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国际医学放射学杂志 2018年第3期 373-374页

作者： V.Velickaite D.Ferreira l.Cavallin l.lind H.Ahlstr?m l.kilander 于清扬 Department of Surgical Sciences Radiology Uppsala University

摘要目的揭示不同内侧颞叶萎缩(MTA)测量指标(右侧、左侧、平均值和最高值)的阈值,并考虑性别和教育程度的影响,研究其与认知表现的相关性,比较大样本群体5年

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基于动脉自旋标记的Z图较FDG-PET对于神经退行性痴呆具有较高特异性和阳性预测值

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国际医学放射学杂志 2017年第6期 743-743页

作者： D.F?llmar S.Haller J.lilja T.Danfors l.kilander N.Tolboom 宋瑞瑞 Department of Surgical Sciences Radiology Uppsala University

摘要目的对于神经退行性疾病病人,基于动脉自旋标记(ASl)的MRI脑灌注分析被推荐可以替代FDG-PET。Z图可显示与正常对照数据库图像相关的正态分布值。上述方法

关键词：自旋标记 ASl 阳性预测值 PET FDG-PET

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Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers

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Translational Neurodegeneration 2020年第2期9卷 309-321页

作者： Julia Remnestål linn Oijerstedt Abbe Ullgren Jennie Olofsson Sofia Bergström Kim Kultima Martin Ingelsson lena kilander Mathias Uhlén Anna Månberg Caroline Graff Peter Nilsson Division of Affinity Proteomics Department of Protein ScienceKTH Royal Institute of TechnologySciLifeLabTomtebodavägen 23 AAlpha 217165 SolnaStockholmSweden Swedish FTD Initiative StockholmSweden Division of Neurogeriatrics Centre for Alzheimer ResearchDepartment of NeurobiologyCare Sciences and SocietyKarolinska Institutet17164SolnaSweden Unit for hereditary dementias Theme AgingKarolinska University HospitalStockholmSweden Department of Medical Sciences Clinical ChemistryUppsala UniversityUppsalaSweden Department of Public Health and Caring Sciences GeriatricsUppsala UniversityUppsalaSweden Department of Neuroscience Karolinska InstitutetSolnaSweden

Background The clinical presentations of frontotemporal dementia(FTD)are diverse and overlap with other neurological *** are,as of today,no biomarkers in clinical practice for diagnosing the ***,we aimed to find protein markers in cerebrospinal fluid(CSF)from patients with FTD,presymptomatic mutation carriers and *** Antibody suspension bead arrays were used to analyse 328 proteins in CSF from patients with behavioural variant FTD(bvFTD,n=16)and progressive primary aphasia(PPA,n=13),as well as presymptomatic mutation carriers(PMC,n=16)and non-carriers(NC,n=8).A total of 492 antibodies were used to measure protein levels by direct labelling of the CSF *** findings were further examined in an independent cohort including 13 FTD patients,79 patients with Alzheimer’s disease and 18 healthy *** We found significantly altered protein levels in CSF from FTD patients compared to unaffected individuals(PMC and NC)for 26 *** analysis show patterns of separation between unaffected individuals and FTD patients,especially for those with a clinical diagnosis of *** most statistically significant differences in protein levels were found for VGF,TN-R,NPTXR,TMEM132D,PDYN and *** with FTD were found to have higher levels of TN-R and NF-M,and lower levels of VGF,NPTXR,TMEM132D and PDYN,compared to unaffected *** main findings were reproduced in the independent *** In this pilot study,we show a separation of FTD patients from unaffected individuals based on protein levels in *** investigation is required to explore the CSF profiles in larger cohorts,but the results presented here has the potential to enable future clinical utilization of these potential biomarkers within FTD.

关键词： Frontotemporal dementia Cerebrospinal fluid Biomarkers Proteomics Antibody suspension bead array

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多奈哌齐治疗重度阿尔茨海默病患者:双盲、平行分组、安慰剂对照研究

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世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 4-5页

作者： Winblad B. kilander l. Eriksson S. 周永(译) Karolinska Institutet Alzheimer's Disease Research Center Department of Neurotec Huddinge 14186 Stockholm Sweden 不详

Background: The cholinesterase inhibitor donepezil is used to treat mild-to-moderate Alzheimer’s disease. Its efficacy in severe dementia has not been assessed and is controversial. Our aim was to ascertain the effectiveness of donepezil in patients with severe Alzheimer’s disease, by focusing primarily on cognition and activities of daily living. Methods: We did a 6-month, double-blind, parallel-group, placebo-controlled study in 248 patients with severe Alzheimer‘s disease (mini mental state examination score 1-10) who were living in assisted care nursing homes ran by trained staff in Sweden. We assigned patients oral donepezil (5 mg per day for 30 days then up to 10 mg per day thereafter, n=128) or matched placebo (n=120). Our primary endpoints were change from baseline to month 6 in the severe impairment battery (SIB) and modified Alzheimer’s Disease Cooperative Study activities of daily living inventory for severe Alzheimer’s disease (ADCS-ADl-severe). We analysed outcomes for patients with data at baseline and at one or more other timepoints (modified intent-to-treat population) with last observation carried forward used to replace missing data. Findings: 95 patients assigned donepezil and 99 patients assigned placebo completed the study. Patients treated with donepezil improved more in SIB scores and declined less in ADCS-ADl-severe scores at 6 months after initiation of treatment compared with baseline than did controls (least squares [lS] mean difference, 5.7, 95%CI 1.5-9.8; p=0.008, and 1.7, 0.2-3.2; p=0.03, respectively). The incidence of adverse events was comparable between groups (donepezil 82%[n=105] vs placebo 76%[n=91]), with most being transient and mild or moderate in severity. More patients discontinued treatment because of adverse events in the donepezil group (n=20) than in the placebo group (n=8). Interpretation: Donepezil improves cognition and preserves function in individuals with severe Alzheimer’s disease who live in nursing homes.

关键词：阿尔茨海默病患者意向性治疗安慰剂对照多奈哌齐重度对照研究双盲平行

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