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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl james Ferguson nicole Swiadek Xavier Monforte johannes C.heinzel Antal nógrádi Andreas h.Teuschl-Woller David hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). however, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： nathanael j.lee Ryota l.Matsuoka Department of neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.nugent Uniformed Services University of the health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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nUMERICAl SIMUlATIOn STUDY On DEFORMATIOn UnIFORMITY OF EQUAl CROSS SECTIOn lATERAl EXTRUSIOn

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Acta Metallurgica Sinica(English letters) 2004年第1期17卷 61-63页

作者： Z.l.Chang j.l.Song n.h.hao Department of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 China

Equal cross section lateral extrusion (ECSlE) is an effective method realizing pure shear deformation. The influence of friction factor on the deformation uniformity of ECSlE was investigated with rigid plastic finite element method. The result shows that the non-uniform deformation in extrusion is caused mainly by the friction between workpiece and die. The higher the friction factor is, the more uneven plastic deformation resulted in extruded workpiece. The relation curve of deformation uniformity vs. friction factor was drawn based on the analysis result. The curve can be used as a basis of ECSlE process design.

关键词： equal cross section lateral extrusion strain finite element method

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Synthesis and Crystal Structure of (CO) 5ReSnMe 2Re(CO) 5

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Chinese journal of Structural Chemistry 1999年第2期18卷 39-43页

作者： li, j liu, h Song, XQ Kai, l Yin, n nankai Univ State Key Lab Elementoorgan Chem Tianjin 300071 Peoples R China nankai Univ Inst Elementoorgan Chem Tianjin 300071 Peoples R China

The crystal structure of the title complex (CO) 5ReSnMe 2Re(CO) 5, (C 12 h 6O 10 Re 2Sn, M r =801.27), has been determined by single crystal X ray diffraction. The crystal is monoclinic with space group P2 1/n (nO.14), a=10.587(2), b=12.392(2), c = 14.594(3) , β = 100.59(3)°, V = 1882(1) 3, D x = 2.828 g·cm -3 , F(000)=1432, μ =14.3759mm -1 , Z =4, and final R =0 0440 and R w =0 0483 for 1954 reflections ( I≥3σ(I )). In the complex the Sn atom is connected to two methyl groups and two Re atoms which are in slightly distorted tetrahedral arrangement. The Re atom is coordinated by five carbonyl ligands and one Sn atom, forming an octahedral structure.

关键词： metal carbonyl cluster Re complex synthesis crystal structure

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Atomic-scale roles of Zn element in age-hardened AlMgSiZn alloys

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journal of Materials Science & Technology 2021年第11期70卷 105-112页

作者： n.n.jiao Y.X.lai S.l.Chen P.Gao j.h.Chen Center for high-Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha410082China Electron Microscopy laboratory and International Center for Quantum Materials School of PhysicsPeking UniversityBeijing100871China

Adding alloying elements to improve the performances or the manufacturing processes of Al-Mg-Si alloys has long been a serious issue in developing advanced automotive aluminum *** Zn element,among those promising ones,has demonstrated positive alloying effects on Al-Mg-Si ***,the atomic-scale roles of Zn in an age-hardened Al-Mg-Si-Zn alloy have not been adequately *** atomic-resolution electron microscopy,here we report the precise locations of Zn elements in all hardening precipitates involved and their alloying mechanism at the atomic scale when alloying the *** results show that Zn atoms enter all the major hardening phases to occupy specific featured atomic sites of the original elements,*** Si1 and Mg2 sites in theβ’-2 phase,and modify their crystal structures,interfacial structures and morphologies in characteristic *** is revealed that for theβ’-phase,Zn atoms occupy unique atomic sites,whereas for other phases,they demonstrate similar behaviors as other additive alloying elements such as Ag and Cu do.

关键词： Al-Mg-Si alloy Zn addition Precipitate Electron microscopy

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Unexpected creep behavior in a rejuvenated metallic glass

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journal of Materials Science & Technology 2023年第32期163卷 140-149页

作者： j.P.Wu Y.lin F.h.Duan Q.Chen h.T.Wang n.li j.l.Wen j.Pan l.liu Shenyang national laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China State Key laboratory of Material Processing and Die&Mould Technology and School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China laboratory of nanomaterials&nanomechanics Department of Mechanical EngineeringCity University of Hong KongHong KongChina Wuhan national high Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China Shenzhen Polytechnic Shenzhen 518055China

Rejuvenation,bringing metallic glasses(MGs)to the younger and higher energy states,provides an alternative avenue to explore the interplay between the property and microstructures of *** this study,the creep behavior of the Zr_(69.5)Cu_(12)ni_(11)Al_(7.5)MGs was experimentally examined by controlling the energy state in terms of structural rejuvenation and thermal *** is found that compared to the as-cast counterpart,the annealed MG at a lower energy state exhibits a higher hardness,a smaller displacement,and a lower creep rate due to the decreased free volume and the inhibited activation of the shear transformation ***,the rejuvenated MG at a high energy state displays lower hardness and increased free volume content,yet it demonstrates superior creep resistance compared to its as-cast counterpart,which deviates from conventional *** unexpected phenomenon occurs as the initial high-content free volume annihilates during creep,and strain hardening takes precedence over strain softening as the prevailing process during creep deformation,leading to a superior creep performance in extremely rejuvenated MGs.

关键词： Metallic glass Energy state Rejuvenation Creep Strain-hardening

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nonlinear stability of advanced sandwich cylindrical shells comprising porous functionally graded material and carbon nanotube reinforced composite layers under elevated temperature

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Applied Mathematics and Mechanics(English Edition) 2021年第9期42卷 1327-1348页

作者： h.V.TUnG l.T.n.TRAnG Faculty of Civil Engineering Hanoi Architectural UniversityHa Noi 10000Viet Nam Faculty of Civil Engineering University of Transport TechnologyHa Noi 10000Viet Nam

The nonlinear stability of sandwich cylindrical shells comprising porous functionally graded material(FGM) and carbon nanotube reinforced composite(CnTRC)layers subjected to uniform temperature rise is investigated. Two sandwich models corresponding to CnTRC and FGM face sheets are proposed. Carbon nanotubes(CnTs) in the CnTRC layer are embedded into a matrix according to functionally graded distributions. The effects of porosity in the FGM and the temperature dependence of properties of all constituent materials are considered. The effective properties of the porous FGM and CnTRC are determined by using the modified and extended versions of a linear mixture rule, respectively. The basic equations governing the stability problem of thin sandwich cylindrical shells are established within the framework of the Donnell shell theory including the von K’arm’an-Donnell nonlinearity. These equations are solved by using the multi-term analytical solutions and the Galerkin method for simply supported *** critical buckling temperatures and postbuckling paths are determined through an iteration procedure. The study reveals that the sandwich shell model with a CnTRC core layer and relatively thin porous FGM face sheets can have the best capacity of thermal load carrying. In addition, unlike the cases of mechanical loads, porosities have beneficial effects on the nonlinear stability of sandwich shells under the thermal load. It is suggested that an appropriate combination of advantages of FGM and CnTRC can result in optimal efficiency for advanced sandwich structures.

关键词： carbon nanotube reinforced composite(CnTRC) porous functionally graded material(FGM) thermal instability cylindrical shell advanced sandwich model

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