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Biomaterials and emerging technologies for tissue engineering and in vitro models

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Bio-Design and Manufacturing 2024年第3期7卷 237-239页

作者： J.Miguel Oliveira rui l.Reis 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate laboratory 4806-909 Braga/GuimarãesPortugal

The latest advances in the field of biomaterials have opened new avenues for scientific breakthroughs in tissue engineer-ing which greatly contributed for the successful translation of tissue engineering products into the market/***-materials are easily processed to become similar to natural extracel.ular matrix,making them ideal temporary supports for mimicking the three-dimensional(3D)microenvironment required for maintaining the adequate cell/tissue functions both in vitro and in vivo^([1]).

关键词： breakthrough biomaterials engineer

Variational data encoding and correlations in quantum-enhanced machine learning

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Chinese Physics B 2024年第9期33卷 298-306页

作者： Ming-Hao Wang Hua l.u School of Physics Hubei UniversityWuhan 430062China School of Science Hubei University of TechnologyWuhan 430068China

leveraging the extraordinary phenomena of quantum superposition and quantum correlation,quantum computing offers unprecedented potential for addressing challenges beyond the reach of classical *** paper tackles two pivotal challenges in the realm of quantum computing:firstly,the development of an effective encoding protocol for translating classical data into quantum states,a critical step for any quantum *** encoding strategies can significantly influence quantum computer ***,we address the need to counteract the inevitable noise that can hinder quantum *** primary contribution is the introduction of a novel variational data encoding method,grounded in quantum regression algorithm *** adapting the learning concept from machine learning,we render data encoding a learnable *** allowed us to study the role of quantum correlation in data *** numerical simulations of various regression tasks,we demonstrate the efficacy of our variational data encoding,particularly post-learning from instructional ***,we delve into the role of quantum correlation in enhancing task performance,especially in noisy *** findings underscore the critical role of quantum correlation in not only bolstering performance but also in mitigating noise interference,thus advancing the frontier of quantum computing.

关键词： quantum machine learning variational data encoding quantum correlation

Effects of slag fineness on durability of mortars

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Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2007年第11期8卷 1725-1730页

作者： TOPu lker Bekir BlR Turhan Department of Civil Engineering Eski■ehir Osmangazi university Eski■ehir 26480 Turkey

In recent years, the usages of by-products and wastes in industry have become more important. The importance of the sustainable development is also of increasing. The utilizations of wastes, as mineral admixture or fine aggregate, reduce the consumption of the natural resources and improve the durability of concrete. In this study, the effect of the fineness on the high temperature and sulphate resistances of concrete mortar specimens, produced with ground granulated blast-furnace slag (GBFS) replacing cement, is investigated. The compressive and flexural strength test results for all series related to durability effects, exposing temperature and solutions, exposure times for these durability effects, slag content and fineness are discussed. Conse- quently, the optimum slag contents are determined for producing the sulphate and high temperature resistant mortars.

关键词： Cement Fineness Ground slag High temperature effect Sulphate attack Sustainable development

缺血性脑卒中铁死亡特征基因NFE2l2的鉴定与验证

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中国组织工程研究 2025年第7期29卷 1466-1474页

作者：王咪马书杰刘杨齐瑞上海中医药大学附属岳阳中西医结合医院康复医学科上海市200437 上海中医药大学上海市201203 上海市第二康复医院上海市200431

背景:铁死亡与缺血性脑卒中的发病密切相关,靶向铁死亡是一种治疗缺血性脑卒中有前景的方案,但具体调控靶点尚不明确。目的:通过生物信息学和机器学习方法筛选缺血性脑卒中铁死亡相关特征基因,并通过细胞实验进行验证,探讨铁死亡在缺血... 详细信息

背景:铁死亡与缺血性脑卒中的发病密切相关,靶向铁死亡是一种治疗缺血性脑卒中有前景的方案,但具体调控靶点尚不明确。目的:通过生物信息学和机器学习方法筛选缺血性脑卒中铁死亡相关特征基因,并通过细胞实验进行验证,探讨铁死亡在缺血性脑卒中的作用。方法:基于GEO数据库和FerrDb数据库选取符合条件的缺血性脑卒中相关数据集和铁死亡表达数据集,通过t检验筛选铁死亡相关差异基因。对铁死亡相关差异基因进行GO功能富集分析与KEGG信号通路富集分析。通过PPI网络分析和机器学习筛选缺血性脑卒中铁死亡的特征基因,利用ROC分析和GSEA分析探究特征基因的准确性和生物功能。然后进行细胞实验,将HT22细胞分为对照组与缺血性脑卒中组,对照组不作任何干预,缺血性脑卒中组加入0.1 mol/l的H_(2)O_(2)干预24 h诱导细胞氧化应激和铁死亡,通过实时荧光定量RT-PCR和Western Blot验证铁死亡的发生和特征基因表达。结果与结论:(1)共获取45个铁死亡相关差异基因,GO和KEGG富集分析发现差异基因与氧化应激、自噬、铁死亡、脂肪细胞因子信号通路和线粒体代谢密切相关。(2)通过PPI网络中的MCODE插件和cytoHubba插件与机器学习中的lASSO算法和SVM-RFE算法共鉴定出1个铁死亡特征基因核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,NFE2l2)。(3)对NFE2l2进行ROC曲线分析,发现在训练集和验证集中构建的诊断预测模型具有良好的准确性与特异性;对NFE2l2进行GSEA分析,发现特征基因通过免疫、炎症反应、氨基酸代谢及神经因子调控等方面参与缺血性脑卒中发病机制的调控。(4)细胞实验的RT-PCR和Western Blot分析表明,与对照组对比,缺血性脑卒中组中的酰基辅酶A合成酶长链家族成员4 mRNA和蛋白表达水平显著增高(Pl2 mRNA和蛋白表达水平显著增高(Pl2可以为研究和治疗缺血性脑卒中提供一定的思路与方向。

关键词：缺血性脑卒中铁死亡生物信息学 HT22细胞机器学习特征基因细胞实验 NFE2l2 ASCl4 GPX4

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减少无线传感器网络节点定位误差的方法

清华大学学报（自然科学版） 2008年第S2期48卷 1839-1843页

作者：吕睿阳宪惠清华大学自动化系北京100084

为提高无线传感器网络节点定位精度,提出3种基于距离信息的改进定位算法:改进三边测量法、加权最小二乘估计、抗差最小二乘估计。在一定先验假设情况下,对三边测量法以及由其衍生出最小二乘估计进行改进,并将抗差最小二乘估计方法引入... 详细信息

为提高无线传感器网络节点定位精度,提出3种基于距离信息的改进定位算法:改进三边测量法、加权最小二乘估计、抗差最小二乘估计。在一定先验假设情况下,对三边测量法以及由其衍生出最小二乘估计进行改进,并将抗差最小二乘估计方法引入到节点定位计算之中。仿真结果表明:3种算法能够有效减少定位误差。抗差最小二乘估计在系统存在粗差情况下效果尤其显著。当系统对能耗要求严格时,可采用改进三边测量法或加权最小二乘估计替代抗差最小二乘估计。

关键词：无线传感器网络节点定位抗差最小二乘估计基于距离

Simulation of rainfall-runoff and watershed convergence process in the upper reaches of Heihe River Basin,July 2002

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Science China Earth Sciences 2004年第z1期47卷 1-8页

作者： GAO Yanhong l.u) Shihua CHENG Guodong Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China

The watershed flow concentration scheme in the distributed hydrology-soil- vegetation model (DHSVM) is coupled with the mesoscale atmospheric model MM5 version 3.5, in which the Oregen States university land surface model (OSulSM) was involved. The flood event which happened in July 2002 in the upper reaches of Heihe river basin is simulated and the surface flow convergence process is shown with this coupled model. It has been concluded that times water head reaches each place of the basin are different. Water amount at each point is split-flow proportionally as the drops in elevation between it and neighbor points. large part of the water amount pass away in greater slope direction and small part pass away in smaller slope *** of the slope convergence makes the atmospheric model redistributes the surface water laterally.

关键词： distributed hydrology-soil-vegetation model, mesoscale atmospheric model, watershed flow concentration process.

Adsorption equilibrium, kinetics, and dynamic separation of Ca2+ and Mg2+ ions from phosphoric acid–nitric acid aqueous solution by strong acid cation resin

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Chinese Journal of Chemical Engineering 2019年第12期27卷 2930-2936页

作者： rui lü Qing Xi Tan li rui li Xiaochao Zhang Jianxin l.u Caimei Fan Junqiang Feng lingyun Zhang ZhihuaWang College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China Shenzhen Batian Ecological Engineering Co.ltd. Shenzhen 518057China Tianji Coal Chemical Group Co.ltd. Changzhi 047507China

The separation of Ca2+and Mg2+ions from phosphoric acid-nitric acid aqueous solution is very significant for the neutralization process of nitrophosphate *** paper studied the adsorption equilibrium,kinetics,and dynamic separation of Ca2+and Mg2+ions by strong acid cation resin,and the effects of phosphoric acid and nitric acid on the adsorption process were *** results reveal that the adsorption process of Ca2+and Mg2+ions in pure water on resin is in good agreement with the langmuir isotherm model and their maximal adsorption capacities are 1.86 mmol·g-1 and 1.83 mmol·g-1,*** adsorption kinetics of Ca2+and Mg2+ions on resin fits better with the pseudo-first-order model,and the adsorption equilibrium in pure water is reached within 10 min contact time,while at the present of phosphoric acid,the adsorption rate of Ca2+and Mg2+ions on resin will go *** dynamic separation experiments demonstrate that the designed column adsorption is able to undertake the separation of metal ions from the mix acids aqueous solution,but the dynamic operation should control the flow rate of mix acid *** nitric acid solution was proved to be effective to completely regenerate the spent resin and achieve the recyclable operation of separation process.

关键词： Ca2+and Mg2+ions Strong acid cation resin Adsorption equilibrium Kinetics Dynamic separation

RATIONAl GENERAl SOluTIONS OF HIGHER ORDER AlGEBRAIC ODES

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Journal of Systems Science & Complexity 2013年第2期26卷 261-280页

作者： HuANG Yanli NG l X Chu WINKlER Franz School of Computer Science and Software Engineering Tianjin Polytechnic University Research Institute for Symbolic Computation(RISC) Johannes Kepler University Department of Mathematics Quy Nhon University

This paper generalizes the method of Ng6 and Winkler （2010, 2011） for finding rational general solutions of a first order non-autonomous algebraic ordinary differential equation （AODE） to the case of a higher order AODE, provided a proper parametrization of its solution hypersurface. The authors reduce the problem of finding the rational general solution of a higher order AODE to finding the rational general solution of an associated system. The rational general solutions of the original AODE and its associated system are in computable 1-1 correspondence. The authors give necessary and sufficient conditions for the associated system to have a rational solution based on proper reparametrization of invariant algebraic space curves. The authors also relate invariant space curves to first integrals and characterize rationally solvable systems by rational first integrals.

关键词： Algebraic ODE associated system invariant algebraic space curve rational first integral rational general solution.

A Duplex Grain Structure of Dense(K,Na)NbO_(3) Ceramics Constructed by using Microcrystalline as Seed

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Journal of Wuhan university of Technology(Materials Science) 2022年第3期37卷 385-392页

作者： l.u liangliang JIANG Xinyu lü rui GuO Zhuangzhuang HOu Zhaoping College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

A new raw material was developed for the preparation of dense(K,Na)NbO_(3)(KNN)*** the absence of dopants,two kinds of KNN powder,calcined and microcrystalline powder,were used as matrix and seed to construct a duplex grain *** former was synthesized by the traditional solid phase reaction method and the latter by molten salt *** effects of microcrystalline powder content on sintering behavior,microstructure and electric properties were *** was found that appropriate microcrystalline powder content(x=0.4)promoted the grain growth and the gas diffusion,which resulted in a denser duplex grain structure and obtained a wide sintering temperature *** work gives a basic raw material system for the development of high performance KNN *** addition,it also provides a new way to prepare dense ceramics by the design of a duplex structure.

关键词： niobate piezoelectric ceramics microstructure microcrystalline