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Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & cirrhosis 2024年第2期3卷 67-74页

作者： Jerome c.Edelson Scott F.D.Edelson John G.Quiles cyrus V.Edelson Eric M.Montminy christian l.Horn John P.Magulick Don c.Rockey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of cook county ChicagoIllinoisUSA Digestive Disease Research center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of child-Pugh,Model for End-Stage liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(cSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** child-Pugh score did not correlate well with the presence of cSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

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Does HSP27 injection induce glaucoma damage in mice?

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Neural Regeneration Research 2024年第11期19卷 2347-2348页

作者： Stephanie c.Joachim Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of *** good vision is crucial to maintaining mobility,independence,and mental *** can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

关键词： HSP27 injection damage

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Apoer2/lrp8:the undercover cop of synaptic homeostasis

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Neural Regeneration Research 2024年第12期19卷 2563-2564页

作者： Gordon c.Werthmann Joachim Herz Department of Molecular Genetics and center for Translational Neurodegeneration Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neuroscience Department of Neurology University of Texas Southwestern Medical center at Dallas DallasTXUSA

Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric *** this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关键词： homeostasis ApoE Alzheimer

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An improved pulse coupled neural networks model for semantic IoT

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Digital communications and Networks 2024年第3期10卷 557-567页

作者： Rong Ma Zhen Zhang Yide Ma Xiping Hu Edith c.H.Ngai Victor c.M.leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of Medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China college of computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic communication has attracted great attention as a new communication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse coupled Neural Network(PcNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PcNN are determined by trial and error,which limits its *** overcome this limitation,an Improved Pulse coupled Neural Networks(IPcNN)model is proposed in this *** IPcNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPcNN on the gray images and natural images from the Matlab and Berkeley Segmentation *** IPcNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

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Determination of the standardized ileal digestible calcium requirement of Ross broilers from hatch to day 14 post-hatch

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Animal Nutrition 2024年第1期16卷 122-129页

作者： carrie l.Walk Raffaella Aureli Pauline Jenn DSM Nutritional Products Delves RoadHeanorDerbyshireDE757SGUnited Kingdom Research center for Animal Nutrition and Health DSM Nutritional ProductsVillage-Neuf68128France

An experiment was conducted to determine the standardized ileal digestible(SID)calcium requirement of fast-growing broilers from hatch to d 14 *** 308(n=360)male broilers were obtained on day of hatch and allocated to 1 of 5 treatments in battery *** were 6 birds per cage and 12 pens per *** treatments were formulated to contain 0.60%,0.46%,0.32%or 0.18%SID *** final treatment was formulated using total ca to meet or exceed all nutrient requirements,including 0.90%total ca and 0.49%non-phytate P(nPP),using the same *** treatment was the reference diet for comparison and validation of the SID ca *** and feed were weighed at placement and on d *** and ileal contents were obtained on d 14 and excreta was collected per pen and pooled on d *** were analyzed using JMP Pro and requirements were estimated using 3different non-linear regression *** the SID ca content in the diet from 0.18%to 0.60%improved(quadratic,Plity corrected feed conversion ratio(mFcR).The estimated SID ca requirement to optimize gain or m FcR was between 0.39%and 0.52%.Tibia ash percent and weight increased(quadratic,Pca content in the diet increased and the estimated SID ca requirement was between 0.32%and 0.58%.Phosphorus utilization was improved in birds fed diets formulated using SID ca compared with birds fed the reference *** conclusion,the SID ca requirement of fast-growing broilers from hatch to d 14 was estimated between 0.534%and 0.398%when quadratic,straight-broken line,or quadratic-broken line regressions were *** results agree with previously published data evaluating the SID ca requirement of fast-growth broilers from hatch to d 10.

关键词： Apparent ileal digestibility Digestible calcium Requirements Retention Tibia ash

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Assessment of portable FTIR and Raman spectroscopy for the detection of 2,3-dimethyl-2,3-dinitrobutane(DMDNB)in plastic explosives

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Defence Technology（防务技术） 2024年第4期34卷 11-18页

作者： Jacky cailes Robert Dunsmore Kathryn l.linge chemcentre PO Box 1250PerthAustralia

The Marplex convention was established to prevent the manufacture of unmarked plastic explosives and stipulates that a volatile detection agent must be added at the time of ***,to-date,laboratory testing remains the internationally accepted practice for identifying and quantifying the taggants stipulated in the *** this project,portable FTIR and Raman instruments were tested for their ability to detect 2,3-dimethyl-2,3-dinitrobutane(DMDNB),the chemical marker incorporated in plastic explosives that are manufactured within *** both FTIR and Raman instruments detected solid DMDNB(98%purity),field analysis of plastic explosives at an Australian Defence establishment showed that both FTIR and Raman spectra were matched the relevant explosive(RDX or PETN),rather than the DMDNB *** all three plastic explosives tested,the concentration of DMDNB was measured by SPME-Gc-MS to be between 1.8 and 2%,greater than the minimum 1%concentration stipulated by the Marplex *** testing with a plastic explosive analogue confirmed that the minor absorption peaks that would characterize low concentrations of DMDNB were masked by absorption bands from other compounds within the ***,while both FTIR and Raman spectroscopy are suitable for detection of plastic explosives,neither rely on the presence of DMDNB for *** is likely that similar results would be found for other taggants stipulated by the Marplex convention,given they are also present in concentrations less than 1%.

关键词： Explosive IcAO taggants 2,3-Dimethyl-2,3-dinitrobutane(DMDNB) Fourier transform infrared(FTIR) Raman

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cOVID-19 vaccination produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest l.Baker Helena Batatinha charles R.Pedlar Shane c.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona cancer center The University of ArizonaTucsonAZ 85719USA laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(cOVID-19).We sought to determine if cOVID-19 vaccination would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a cOVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-coV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of cD4+and cD8+naive T-cells,as well as cD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-coV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral cOVID-19 Exercise immunology SARS-coV-2 T-cells Vaccine

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Optimal control of Service Rates of Discrete-Time(s,Q)Queueing-Inventory Systems with Finite Buffer

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 261-280页

作者： l.Iniya B.Sivakumar G.Arivarignan School of Mathematics Madurai Kamaraj UniversityMaduraiTamilnaduIndia Department of Statistics Manonmaniam Sundaranar UniversityTirunelveliTamilnaduIndia

This article,we develop an optimal policy to control the service rate of a discrete time queueing-inventory system with finite *** customers arrive according to a Bernoulli process and the service time for the customers are *** the buffer size attains its maximum,any arriving new customers are considered to be *** customers are served one by one according to FcFS rule and each customers request random number of *** inventory is replenished according to a(s,Q)inventory policy with geometric lead *** main objectives of this article are to determine the service rates to be employed at each slot so that the long run expected cost rate is minimized for fixed inventory level and fixed buffer size and to minimize the expected waiting time for a fixed inventory level and fixed buffer *** problems are modelled as Markov decision *** establish the existence of a stationary policy and employ linear programming method to find the optimal service *** provide some numerical examples to illustrate the behaviour of the model.

关键词： Queueing-inventory system discrete time batch demand-Markov decision process

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Early Phases of Star Formation: Testing chemical Tools

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Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： N.c.Martinez S.Paron cONIcET-Universidad de Buenos Aires.Instituto de Astronomía y Física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

Star-forming processes strongly influence the ISM ***,many high-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve large samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing these tools such as the use of the HcN/HNc ratio as a thermometer,and the use of H^(13)cO^(+),Hc_(3)N,N_(2)H^(+) and c_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing massive young stellar objects at different evolutionary stages:infrared dark clouds(IRDcs),highmass protostellar objects(HMPOs),hot molecular cores(HMcs) and ultracompact H II *** found that the use of the HcN/HNc ratio as a universal thermometer in the ISM should be taken with care because the HcN optical depth is a big issue that can affect the ***,this tool should be utilized only after a careful analysis of the HcN spectrum,checking that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)cO^(+),Hc_(3)N,N_(2)H^(+) and c_(2)H could be useful to trace and distinguish regions among IRDcs,HMPOs and *** molecular line widths of these four species increase from the IRDc to the HMc stage,which can be a consequence of the gas dynamics related to the starforming processes taking place in the molecular *** results not only contribute with more statistics,acting as a probe of such chemical tools,useful to obtain information in large samples of sources,but also complement previous works through the analysis of other types of sources.

关键词： stars:formation ISM:molecules ISM:clouds

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Experimental clearance rate and intraguild predation of jellyfish cyanea nozakii

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Journal of Oceanology and limnology 2024年第1期42卷 128-140页

作者： Pengpeng WANG Fang ZHANG Song SUN Shuguo lÜ cAS Key laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China laboratory for Marine Ecology and Environmental Sciences Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of chinese Academy of Sciences Beijing 100049China Jiaozhou Bay Marine Ecosystem Research Station Chinese Academy of SciencesQingdao 266071China center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Institute of Marine Ecology and Environment Hainan Academy of Environmental SciencesHaikou 570100China

cyanea nozakii,a common jellyfish distributed in offshore china,has a complex trophic relationship with other zooplankton ***,few studies have reported the predation rates and prey selection patterns of *** medusae on different prey *** is also lacking on the intraguild predation of Aurelia coerulea(another common bloom jellyfish in offshore china)by *** address the knowledge gaps,the clearance rates of *** for different prey items,including copepods(smalllarge>1000μm),fish larvae,and gelatinous prey(hydromedusae,*** ephyrae,and chaetognaths),were *** influence of predator size on the clearance rate was also ***,we examined the intraguild predation of *** on *** *** clearance rates of *** varied widely with prey organisms,being independent of prey *** organisms,except for chaetognaths,were captured with considerably high efficiency,followed by fish larvae and copepods,indicating the preferential prey selection of gelatinous organisms by *** clearance rate increased linearly with the cross-sectional area of *** size in medusae may,to some extents,underpin their capacity to capture more prey by increasing the encounter rate and capture success through *** preyed voraciously on *** in high feeding efficiency,but the clearance rate decreased with increasing ***(as prey)*** phenomenon of intraguild predation suggests a speculative hypothesis of potential population regulation of *** by *** information regarding the feeding ecology of *** reported in this study is important for understanding plankton dynamics in marine ecosystems with extensive occurrences of this jellyfish.

关键词： Scyphomedusae predation rate gelatinous organisms prey selection feeding mechanism

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