanding the molecular basis of these tradeoffs in plants should provide a foundation for the development of breeding strategies that optimize the growth-defense balance to maximize crop yield to meet rising global food and biofuel demands.

关键词： plant immunity plant hormone salicylic acid jasmonate PAMP plant growth.

Crystal Structure and luminescence of a New Two-dimensional Sr(Ⅱ) Coordination Polymer Based on 3,5-Dinitro-salicylic Acid and 1,10-Phenanthroline

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Chinese Journal of Structural Chemistry 2015年第8期34卷 1295-1299页

作者： KONG zhi-Guo GUO sheng-Nan HE Gui-Yuan lI Xin-Hang JIAO Yu-Qi WANG Xiu-Yan Key laboratory of Preparation and Applications of Environmental Friendly Materials Jilin Normal University Department of Chemistry Jilin Normal University

In this work, we report a new two-dimensional Sr（II） coordination polymer, namely, [Sr（l）（phen）（H20）] （1）, based on 3,5-dinitro-salicylic acid （H2l） and 1,10-phenanthroline （phen）. It crystallizes in monoclinic, space group P2/1 with a = 15.479（3）, b = 9.4020（19）, c = 13.884（3）/k, β= 103.76（3）°, V= 1962.5（7） A3, Z = 4, C19H12SrN4O8, Mr = 511.95, Dc = 1.733 g/cm^3, F（000） = 1024,μ（MoKa） = 2.805 mm^-1, R = 0.0411 and wR = 0.1069. In 1, each l anion bridges three Sr（II） atoms by using carboxylate and hydroxyl groups, yielding a two-dimensional layer structure. The phen ligands are alternately attached to both sides of the layer. The π-π stacking between l and phen in the same layer and hydrogen-bonding interactions between water molecule and carboxylate oxygen atom play an important role in stabilizing the layer structure of 1. The solid state luminescent property of 1 was also studied at room temperature.

关键词： crystal structure coordination polymer 3,5-dinitro-salicylic acid,

Improved Method for lacosamide Synthesis with Chemoenzymatic Method

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Chemical Research in Chinese Universities 2012年第5期28卷 833-836页

作者： WANG zhi-yuan XU li-sheng lIU Jun-zhong ZHANG Hong-juan GAO Ji lIU Qian JIAO Qing-cai State Key laboratory of Pharmaceutical Biotechnology School of Life ScienceNanjing UniversityNanjing 210093P.R.China

lacosamide was prepared by chemical method coupled with enzymatic method. N-Acetyl-D, l-3-methoxy-alanine, derived from D,l-3-methoxy-alanine, was used in the resolution process catalyzed by immobilized Escherichia coli cells with aminoacylase（EC3.***.1.14） activity. N-Acetyl-D-3-methoxy-alanine and l-3- methoxy-alanine were obtained from the resolution system. lacosamide was synthesized by the amidation of N-acetyl-D-3-methoxy-alanine with benzylamine.

关键词： lacosamide Aminoacylase N-Acetyl-D l-3-methoxy-alanine Immobilized cell

The green tide in Yingkou,China in summer 2021 was caused by a subtropical alga——Ulva meridionalis(Ulvophyceae,Chlorophyta)

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Journal of Oceanology and limnology 2022年第6期40卷 2354-2363页

作者： Xiaoqian lÜ Hao XU sheng ZHAO Fanzhou KONG Tian YAN Peng JIANG CAS and Shandong Province Key laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China North China Sea Environmental Monitoring Center State Oceanic AdministrationQingdao 266033China CAS Key laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The large-scale green tide caused by Ulva has occurred successively in the Yellow Sea since 2007,and new events of green tide also continued to appear in nearby sea areas,indicating an undergoing rapid development of occurrence patterns for harmful macroalgal blooms(HMBs)along coastal *** August 2021,a green tide occurred for the first time in Bayuquan sea area of Yingkou city,liaoning Province in the Bohai *** this study,morphological and molecular approaches were used to identify the causative species as ***,an alien subtropical alga previously found to dominate green tides in the South China *** to the hydrological data of Bayuquan in summer 2021,combined with morphological and developmental observations for this alga,we hypothesized that the disturbance caused by the typhoon In-Fa might have detached the local *** from substrates,especially for those thalli with poorly developed holdfasts,and the ensuing wave-free period with unusually high temperature,which fell in the reported optimum growth temperature for ***,might have provided the favorable conditions for the final bloom of the floating *** is the first report on the bloom of subtropical *** in the north temperate sea zone,indicating that the ecological risk of causing green tides in the future by this rapidly spreading species deserves high attention.

关键词： Bohai Sea green tide holdfast alien species Ulva meridionalis Yingkou

Tomato mottle mosaic virus: Characterization, resistance gene effectiveness, and quintuplex RT-PCR detection system

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Journal of Integrative Agriculture 2022年第9期21卷 2641-2651页

作者： Carlos Kwesi TETTEY YAN zhi-yong MA Hua-yu ZHAO Mei-sheng GENG Chao TIAN Yan-ping lI Xiang-dong Shandong Provincial Key laboratory of Agricultural Microbiology College of Plant ProtectionShandong Agricultural University Tai'an 271018P.R.China

Tomato mottle mosaic virus(ToMMV), an economically important species of the genus Tobamovirus, causes significant loss in yield and quality of tomato fruits. Here, we identified the Shandong isolate of ToMMV(ToMMV-SD) collected from symptomatic tomato fruits in Weifang, Shandong Province of China. ToMMV-SD caused symptoms such as severe mosaic, mottling, and necrosis of tomato leaves, yellow spot and necrotic lesions on tomato fruits. The obtained full genome of ToMMV-SD was 6 399 nucleotides(accession number MW373515) and had the highest identity of 99.5% with that of isolate SC13-051 from the United States of America at the genomic level. The infectious clone of ToMMV-SD was constructed and induced clear mosaic and necrotic symptoms onto Nicotiana benthamiana leaves. Several commercial tomato cultivars, harboring Tm-2~2 resistance gene, and pepper cultivars, containing l resistance gene, were susceptible to ToMMV-SD. Plants of Solanum melongena(eggplant) and Brassica pekinensis(napa cabbage) showed mottling symptoms, while N. tabacum cv. Zhongyan 100 displayed latent infection. ToMMV-SD did not infect plants of N. tabacum cv. Xanthi NN, Brassica rapa ssp. chinensis(bok choy), Raphanus sativus(radish), Vigna unguiculata cv. Yuanzhong 28-2(cowpea), or Tm-2~2 transgenic N. benthamiana. A quintuplex RT-PCR system differentiated ToMMV from tomato mosaic virus, tomato brown rugose fruit virus, tobacco mosaic virus, and tomato spotted wilt virus, with the threshold amount of 0.02 pg. These results highlight the threat posed by ToMMV to tomato and pepper cultivation and offer an efficient detection system for the simultaneous detection of four tobamoviruses and tomato spotted wilt virus infecting tomato plants in the field.

关键词： host range multiplex RT-PCR resistance genes symptom Tobamovirus tomato mottle mosaic virus