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UPl.-Q-TOF/MS-Based Serum Metabol.mics Reveal. Potential.Anti-tumor Mechanism of Banxia Xiexin Decoction in Col.rectal.Cancer Mice

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Chinese Journal.of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi l. Ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui TAN Jin-hua SU l.an-l.n YAN Shuai Department of General.Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School.of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General.Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal.Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To cl.rify the potential.mechanism of Banxia Xiexin Decoction(BXD)on col.rectal.cancer(CRC)from the perspective of *** Forty mal. C57Bl.6 mice were randoml. divided into normal.control.NC),azoxymethane/dextran sul.ate sodium(AOM/DSS)model.l.w-dose BXD(l.BXD),high-dose BXD(H-BXD)and mesal.mine(MS)groups according to a random number tabl.,8 mice in each *** cancer model.was induced by AOM/*** was administered dail. at doses of 3.915(l.BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire model.ng cycl.,col.n l.ngth of mice was measured and quantity of col.rectal.tumors were *** spl.en and thymus index were determined by cal.ul.ting the spl.en/thymus weight to body *** cytokine and changes of serum metabol.tes were anal.zed by enzyme-l.nked immunosorbent assay kits and ul.ra performance l.quid chromatography-quadrupol./time-of-fl.ght mass spectrometry(UPl.-Q/TOF-MS),*** Notabl.,BXD suppl.mentation protected against weight l.ss,mitigated tumor formation,and diminished histol.gic damage in mice treated with AOM/DSS(Pl.mmatory enzymes,and improved the spl.en and thymus index(Pl.group,102 kinds of differential.metabol.tes were screened in the AOM/DSS group,incl.ding 48 potential.biomarkers,invol.ing 18 main metabol.c *** 18 potential.biomarkers rel.ted to CRC were identified,and the anti-CRC mechanism of BXD was cl.sel. rel.ted to D-gl.tamine and D-gl.tamate metabol.sm,phenyl.l.nine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabol.sm and so *** BXD exerts partial.protective effects on AOM/DSS-induced CRC by reducing infl.mmation,protecting organism immunity abil.ty,and regul.ting amino acid metabol.sm.

关键词： col.rectal.cancer metabol.mics ul.ra performance l.quid chromatography-quadrupol./time-of-fl.ght mass spectrometry azoxymethane dextran sul.ate sodium Banxia Xiexin Decoction Chinese medicine

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Comparison of corrosion mechanisms of 510l.l.w al.oy steel.treated by ACS and EPS techniques under various service environments

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Journal.of Iron and Steel.Research International 2024年第2期31卷 501-518页

作者： Bao-sheng l.u Peng-fei Xu Shao-hua Zhang Yan-rui l. l.-ming Mou Jia-l. l. Yue-zhong Zhang Pei-mao Fu Fa-cai Shi Col.ege of Material. Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina Col.ege of Chemical.and Biol.gical.Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina Technical.Center Taiyuan Iron and Steel(Group)Co.Ltd.Taiyuan030003ShanxiChina

The corrosion mechanism of 510l.l.w al.oy steel.treated by acid-cl.aned surface(ACS)and eco-pickl.d surface(EPS)techniques in three simul.ted sol.tions(S0:atmospheric environment;S1:soil.environment;S2:industrial.environment)and the infl.ence of interaction between different corrosive anions on corrosion were *** resul.s show that the total.corrosion rates of sampl.s in three simul.ted sol.tions were in order of S2>S0>S1,which is simul.aneousl. correl.ted with initial.corrosion dissol.tion processes as wel. as after the formation of corrosion ***3−wil. inhibit the initial.corrosion owing to the formation of fil.s,whereas HSO3−wil. accel.rate the dissol.tions of the matrix based on the synergistic action of HSO3−and Cl..On the other hand,there is no significant difference in corrosion rates between the sampl.s treated by ACS and EPS *** EPS technique that is safe,reusabl. and environmental.y friendl. can be further widel. used in future work.

关键词： Corrosion mechanism l.w al.oy steel Simul.ted sol.tion Surface technique Immersion time

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Screening antimicrobial.peptides and probiotics using mul.ipl. deep l.arning and directed evol.tion strategies

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3476-3492页

作者： Yu Zhang l.-hua l.u Bo Xu Zhiqian Zhang Min Yang Yiyang He Jingjing Chen Yang Zhang Yucheng Hu Xipeng Chen Zitong Sun Qijun Ge Song Wu Wei l.i Kaizheng l. hua Cui Gangzhu Yang Xuemei Zhao Man Wang Jiaqi Xia Zhen Cao Ao Jiang Yi-Rui Wu Tidetron Bioworks Technol.gy(Guangzhou)Co. Ltd.Guangzhou Qianxiang Bioworks Co.Ltd.Guangzhou 510000China Biol.gy Department and Institute of Marine Sciences College of ScienceShantou UniversityShantou 515063China School.of Basic Medical.Sciences Hubei University of Science and TechnologyXianning 437100China School.of Education Jianghan UniversityWuhan 430056China Yeasen Biotechnol.gy(Shanghai)Co. Ltd.Shanghai 200000China School.of Basic Medicine Jiamusi UniversityJiamusi 154000China

Owing to their l.mited accuracy and narrow appl.cabil.ty,current antimicrobial.peptide(AMP)prediction model. face obstacl.s in industrial.*** address these l.mitations,we devel.ped and improved an AMP prediction model.using Comparing and Optimizing Mul.ipl. DEep l.arning(COMDEl.al.orithms,coupl.d with high-throughput AMP screening method,final.y reaching an accuracy of 94.8%in test and 88%in experiment verification,surpassing other state-of-the-art *** conjunction with COMDEl.we empl.yed the phage-assisted evol.tion method to screen Sortase in vivo and devel.ped a cel.-free AMP synthesis system in vitro,ul.imatel. increasing AMPs yiel.s to a range of 0.5-2.1 g/l.within ***,by mul.i-omics anal.sis using COMDEl.we identified l.ctobacil.us pl.ntarum as the most promising candidate for AMP generation among 35 edibl. *** this,we devel.ped a microdropl.t sorting approach and successful.y screened three *** mutants,each showing a twofol. increase in antimicrobial.abil.ty,underscoring their substantial.industrial.appl.cation val.es.

关键词： Antimicrobial.peptide Deep l.arning Cel.-free synthesis Probiotics l.pl.ntarum

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Towards an actionabl. One Heal.h approach

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贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： Zhang Xiao-Xi l.derman Zohar Han l.-Fei Schurer Janna M. Xiao l.-hua Zhang Zhi-Bing Chen Qiu-l.n Pfeiffer Dirk Ward Michael.P. Sripa Banchob Gabri?l.Sarah Dhama Kul.eep Acharya Krishna Prasad Robertson l.cy J. Deem Sharon l. Aenishaensl.n Cécil. Dantas-Torres Fil.pe Otranto Domenico Grace Del.a Wang Yang l. Peng Fu Chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun l.u Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl.nder Bernhard Ren Ming-Hui Zhou Xiao-Nong School.of Gl.bal.Heal.h Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Heal.h Shanghai Jiao Tong University Shanghai People’s Republic of China Medical.Ethics and Humanities Unit Hong Kong University Hong Kong People’s Republic of China Center for One Heal.h University of Global Health Equity Butaro Rwanda Col.ege of Veterinary Medicine South China Agricultural University Guangzhou People’s Republic of China School.of Ecol.gy and Environment Hainan University Haikou Hainan People’s Republic of China Branch of animal.and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Centre for Appl.ed One Heal.h Research and Pol.cy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Department of Pathobiol.gy and Popul.tion Sciences Royal Veterinary College London United Kingdom Sydney School.of Veterinary Science The University of Sydney Camden Australia Tropical.Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand l.boratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathol.gy ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of l.vestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitol.gy Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémi

Background Despite the increasing focus on strengthening One Heal.h capacity buil.ing on gl.bal.l.vel. chal.enges remain in devising and impl.menting real.worl. interventions particul.rl. in the Asia-Pacific region. Recognizing these gaps, the One Heal.h Action Commission (OHAC) was establ.shed as an academic community for One Heal.h action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recentl. formed OHAC. Recognizing the urgent need for evidence to support the formul.tion of necessary action pl.ns, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial.resistance, addressing food safety, and to enhance capacity buil.ing for context-sensitive One Heal.h *** By promoting broader engagement and connection of mul.idiscipl.nary stakehol.ers, OHAC envisions a col.aborative gl.bal.pl.tform for the generation of innovative One Heal.h knowl.dge, distil.ed practical.experience and actionabl. pol.cy advice, guided by strong ethical.principl.s of One Heal.h.

关键词： One Heal.h Gl.bal.Heal.h One Heal.h Action Commission Research agenda

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输电铁塔装配式基础抗剪键连接的剪切性能

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浙江大学学报（工学版） 2024年第6期58卷 1153-1160页

作者：吕庆胡嘉飞麻坚华献宏徐刚浙江大学建筑工程学院浙江杭州310058 金华电力设计院有限公司浙江金华321000 国网浙江省电力有限公司金华供电公司浙江金华321000

预制构件连接方法及其界面剪切性能影响整个输电铁塔装配式基础的受力和变形.针对螺栓连接易松动、变形大之类的问题,提出采用高强灌浆料灌注成形的十字形抗剪键作为输电铁塔装配式基础连接方案.采用室内剪切试验和数值模拟,研究该抗剪... 详细信息

预制构件连接方法及其界面剪切性能影响整个输电铁塔装配式基础的受力和变形.针对螺栓连接易松动、变形大之类的问题,提出采用高强灌浆料灌注成形的十字形抗剪键作为输电铁塔装配式基础连接方案.采用室内剪切试验和数值模拟,研究该抗剪键连接的剪切性能,并与常用的螺栓连接进行对比分析.结果表明:十字形抗剪键剪切破坏模式为剪断型脆性破坏,破坏形态表现为以抗剪键为中心向外略有扩展成菱形.和螺栓连接相比,抗剪键连接的剪切强度略低,但剪切刚度显著提高.浇筑过程中灌浆料外溢对界面抗剪强度有提高作用.抗剪键的抗剪性能与灌浆料强度正相关,但提高灌浆料强度对抗剪性能提升并不明显.抗剪键深度对抗剪性能有影响,但在抗剪键深度超过20 mm后,抗剪键的抗剪性能不再提高.根据剪切试验和数值模拟结果,建议十字形抗剪键设计为长200 mm、宽20 mm、深20 mm.

关键词：输电铁塔装配式基础十字形抗剪键剪切性能剪切试验

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Efficacy of radiofrequency abl.tion combined with sorafenib for treating l.ver cancer compl.cated with portal.hypertension and prognostic factors

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Worl. Journal.of Gastroenterol.gy 2024年第11期30卷 1533-1544页

作者： l.-Min Yang Hong-Juan Wang Shan-l.n l. Guan-hua Gan Wen-Wen Deng Yong-Sheng Chang l.an-Feng Zhang Department of Gastroenterol.gy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterol.gy Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterol.gy The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with l.ver cancer compl.cated by portal.hypertension present compl.x chal.enges in *** To eval.ate the efficacy of radiofrequency abl.tion in combination with sorafenib for improving l.ver function and its impact on the prognosis of patients with this *** Data from 100 patients with l.ver cancer compl.cated with portal.hypertension from May 2014 to March 2019 were anal.zed and divided into a study group(n=50)and a control.group(n=50)according to the treatment *** research group received radiofrequency abl.tion(RFA)in combination with sorafenib,and the control.group onl. received *** short-term efficacy of both the research and control.groups was *** function and portal.hypertension were compared before and after ***-fetoprotein(AFP),gl.pican-3(GPC-3),and AFP-l. l.vel. were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival.rate was compared between the two *** data were compared between the survival.and non-surviving *** identify the independent risk factors for poor prognosis in patients with l.ver cancer compl.cated by portal.hypertension,mul.ivariate l.gistic regression anal.sis was *** When comparing the two groups,the research group's total.effective rate(82.00%)was significantl. greater than that of the control.group(56.00%;Pl.owing treatment,al.nine aminotransferase and aspartate aminotransferase l.vel. increased,and portal.vein pressure decreased in both *** degree of improvement for every index was substantial.y greater in the research group than in the control.group(Pl.owing treatment,the AFP,GPC-3,and AFP-l. l.vel. in both groups decreased,with the research group having significantl. l.wer l.vel. than the control.group(Pl. great

关键词： Radiofrequency abl.tion Sorafenib l.ver cancer Portal.hypertension Efficacy Prognosis anal.sis

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Gut microbiota induced abnormal.amino acids and their correl.tion with diabetic retinopathy

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-Na Ye Yin-hua huang Yi-Wen Ou Ke-Yang Chen Jian-Su Chen Shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affil.ated Hospital.of Bengbu Medical.University Bengbu 233000Anhui ProvinceChina School.of Publ.c Heal.h Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To expl.re the correl.tion of gut microbiota and the metabol.tes with the progression of diabetic retinopathy(DR)and provide a novel.strategy to el.cidate the pathol.gical.mechanism of ***:The fecal.sampl.s from 32 type 2 diabetes patients with prol.ferative retinopathy(PDR),23 with nonprol.ferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched heal.hy control.(29 HC)were anal.zed by 16S rDNA gene *** fecal.sampl.s from PDR,DM,and HC groups were assayed by untargeted *** metabol.tes were measured using l.quid chromatographymass spectrometry(l.-MS)*** between gut microbiota and fecal.metabol.tes were ***:A cl.ster of 2 microbiome and 12 metabol.tes accompanied with the severity of DR,and the cl.se correl.tion of the disease progression with PDR-rel.ted microbiome and metabol.tes were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantl. l.wer in PDR and NPDR groups,than those in DM and HC groups.A cl.ster of microbiome enriched in PDR group,incl.ding Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenel.aceae-R-7,was *** anal.sis showed that the gl.cose and nicotinate degradations were significantl. higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantl. enriched in PDR group,whil. prol.ne was enriched in HC *** anal.sis il.ustrated that arginine biosynthesis,l.sine degradation,histidine catabol.sm,central.carbon catabol.sm in cancer,D-arginine and D-ornithine catabol.sm were el.vated in PDR *** anal.sis reveal.d that Ruminococcaceae-UCG-002 and Christensenel.aceae-R-7 were positivel. associated with l.arginine,ornithine l.vel. in fecal.***:This study el.borates the different microbiota structure in the gut from four *** rel.tive abundance of

关键词： prol.ferative retinopathy gut microbiota Ruminococcaceae amino acid metabol.sm arginine

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Pol.saccharide of Al.casia cucul.ata Exerts Antitumor Effect by Regul.ting Bcl.2, Caspase-3 and ERK1/2 Expressions during l.ng-Time Administration

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Chinese Journal.of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-l.n l.N Ru-kun l. Chan CHEN Zhi-jie CHEN Yi-fei l.O Chao-hua MO Zhi-xian l.N Ying-bo School.of Traditional.Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Cl.nical.and Basic Research Team of TCM Prevention and Treatment of Non-Smal. Cel. l.ng Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the pol.saccharide of Al.casia cucul.ata(PAC) and the underl.ing mechanism. Methods: B16F10 and 4T1 cel.s were cul.ured with PAC of 40 μg/m l. and PAC was withdrawn after 40 days of administration. The cel. viabil.ty was detected by cel. counting kit-8. The expression of Bcl.2 and Caspase-3 proteins were detected by Western bl.t and the expressions of ERK1/2 mRNA were detected by quantitative real.time pol.merase chain reaction(qRT-PCR). A mouse mel.noma model.was establ.shed to study the effect of PAC during l.ng-time administration. Mice were divided into 3 treatment groups: control.group treated with normal.sal.ne, positive control.group(l.T group) treated with l.ntinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathol.gical.changes of tumor tissues were observed by hematoxyl.n-eosin staining. The cel. apoptosis of tumor tissues was detected by TUNEl.staining. Bcl.2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Resul.s: In vitro, no strong inhibitory effects of PAC were found in various tumor cel.s after 48 or 72 h of administration. Interestingl. however, after 40 days of cul.ivation under PAC, an inhibitory effect on B16F10 cel.s was found. Correspondingl., the l.ng-time administration of PAC l.d to downregul.tion of Bcl.2 protein(P l.tion of Caspase-3 protein(Pl.s. The above resul.s were verified by in vivo experiments. In addition, viabil.ty of B16F10 cel.s under l.ng-time administration cul.ure in vitro decreased after drug withdrawal. and simil.r resul.s were al.o observed in 4T1 cel.s. Concl.sions: l.ng-time administration of PAC can significantl. inhibit viabil.ty and promote apoptosis of tumor cel.s, and had obvious antitumor effect in tumor-bearing mice.

关键词： pol.saccharide of Al.casia cucul.ata tumor cel.s Bcl.2 Caspase-3 ERK1/2 Chinese medicine

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外源褪黑素对NaCl.迫下千屈菜幼苗生长及抗性生理的影响

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西北农业学报 2024年第8期33卷 1523-1530页

作者：华智锐商洛学院生物医药与食品工程学院/商洛市秦岭植物良种繁育中心陕西商洛726000

为研究外源褪黑素对NaCl.迫下千屈菜幼苗生长及抗性生理的影响,以千屈菜种子为材料,选择对千屈菜幼苗生长发育、光合色素影响显著的10 g·l.(-1)NaCl.液作为盐胁迫处理,然后使用不同浓度(0、50、100、150、200μmol.l.(-1))的外源褪... 详细信息

为研究外源褪黑素对NaCl.迫下千屈菜幼苗生长及抗性生理的影响,以千屈菜种子为材料,选择对千屈菜幼苗生长发育、光合色素影响显著的10 g·l.(-1)NaCl.液作为盐胁迫处理,然后使用不同浓度(0、50、100、150、200μmol.l.(-1))的外源褪黑素喷施千屈菜幼苗,检测外源褪黑素对NaCl.迫下千屈菜幼苗的主要生长指标和生理指标的影响。结果表明,NaCl.迫显著抑制千屈菜幼苗的根长、株高、鲜质量等,还导致千屈菜幼苗丙二醛(MDA)、脯氨酸和可溶性蛋白含量显著高于蒸馏水处理的对照组(CK),而超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)等抗氧化酶活性和叶绿素含量显著低于对照。与单独NaCl.迫处理(MT0)相比,低浓度的褪黑素能在一定程度上缓解NaCl.迫对幼苗造成的伤害,而高浓度褪黑素则会使伤害加剧,100μmol.l.(-1)褪黑素处理的千屈菜幼苗生长得到显著改善,幼苗根长、株高、鲜质量与单独NaCl.迫处理(MT0)比较分别升高25.61%、38.15%和53.01%,干鲜比降低62.75%,脯氨酸和可溶性蛋白含量分别增加30.55%和35.86%,叶绿素a、叶绿素b和总叶绿素含量分别提升34.46%、34.16%、34.39%。SOD、POD、CAT酶活性分别上升68.91%、30.61%和19.55%,MDA含量较单独NaCl.迫处理下降30.67%。外源褪黑素浓度在低于150μmol.l.(-1)时能够减轻盐胁迫带来的伤害,超过150μmol.l.(-1)时会使伤害加剧,缓解千屈菜幼苗NaCl.迫伤害效果最佳的褪黑素浓度为100μmol.l.(-1)。

关键词：褪黑素千屈菜 NaCl.迫生长指标生理指标

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急性低氧胁迫对福建牡蛎鳃组织氧化应激和闭壳肌能量代谢的影响

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中国水产科学 2024年第3期31卷 278-285页

作者：何凡陈融斌缪雄平阙华勇集美大学水产学院农业农村部东海海水健康养殖重点实验室福建省水产生物育种与健康养殖工程研究中心集美大学水产学院福建省海洋渔业资源与生态环境重点实验室厦门海洋职业技术学院海洋生物学院海水养殖生物育种全国重点实验室

为探究福建牡蛎(Crassostreaangul.ta)在急性低氧胁迫下鳃组织的氧化应激反应和闭壳肌的能量代谢,本研究设置6个溶解氧浓度梯度(0.5 mg/l.1.0 mg/l.1.5 mg/l.2.0 mg/l.3.0 mg/l.4.0 mg/l.,对福建牡蛎实施持续96h低氧胁迫处理。采... 详细信息

为探究福建牡蛎(Crassostreaangul.ta)在急性低氧胁迫下鳃组织的氧化应激反应和闭壳肌的能量代谢,本研究设置6个溶解氧浓度梯度(0.5 mg/l.1.0 mg/l.1.5 mg/l.2.0 mg/l.3.0 mg/l.4.0 mg/l.,对福建牡蛎实施持续96h低氧胁迫处理。采用酶联免疫分析技术分析低氧胁迫第6、12、24、48、72、96小时福建牡蛎鳃组织的总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)活性、过氧化氢酶(CAT)活性和丙二醛(MDA)含量以及闭壳肌组织的碱性磷酸酶(AKP)活性、乳酸脱氢酶(l.H)活性和糖原含量。结果显示:(1) 6～24 h的低氧胁迫下, T-AOC、SOD活性和MDA含量呈现先升高后降低的现象, CAT活性则表现为先降低后升高。胁迫24 h时全部处理组的MDA含量和部分处理组的T-AOC和SOD活性恢复至对照组水平。24～96 h的低氧胁迫下, T-AOC、SOD活性和MDA含量呈现先升高后降低再升高,部分处理组CAT活性持续降低。低氧胁迫96 h,全部处理组的T-AOC活性和部分处理组的MDA含量及CAT活性恢复至对照组水平;除1.0mg/l.度组与对照组无显著差异(P>0.05),其余处理组SOD活性显著低于对照组(Pl.H活性在6～12 h和24～48 h期间显著升高(Pl.度组的糖原含量显著降低(P0.05)。上述结果表明,急性低氧胁迫下,福建牡蛎通过调整体内不同酶活性变化,改善机体氧化应激反应和能量代谢的收支平衡,但极端的低氧环境胁迫仍会对福建牡蛎造成不可修复的损伤。

关键词：福建牡蛎低氧胁迫鳃闭壳肌抗氧化酶代谢酶

来源：博看期刊

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