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FHl2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China life Sciences 2025年

作者： Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling lü Qian Ren Fei liu Song Chen Fengxia Ma Tao Cheng Hui Cheng State Key laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHl2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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荷兰STIllS旗舰店

现代装饰 2012年第3期 96-99页

作者： Duzan doepel Eline Strijkers Chantal Vos Wouter vandenBrink 肖俊 doepel Strijkers Architects

STIllS旗舰店位于阿姆斯特丹的Comelis Schuytstraat商业街。设计师将鲜明的现代感空间与精细的手工艺相结合以突显全新品牌概念，倾力打造了一间极具设计感的旗舰店。

关键词：旗舰店荷兰阿姆斯特丹设计师商业街手工艺现代感

预成[牙合]垫治疗肌筋膜疼痛的短期疗效观察

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中国口腔医学继续教育杂志 2009年第6期12卷 10-16页

作者： Maria Nilner EwaCarin Ekberg Marika doepel 张薇（译）傅开元（审）不详北京大学口腔医学院颞下颌关节病口颌面疼痛中心 100081

目的：用随机对照试验比较稳定型[牙合]垫与预成[牙合]垫治疗肌筋膜疼痛患者的短期疗效。方法：2个中心的60名患者被分配到稳定型[牙合]垫（S组，n=33）或预成[牙合]垫组（R组．n=32）。患者均罹患颞下颌关节紊乱病（TMD）疼痛，持续时... 详细信息

目的：用随机对照试验比较稳定型[牙合]垫与预成[牙合]垫治疗肌筋膜疼痛患者的短期疗效。方法：2个中心的60名患者被分配到稳定型[牙合]垫（S组，n=33）或预成[牙合]垫组（R组．n=32）。患者均罹患颞下颌关节紊乱病（TMD）疼痛，持续时间为3个月至40年不等。用RDC／TMD诊断标准对患者进行症状和体征的检查．指定一名全科医师进行治疗。疼痛治疗的结果用视觉模拟刻度尺来评价．在6周和10周随访时并让患者对疼痛缓解进行语言评价，其组间数据运用统计学方法进行比较。结果：[牙合]垫治疗结果均使症状改善．第6周和第10周的随访结果两组间没有任何统计学差异。在6周的随访中．72％的患者疼痛减轻30％．55％的患者疼痛减轻50％，而在10周的随访中，该百分比分别为69％和61％。根据患者语言评价，在6周随访时，85％的患者汇报自己是“较好”、”好得多”或“无症状”．在10周随访时该数据为83％。结论：预成[牙合]垫与稳定型骀垫基本上有相同功效。因此．可以将预成[牙合]垫作为治疗成年肌筋膜疼痛患者的一种短期疗法。

关键词：肌筋膜疼痛 [牙合]垫疼痛随机对照试验颞下颌关节紊乱病

Experimental study on reduction of U (Ⅵ) by an anaerobic bacterium, Shewanella putrefaciens: Application to sandstone-hosted interlayer oxidation-zone type uranium deposits, China

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Science China Earth Sciences 2005年第3期48卷 346-352页

作者： l.l.Barton Department of Biology University of New Mexico Albuquerque NM 87131-1116USA

An experimental study on reduction of U (VI) by anaerobic bacteria, Shewanella putrefaciens, is first reported here in China. The experimental conditions were: 35℃ and pH = 7.0—7.4, corresponding to a physicochemical environments in which the sandstone-hosted in- terlayer oxidation-zone type uranium deposit formed in Northwest China’s Xinjiang. Bacteria adopted in the present experiment, Shewanella putrefaciens, occur extensively in natural envi- ronment. Our study shows that nano-crystal precipitates of uraninite quickly occurred on the surface of the cells within one week. It was found that the pitchblende was characterized by a random arrangement of uraninite nanocrystals (2—4 nm) in it, significantly different from natural pitchblende in which uraninite nanocrystals are arranged in order. Finally, a possible mechanism of uranium biomineralization by microorganisms in the deposits is discussed. Our investigation may supply a technical train of thoughts for bioremediation of nuclear-contaminated water envi- ronments and for underground dissolving extraction of the sandstone-hosted uranium ores.

关键词： anaerobic bacteria, reduction, pitchblende, sandstone-hosted uranium deposit, experimental study.

Three-dimensional dynamics of supported pipes conveying fluid

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Acta Mechanica Sinica 2017年第6期33卷 1065-1074页

作者： l.Wang T.l.Jiang H.l.Dai Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074 China

This paper deals with the three-dimensional dynamics and postbuckling behavior of flexible supported pipes conveying fluid, considering flow velocities lower and higher than the critical value at which the buckling instability occurs. In the case of low flow velocity, the pipe is stable with a straight equilibrium position and the dynamics of the system can be examined using linear theory. When the flow velocity is beyond the critical value, any motions of the pipe could be around the postbuckling configuration(non-zero equilibrium position) rather than the straight equilibrium position, so nonlinear theory is required. The nonlinear equations of perturbed motions around the postbuckling configuration are derived and solved with the aid of Galerkin discretization. It is found, for a given flow velocity,that the first-mode frequency for in-plane motions is quite different from that for out-of-plane motions. However, the second-or third-mode frequencies for in-plane motions are approximately equal to their counterparts for out-of-plane motions, keeping almost constant values with increasing flow velocity. Moreover, the orientation angle of the postbuckling configuration plane for a buckled pipe can be significantly affected by initial conditions, displaying new features which have not been observed in the same pipe system factitiously supposed to deform in a single plane.

关键词： Pipe conveying fluid Three-dimensional dynamics Instability Natural frequency Postbuckling configuration

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浮游的网格

缤纷 2013年第Z1期 34-35页

作者： Duzan doepel Eline Strijkers Chantal Vos 赵雨思 Wouter vandenBrink

位于荷兰阿姆斯特丹的STIllS品牌女装旗舰店,令往来于这条街道的人们过目不忘。这家店铺的设计并不像普通商店那样,有着平滑舒适的视觉效果和一目了然的空间格局。相反,它利用层层叠叠的框架结构连接地面与天花。

关键词：三维坐标轴结构实验女装品牌框架结构结构设计品牌精神室内装饰对比效果人体工程学引导效果

The dynamic compensation temperature in a kinetic spin-5/2 Ising model on a hexagonal lattice

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Chinese Physics B 2013年第3期22卷 471-480页

作者： mt Temizer Aysegl Ozkιlι Department of Physics Bozok University66200 YozgatTurkey Institute of Science Bozok University66200 YozgatTurkey

We present a study of the dynamic behavior of a two-sublattice spin-5/2 Ising model with bilinear and crystal-field interactions in the presence of a time-dependent oscillating external magnetic field on alternating layers of a hexagonal lattice by using the Glauber-type stochastic *** lattice is formed by alternate layers of spins σ=5/2 and S=5/*** employ the Glauber transition rates to construct the mean-field dynamic ***,we investigate the time variations of the average sublattice magnetizations to find the phases in the system and then the thermal behavior of the dynamic sublattice magnetizations to characterize the nature（first-or second-order） of the phase transitions and to obtain the dynamic phase transition（DPT） *** also study the thermal behavior of the dynamic total magnetization to find the dynamic compensation temperature and to determine the type of the dynamic compensation *** present the dynamic phase diagrams,including the dynamic compensation temperatures,in nine different *** phase diagrams contain seven different fundamental phases,thirteen different mixed phases,in which the binary and ternary combination of fundamental phases and the compensation temperature or the l-type behavior strongly depend on the interaction parameters.

关键词： kinetic Ising model dynamic phase transition dynamic compensation temperature

DIPOlE POlARIZATION RElAXATION AND MOlECUlAR STRUCTURE OF MAIN-AND SIDE-CHAIN lIQUID-CRYSTAllINE POlYMERS

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Chinese Journal of Polymer Science 1996年第1期14卷 1-18页

作者： T.P.Stepanova l.l.Burshtein Institute of Macromolecular Compounds of Russian Academy of Sciences Bolshoy pr. 31 St. Petersburg 199004 RussiaInstitute of Macromolecular Compounds of Russian Academy of Sciences Bolshoy pr. 31 St. Petersburg 199004 Russia

Molecular mobility in thermotropic polyesters and side-chain polymers with different struc-ture of mesogens and spacers has been studied by dielectrical method in dilutesolutions. The results made it possible to establish the multiplicity of dielectric relaxationtransitions which reflects the small- and large-scale types of molecular motion. It was shownthat dielectric relaxation processes occurring in accordance with local mechanism (relaxationtimes 10^(-9)--10^(-7)s. and the activation energy 10--50kJ/mol) are due to the mobility of kineticchain elements of different length within a monomer units. It was found that the dielectricrelaxation process connected with a large-scale form of molecular motion (relaxation times10^(-5)--10^(-6)s. and the activation energy 100kJ/mol) did not depend on the molecular massbut was infiuenced by factors changing the conformational state of the macromolecule. It isestablished tha the cooperative reorientation mobility of associated mesogenic fragments isthe source of the large-scale process.

关键词： liquid crystal polymers Dielectric polarization Relaxation transitions Dilute solution Aggregation

ON BOUNDARY TREATMENT FOR THE NUMERICAl SOlUTION OF THE INCOMPRESSIBlE NAVIER-STOKES EQUATIONS WITH FINITE DIFFERENCE METHODS

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Journal of Computational Mathematics 1996年第2期14卷 135-142页

作者： Huang l C 中科院计算数学与科学工程计算所北京