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Determining the IgG concentrations in bovine colostrum and calf sera with a novel enzymatic assay

Journal of Animal Science and Biotechnology 2019年第1期10卷 239-247页

作者： M.Drikic C.Windeyer S.Olsen Y.Fu l.doepel J.De Buck Department Production Animal Health Faculty of Veterinary MedicineUniversity of Calgary

Background: Immune protection in newborn calves relies on a combination of the timing,volume and quality of colostrum consumed by the calf after *** quality colostrum with inadequate immunoglobulin concentration contributes to failed transfer of passive immunity in calves,leading to higher calf morbidity and ***,estimating colostrum quality and ensuring the transfer of passive immunity on farm is of critical ***,there are no on-farm tools that directly measure immunoglobulin content in colostrum or *** aim of this study was to apply a novel molecular assay,split trehalase immunoglobulin G assay(STIGA),to directly estimate immunoglobulin content in dairy and beef colostrum and calf sera,and to examine its potential to be developed as on-farm *** STIGA is based on a split version of trehalase TreA,an enzyme that converts trehalose into glucose,enabling the use of a common glucometer for signal *** a first study,60 dairy and64 beef colostrum and 83 dairy and 84 beef calf sera samples were tested with STIGA,and the resulting glucose production was measured and compared with radial immunodiffusion,the standard method for measuring immunoglobulin ***: Pearson correlation coefficients between the methods were determined and the sensitivity,specificity,and accuracy of the test were calculated for different colostrum quality and failed transfer of passive immunity cut-off *** correlations of the STIGA measured by colorimetric enzymatic reaction compared to radial immunodiffusion for dairy and beef colostrum were 0.72 and 0.73,respectively,whereas the correlations for dairy and beef sera were 0.9 and 0.85,***,STIGA was tested in a blinded study with fresh colostrum and serum samples where the correlation coefficient was 0.93 and 0.94,***,the performance of STIGA followed by glucometer readings resulted in correlations with radial immunodiffusion of 0.7 and

关键词： Cattle Colostrum Immunoglobulins Passive immunity Radial immunodiffusion Split trehalase

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灌注必需和非必需氨基酸对泌乳奶牛乳腺代谢和产奶量变化的影响

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中国畜牧兽医 2010年第8期37卷 72-72页

作者： l.doepel 张养东

本试验旨在研究乳腺对不同类型的氨基酸需求和乳腺对不同的氨基酸供给模式其代谢模式的变化。试验采用带14d残差效应的重复4×4平衡拉丁方试验设计,8头荷斯坦奶牛(泌乳日龄61d±4d)被随机分配到4个处理组中。试验日粮满足100%净能需要和... 详细信息

本试验旨在研究乳腺对不同类型的氨基酸需求和乳腺对不同的氨基酸供给模式其代谢模式的变化。试验采用带14d残差效应的重复4×4平衡拉丁方试验设计,8头荷斯坦奶牛(泌乳日龄61d±4d)被随机分配到4个处理组中。试验日粮满足100%净能需要和72%代谢蛋白需要。4个处理组分别为皱胃灌注水处理组(1组)、皱胃灌注必需氨基酸组(359g/d)(2组)、皱胃灌注非必需氨基酸组(356g/d)(3组)、皱胃灌注必需氨基酸(359g/d)和非必需氨基酸(356g/d)组(总计715g/d)(4组)。灌注液氨基酸组成除了蛋氨酸被提高到与赖氨酸保持3∶1比例、酪氨酸由于其溶解性低全部由苯丙氨酸替代和部分谷氨酸由谷氨酰胺替代外,灌注氨基酸谱图与酪蛋白氨基酸谱图相同;与其他处理组相比,必需氨基酸处理组提高了乳产量和乳蛋白产量,非必需氨基酸处理组趋向于提高乳腺对葡萄糖的摄取率。必需氨基酸处理组,乳腺摄取的氨基酸(His、Met、Phe、Trp和Tyr)与乳蛋白排出的氨基酸(His、Met、Phe、Trp和Tyr)比例不一致且这种比值有增加的趋势。灌注必需氨基酸时,Ile、leu、lys和Val表现出相同的试验结果。结果表明,当供给的氨基酸谱图和剂量不同时,乳腺能选择性的吸收氨基酸和产能营养素;当供给蛋白质缺乏非必需氨基酸时,未发现乳产量和乳蛋白合成的提高。

关键词：乳腺氨基酸能量营养素

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增加日粮中小麦的比例对荷斯坦奶牛生产性能和瘤胃发酵的影响

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饲料与畜牧（新饲料） 2009年第8期 62-62页

作者：刘冰 l.doepel A.Cox A.Hayirli

12头处于第二次泌乳的荷斯坦奶牛，采用拉丁方设计研究增加日粮巾小麦比例对泌乳性能、瘤胃发酵和全肠养分消化率的影响。供试奶牛随机分为3组，分别饲喂0％、10％、20％蒸汽压片小麦（在干物质基础上替代等量蒸汽压片大麦）。每天饲喂... 详细信息

12头处于第二次泌乳的荷斯坦奶牛，采用拉丁方设计研究增加日粮巾小麦比例对泌乳性能、瘤胃发酵和全肠养分消化率的影响。供试奶牛随机分为3组，分别饲喂0％、10％、20％蒸汽压片小麦（在干物质基础上替代等量蒸汽压片大麦）。每天饲喂2次，挤奶2次。其中6头试验牛安装瘤胃瘘管，试验结束前2d采瘤胃液样本共计18次。不同处理的试验牛干物历摄入量（20．9kg／d）、产奶量（36．1kg／d）、乳成分（脂肪、蛋白、乳糖含量分别为1．25kg／d、1．10kg／d、1．67kg／d）差异不品著。

关键词：小麦奶牛消化率发酵

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science China Mathematics 2025年

作者： Xin lü Shengli Tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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