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SMXl5 attenuates strigolactone signaling in Arabidopsis thaliana by inhibiting SMXl7 degradation

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Molecular Plant 2024年第4期17卷 631-647页

作者： Qingtian li Haiyang Yu Wenwen Chang Sunhyun Chang Michael.guzman lionel Faure Eva-Sophie Wallner Heqin Yan Thomas Greb lei Wang Ruifeng Yao David C.Nelson Department of Botany and Plant Sciences University of CaliforniaRiversideRiversideCA 2521USA Yazhouwan National laboratory Sanya 572025China Hainan Seed Industry laboratory Sanya 57205China State Key laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of BiologyHunan UniversityChangsha 410082China Key laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei 050021China University of Chinese Academy of Sciences Beijing 10004China School of the Sciences Biology DivisionTexas Woman’s UniversityDentonTX 76204USA Centre for Organismal Studies(COS) Heidelberg University6120 HeidelbergGermany

Hormone-activated proteolysis is a recurring theme of plant hormone signaling *** strigolactone signaling,the enzyme receptor DWARF14(D14)and an F-box protein,MORE AXIllARY GROWTH2(MAX2),mark SUPPRESSOR OF MAX21-lIKE(SMXl)family proteins SMXl6,SMXl7,and SMXl8 for rapid *** of these transcriptional corepressors initiates downstream growth *** homologous proteins SMXl3,SMXl4,and SMXl5,however,are resistant to MAX2-mediated *** discovered that the smxl4 smxl5 mutant has enhanced responses to ***5 attenuates strigolactone signaling by interfering with AtD14-SMXl7 ***5 interacts with AtD14 and SMXl7,providing two possible ways to inhibit SMXl7 ***5 function is partially dependent on an ethylene-responsive-element binding-factor-associated amphiphilic repression(EAR)motif,which typically mediates interactions with the TOPlESS family of transcriptional ***,we found that loss of the EAR motif reduces SMXl5-SMXl7 interactions and the attenuation of strigolactone signaling by *** hypothesize that integration of SMXl5 into heteromeric SMXl complexes reduces the susceptibility of SMXl6/7/8 proteins to strigolactone-activated degradation and that the EAR motif promotes the formation or stability of these *** mechanism may provide a way to spatially or temporally fine-tune strigolactone signaling through the regulation of SMXl5 expression or translation.

关键词： Arabidopsis typically inhibiting

间隔1周的CT复查对肺气肿容积和密度测量的可重复性

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国际医学放射学杂志 2012年第2期 197-197页

作者： D.Chong M.S.Brown H.J.Kim E.M.van Rikxoort l.guzman M.F.McNitt-Gray 肖立志 Center for Computer Vision and Imaging Biomarkers David Geffen School of MedicineUCLA924 Westwood BLVD.Ste.615Los AngelesCAUSA

目的肺气肿病人CT肺容积和密度测量1周后重复评估。评估屏气对重复性的影响。方法 44例病人间隔7d在吸气状态行HRCT检查,计算CT肺容积、密度在-950HU(RA950-raw)以下相关区,第15百分位数密度(PD15-raw)。通

关键词：慢性阻塞性肺疾病肺气肿 CT 密度测量法重复性

Gamma-aminobutyric acid A receptors in Alzheimer＇s disease： highly localized remodeling of a complex and diverse signaling pathway

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Neural Regeneration Research 2018年第8期13卷 1362-1363页

作者： Andrea Kwakowsky Beatriz Calvo-Flores guzman Karan Govindpani Henry J. Waldvogel Richard l. Faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health Sciences University of Auckland AucklandNew Zealand

Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide （Prince et al., 2015）, and with 60-80% of cases attributable to AD.

关键词： AD highly localized remodeling of a complex and diverse signaling pathway Gamma-aminobutyric acid A receptors in Alzheimer’s disease

Species diversity of thrips (Thysanoptera) in selected avocado orchards from Mexico based on morphology and molecular data

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Journal of Integrative Agriculture 2018年第11期17卷 2509-2517页

作者： Daniel Bravo-Perez Ma. Teresa Santillbn-Galicia Roberto M. Johansen-Naime Hector Gonzalez-Hernandez Obdulia l. Segura-leon Daniel l, Ochoa-Martinez Stephanie guzman-Valencia Posgrado en Fitosanidad-Entomologia y Acarologia Colegio de Postgraduados Km 36.5 Carretera Mexico-Texcoco Montecillo Texcoco Estado de Mexico 56230 Mexico Instituto de Biologia de la Universidad Nacional Autonoma de Mexico (IBUNAM) Circuito exterior s/n Ciudad Universitaria Coyoacan Ciudad de Mexico 04510 Mexico Posgrado en Fitosanidad-Fitopatologia Colegio de Postgraduados Km 36.5 Carretera Mexico-Texcoco Montecillo Texcoco Estado de Mexico 56230 Mexico

Avocado is one of the most important crops in the world, and Mexico is the largest producer of this fruit. Several insect pests affect its production, and thrips are amongst the most important. A key step in the design of control methods is accurate species identification. Despite this, formal reports on species diversity of thrips in Mexico are very scarce. Morphological identification can sometimes be time-consuming and inconclusive. Therefore, we explored the species diversity of thrips in Mexican avocado orchards （Michoacan state） based on partial sequences of the mitochondrial gene cytochrome oxidase subunit I （COl）. Forty-four specimens were analysed, which represented approximately 8% of all individuals collected from five localities distributed in three Municipalities. All specimens were analysed using the COl marker, and specimens within the genera Frankliniella were also analysed using a marker within the D2 domain of the 28S （28SD2） nuclear ribosomal DNA. Molecular identifications were confirmed using morphological taxonomy. Overall, six genera were found （Neohydatothrips, Scirtothrips, Frankliniella, Arorathrips, Caliothrips and leptothrips）. AII genera contained only one species, except Frankliniella, for which there were six species. Data from the two molecular markers suggest the existence of cryptic species within Mexican F. occidentalis populations.

关键词： molecular taxonomy morphological identification cytochrome oxidase subunit I 28S nuclear ribosomal DNA.

A Direct link between Abscisic Acid Sensing and the Chromatin-Remodeling ATPase BRAHMA via Core ABA Signaling Pathway ComDonents

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Molecular Plant 2016年第1期9卷 136-147页

作者： Marta Peirats-llobet Soon-Ki Han Miguel Gonzalez-guzman Cheol Woong Jeong lesia Rodriguez Borja Belda-Palazon Doris Wagner Pedro l. Rodriguez Instituto de Biologia Molecular y Celular de Plantas Consejo Superior de Investigaciones Cientfficas-Universidad Politecnica de Valencia 46022 Valencia Spain Department of Biology University of Pennsylvania Philadelphia PA 19104 USA These authors contributed equally to this article

Optimal response to drought is critical for plant survival and will affect biodiversity and crop performance during climate change. Mitotically heritable epigenetic or dynamic chromatin state changes have been implicated in the plant response to the drought stress hormone abscisic acid （ABA）. The Arabidopsis SWI/SNF chromatin-remodeling ATPase BRAHMA （BRM） modulates response to ABA by preventing pre- mature activation of stress response pathways during germination. We show that core ABA signaling pathway components physically interact with BRM and post-translationally modify BRM by phosphoryla- tion/dephosphorylation. Genetic evidence suggests that BRM acts downstream of SnRK2.2/2.3 kinases, and biochemical studies identified phosphorylation sites in the C-terminal region of BRM at SnRK2 target sites that are evolutionarUy conserved. Finally, the phosphomimetic BRMs17s^D S1762D mutant displays ABA hypersensitivity. Prior studies showed that BRM resides at target loci in the ABA pathway in the presence and absence of the stimulus, but is only active in the absence of ABA. Our data suggest that SnRK2- dependent phosphorylation of BRM leads to its inhibition, and PP2CA-mediated dephosphorylation of BRM restores the ability of BRM to repress ABA response. These findings point to the presence of a rapid phosphorylation-based switch to control BRM activity; this property could be potentially harnessed to improve drought tolerance in plants.

关键词： abscisic acid hormone signaling chromatin remodeling

FOXO3a as a sensor of unilateral nerve injury in sensory neurons ipsilateral, contralateral and remote to injury

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Neural Regeneration Research 2020年第12期15卷 2353-2361页

作者： Jovan CDHasmatali Jolly De guzman Jayne MJohnston Hossein Noyan Bernhard HJuurlink Vikram Misra Valerie MKVerge Department of Anatomy Physiologyand PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada Department of Veterinary Microbiology University of SaskatchewanSaskatoonSKCanada

Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron,with alterations in associated transcription factors detected both locally and remote to the ***-induced nuclear translocation of the transcription factor forkhead class box O3a(FOXO3a)was initially linked to activation of apoptotic genes in many neuronal ***,a more complex role of FOXO3a has been suggested in the injury response of sensory neurons,with the injured neuron expressing less *** elucidate this response and test whether non-injured sensory neurons also alter FOXO3a expression,the temporal impact of chronic unilateral l4–6 spinal nerve transection on FOXO3a expression and nuclear localization in adult rat dorsal root ganglion neurons ipsilateral,contralateral or remote to injury relative to na?ve controls was *** na?ve neurons,high cytoplasmic and nuclear levels of FOXO3a colocalized with calcitonin gene related peptide,a marker of the nociceptive *** hour post-injury,an acute increase in nuclear FOXO3a in small size injured neurons occurred followed by a significant decrease after 1,2 and 4 days,with levels increasing toward pre-injury levels by 1 week post-injury.A more robust biphasic response to the injury was observed in uninjured neurons contralateral to and those remote to *** levels of FOXO3a peaked at 1 day,decreased by 4 days,then increased by 1 week post-injury,a response mirrored in C4 dorsal root ganglion neurons remote to *** altered expression contralateral and remote to injury supports that spinal nerve damage has broader systemic impacts,a response we recently reported for another stress transcription factor,luman/*** early decreased expression and nuclear localization of FOXO3a in the injured neuron implicate these changes in the cell body response to injury that may be ***,the broader systemic changes support the existence of stress/inj

关键词： cell body response contralateral response dorsal root ganglion peripheral nerve injury plasticity sciatic nerve sensory neuron stress systemic transcription factor unilateral peripheral nerve injury

lignocellulosic Micro and Nanofibrillated Cellulose Produced by Steam Explosion for Wood Adhesive Formulations

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Journal of Renewable Materials 2022年第2期10卷 263-271页

作者： Saad Nader Felipe guzman Raphael Becar Cesar Segovia Cecilia Fuentealba Miguel Peirera Evelyne Mauret Nicolas Brosse laboratoire d’Etude et de Recherches sur le Materiau Bois-Green Process For Wood(lERMaB-GP4W) Facultedes Sciences et TechnologiesUniversitede LorraineVandœuvre-les-NancyFrance laboratoire de Genie des Procedes Papetiers(lGP2) Saint Martin D’HèresFrance Unidad de Desarrollo Tecnologico(UDT) Universidad de ConcepcionCoronelChile Centre d’Essais TEchnique lORrain(CETElOR) EpinalFrance

The reinforcing impact of lignocellulosic micro and nanofibrillated cellulose(l-MNFCs)obtained from Eucalyp-tus Globulus bark in Urea-Formaldehyde UF adhesive was tested.l-MNFCs were prepared by an environmentally friendly,low-cost process using a combination process involving steam explosion followed by refining and ultra-fine *** l-MNFCs showed a web-like morphology with some aggregates and lignin *** present a mixture of residual fibers and fine elements with a width varying between 5 nm to 20μm,*** effects of the addition of low amounts of l-MNFCs(1%wt.)on the properties of three different adhe-sives(Urea-Formaldehyde UF,Phenol-Formaldehyde PF,and Tannin-Hexamine TH)were studied by the evolution of the pH,the viscosity,and the mechanical *** showed that the viscosity of PF and UF adhesives increased with the addition of l-MNFCs,unlike ***,the addition led to better mechan-ical behavior for the three *** were then prepared using modified UF with l-MNFCs and *** showed that an amount of 1%*** l-MNFCs was sufficient to increase the internal bonding by≈67%,the modulus of elasticity by≈43%,and the modulus of rupture by≈29%.

关键词： lignocellulosic microfibrils Eucalyptus globulus bark wood adhesives steam explosion wood panels

Arginine Metabolism in Cancer:A Valid Therapeutic Target?

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Journal of Nutritional Oncology 2017年第1期2卷 7-15页

作者： Vance l. Albaugh Carolina Pinzon-guzman Adrian Barbul Division of General Surgery Department of Surgery Vanderbilt University School of Medicine Nashville TN 37232 USA

Arginine is a conditionally essential amino acid that has been identified as an important player in a number of biologic processes,including normal functions of the cardiovascular and immune *** studies have demonstrated that arginine is necessary for cellular growth and can become limiting in states of rapid growth like *** this requirement for arginine in malignant cells,investigators have examined the potential for arginine deprivation therapy as an adjuvant treatment for cancers that are unable to synthesize arginine de ***,arginine has been identified as being critically important for immune surveillance that targets and destroys malignant ***,paradoxically,arginine has been identified as being both necessary for cancer growth and normal immune destruction of malignant cells.A number of factors,including the type of cancer,expression of arginine synthetic genes,tumor microenvironment and host immune cell-cancer cell interactions,can affect the progression of *** we review the data supporting arginine deprivation and supplementation in cancer therapies and the currently registered trials that aim at understanding which of these strategies may lead to advances in cancer therapy.

关键词： Tumors Arginine metabolism Anti-cancer activity

On a Generalized Model in Accelerated life Testing

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Open Journal of Statistics 2012年第2期2卷 184-187页

作者： Eduardo l. Cruz Adolfo M. De guzman Department of Epidemiology and Biostatistics University of the Philippines Manila Philippines School of Statistics University of the Philippines Quezon City Philippines

The main objective of accelerated life tests in this setting is the recovery of the distribution of the random variable representing lifetime which is difficult to observe at a certain level of a given stress factor. A general model for accelerated life test is proposed that utilizes the inverse problem approach, that is, the variable is observe at different level/s and the transfer function is used to recover the elusive random variable (life time). The problem then is reduced to finding the transfer function. We derive some properties of the proposed general model. The lognormal distribution and the Arrhenius model for lifetime are used as examples. Its relationship with the Cox proportional hazards model is also discussed.

关键词： Accelerated life Test Arrhenius Model Inverse Problem