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商学院 2013年第12期 102-105页

作者：麦维德 Neeraj Aggarwal Derek kennedy john Wenstrup Michael Rüβmann Ruba Bomo Julia Chen Julio Bezerra 波士顿咨询公司

技术先锋企业运用各类技术来推动自身的业务发展，它们的业绩表现显著优于其它中小企业。它们欣然地接受新一轮的信息技术浪潮，并因此在市场中脱颖而出。

关键词：信息技术中小企业范式业务发展业绩表现市场

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患者需要知道什么样的药物信息?

英国医学杂志中文版 2004年第2期7卷 117-118页

作者： David Dickinson D K Raynor James G kennedy Silvia Bonaccorso Jeffrey l Sturchio 翟晓梅 Consumation 53 Hosack Road London SW17 7QW consultant in consumer information design Pharmacy Practice and Medicines Management Group University of LeedsLeeds LS2 9JT professor of pharmacy practice medicines and their users

提供和交换准确可靠的药物信息是医患关系的一部分,不过谁应该提供这些信息?我们邀请患者、临床医生和制药工业的代表来回答这个问题。

关键词：药物信息副作用注意事项眼药方法

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氟对大鼠腰椎松质骨超微结构的影响

中国公共卫生 2004年第7期20卷 801-803页

作者：钱聪张志瑜郭晓英张莹安丽翟城 David kennedy 孙贵范中国医科大学公共卫生学院地球化学性疾病研究室沈阳110001

目的　研究氟对大鼠腰椎松质骨超微结构的影响。方法　 32只体重为 (80± 10 ) g的健康雌性Wistar大鼠分别经饮水给不同剂量 (0 ,2 5 ,5 0 ,10 0mgF-/l)的氟 ,染毒 3个月。处死动物后 ,立即取第 2腰椎 ,剔除表面附着的软组织 ,沿正中线... 详细信息

目的　研究氟对大鼠腰椎松质骨超微结构的影响。方法　 32只体重为 (80± 10 ) g的健康雌性Wistar大鼠分别经饮水给不同剂量 (0 ,2 5 ,5 0 ,10 0mgF-/l)的氟 ,染毒 3个月。处死动物后 ,立即取第 2腰椎 ,剔除表面附着的软组织 ,沿正中线作矢状剖开 ,暴露骨髓腔 ,用生理盐水冲洗后 ,经固定、脱水、脱脂、干燥、喷金等处理步骤 ,用扫描电镜观察松质骨超微结构改变。结果　随着染氟剂量的增加 ,大鼠腰椎椎体松质骨骨量明显增加 ,骨小梁数目增加 ,表面凸凹不平、小梁不规则变厚、变粗 ,骨小梁裂纹和微骨折较多见 ,骨吸收陷窝缩小、变浅。胶原纤维出现板结硬化样改变和较宽的不规则裂隙。结论　长期过量摄入氟可使大鼠腰椎椎体松质骨的骨形成增加 ,但所形成的骨排列多不规则 ,骨小梁裂纹和微骨折较多见 ,导致骨的质和量分离现象。

关键词：氟扫描电镜腰椎松质骨

The influence of genetics on epilepsy syndromes in infancy and childhood

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Acta Epileptologica 2022年第4期5卷 217-226页

作者： Elissa Yozawitz Solomon l.Moshé Isabelle Rapin Division of Child Neurology and Saul R.Korey Department of Neurology Albert Einstein College of MedicineBronxNY10467USA Department of Pediatrics Albert Einstein College of MedicineBronxNY10467USA laboratory of Developmental Epilepsy Albert Einstein College of MedicineBronxNY10461USA Comprehensive Einstein/Montefiore Epilepsy Center Albert Einstein College of MedicineBronxNY10467USA Dominick P.Purpura Department of Neuroscience Albert Einstein College of Medicine1410 Pelham Parkway SouthKennedy Center Rm 316BronxNY10461USA

Genetics is rapidly evolving and is actively playing a role in how we diagnose and manage *** definition of an epilepsy syndrome has changed throughout the *** International league Against Epilepsy(IlAE)has developed a classification of the epilepsies and has recently described specific epilepsy syndromes taking into account emerging genetic information which is rapidly evolving as well as etiology-specific *** genetics can help clarify the syndrome and its *** review provides a history of the definition of a syndrome,and the evolving contribution of genetic information that is part of the syndromic *** provide few examples of several phenotypes/genotypes of epilepsy syndromes in infancy and childhood and treatment issues that may arise from the available genetic *** syndromes and their genetics have been rapidly changing as new gene technologies are being *** genetics can help clarify the syndrome,its treatment,and will help change the field of epilepsy to improve patients qualify of life by creating new means of preventing,controlling,and curing epilepsy.

关键词： Syndrome Epilepsy syndrome Genetics History of epilepsy genetics IlAE history

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研究结果的解释和报告

国际结核病与肺部疾病杂志 2006年第3期1卷 153-156页

作者： D.A.Enarson S.M.kennedy D.l.Miller P.Bakke 贺晓新 Scientific Activities Unit International Union Against Tuberculosis and Lung DiseaseParisFrance University of British Columbia VancouverCanada Emeritus Professor of Public Health Medicine Imperial CollegeUniversity of LondonLondonUnited Kingdom Department of Thoracic Medicine Haukeland University HospitalBergenNorway

科学研究的目标是创造和传播知识。这得通过对系统收集以及报告信息的批判性分析来完成。批判性分析始于一个简单的步骤,即在运用复杂统计学分析方法进行比较之前对所收集的数据进行深入检查。根据所收集的数据类型按照标准化方式进行... 详细信息

科学研究的目标是创造和传播知识。这得通过对系统收集以及报告信息的批判性分析来完成。批判性分析始于一个简单的步骤,即在运用复杂统计学分析方法进行比较之前对所收集的数据进行深入检查。根据所收集的数据类型按照标准化方式进行统计学分析。在为解决研究问题而需采用合理、标准化步骤进行比较时,新知识就产生了,同时要避免错误的结论。在对数据进行仔细检查和分析之后,为了保证结论的正确性,再对数据进行一次批判性评论是非常重要的补充步骤。在科学文献中发表研究成果过程中涉及的同行评价对于传播新知识并保证其质量方面是一个非常重要的步骤。如果没有将研究成果发表供同行参考,这项研究就不算完整。

关键词：科学研究研究方案肺部健康教育

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肛管测压术:技术上的比较

世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 16-17页

作者： Simpson R.R. kennedy M.l. Nguyen M.H. D.Z.lubowski 程妍 St.George Private Medical Centre South StreetKogarahNSW 2217Australia

PURPOSE:Methods of anal manometry vary between centers,resulting in potential difficulties in interpretation of *** study compared several accepted manometric techniques in healthy control subjects and in patients with fecal ***:Eleven patients with fecal incontinence(M∶ F = 3∶ 8;mean age = 67 years) and ten healthy control subjects(M∶ F = 3∶ 7;mean age = 64 years) underwent anal manometry using five different methods:1) water-perfused side hole;2) water-perfused end hole;3) microtransducer;4) microballoon;5) portable *** a station pull-through technique,anal pressures(resting,squeeze,and cough pressures) were recorded at 1-cm intervals from rectum to anal verge,as well as radial pressures in four quadrants for Methods 1 and ***:Water perfusion side hole recorded slightly higher maximal resting pressures;however,there were no significant differences between any of the *** healthy control subjects,distal maximal squeeze pressures were significantly higher(P lly as measured by *** were slight(nonsignificant) variations in radial pressures with water perfusion and *** values for maximum resting pressure and maximum squeeze pressure were lower than those recorded by water perfusion side hole by a factor of ***:There is no significant variation in anal pressure recordings using standard manometry *** in radial pressures are slight and not significant in clinical *** obtained with portable nonperfusion systems must be interpreted appropriately.

关键词：大便失禁测压法测压方法传感器法拉法径向压力端孔近端灌注法无显著性差异

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研究设计的确定与研究群体的选择

结核与肺部疾病杂志 2005年第3期8卷 81-84页

作者： D. A. Enarson S. M. kennedy D. l. Miller 张宗德 Scientific Activities Unit International Union Against Tuberculosis and Lung Disease Paris France University of British Columbia Vancouver British Columbia Canada Emeritus Professor of Public Health Medicine Emperor College University of London London United Kingdom

流行病学研究已经标准化成为一组“研究设计”。描述性研究是按时间、地点、人物来描述疾病并探讨其与可能危险因素间关联假设的研究。分析性研究则是检验这些假设。横断面研究是在一个特定时间点测量疾病与各种危险因素的现状。队列研... 详细信息

流行病学研究已经标准化成为一组“研究设计”。描述性研究是按时间、地点、人物来描述疾病并探讨其与可能危险因素间关联假设的研究。分析性研究则是检验这些假设。横断面研究是在一个特定时间点测量疾病与各种危险因素的现状。队列研究则是确定某危险因素的暴露人群和对照人群,观察比较二组间的疾病的发生情况。病例对照研究则是确定病人组以及从同一无病群体中选择的对照组,比较两组间危险因素的差异。实验性研究是队列研究的一个类型,在一个群体中,研究者指定一组接受某因素(治疗),另一组无此因素,然后比较两组的疾病的发生情况。所有上述研究必须保证所作比较对特定群体的适用性。这取决于是否从特定群体抽取了有代表性的样本。细致确定研究设计以及选择研究群体既有利新见解的产生,又可避免严重误差的发生。

关键词：研究草案肺教育群体设计流行病学研究危险因素病例对照研究暴露人群队列研究发生情况描述性研究

Prediabetes and cardiovascular complications study:Highlights on gestational diabetes, self-management and primary health care

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World Journal of Meta-Analysis 2021年第6期9卷 543-556页

作者： Ezekiel Uba Nwose Phillip Taderera Bwititi Otovwe Agofure Echinei Jacob Oshionwu Ekenechukwu Esther Young Eferhire Aganbi Solomon Ekwuweokwuenu Egwenu Helen Egoyibo Chime Fortunatus Darius Gbeinbo Alex Odufu john Nwakaego Okuzor Azuka Okuleye kennedy Aninze Innocent Chuks Onyia Euzebus Chinonye Ezugwu Eunice Obiajuru Igumbor Ifeoma Isabel Ulasi Department of Public and Community Health Novena UniversityKwale 322107Nigeria School of Dentistry and Medical Sciences Charles Sturt UniversityWagga campusNew South Wales 2650Australia Global Medical Research and Development Organization(GMRDO)group Abbi Delta State 322107Nigeria California Department of State Hospital StocktonCA 95215United States Department of Medicine College of MedicineUniversity of NigeriaItuku-Ozalla campusEnugu 402109Nigeria Biochemistry Department Delta State UniversityAbraka 330105Nigeria Department of Clinical laboratory Services Texas Health(HMH HEB)BedfordTX 76022United States Clinic Department Donak HospitalKwale 2539083Nigeria Clinic Department U-Turn HospitalU-Turn Abule Egba 100276Nigeria

International collaboration on the prediabetes and cardiovascular complications study started in *** 2017,a reflection was *** of documentation and screening of antenatal cases for gestational diabetes mellitus(GDM)was ***,further observations have been made that warrant an *** objective of this review is to highlight gaps between clinical knowledge and practice in GDM,diabetes self-management and primary health care(PHC)for rural *** followed a descriptive field notes *** records of patients screened for GDM with incomplete documentation were examined to determine incompleteness of data in those that also met the criteria for GDM risk *** on development of a diabetes register and education and notes on behavioural change wheel were also *** data included cross-sectional evaluation of activities of daily living at two private *** to 29%had high GDM risk factors,which fulfilled selection criteria for laboratory *** data was complete in all women;however,incomplete documentation was observed with as much as 98%of basic *** levels of physical activity were found in the population,and health lectures proved effective in food *** workforce need for diabetes care seems underestimated,but this may be better understood with reactivation of PHC *** observations highlight behavioural change wheel issues on GDM and PHC services that need concerted *** proposals are to advance the use of a‘risk assessment and screening sheet’for GDM screening and enlightenment of stakeholders on the central hub role of PHC in diabetes management.

关键词： Behavioural change wheel Community health Diabetes education Knowledge vs practice gap lifestyle Patient follow-up Screening services Telehealth

Male Reproductive Toxicology

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Biomedical and Environmental Sciences 1991年第1期4卷 35-47页

作者： WIllIAM R.KElCE lARRY l.EWING Department of Population Dynamics Division of Reproductive Biology School of Hygiene and Public Health The Johns Hopkins UniversityDepartment of Population Dynamics Division of Reproductive Biology School of Hygiene and Public Health The Johns Hopkins University Baltimore Maryland 21205Baltimore Maryland 21205

The objective of this paper is to discuss recent developments in the application of biological markers to animal models of male reproductive toxicology. We have divided this paper into three major sections: First, a discussion of the testing protocols currently under investigation by the National Toxicology Program (NTP) and the EPA's Health Effects Research laboratory; second, an examination of what we consider to be important and practical biological markers available to investigators to assess the effects of toxicants on the male reproductive system; and third, a discussion of promising new technologies, such as molecular and immunological probes, and in vitro techniques using isolated and cultured cells, which in the future may be exploited for the development of additional biological markers of male reproductive toxicity. Where appropriate we have made specific recommendations for the use of these biological markers in animal protocols and have pointed out those noninvasive markers which have application to screening human males.

关键词： Male Reproductive Toxicology