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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia Nürnberger barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik biverstål Nicolas Gbazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa b pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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Generalized Supersymmetric Perturbation Theory

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Chinese Physics letters 2004年第12期21卷 2330-2333页

作者： b.Goenül DepartmentofEngineeringPhysics UniversityofGaziantep27310GaziantepTurkey

Using the basic ingredient of supersymmetry, a simple alternative approach is developed to perturbation theory in one-dimensional non-relativistic quantum mechanics. The formulae for the energy shifts and wavefunctions do not involve tedious calculations which appear in the available perturbation theories. The model applicable in the same form to both the ground state and excited bound states, unlike the recently introduced supersymmetric perturbation technique which, together with other approaches based on logarithmic perturbation theory, are involved within the more general framework of the present formalism.

关键词： Quantum information and quantum mechanics

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Forced motion of an elastic filament through a narrow tube

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Acta Mechanica Sinica 2015年第6期31卷 789-790页

作者： l.b.Freund Department of Materials Science and Engineering University of Illinois at Urbana Champaign

A polymer filament consisting of many similar molecules linked in a one-dimensional array is very flexible. As a result, shapes with a relatively large curvature can be accommodated elastically. When loosely confined in a thermal environment, such a flexible strand may become tangled owing to its flexibility. When confined within a narrow ＂tube＂ over its full length, a flexible molecule may behave quite differently. Here, we consider the qualitative nature of deformation of an individual filament when confined within a tube. Commonly the tube is formed within the cluster by a large number of surrounding filaments of the same type.

关键词： Statistical mechanics. biofilament. Reptation Partition function

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A Search on the Klein-Gordon Equation

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Chinese Physics letters 2006年第10期23卷 2640-2643页

作者： b.Gonül Department of Engineering Physics University of Gaziantep Gaziantep 27310 Turkey

The s-wave Klein-Gordon equation for the bound states is separated in two parts to see clearly the relativistic contributions to the solution in the non-relativistic limit. The reliability of the model is discussed wi... 详细信息

关键词： ARbITRARY DIMENSIONS POTENTIAlS COUlOMb SCAlAR VECTOR DIRAC

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EVOlUTION OF ROUGHNESS ON THE SURFACE OF A STRAINED ElASTIC MATERIAl DUE TO STRESS-DRIVEN SURFACE DIFFUSION

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Acta Mechanica Sinica 1994年第1期10卷 16-26页

作者： l.b.Freund Division of Engineering Brown University Providence RI 02912 USA

The free energy of a stressed crystal is assumed to consist of elastic strain energy and surface energy, and the chemical potential for surface diffusion at constant temperature is obtained under this assumption. A gradient in chemical potential results in diffusive mass transport along the surface. The result is applied in considering the phenomena of instability of a flat surface in a stressed material under fluctuations in surface shape, and the transient evolution of surface roughness due to an initial perturbation in the nearly flat free surface of the material, both under plane strain conditions.

关键词： elastic material surface energy diffusion

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Melting, Oxidation, Evaporation of Particle in-Flight in Plasma Spray Processes

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Journal of Materials Science & Technology 2003年第z1期19卷 49-52页

作者： H.b.Xiong l.l.Zheng Department of Mechanical Engineering State University of New York at Stony Brook Stony Brook NY 11794-2300 USA Department of Mechanical Engineering State University of New York at Stony Brook Stony Brook NY 11794-2300 USA

A comprehensive numerical model has been developed to investigate the transient behaviors of particle characteristics, such as temperature, melting, evaporation, and oxidation status during argon-hydrogen DC plasma *** model includes heat, momentum and mass transfer of carrier gas, and particle heating, melting, evaporationand oxidation. Special attentions have been paid to the evaporation-induced mass transfer and oxidation-inducedevaporation as well as variable non-continuum phenomena.

关键词： Melting, Oxidation, Materials processing, Multi-components reacting flow, Computational heat transfer

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USING THE SKEW-SYMMETRIC ITERATIVE METHODS FOR SOlUTION OF AN INDEFINITE NONSYMMETRIC lINEAR SYSTEMS

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Journal of Computational Mathematics 2014年第3期32卷 266-271页

作者： b.l. Krukier l.A. Krukier Southern Federal University Computer Center Rostov-on-Don Russia

The concept of the field of value to localize the spectrum of the iteration matrices of the skew-symmetric iterative methods is further exploited. Obtained formulas are derived to relate the fields of values of the original matrix and the iteration matrix. This allows us to determine theoretically that indefinite nonsymmetric linear systems can be solved by this class of iterative methods.

关键词： Skew-symmetric iterative methods Indefinite nonsymmetric linear systems.

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Repercussion of Hall effect and nonlinear radiation on Couette-Poiseuille flow of Casson-Williamson fluid through upright microchannel

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Applied Mathematics and Mechanics(English Edition) 2022年第12期43卷 1951-1964页

作者： b.J.GIREESHA l.ANITHA Department of Post Graduation Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics Adichunchanagiri Institute of TechnologyChikkamagaluru 577102India

The main aim of the present work is to investigate the flow and heat transport properties of non-Newtonian Casson-Williamson fluid through an upright microchannel along with entropy generation analysis,and explore the effects of convective boundary conditions,Couette-Poiseuille flow,and nonlinear *** movement of liquid is scrutinized with the Hall effect and exponential heat *** rheological characteristics of the Casson-Williamson fluid model are also *** considering the desirable similarity variables,the equations of motion are reduced to nonlinear ordinary differential *** Runge-Kutta-Fehlberg fourth-fifth order method along with the shooting method is adopted to solve these dimensionless *** detailed investigation is pictorially displayed to show the influence of effective parameters on the entropy generation and the bejan *** of the major tasks of the exploration is to compare the Casson fluid and the Williamson *** results show that the rate of heat transfer in the Casson fluid is more remarkable than that in the Williamson fluid.

关键词： entropy generation bejan number convective boundary condition Hall effect nonlinear radiation exponential heat source

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Convective flow of Jeffrey nanofluid along an upright microchannel with Hall current and buongiorno model:an irreversibility analysis

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Applied Mathematics and Mechanics(English Edition) 2023年第9期44卷 1613-1628页

作者： l.ANITHA b.J.GIREESHA Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics Adichunchanagiri Institute of TechnologyChikkamagaluru 577102India

The thermal properties and irreversibility of the Jeffrey nanofluid through an upright permeable microchannel are analyzed by means of the buongiorno *** effects of the Hall current,exponential space coefficient,nonlinear radiation,and convective and slip boundary conditions on the Jeffrey fluid flow are explored by deliberating the buoyant force and viscous *** non-dimensionalized equations are obtained by employing a non-dimensional system,and are further resolved by utilizing the shooting approach and the 4th-and 5th-order Runge-Kutta-Fehlberg *** obtained upshots conclude that the amplified Hall parameter will enhance the secondary flow *** improvement in the temperature parameter directly affects the thermal profile,and hence the thermal field declines.A comparative analysis of the Newtonian fluid and non-Newtonian fluid(Jeffrey fluid)is carried out with the flow across a porous *** the bejan number,thermal field,and entropy generation,the Jeffrey nanofluid is more highly supported than the Newtonian fluid.

关键词： Jeffrey nanofluid entropy generation exponential heat source porous medium convective and slip boundary condition

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