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Peripheral.b.ood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin chen Jinghong Xu bin Jiang lei li Yawei li Yuliang Dai bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological.b.omarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TbCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory b cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral.b.ood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral.b.ood RNA profiles spinal cord injury

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile liang Kanghong Zhang Yuge Xu Gong chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Static and Dynamic Properties of Soil Food Web Structure in a Greenhouse Environment

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Pedosphere 2014年第2期24卷 258-270页

作者： chen Yun-Feng CAO Zhi-Ping l.POPESCU b.H.KIEPPER Institute of Plant Protection and Soil Fertilizer Hubei Academy of Agricultural Sciences College of Resources and Environmental Science China Agricultural University Department of biological and Agricultural Engineering University of Georgia

Soil food web structure is fundamental to ecosystem process and function; most studies on soil food web structure have focused on agro-ecosystems under different management practices and natural terrestrial ecosystems,but seldom on greenhouses. This study explored the static and temporal variability of soil food structure in two greenhouses of Shandong Province,North China over a two-year period. The static properties were measured directly by surveying functional group composition and a series of parameters portraying the species properties,link properties,chain properties and omnivory properties of the web,as well as indirectly through calculation of nematode indices,enrichment index(EI),structure index(SI),and channel index(CI). The dynamic variability of greenhouse soil food structure was described by the dynamics of functional groups,bray-Curtis(bC) similarity and cluster analysis. The results showed that the greenhouse soil food web contained 14 functional groups,with microbes having the highest mean biomass,followed by protozoa. Of the three functional groups of protozoa,flagellates were the dominant group on most sampling dates,amoebae only became the dominant group during the summer,while ciliates were the least prevalent group. All nematodes were assigned into one of the four functional groups,bacterivorous,fungivorous,herbivorous and omnivorous,and the fungivorous nematodes had the lowest mean biomass. Mites were assigned into three functional groups and the omnivorous noncryptostigmatic mites were the dominant group. All the functional groups showed significant seasonal changes. The soil food web connectance was 0.15,the maximum food chain length was 5,and the average food chain length was 3.6. The profiles of the EI and SI showed that the food web was resourcedepleted with minimal structure. The results of CI indicated that the bacterial decomposition pathway was the dominant pathway in the food web of the greenhouse soils studied and the results of bC

关键词： bray-Curtis similarity functional group mites nematodes protozoa

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin Zeng le Wang Wenwu Zhang Gang li Xing cheng Peiqiang Su Yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key l.b.ratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κb/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Non-coding RNAs and Their Roles in Stress Response in Plants

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Genomics, Proteomics & bioinformatics 2017年第5期15卷 301-312页

作者： jingjing wang xianwen meng oxana b.dobrovolskaya yuriy l.orlov ming chen Department of bioinformatics State Key l.b.ratory of Plant Physiology and biochemistry College of Life Sciences Zhejiang UniversityHangzhou 310058China James D.Watson Institute of Genome Sciences Zhejiang UniversityHangzhou 310058China Institute of Cytology and Genetics Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090 Russia

Eukaryotic genomes encode thousands of non-coding RNAs （ncRNAs）, which play cru- cial roles in transcriptional and post-transcriptional regulation of gene expression. Accumulating evidence indicates that ncRNAs, especially microRNAs （miRNAs） and long ncRNAs （lncRNAs）, have emerged as key regulatory molecules in plant stress responses. In this review, we have summa- rized the current progress on the understanding of plant miRNA and incRNA identification, characteristics, bioinformatics tools, and resources, and provided examples of mechanisms of miRNA- and lncRNA-mediated plant stress tolerance.

关键词： lncRNA miRNA Stress response RNA-directed DNAmethylation Small RNA

THE APPROXIMATION SOlUTIONS FOR HIGHER DIMENSIONAl INTEGRO-DIFFERENTIAl EQUATIONS

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Acta Mathematica Scientia 2019年第5期39卷 1309-1318页

作者： lüping chen School of Mathematical Sciences Xiamen University

This work deals with approximation solutions to a type of integro-differential equations in several complex variables. It concerns the Cauchy formula on higher dimensional domains. In our study, we make use of multiple power series expansions and an iterative computation method to solve a kind of integro-differential equation. We introduce a symmetrized topology product area which is called a bicylinder. We expand functions and derivatives of them to power series. Moreover we obtain unknown functions by comparing coefficients of the series on both sides of equations. We express the approximation solutions by a regular product of matrixes.

关键词： integro-differential equations polynomial approach Cauchy formula bicylinder

betti Numbers of locally Standard 2-Torus Manifolds

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Chinese Annals of Mathematics,Series b 2014年第4期35卷 599-606页

作者： Junda chen Zhi lü School of Mathematical Sciences Fudan University School of Mathematical Sciences and the Key l.b.ratory of Mathematics for Nonlinear Sciences of Ministry of Education Fudan University

let Mn be a smooth closed n-manifold with a locally standard （Z2）n-action. This paper deals with the relationship among the rood 2 betti numbers of Mn, the mod 2 betti numbers and the h-vector of the orbit space of ... 详细信息

关键词： locally standard 2-torus action Manifold with corners betti number

Photoelectrochemical Study of Passive Films on Sensitized Stainless Steel

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Journal of Materials Science & Technology 1996年第5期12卷 381-384页

作者： Du, Tb chen, SH Yang, MZ chen, l bEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

Passive films formed on sensitized stainless steel in sulphuric acid solutions have been studied using photoelectrochemical techniques. The results of the photocurrent measurement indicate that the passive films on sensitized stainless steel are characterised with n-type or p-type semiconductor in different potential regions. The difference in the photoelectrochemical.b.haviour can be interpreted assuming that the passive film is an iron-chromium oxide solid solution associated with various hydration degrees of the Cr(III)-oxides at various potentials.

关键词： Protective coatings

Rogue wave solutions and rogue-breather solutions to the focusing nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 33-41页

作者： Si-Jia chen Xing lü College of Science Tianjin University of TechnologyTianjin 300384People's Republic of China Department of Mathematics Beijing Jiaotong UniversityBeijing 100044People's Republic of China beijing l.b.ratory of National Economic Security Early-warning Engineering Beijing Jiaotong UniversityBeijing 100044People's Republic of China

based on the long wave limit method,the general form of the second-order and third-order rogue wave solutions to the focusing nonlinear Schr?dinger equation are given by introducing some arbitrary *** interaction solutions between the first-order rogue wave and one-breather wave are constructed by taking a long wave limit on the two-breather *** applying the same method to the three-breather solutions,two types of interaction solutions are obtained,namely the first-order rogue wave and two breather waves,the second-order rogue wave and one-breather wave,*** influence of the parameters related to the phase on the interaction phenomena is graphically *** occur among the rogue waves and breather *** the collisions,the shape of them remains *** abundant interaction phenomena in this paper will contribute to a better understanding of the propagation and control of nonlinear waves.

关键词： nonlinear Schrodinger equation rogue wave solutions interaction solutions