检索结果-南通市图书馆

Impact of Different Embolic Agents for Transarterial Chemoembolization (TACE) Procedures on Systemic Vascular Endothelial Growth Factor (VEGF) levels

引用

Journal of Clinical and Translational Hepatology 2016年第4期4卷 288-292页

作者： Andreas Schicho Claus Hellerbrand Kristina Krüger lukas P.Beyer Walter Wohlgemuth Christoph Niessen Ernst Hohenstein Christian Stroszczynski Philippe l.pereira Philipp Wiggermann Department of Radiology University Hospital Regensburg Regensburg Germany Friedrich-Alexander University Erlangen-Nürnberg Institute of Biochemistry(Emil-Fischer Zentrum) Erlangen Germany Clinic for Radiology Minimally-invasive Therapies and Nuclear Medicine SLK Kliniken Heilbronn GmbH Heilbronn Germany

Background and Aims:Intermediate stage hepatocellular carcinoma (HCC) can be treated by transarterial chemoem-bolization (TACE).However,there appear to be side effects,such as induction of proangiogenic factors,*** endothelial growth factor (VEGF),which have been shown to be associated with a poor *** prospective study was designed to compare serum VEGF level response after TACE with different embolic agents in patients with ***:Patients were assigned to one of three different TACE regimens:degradable starch microspheres (DSM) TACE,drugeluting bead (DEBDOX) TACE or lipiodol TACE (cTACE).All patients received 50 mg doxorubicin/m2 body surface area (BSA) during *** VEGF levels were assessed before TACE treatment,24 h post-treatment and 4 weeks ***:Twenty-two patients with 30 TACE treatments were *** to baseline VEGF levels,a marked increase was observed for 24 h post-TACE (164% of baseline level) and during the 4-week follow-up (170% of baseline level) only for the cTACE arm (p levels were only 114% and 123% for DEBDOX and 121% and 124% for DSM,***:Conventional TACE using lipiodol shows marked increase in blood levels of the proangiogenic factor VEGF,while DEBDOX and DSM TACE induce only a moderate VEGF response.

关键词： Transarterial chemoembolization Vascular endothelial growth factor Embolic agents Hepatocellular carcinoma Angiogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

THE USE OF SUB 2μ PARTIClES TO ACHIEVE ENHANCED RESOlUTION AND SPEED

THE USE OF SUB 2μ PARTICLES TO ACHIEVE ENHANCED RESOLUTION ...

引用

第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： M.WOODRUFF C.BlYTHE S.ASPEY l.pereira H.RITCHIE Thermo Electron Corporation

In this poster we discuss the use of sub 2μparticles for use in *** in the use of current 3 and 5μparticles sizes have lead to interesting theories of how an expanded Van Deemter curve can be utilised with smaller *...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Cyto-protective Effects of Extracts of Panax Quinquefolius

Cyto-protective Effects of Extracts of Panax Quinquefolius

引用

第十四届全国中药和天然药物学术研讨会

作者： EMK lui l.pereira J.Ma Q Zhang T.Fatima S.lee I Welch Ontario Ginseng Innovation Research Consortium Western University

＜正＞Ginseng is known to have anti-oxidative anti-inflammatory *** our study we have examined extracts derived from Ontario grown Panax quinquefolius for its cyto-protective and immunomodulatory effects in two experi...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

引用

Petroleum 2024年第1期10卷 150-164页

作者： leonardo Goliatt C.M.Saporetti l.C.Oliveira E.pereira Department of Computational and Applied Mechanics Federal University of Juiz de Fora Department of Computational Modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOC content is the best indicator of the organic matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. Machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOC. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. Core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOC. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon Monoxide as C1 Building Block in Fine Chemical Synthesis

引用

Chinese Journal of Chemistry 2024年第2期42卷 199-221页

作者： Rui M.B.Carrilho Mario J.F.Calvete Gabor Mikle laszlo Kollar Mariette M.pereira University of Coimbra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Department of General and Inorganic Chemistry and ElKH-PTE Research Groupfor Selective Chemical Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

Carbon monoxide(CO)has become one of the most relevant and versatile renewable C1 building blocks for chemical synthesis,especially in the fine chemicals industry,due to the development of efficient and selective catalysts for its *** this review,we present a comprehensive critical analysis of the last 10 years literature on the use of CO as a renewable feedstock for fine chemicals *** review is organized by type of catalytic reaction,namely alkene and alkyne carbonylation,hydroformylation,carbonylation of aryl halides,carbonylative cross-coupling and C-H *** examples of the synthesis of relevant building blocks and/or known pharmaceuticals are *** is placed on examples of utilizing CO as the C1 building block in one or more catalytic *** catalyst used and the reaction conditions are consistently presented throughout all of the examples.

关键词： Carbon monoxide Fine chemicals Carbonylation Hydroformylation C-H functionalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Passive Heating Systems:A Case Study in a Brazilian Mountainous Region

引用

Journal of Civil Engineering and Architecture 2019年第11期13卷 676-685页

作者： Ana Clara l.pereira Ana lúcia T.S.da Motta Bruno B.F.da Costa Priscilla C.P.F.de Oliveira Thiago V.Miranda Programa de Pós-graduacao em Engenharia Civil Universidade Federal FluminenseRio de Janeiro 22211-200Brazil Departamento de Engenharia Civil da Universidade Federal do Rio de Janeiro—Campus Macaé Rio de Janeiro 22211-200Brazil

The study of thermal comfort in the built environment is of great relevance since it stimulates the development of more sustainable buildings suited to the local climate and able to meet the human need for *** objective of this research was to develop,construct and test a passive heating system adaptable to existing buildings,reducing the need for major interventions and increasing thermal comfort in the indoor *** adopted methodological approach was a case study in a single-family residence located in the Brazilian city of Petrópolis,a mountainous region with a humid subtropical climate and a rigorous *** proposed passive heating system is totally isolated,thus mitigating air infiltration and promoting increase of temperature in the internal environment through the absorption of solar energy and greenhouse *** kind of solution is especially interesting for residents of this region,since most of the city buildings are not adequately prepared to handle low ***,given local climatic conditions,residents need to spend a lot of money on the acquisition and operation of electric or gas heating *** results indicated that the developed system,in fact,increased the temperature of the studied room when compared to an adjacent room,which did not receive the *** findings of this paper,therefore,provide a valuable reference for experts and practitioners in the selection of heating systems to be used in cold regions,and proved that passive systems can provide thermal comfort at the same time that optimize the interaction of the building with the local ecosystem.

关键词： Passive heating systems thermal comfort bioclimatic architecture sustainable buildings

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Faces of Fungi database:fungal names linked with morphology,phylogeny and human impacts

引用

Fungal Diversity 2015年第5期74卷 3-18页

作者： Subashini C.Jayasiri Kevin D.Hyde Hiran A.Ariyawansa Jayarama Bhat Bart Buyck lei Cai Yu-Cheng Dai Kamel A.Abd-Elsalam Damien Ertz Iman Hidayat Rajesh Jeewon E.B.Gareth Jones Ali H.Bahkali Samantha C.Karunarathna Jian-Kui liu J.Jennifer luangsa-ard H.Thorsten lumbsch Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Jean-Marc Moncalvo Masoomeh Ghobad-Nejhad Henrik Nilsson Ka-lai Pang Olinto l.pereira Alan J.l.Phillips Olivier Raspé Adam W.Rollins Andrea I.Romero Javier Etayo Faruk Selçuk Steven l.Stephenson Satinee Suetrong Joanne E.Taylor Clement K.M.Tsui Alfredo Vizzini Mohamed A.Abdel-Wahab Ting-Chi Wen Saranyaphat Boonmee Dong Qin Dai Dinushani A.Daranagama Asha J.Dissanayake Anusha H.Ekanayaka S.C.Fryar Sinang Hongsanan Ruvishika S.Jayawardena Wen-Jing li Rekhani H.Perera R.Phookamsak Nimali Ide Silva Kasun M.T.hambugala Qing Tian Nalin N.Wijayawardene Rui-lin Zhao Qi Zhao Ji-Chuan Kang Itthayakorn Promputtha Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agro forestry Centre East and Central Asia Office 132 Lanhei RoadKunming 650201China Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadh 1145Saudi Arabia Guizhou Key laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha403108 GoaIndia Department of Botany Goa UniversityGoa 403206India Muséum National d’Histoire Naturelle Département Systématique et EvolutionCP 39ISYEBUMR 7205 CNRS MNHN UPMC EPHE12 Rue BuffonF-75005 ParisFrance State Key laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesWest Beicheng RdBeijingChina Institute of Microbiology Beijing Forestry UniversityPO Box 61Beijing 100083China Plant Pathology Research Institute Agricultural Research Center(ARC)12619 GizaEgypt Botanic Garden Meise Department Bryophytes-Thallophytes(BT)Nieuwelaan 38B-1860 MeiseBelgium Fédération Wallonie-Bruxelles Direction Générale de l’Enseignement non obligatoire et de la Recherche scientifiqueRue A.Lavallée 11080 BruxellesBelgium Microbiology Division Research Center for BiologyIndonesian Institute of Sciences(LIPI)Jl.Raya Jakarta-Bogor KM 46Cibinong 16911West JavaIndonesia Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Microbe Interaction laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Science&Education The Field Museum1400 S.Lake Shore DriveChicagoIL 60605USA Manaaki Whenua landcare Research Private Bag 92170AucklandNew Zealand Department of Natural History Royal Ontario Museumand Department of Ecology and Evolutionary BiologyUniversity of Toronto100 Queen’s ParkTorontoON M5S2C6Canada Department of Biotechnology Iranian Research Organiza

Taxonomic names are key links between various databases that store information on different *** global fungal nomenclural and taxonomic databases(notably Index Fungorum,Species Fungorum and MycoBank)can be sourced to find taxonomic details about fungi,while DNA sequence data can be sourced from NCBI,EBI and UNITE *** the sequence data may be linked to a name,the quality of the metadata is variable and generally there is no corresponding link to images,descriptions or herbarium *** is generally no way to establish the accuracy of the names in these genomic databases,other than whether the submission is from a reputable *** tackle this problem,a new database(FacesofFungi),accessible at ***(FoF)has been *** fungal database allows deposition of taxonomic data,phenotypic details and other useful data,which will enhance our current taxonomic understanding and ultimately enable mycologists to gain better and updated insights into the current fungal classification *** addition,the database will also allow access to comprehensive metadata including descriptions of voucher and type *** database is user-friendly,providing links and easy access between taxonomic ranks,with the classification system based primarily on molecular data(from the literature and via updated web-based phylogenetic trees),and to a lesser extent on morphological data when molecular data are *** FoF species are not only linked to the closest phylogenetic representatives,but also relevant data is provided,wherever available,on various applied aspects,such as ecological,industrial,quarantine and chemical *** data include the three main fungal groups(Ascomycota,Basidiomycota,Basal fungi)and fungus-like *** FoF webpage is an output funded by the Mushroom Research Foundation which is an NGO with seven directors with mycological *** webpage has 76 curators,and with the help of these s

关键词： Classification Database Faces of Fungi Fungi Phylogeny Taxonomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contribution of extracellular vesicles to steatosis-related liver disease and their therapeutic potential

引用

World Journal of Hepatology 2024年第9期16卷 1211-1228页

作者： Margarita Montoya-Buelna Inocencia G Ramirez-lopez Cesar A San Juan-Garcia Jose J Garcia-Regalado Mariana S Millan-Sanchez Ulises de la Cruz-Mosso Jesse Haramati Ana l.pereira-Suarez Jose Macias-Barragan laboratorio de Inmunología Departamento de FisiologíaUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de Ciencias de la Salud Centro Universitario de los VallesUniversidad de GuadalajaraAmeca 46600JaliscoMexico Doctorado en Ciencias Biomédicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico laboratorio de Inmunología Departamento de FisiologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Red de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico laboratorio de Inmunobiología Departamento de Biología Celular y MolecularCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraZapopan 45200JaliscoMexico Instituto de Investigación en Ciencias Biomédicas Departamento de Microbiología y PatologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Extracellular vesicles(EVs)are small particles released by many cell types in different tissues,including the liver,and transfer specific cargo molecules from originating cells to receptor *** process generally culminates in activation of distant cells and inflammation and progression of certain *** global chronic liver disease(ClD)epidemic is estimated at 1.5 billion patients *** and liver cancer are the most common risk factors for ***,hepatitis C and B virus infection and obesity are also highly associated with ***,the etiology of many ClD pathophysiological,cellular,and molecular events are *** in hepatic lipid metabolism can lead to lipotoxicity events that induce EV ***,we aimed to present an overview of EV features,from definition to types and biogenesis,with particular focus on the molecules related to steatosis-related liver disease,diagnosis,and therapy.

关键词： Extracellular vesicles Exosomes Chronic liver disease Hepatocellular carcinoma Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra pereira leonardo Cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-l1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-l1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-l1 status in PT and matched lymph node metastases(lNM)of GC patients and to determine the correlation between the PD-l1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-l1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-l1+PT staged as pN+were also tested for PD-l1 expression in their ***-l1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-l1+PT and 24 of them had pN+.For comparison,44 PD-l1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-l1+PT,54.2%(13/24 cases)were also PD-l1+in the *** PD-l1(-)PT,9.1%(4/44)had PD-l1+in the *** agreement between PT and lNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-l1 positivity in both *** was no statistical difference in overall survival for PT and lNM according to the PD-l1 status(P=0.166 and P=0.837,respectively).CONClUSION Intra-patient heterogeneity in PD-l1 expression was observed between the PT and matched *** disagreement in PD-l1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

引用

World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno pereira Richard Bonnet Nicolas Barnich Frédéric Antonio Carvalho Denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57Bl6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESUlTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57Bl6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：