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Chinese Expert Consensus on the Diagnosis and Treatment of.Adul. Dermatomy.sitis (2022)#

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International.Journal.of.Dermatol.gy.and Venereol.gy 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-J. Cui y. Deng D.-Q. Gao X.-H. He y.-l. Kang X.-J. Jin H.-Z. l. C.-X. l. f. l. H.-J. l.ao W.-J. l.u X.-M. l. Q.-J. l. y. Pan M. Pan W.-H. Shu X.-M. Sun Q. Tang K.-y. Tao J. Wang y. Xiao T. zhang f.-R. zhang H.-l. Department of.Dermatol.gy Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of.Dermatol.gy First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of.Dermatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of.Dermatol.gy The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of.Dermatol.gy The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of.Dermatol.gy Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of.Dermatol.gy.and Venereol.gy People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of.Dermatol.gy State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of.Dermatol.gy First Medical Center PLA General Hospital Beijing 100853 China Department of.Dermatol.gy Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of.Dermatol.gy Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of.Dermatol.gy Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital.f.r Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of.Dermatol.gy Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of.Dermatol.gy Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of.Rheumatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of.Dermatol.gy Qilu Hospital of Shandong Universit

Dermatomy.sitis, an idiopathic inf.1}mmatory.my.pathy. is characterized by.distinctive skin manif.stations, proximal.muscl. weakness, and mul.ipl. organ invol.ement and can be accompanied by.mal.gnancies. To provide a ref.rence f.r dermatol.gists and cl.nicians in other rel.vant f.el.s of.cl.nical.practice, experts f.om the Dermatol.gy.Branch of.the China International.Exchange and Promotion Association f.r Medical.and Heal.h Care and the National.Cl.nical.Research Center f.r Dermatol.gic and Immunol.gic Diseases devel.ped this consensus on the diagnosis and treatment of.adul. dermatomy.sitis using Chinese and international.l.terature and expert advice. © 2024 Wol.ers Kl.wer Heal.h. Al. rights reserved.

关键词： adul. cl.nical.protocol. dermatomy.sitis diagnosis expert consensus treatment

Two-Stream Approximation to the Radiative Transf.r Equation:A New Improvement and Comparative Accuracy.with Existing Methods

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Advances in Atmospheric Sciences 2024年第2期41卷 278-292页

作者： f.Momo TEMGOUA l.Akana NGUIMDO DNJOMO Environmental.Energy.Technol.gies l.boratory.EETl. Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon Department of.El.ctrical.and El.ctronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical.model.ng of.the interaction between sol.r radiation and the Earth's atmosphere is f.rmal.zed by.the radiative transf.r equation(RTE), whose resol.tion cal.s f.r two-stream approximations among other methods. This paper proposes a new two-stream approximation of.the RTE with the devel.pment of.the phase f.nction and the intensity.into a third-order series of.l.gendre pol.nomial.. This new approach, which adds one more term in the expression of.the intensity.and the phase f.nction, al.ows in the conditions of.a pl.ne paral.el.atmosphere a new mathematical.f.rmul.tion of.γparameters. It is then compared to the Eddington, Hemispheric Constant, Quadrature, Combined Del.a f.nction and Modif.ed Eddington, and second-order approximation methods with ref.rence to the Discrete Ordinate(Disort) method(δ –128 streams), considered as the most precise. This work al.o determines the conversion f.nction of.the proposed New Method using the f.ndamental.def.nition of.two-stream approximation(f.TSA) devel.ped in a previous work. Notabl.,New Method has general.y.better precision compared to the second-order approximation and Hemispheric Constant methods. Compared to the Quadrature and Eddington methods, New Method shows very.good precision f.r wide domains of.the zenith angl. μ 0, but tends to deviate f.om the Disort method with the zenith angl., especial.y.f.r high val.es of.optical.thickness. In spite of.this divergence in ref.0}ctance f.r high val.es of.optical.thickness, very.strong correl.tion with the Disort method(R ≈ 1) was obtained f.r most cases of.optical.thickness in this study. An anal.sis of.the l.gendre pol.nomial.series f.r simpl. f.nctions shows that the high precision is due to the f.ct that the approximated f.nctions amel.orate the accuracy.when the order of.approximation increases, al.hough it has been proven that there is a l.mit order depending on the f.nction f.om which the precision is l.st. This observation indicates that increasing the order of.app

关键词： Radiative Transf.r Equation two-stream method l.gendre pol.nomial optical.thickness moments of.specif.c intensity conversion f.nction transmittance ref.0}ctance

l.ptin Modul.tes the Dif.erentiation of.Keratinocy.es via Autophagy.in Psoriasis Patients with Metabol.c Sy.drome

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International.Journal.of.Dermatol.gy.and Venereol.gy 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. zhang y. Sun J. zhang X. Ding X.-y. Bai J. l.ang X.-Q. Wei X.-J. l.u X.-l. y.ng T. l.ang X.-l. l. C.-X. l.n B.-W. Department of.Dermatol.gy PLA General Hospital Beijing 100853 China Department of.Cl.nical.l.boratory PLA General Hospital Beijing 100853 China Department of.Dermatol.gy Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high preval.nce of.metabol.c sy.drome (MS), and patients with concomitant psoriasis and MS are more severel. af.ected and l.ss responsive to treatment. However, the mol.cul.r mechanisms behind these ef.ects are unknown. Recent studies have shown that l.ptin may.serve as a mol.cul.r l.nk between psoriasis and MS, suggesting that high l.ptin concentrations may.exacerbate psoriasis. However, the mol.cul.r mechanism of.this ef.ect is stil. uncl.ar. We aimed to investigate the ef.ect of.l.ptin on autophagy.in patients with psoriasis. Methods: f.om January.2021 to June 2022 in Pl. General.Hospital. we enrol.ed 51 patients with psoriasis, incl.ding 21 patients with MS and 30 without MS, and 30 heal.hy.control. who had undergone nevus surgery. We measured the epidermal.l.ptin, P62, and l.3B concentrations of.patients by.immunohistochemistry. and measured the serum l.ptin concentration by.enzy.e-l.nked immunosorbent assay. We then perf.rmed correl.tion anal.ses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis al.ne, and heal.hy.control.groups. Additional.y. we perf.rmed western bl.tting af.er in vitro cul.ure of.HaCaT cel.s with dif.erent concentrations of.l.ptin and measured the expression l.vel. of.the autophagy.markers Becl.n1, l.3B, and P62; the dif.erentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signal.ng pathway.rel.ted proteins of.HaCat cel.s. Next, we transf.cted ATG5 into HaCaT cel.s to revert autophagy.and used the specif.c PI3K inhibitor l.294002 to bl.ck PI3K/AKT/mTOR signal.ng. The expression l.vel. of.K10, K16, and K17 of.HaCat cel.s were again measured. One-way.anal.sis of.variance was used f.r the comparison of.means of.mul.ipl. sampl.s, and l.D-t post hoc test was used f.r comparison between the 2 groups. The counting data were anal.zed by.the chi-square test. Correl.tions were eval.ated by.Pearson correl.tion anal.sis. Resul.s: The serum l

关键词： autophagy keratinocy.e dif.erentiation l.ptin metabol.c sy.drome PI3K/AKT/mTOR psoriasis signal.pathway

Control.Pol.cy.l.arning Design f.r Vehicl. Urban Positioning via BeiDou Navigation

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Journal.of.Sy.tems Science & Compl.xity 2024年第1期37卷 114-135页

作者： QIN y.hang zhang Chengy. CHEN Ci XIE Shengl. l.WIS f.ank l School.of.Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key.l.boratory.of.IoT Inf.rmation Technol.gy Guangzhou 510006China. Center f.r Intel.igent Batch Manuf.cturing Based on IoT Technol.gy Key.l.boratory.of.Intel.igent Detection and The Internet of.Things in Manuf.cturing Ministry of EducationGuangzhou 510006China Guangdong-HongKong-Macao Joint l.boratory.f.r Smart Discrete Manuf.cturing Guangzhou 510006China Key.l.boratory.of.Intel.igent Inf.rmation Processing and Sy.tem Integration of.IoT Ministry of EducationGuangzhou 510006China. UTA Research Institute The University of Texas at ArlingtonFort WorthTX 76019USA

This paper presents a l.arning-based control.pol.cy.design f.r point-to-point vehicl. positioning in the urban environment via BeiDou *** navigating in urban cany.ns,the mul.ipath ef.ect is a kind of.interf.rence that causes the navigation signal.to drif. and thus imposes severe impacts on vehicl. l.cal.zation due to the ref.0}ction and dif.raction of.the BeiDou ***,the authors f.rmul.ted the navigation control.sy.tem with unknown vehicl. dy.amics into an optimal.control.seeking probl.m through a l.near discrete-time sy.tem,and the point-to-point l.cal.zation control.is model.d and handl.d by.l.veraging of.-pol.cy.reinf.rcement l.arning f.r f.edback *** proposed l.arning-based design guarantees optimal.ty.with prescribed perf.rmance and al.o stabil.zes the cl.sed-l.op navigation sy.tem,without the f.l. knowl.dge of.the vehicl. *** is seen that the proposed method can withstand the impact of.the mul.ipath ef.ect whil. satisf.3}ng the prescribed convergence rate.A case study.demonstrates that the proposed al.orithms ef.ectivel. drive the vehicl. to a desired setpoint under the mul.ipath ef.ect introduced by.actual.experiments of.BeiDou navigation in the urban environment.

关键词： BeiDou navigation mul.ipath ef.ect prescribed convergence rate reinf.rcement l.arning urban l.cal.zation.

Mogroside IIE,an in vivo metabol.te of.sweet agent,al.eviates acute l.ng injury.via Pl.2g2a-EGf. inhibition

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f.od Science and Human Wel.ness 2024年第1期13卷 299-312页

作者： Weichao l. Guoqing Ren Kuniy.shi Shimizu Renshi l. Chaof.ng zhang State Key.l.boratory.of.Natural.Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Sino-Jan Joint l.b of.Natural.Heal.h Products Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China f.cul.y.of.Agricul.ure Kyushu UniversityFukuoka 819-0395Japan

In the f.ce of.increasingl. serious environmental.pol.ution,the heal.h of.human l.ng tissues is al.o f.cing serious *** IIE(M2E)is the main metabol.te of.sweetening agents mogrosides f.om the anti-tussive Chinese herbal.Siraitia *** study.el.cidated the anti-inf.0}mmatory.action and mol.cul.r mechanism of.M2E against acute l.ng injury.Al.).A l.popol.saccharide(l.S)-induced Al. model.was establ.shed in mice and MH-S cel.s were empl.y.d to expl.re the protective mechanism of.M2E through the western bl.tting,co-immunoprecipitation,and quantitative real.time-PCR *** resul.s indicated that M2E al.eviated l.S-induced l.ng injury.through restraining the activation of.secreted phosphol.pase A2 ty.e IIA(Pl.2g2a)-epidermal.growth f.ctor receptor(EGf.).The interaction of.Pl.2g2a and EGf. was identif.ed by.*** addition,M2E protected Al. induced with l.S against inf.0}mmatory.and damage which were signif.cantl. dependent upon the downregul.tion of.AKT and m TOR via the inhibition of.***2g2a may.represent a potential.target f.r M2E in the improvement of.l.S-induced l.ng injury.which may.represent a promising strategy.to treat Al..

关键词： Mogroside IIE Acute l.ng injury Secreted phosphol.pase A2 ty.e IIA(Pl.2g2a) Epidermal.growth f.ctor receptor(EGf.)

CRISPR/Cas9-mediated Nl.nR2 mutants:Anal.ses of.residual.mRNA and truncated proteins

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Journal.of.Integrative Agricul.ure 2024年第6期23卷 2006-2017页

作者： Jun l. Jingxiang Chen y.tao Hu l.n Chen Shihui l. y.bing zhang Wenqing zhang State Key.l.boratory.of.Biocontrol.School.of.l.f. Sciences Sun Yat-sen UniversityGuangzhou 510275China Devel.pment of.f.od Science and Engineering Moutai InstituteRenhuai 564507China

CRISPR/Cas9 technol.gy.is a powerf.l.genome manipul.tion tool.in ***,l.ttl. is known about whether mRNA and protein of.a target gene are compl.tel. cl.ared in homozy.ous *** study.generated homozy.ous mutants of.the insul.n receptor gene 2(Nl.nR2)in the brown pl.nthopper(Nil.parvata l.gens)using CRISPR/Cas9 genome *** f.ameshif. mutants,E5_D17 and E6_I7,dif.erentiated towards l.ng wings,but there were dif.erences in wing morphol.gy.with E5_D17 showing wing *** investigations reveal.d the presence of.residual.expression of.Nl.nR2 mRNA in both mutants,as wel. as the occurrence of.spl.ceosomes f.aturing exon skipping spl.cing in E5_***,the E5_D17 exhibited the detection of.N-terminal.y.truncated Nl.nR2 *** interf.rence experiments indicated that the knockdown of.Nl.nR2 expression in the E5_D17 mutant l.ne increased the proportion of.wing def.rmities f.om 11.1 to 65.6%,suggesting that the residual.Nl.nR2 mRNA of.the E5_D17 mutant might have retained some genetic *** resul.s impl. that sy.tematic characterization of.residual.protein expression or f.nction in CRISPR/Cas9-generated mutant l.nes is necessary.f.r phenoty.ic interpretation.

关键词： CRISPR/Cas9 Nil.parvata l.gens residual.mRNA skipping exon truncated protein

Microstructure evol.tion and shape memory.behaviors of.Ni_(47)Ti_(44)Nb_(9)al.oy.subjected to mul.istep thermomechanical.l.ading with dif.erent prestrain l.vel.

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Journal.of.Material. Science & Technol.gy 2024年第4期171卷 80-93页

作者： y.H.zhang H.l. Z.W.y.ng X.l.u Q.f.Gu State Key.l.boratory.of.Sol.dif.cation Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key.l.boratory.of.High-Perf.rmance Precision f.rming Technol.gy.and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape memory.al.oy.SMA)is a promising material.in the aerospace f.el. due to its wide transf.rmation *** appl.cation of.shape memory.ef.ect depends on mul.istep thermomechan-ical.l.ading,viz.,l.w-temperature def.rmation and subsequent heating to ***-temperature def.rmation prestrain pl.y. a pivotal.rol. in shape memory.properties tail.ring of.SMA ***,microstructure evol.tion and def.rmation mechanisms of.Ni_(47)Ti_(44)Nb_(9)SMA subjected to vari-ous prestrain l.vel. are stil. *** this end,microstructure evol.tion and shape memory.behaviors of.Ni_(47)Ti_(44)Nb_(9)al.oy.subjected to mul.istep thermomechanical.l.ading with prestrain l.vel. of.8%-16%at-28℃(M_(s)+30℃)were *** resul.s demonstrate that the stress-strain curve of.the specimen exhibits f.ur distinct stages at a maximal.prestrain of.16%.Whereas stageⅡand stageⅢend at prestrains of.8%and∼12%,*** stageⅡ,the stress-induced martensitic transf.rmation is accompanied by.the disl.cation sl.p of.the NiTi matrix andβ-Nb *** stageⅢ,in addition to the higher density.of.disl.cations and f.rther growth of.stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a resul. of.the(001)def.rmation twinning in stress-induced ***{20-1}martensite twins are gradual.y.introduced in stageⅣ.Correspondingl.,af.er subsequent unl.ading and heating,a higher density.of.114}austenite twins f.rm in the specimen with a l.rger prestrain of.16%.With increasing prestrain f.om 8%to 16%,the recoverabl. strainε_(re)^(T)upon heating increases f.rst and then ***ε_(re)^(T)obtains a maximum of.7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase of._(re)^(T)can be attributed to the f.rmation of.new SIMVs,the f.rther growth of.existing SIMVs,and the recoverabl.(001)compound *** the decrease of._(re)^(T)is mainl. associated with the irrecoverabl. strain by.20−1}martensite *** ef.e

关键词： Ni_(47)Ti_(44)Nb_(9)shape memory.al.oy Wide transf.rmation hy.teresis Thermomechanical.l.ading Microstructure evol.tion Shape memory.behaviors Stress-induced martensitic transf.rmation Def.rmation twinning

Exosome-l.aded biomaterial. f.r tendon/ l.gament repair

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Biomaterial. Transl.tional 2024年第2期5卷 129-143页

作者： Wang H. Guo y. Jiang y. Ge y. Shi D. zhang G. Zhao J. Kang y. Wang l. Shanghai Jiao Tong University.School.of.Medicine Shanghai China School.of.Material. Science and Engineering East China University of Science and Technology Shanghai China Department of.Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Exosomes, a special.sed ty.e of.extracel.ul.r vesicl., have attracted signif.cant attention in the real. of.tendon/l.gament repair as a potential.biol.gic therapeutic tool. Whil. the competence of.key.substances responsibl. f.r the del.very.f.nction was gradual.y.el.cidated, series of.shortcomings exempl.f.ed by.the l.mited stabil.ty.stil. need to be improved. Theref.re, how to take maximum advantage of.the biol.gical.characteristics of.exosomes is of.great importance. Recentl., the comprehensive expl.ration and appl.cation of.biomedical.engineering has improved the avail.bil.ty.of.exosomes and reveal.d the f.ture direction of.exosomes combined with biomaterial.. This review del.es into the present appl.cation of.biomaterial. such as nanomaterial., hy.rogel., and el.ctrospun scaf.ol.s, serving as the carriers of.exosomes in tendon/l.gament repair. By.pinpointing and expl.ring their strengths and l.mitations, it of.ers val.abl. insights, paving the way.the f.ture direction of.biomaterial. in the appl.cation of.exosomes in tendon/ l.gament repair in this f.el.. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： biomaterial. el.ctrospinning exosomes hy.rogel.microspheres hy.rogel. nanoparticl.s

f.st ef.icient photon decel.ration in pl.smas by.using two l.ser pul.es at dif.erent f.equencies

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Matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： y.X.Wang X.l.Zhu S.M.Weng P.l. X.f.l. H.Ai H.R.Pan Z.M.Sheng Key.l.boratory.f.r l.ser Pl.smas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Col.aborative Innovation Center of.If.A Shanghai Jiao Tong UniversityShanghai 200240China Research Center of.l.ser f.sion of.China Academy.of.Engineering Phy.ics MianyangSichuan 621900China State key.l.boratory.of.High f.el. l.ser Phy.ics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao l.e Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of.ul.rashort high-power l.ght sources in the mid-inf.ared(mid-IR)to terahertz(THz)range is of.interest f.r appl.cations in a number of.f.el.s,f.om f.ndamental.research to biol.gy.and *** conventional.l.ser technol.gy.photon decel.ration in pl.sma wakes provides an al.ernative approach to the generation of.ul.rashort mid-IR or THz ***,we present a photon decel.ration scheme f.r the ef.icient generation of.ul.rashort mid-IR or THz pul.es by.using an intense driver l.ser pul.e with a rel.tivel. short wavel.ngth and a signal.l.ser pul.e with a rel.tivel. l.ng *** signal.pul.e trail. the driver pul.e with an appropriate time del.y.such that it sits at the f.ont of.the second wake bubbl. that is driven by.the driver *** to its rel.tivel. l.ng wavel.ngth,the signal.pul.e wil. be subjected to a l.rge gradient of.the ref.active index in the pl.sma wake ***,the photon decel.ration in the pl.sma wake becomes f.ster and more ef.icient f.r signal.pul.es with l.nger *** greatl. enhances the capacity.and ef.iciency.of.photon decel.ration in the generation of.ul.rashort high-power l.ght sources in the l.ng-wavel.ngth IR and THz spectral.ranges.

关键词： l.ser ul.rashort photon