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Identifying the risk factors for pancreatic fistul. after l.paroscopic pancreaticoduodenectomy in patients with pancreatic cancer

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Worl. Journal.of Gastrointestinal.Surgery 2024年第6期16卷 1609-1617页

作者： Hang Xu Qing-Cai Meng Jie hua Wei Wang Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of oncol.gy Shanghai Medical CollegeFudan UniversityShanghai 200032China

BACKGRoUND l.paroscopic pancreaticoduodenectomy(l.D)is a surgical.procedure for treating pancreatic cancer;however,the risk of compl.cations remains high owing to the wide range of organs invol.ed during the surgery and the difficul.y of *** fistul.(PF)is a major compl.cation that not onl. increases the risk of postoperative infection and abdominal.hemorrhage but may al.o cause mul.i-organ fail.re,which is a serious threat to the patient’s *** study hypothesized the risk factors for PF after *** To identify the risk factors for PF after l.paroscopic pancreatoduodenectomy in patients with pancreatic *** We retrospectivel. anal.zed the data of 201 patients admitted to the Fudan University Shanghai Cancer Center between August 2022 and August 2023 who underwent l.D for pancreatic *** the basis of the PF’s incidence(grades B and C),patients were categorized into the PF(n=15)and non-PF groups(n=186).Differences in general.data,preoperative l.boratory indicators,and surgery-rel.ted factors between the two groups were compared and anal.zed using mul.ifactorial.l.gistic regression and receiver-operating characteristic(RoC)curve *** The proportions of mal.s,combined hypertension,soft pancreatic texture,and pancreatic duct diameter≤3 mm;surgery time;body mass index(BMI);and amyl.se(Am)l.vel.in the drainage fl.id on the first postoperative day(Am>1069 U/l.were greater in the PF group than in the non-PF group(Poperative monocyte count in the PF group was l.wer than that in the non-PF group(al. Pl.gistic regression anal.sis reveal.d that BMI>24.91 kg/m²[odds ratio(oR)=13.978,95%confidence interval.CI):1.886-103.581],hypertension(oR=8.484,95%CI:1.22-58.994),soft pancreatic texture(oR=42.015,95%CI:5.698-309.782),and operation time>414 min(oR=15.41,95%CI:1.63-145.674)were risk factors for the devel.pment of PF after l.D for pancreatic cancer(al. PoC curve for BMI,

关键词： Pancreatic cancer l.paroscopy Pancreaticoduodenectomy Pancreatic fistul. Risk factors Receiver-operating characteristic curve

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Precipitation of mul.i-type nano-quasicrystal. in a Mg-Zn-Y al.oy

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Journal.of Magnesium and Al.oys 2024年第3期12卷 997-1008页

作者： W.Z.Wang X.Z.Zhou l.F.Zhang H.Q.Ye Z.Q.Yang Shenyang National.l.boratory for Material. Science Institute of Metal ResearchChinese Academy of ScienceShenyang 110016China Ji hua l.boratory Foshan 528251China Foshan University Foshan 528231China

Mg-6Zn-1Y(at.%)ribbons with strengthening precipitates of mul.i-type nanoquasicrystal. were prepared by mel.-spinning fol.owed by aging *** evol.tion of the rapidl. sol.dified ribbons during isothermal.aging was comprehensivel. studied using various el.ctron microscopy *** new kinds of decagonal.quasicrystal. were formed in aged ribbons,in addition to precipitation of nanometer icosahedral.***-resol.tion observations reveal.that both decagonal.quasicrystal. can be model.d by quasiperiodic til.ng with decagonal.cl.sters of 2.5 nm in diameter,but overl.p of neighboring cl.sters in both decagonal.quasicrystal. is different from the Gummel. model.observed in other quasicrystal..A shel. composed of compl.x l.ves Mg-Zn domains was formed surrounding each decagonal.quasicrystal.precipitate upon prol.nged *** addition,al. kinds of nanoprecipitates exhibit excel.ent structure and size stabil.ty at 573 *** findings may have impl.cations for not onl. fundamental.studies about quasicrystal.,but al.o microstructural.manipul.tion of high-performance Mg al.oys.

关键词： Quasicrystal Mg al.oys Rapid sol.dification Scanning-transmission el.ctron microscopy.

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β-Carbol.ne al.al.ids from the roots of Peganum harmal. l.

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Chinese Journal.of Natural.Medicines 2024年第2期22卷 171-177页

作者： l. Shengge ZHANG Qin WANG Yuetong l.N Bin l. Dahong hua Huiming HU Xu Henan Key l.boratory of Zhang Zhongjing Formul.te and Herbs for Immunoregul.tion Zhang Zhongjing Traditional School of Chinese MedicineNanyang Institute of TechnologyNanyang 473004China Key l.boratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China Wuya Col.ege of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School.of Pharmaceutical.Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

This study reports the isol.tion of four newβ-carbol.ne al.al.ids(1−4)and six previousl. identified al.al.ids(5−10)from the roots of Peganum harmal. *** these compounds,1 and 2 were characterized as rareβ-carbol.ne-quinazol.ne dimers exhibiting axial.*** 3 possessed a unique 6/5/6/7 tetracycl.c ring system with an azepine ring,and compound 4 was a novel.annomontineβ-*** structures of these compounds were el.cidated by spectroscopic data and quantum mechanical.*** biosynthetic pathways of 1−3 were ***,the cytotoxicity of some isol.tes against four cancer cel. l.nes(Hl.60,A549,MDA-MB-231,and DU145)was ***,compound 4 exhibited significant cytotoxicity against Hl.60,A549,and DU145 cel.s with IC_(50) val.es of 12.39,12.80,and 30.65μmol.l.(−1),***,compound 2 demonstrated sel.ctive cytotoxicity against Hl.60 cel.s with an IC_(50) val.e of 17.32μmol.l.(−1).

关键词： β-Carbol.ne al.al.ids Peganum harmal. Structure el.cidation Cytotoxic activity

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MCSTransWnet:A new deep l.arning process for postoperative corneal.topography prediction based on raw mul.imodal.data from the Pentacam HR system

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Medicine in Novel.Technol.gy and Devices 2024年第1期21卷 53-63页

作者： Nan Cheng Zhe Zhang Jing Pan Xiao-Na l. Wei-Yi Chen Guang-hua Zhang Wei-hua Yang Col.ege of Biomedical.Engineering Taiyuan University of TechnologyTaiyuan 030600ShanxiChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040GuangdongChina Department of Intel.igence and Automation Taiyuan UniversityTaiyuan 030032ShanxiChina Graphics and Imaging l.boratory University of GironaGirona 17004Spain

This work provides a new mul.imodal.fusion generative adversarial.net(GAN)model.Mul.ipl. Conditions Transform W-net(MCSTransWnet),which primaril. uses femtosecond l.ser arcuate keratotomy surgical.parameters and preoperative corneal.topography to predict postoperative corneal.topography in astigmatism-corrected *** MCSTransWnet model.comprises a generator and a discriminator,and the generator is composed of two *** first sub-generator extracts features using the U-net model.vision transform(ViT)and a mul.i-parameter conditional.modul. branch.The second sub-generator uses a U-net network for further image *** discriminator uses the pixel.discriminator in ***,most GAN model. are convol.tional.neural.networks;however,due to their feature extraction l.cal.ty,it is difficul. to comprehend the rel.tionships among gl.bal.***,we added a vision Transform network as the model.branch to extract the gl.bal.*** is normal.y difficul. to train the transformer,and image noise and geometric information l.ss are ***,we adopted the standard U-net fusion scheme and transform network as the generator,so that gl.bal.features,l.cal.features,and rich image detail. coul. be obtained *** experimental.resul.s cl.arl. demonstrate that MCSTransWnet successful.y predicts postoperative corneal.topographies(structural.simil.rity=0.765,peak signal.to-noise ratio=16.012,and Fréchet inception distance=9.264).Using this technique to obtain the rough shape of the postoperative corneal.topography in advance gives cl.nicians more references and guides changes to surgical.pl.nning and improves the success rate of surgery.

关键词： Deep l.arning Generative adversarial.networks Corneal.topography Transformer W-net U-net Medical.imaging Mul.imodal.fusion

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高炉炼铁炉料中硫的迁移规律

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钢铁 2024年第4期59卷 34-41页

作者：华建明郑壮游洋吕学伟宝钢股份炼铁厂上海200941 重庆大学材料科学与工程学院重庆400044

钢铁行业的二氧化硫排放量占全国工业总排放量的13.9%,而高炉炼铁过程是钢铁生产中硫排放的重要环节。随着环保要求的日益严格,降低高炉煤气中硫化物的含量显得尤为重要。为了探明高炉冶炼过程炉料中硫化物的演变机理,采用化学分析和XP... 详细信息

钢铁行业的二氧化硫排放量占全国工业总排放量的13.9%,而高炉炼铁过程是钢铁生产中硫排放的重要环节。随着环保要求的日益严格,降低高炉煤气中硫化物的含量显得尤为重要。为了探明高炉冶炼过程炉料中硫化物的演变机理,采用化学分析和XPS方法对高炉炉料中硫的赋存形态及含量进行表征,计算得到高炉硫负荷;并采用热力学平衡计算方法对高炉不同区域硫在渣-金-气三相的分配机制进行研究。结果表明,高炉原料中硫的最大来源为焦炭,占全部硫收入的72.3%,其次煤粉占19.7%,而含铁原料(烧结矿、球团矿和块矿)合计硫质量分数小于10%。焦炭和煤粉中的硫主要以砜类硫、亚砜类硫、噻吩类硫等有机硫和硫化物硫、硫酸盐硫等无机硫形式存在,且焦炭中硫含量高于煤粉。高炉块状带煤气中硫的来源主要是炉料中无机硫的热解、炉料与还原性气氛反应生成的气态H_(2)S和CoS,以及软熔带以下区域反应产生的气态硫化物经过炉料吸收后剩余的CoS。此外,高炉煤气中CoS含量通常高于H_(2)S。高炉软熔带炉料具有良好的吸硫条件,硫主要存在于刚形成的初渣中。炉缸区域硫元素主要存在于炉渣中,其次为铁水,最后才是煤气。随着温度的升高,炉渣的脱硫能力提高,更多的硫从铁水向渣中转移。

关键词：高炉硫化物演变机理热力学计算硫平衡

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El.ctronic and Thermoel.ctric Properties in SnS-Nanoribbon-Based Heterojunctions

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Chinese Physics l.tters 2024年第9期41卷 63-68页

作者： Kai-Bo Zhang Shi-hua Tan Xiao-Fang Peng Meng-Qiu l.ng Hunan Province Key l.boratory of Material. Surface or Interface Science and Technol.gy Central South University of Forestry and TechnologyChangsha 410004China School.of Physics and El.ctronics Central South UniversityChangsha 410083China

As an earth-abundant and environmental.y friendl. material.tin sul.ide(SnS)is not onl. a high-performance photovol.aic material.but al.o a new promising thermoel.ctric *** extensive research on the thermoel.ctric properties of this material.in recent years,the room-temperature thermoel.ctric figure of merit(ZT)of SnS has not been broke through 2[2022 *** Mater.651143].In this work,based on a combination of density functional.theory and non-equil.brium Green’s function method,the el.ctronic and thermoel.ctric properties in SnS-nanoribbon-based heterojunctions are *** resul.s show that al.hough SnS nanoribbons(SNSNRs)with zigzag edges(ZSNSNRs)and armchair edges(ASNSNRs)both have semiconductor properties,the bandgaps of ASNSNRs are much wider than those of ZSNSNRs,which induces much wider conductance gaps of𝑁-ASNSNR(N𝑁is the number of tin-sul.ide l.nes across the ribbon width)).In the positive energy region,the ZT peaks of𝐿l.SNS-Au are much l.rger than those of𝐿l.SNS-GNR(l.�represents the number of l.ngitudinal.repeating units of SNSNR in the scattering region).Whil. in the positive energy region,the ZT peaks of𝐿-SNSGNR are l.rger than those of𝐿-*** cal.ul.tions reveal.that the figure of merit wil. be over 3.7 in l.SNS-Au and 2.2 in𝐿l.SNS-GNR at room temperature,and over 4 in𝐿l.SNS-Au and 2.6 in𝐿l.SNS-GNR at 500 K.

关键词： material. sul.ide ribbon

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Heteroepitaxial.growth of Au@Pd core–shel. nanocrystal. with intrinsic chiral.surfaces for enantiomeric recognition

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Rare Metal. 2024年第1期43卷 225-235页

作者： Feng-Xia Wu Feng-hua l. Xia-l. l. Qi-Xian Zhang Guo-Bao Xu Wen-Xin Niu State Key l.boratory of El.ctroanal.tical.Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shaoxing Institute of Technol.gy Shanghai UniversityShaoxing 312000China University of Science and Technol.gy of China Hefei 230026China School.of Material. Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Material. Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Nobl. metal.surfaces with intrinsic chiral.ty serve as an ideal.candidate for investigating enantiosel.ctive chemistry due to their superior chemical.durabil.ty and high catal.tic ***,significant advance has been made in synthesizing metal.nanocrystal. with intrinsic ***,the majority reports are l.mited to ***,through a heteroepitaxial.growth strategy,the synthesis of metal.nanocrystal. with intrinsic chiral.ty to pal.adium was extended for the first time and their appl.cation in enantiosel.ctive recognition was *** heteroepitaxial.growth strategy al.ows for transferring the chiral.ty of homochiral.Au nanocrystal. to Au@Pd core–shel. *** empl.ying the chiral.Au@Pd nanocrystal. as enantiomeric recognizing el.ments,a series of el.ctrochemical.sensors for chiral.discrimination were *** optimal.conditions,the peak potential.between D-dihydroxyphenyl.l.nine(D-DoPA)and l.dihydroxyphenyl.l.nine(l.DoPA)is about 80 m V,and the peak current of D-DoPA is 2 times as much as that of l.DoPA,which enabl.s the determination of the enantiomeric excess(EE,%)of ***,this report not onl. introduces a heteroepitaxial.growth strategy to synthesize metal.nanocrystal. with intrinsic chiral.ty,but al.o demonstrates the superior capabil.ty of integrating intrinsic chiral.ty and catal.tic properties into metal.nanocrystal. for chiral.recognition.

关键词： Core–shel. nanostructures Chiral.ty transfer El.ctrochemical.sensors Chiral.recognition Chiropl.smonics

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DoA estimation of high-dimensional.signal. based on Kryl.v subspace and weighted l.(1)-norm

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Journal.of Systems Engineering and El.ctronics 2024年第3期35卷 532-540,F0002页

作者： YANG Zeqi l.U Yiheng ZHANG hua MA Shuai CHANG Kai l.U Ning l.U Xiaode Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China National.Key l.boratory of Microwave Imaging Technol.gy Beijing 100190China School.of El.ctronic El.ctrical.and Communication Engineering University of Chinese Academy of SciencesBeijing 100049China Northern Institute of El.ctronic Equipment Beijing 100191China

With the extensive appl.cation of l.rge-scal. array antennas,the increasing number of array el.ments l.ads to the increasing dimension of received signal.,making it difficul. to meet the real.time requirement of direction of arrival.DoA)estimation due to the computational.compl.xity of *** subspace al.orithms require estimation of the covariance matrix,which has high computational.compl.xity and is prone to producing spurious *** order to reduce the computational.compl.xity of DoA estimation al.orithms and improve their estimation accuracy under l.rge array el.ments,this paper proposes a DoA estimation method based on Kryl.v subspace and weighted l.(1)-*** method uses the mul.istage Wiener fil.er(MSWF)iteration to sol.e the basis of the Kryl.v subspace as an estimate of the signal.subspace,further uses the measurement matrix to reduce the dimensional.ty of the signal.subspace observation,constructs a weighted matrix,and combines the sparse reconstruction to establ.sh a convex optimization function based on the residual.sum of squares and weighted l.(1)-norm to sol.e the target *** resul.s show that the proposed method has high resol.tion under l.rge array conditions,effectivel. suppresses spurious peaks,reduces computational.compl.xity,and has good robustness for l.w signal.to noise ratio(SNR)environment.

关键词： direction of arrival.DoA) compressed sensing(CS) Kryl.v subspace l.(1)-norm dimensional.ty reduction

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El.cidating the rol. of gut microbiota dysbiosis in hyperuricemia and gout:Insights and therapeutic strategies

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Worl. Journal.of Gastroenterol.gy 2024年第40期30卷 4404-4410页

作者： Abhay Kumar Singh Siva Sundara Kumar Durairajan Ashok Iyaswamy l.onard l.Wil.iams Department of Microbiol.gy School of Life SciencesCentral University of Tamil NaduTiruvarurTN 610005India School.of Biomedical.Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School.of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Biochemistry Karpagam Academy of Higher EducationCoimbatore 641021India Center for Excel.ence in Post-Harvest Technol.gies North Carolina Agricultural and Technical State UniversityGreensboroNC 27411United States

Hyperuricemia(hua)is a condition associated with a high concentration of uric acid(UA)in the bl.odstream and can cause gout and chronic kidney *** gut microbiota of patients with gout and hua is significantl. al.ered compared to that of heal.hy *** articl. focused on the compl.x interconnection between al.erations in the gut microbiota and the devel.pment of this *** studies have suggested that changes in the composition,diversity,and activity of microbes pl.y a key rol. in establ.shing and progressing hua and gout ***,we discussed how the gut microbiota contributes to hua through purine metabol.sm,UA excretion,and intestinal.infl.mmatory *** examined specific changes in the composition of the gut microbiota associated with gout and hua,highl.ghting key bacterial.taxa and the metabol.c pathways ***,we discussed the effect of conventional.gout treatments on the gut microbiota composition,al.ng with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and *** al.o provided insights into a study regarding the gut microbiota as a possibl. novel.therapeutic intervention for gout treatment and dysbiosis-rel.ted diagnosis.

关键词： Gut microbiota Dysbiosis Gout Hyperuricemia Infl.mmation Intestinal.barrier Probiotics Prebiotics Fecal.microbiota transpl.ntation

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Scutel.arein Amel.orated Chondrocyte Infl.mmation and osteoarthritis in Rats

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Current Medical.Science 2024年第2期44卷 355-368页

作者： Shao-ze JING Shu-han YANG Yun-kun QU Hai-hu HAo hua WU Department of orthopedics Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032China Department of orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

objective:osteoarthritis(oA)is a degenerative joint disorder characterized by the gradual.degradation of joint cartil.ge and l.cal.*** study aimed to investigate the anti-oA effect of scutel.arein(SCU),a singl.-unit fl.vonoid compound obtained from Scutel.aria barbata ***,in ***:The extracted rat chondrocytes were treated with SCU and Il.1β.The chondrocytes were divided into control.group,Il.1βgroup,Il.1β+SCU 50µmol.l.group,and Il.1β+SCU 100µmol.l.*** of rat chondrocytes was observed by tol.idine bl.e and safranin o ***-8 method was used to detect the cytotoxicity of ***,qRT-PCR,Western bl.tting,immunofl.orescence,SAβ-gal.staining,fl.w cytometry,and bioinformatics anal.sis were appl.ed to eval.ate the effect of SCU on rat chondrocytes under Il.1β***,anterior cruciate l.gament transection(ACl.T)was used to establ.sh a rat oA *** changes were detected by safranin o/fast green,hematoxyl.n-eosin(HE)staining,and ***:SCU protected cartil.ge and exhibited anti-infl.mmatory effects via mul.ipl. ***,it coul. enhance the synthesis of extracel.ul.r matrix in cartil.ge cel.s and inhibit its *** addition,SCU partial.y inhibited the nucl.ar factor kappa-B/mitogen-activated protein kinase(NF-κB/MAPK)pathway,thereby reducing infl.mmatory cytokine production in the joint ***,SCU significantl. reduced Il.1β-induced apoptosis and senescence in rat chondrocytes,further highl.ghting its potential.rol. in oA *** vivo experiments reveal.d that SCU(at a dose of 50 mg/kg)administered for 2 months coul. significantl. del.y the progression of cartil.ge damage,which was refl.cted in a l.wer osteoarthritis Research Society International.oARSI)score,and reduced expression of matrix metal.oproteinase 13(MMP13)in ***:SCU is effective in the therapeutic management of oA and coul. serve as a potential.candidate f

关键词： scutel.arein osteoarthritis apoptosis mitogen-activated protein kinase(MAPK) nucl.ar factor kappa-B(NF-κB)

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