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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.j.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Effect of surface layer softening from previous electrochemical corrosion on electrochemical cold drawing of Q235 steel bar

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journal of Iron and Steel Research International 2022年第5期29卷 819-835页

作者： j.l.Guo T.j.Chen State Key laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050GansuChina

The effects of H_(2)SO_(4)concentration and current in electrochemical corrosion on surface layer softening or plasticizing of Q235 steel bar and their effects on subsequent electrochemical cold drawing(ECD)were *** results indicate that the electrochemical corrosion can soften or plasticize the surface layer of Q235 steel bar and then make the subsequent ECD be conducted more *** softening degree and thickness of the surface layer are continuously enhanced with increasing corrosion rate,i.e.,increasing H_(2)SO_(4)concentration or current,due to the generation of more vacancy clusters in deeper regions of surface *** vacancy clusters then relax dislocations through being absorbed during ECD,and the formation and movement of additional dislocation flux are thereby enhanced,resulting in the further obvious decrease in the drawing *** is also due to the enhanced formation and movement of additional dislocation flux that the dislocation density and thus the hardness of the surface layer are decreased,as well as that the texture structure is *** behaviors are enhanced as the corrosion rate increases.

关键词： Electrochemical corrosion Electrochemical cold drawing Surface layer softening Vacancy Additional dislocation flux

Efficient Orbit Propagation of Orbital Elements Using Modified Chebyshev Picard Iteration Method

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Computer Modeling in Engineering & Sciences 2016年第1期111卷 65-81页

作者： j.l.Read A.Bani Younes j.l.junkins Graduate Research Assistant Texas A&M UniversityCollege StationTXUSA. Assistant Professor Khalifa UniversityAbu DhabiUAE. Distinguished Professor Texas A&M UniversityCollege StationTXUSA.

This paper focuses on propagating perturbed two-body motion using orbital elements combined with a novel integration *** previous studies show that Modified Chebyshev Picard Iteration(MCPI)is a powerful tool used to propagate position and velocity,the present results show that using orbital elements to propagate the state vector reduces the number of MCPI iterations and nodes required,which is especially useful for reducing the computation time when including computationally-intensive calculations such as Spherical Harmonic gravity,and it also converges for>5.5x as many revolutions using a single segment when compared with cartesian *** for the Classical Orbital Elements and the Modified Equinoctial Orbital Elements(the latter provides singularity-free solutions)show that state propagation using these variables is inherently well-suited to the propagation method *** benefits are achieved using a segmentation scheme,while future expansion to the two-point boundary value problem is expected to increase the domain of convergence compared with the cartesian *** is an iterative numerical method used to solve linear and nonlinear,ordinary differential equations(ODEs).It is a fusion of orthogonal Chebyshev function approximation with Picard iteration that approximates a long-arc trajectory at every *** studies have shown that it outperforms the state of the practice numerical integrators of ODEs in a serial computing environment;since MCPI is inherently massively parallelizable,this capability is expected to increase the computational efficiency of the method presented.

关键词： Propagation Integration Orbital Mechanics Classical Elements Modified Equinoctial Chebyshev Picard Iteration MCPI Polynomials Initial Value Problem IVP.

Numerical studies towards practical large-eddy simulation

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journal of Thermal Science 2007年第4期16卷 328-336页

作者： j.Boudet j.Caro l.Shao E.lév(?)que lMFA laboratoire

large-eddy simulation developments and validations are presented for an improved simulation of turbulent internal flows. Numerical methods are proposed according to two competing criteria： numerical qualities （precision and spectral characteristics）, and adaptability to complex configurations. First, methods are tested on academic test-cases, in order to abridge with fundamental studies. Consistent results are obtained using adaptable finite volume method, with higher order advection fluxes, implicit grid filtering and ＂low-cost＂ shear-improved Smagorinsky model. This analysis particularly focuses on mean flow, fluctuations, two-point correlations and spectra. Moreover, it is shown that exponential averaging is a promising tool for lES implementation in complex geometry with deterministic unsteadiness. Finally, adaptability of the method is demonstrated by application to a configuration representative of blade-tip clearance flow in a turbomachine.

关键词： lES adaptable methods validation

Frictionally excited thermoelastic dynamic instability of functionally graded materials

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Acta Mechanica Sinica 2019年第1期35卷 99-111,I0004页

作者： j.liu l.l.Ke Y.S.Wang College of Engineering Huazhong Agricultural UniversityWuhan 430070China Institute of Engineering Mechanics Beijing JiaotongUniversity Beijing 100044China

The perturbation method is applied to investigate the frictionally excited thermoelastic dynamic instability (TEDI) of a functionally graded material (FGM) coating in half-plane sliding against a homogeneous half-plane. We assume that the thermoelastic properties of the FGM vary exponentially with thickness. We also examine the effects of the gradient index, sliding speed, and friction coefficient on the TEDI for various material combinations. The transverse normal stress for two different coating structures is calculated. Furthermore, the frictional sliding stability of two different coating structures is analyzed. The obtained results show that use of FGM coatings can improve the TEDI of this sliding system and reduce the possibility of interfacial failure by controlling the interfacial tensile stress.

关键词： Thermoelastic dynamic instability Frictional heat Functionally graded materials Stress analysis

A novel approach to enhance decrepitation temperature and reducibility of ultrafine iron ore concentrate pellets

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journal of Iron and Steel Research International 2024年第11期31卷 2622-2632页

作者： B.l.Wen Z.H.Fan j.X.li D.l.liu j.l.Yang School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032AnhuiChina jianlong(liaoning)Energy Saving and Environmental Protection

Utilizing ultrafine iron ore concentrate for pellet production can expand domestic iron ore resources in China and promote the utilization of low-grade ***,a challenge arises with the low decrepitation temperature and reducibility in the preparation process of ultrafine iron ore concentrate *** address the challenge,a novel approach was proposed,which incorporated straw powder as an additive to enhance pellet porosity,thereby improving the decrepitation temper-ature and reducibility of ultrafine iron ore concentrate *** effect of varying proportions of straw powder(0.0-2.0%)on the characteristics of ultrafine iron ore concentrate pellets was *** indicate that at a 2.0%straw powder ratio,pellet decrepitation temperature notably rises from 380 to 540℃,while the reducibility index escalates from 25.7%to 48.1%.Nevertheless,the addition of straw powder results in diminished drop strength,compressive strength of green pellets,and cold crushing strength of fired *** addition,enhanced pellet reducibility leads to exacerbated reduction swelling index and reduction degradation *** these effects,all parameters remain within an acceptable range.

关键词： Ultrafine iron ore concentrate:Straw powder Green pellet quality Decrepitation temperature:Metallurgical property

Convective flow of jeffrey nanofluid along an upright microchannel with Hall current and Buongiorno model:an irreversibility analysis

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Applied Mathematics and Mechanics(English Edition) 2023年第9期44卷 1613-1628页

作者： l.ANITHA B.j.GIREESHA Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics Adichunchanagiri Institute of TechnologyChikkamagaluru 577102India

The thermal properties and irreversibility of the jeffrey nanofluid through an upright permeable microchannel are analyzed by means of the Buongiorno *** effects of the Hall current,exponential space coefficient,nonlinear radiation,and convective and slip boundary conditions on the jeffrey fluid flow are explored by deliberating the buoyant force and viscous *** non-dimensionalized equations are obtained by employing a non-dimensional system,and are further resolved by utilizing the shooting approach and the 4th-and 5th-order Runge-Kutta-Fehlberg *** obtained upshots conclude that the amplified Hall parameter will enhance the secondary flow *** improvement in the temperature parameter directly affects the thermal profile,and hence the thermal field declines.A comparative analysis of the Newtonian fluid and non-Newtonian fluid(jeffrey fluid)is carried out with the flow across a porous *** the Bejan number,thermal field,and entropy generation,the jeffrey nanofluid is more highly supported than the Newtonian fluid.

关键词： jeffrey nanofluid entropy generation exponential heat source porous medium convective and slip boundary condition

Repercussion of Hall effect and nonlinear radiation on Couette-Poiseuille flow of Casson-Williamson fluid through upright microchannel

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Applied Mathematics and Mechanics(English Edition) 2022年第12期43卷 1951-1964页

作者： B.j.GIREESHA l.ANITHA Department of Post Graduation Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics Adichunchanagiri Institute of TechnologyChikkamagaluru 577102India

The main aim of the present work is to investigate the flow and heat transport properties of non-Newtonian Casson-Williamson fluid through an upright microchannel along with entropy generation analysis,and explore the effects of convective boundary conditions,Couette-Poiseuille flow,and nonlinear *** movement of liquid is scrutinized with the Hall effect and exponential heat *** rheological characteristics of the Casson-Williamson fluid model are also *** considering the desirable similarity variables,the equations of motion are reduced to nonlinear ordinary differential *** Runge-Kutta-Fehlberg fourth-fifth order method along with the shooting method is adopted to solve these dimensionless *** detailed investigation is pictorially displayed to show the influence of effective parameters on the entropy generation and the Bejan *** of the major tasks of the exploration is to compare the Casson fluid and the Williamson *** results show that the rate of heat transfer in the Casson fluid is more remarkable than that in the Williamson fluid.

关键词： entropy generation Bejan number convective boundary condition Hall effect nonlinear radiation exponential heat source