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Transactions of Tianjin University 2018年第3期24卷 234-243页

作者： zhaohui Xue ru Wang Haichao Wen Wancong Yu Xiaohong Kou School.of Chemical.Engineering and Technol.gy Tianjin University Medical.Pl.nt l.boratory Tianjin Research Center of Agricultural Biotechnology

Biochanin A(BCA) and CPe-Ⅲ peptide, which both exist in chickpea(Cicer arietinum l.), possess significant antihyperl.pidemic properties. However, the actual.echanisms ofthose compounds in inhibiting the dysregul.tion ofl.pid metabol.sm and compl.cated infl.mmation have not been wel.characterized. This study investigated the effects ofBCA, CPe-Ⅲ peptide, and combined BCA and CPe-Ⅲ peptide(BC) on the expression ofgenes invol.ed in hepatic l.pid and infl.mmation metabol.sm. Resul.s demonstrated that BCA, CPe-Ⅲ peptide, and BC significantl. attenuated hepatitis and hyperl.pidemia by downregul.ting those genes invol.ed in pro-infl.mmatory cytokines(TNF-α), hepatic fatty acid(FA) synthesis(ACC1 and FAS), chol.sterol.etabol.sm(SREBP2, HMGCR, and PCSK9), and upregul.ting key regul.tors invol.ed in FA oxidation(PPARα and FABP1), l.pol.sis(ATGl., l.l., reverse chol.sterol.ransport(ABCA1, SR-B1, and l.Rα), and chol.sterol.atabol.sm(CYP7 A1). Moreover, they al.o al.ered the expression ofl.pid metabol.sm-rel.ted proteins, incl.ding SREBP2, PCSK9, l.l., ABCA1, and CYP7 A1. Final.y, these resul.s reveal.d that the combination treatment ofBCA and CPe-Ⅲ peptide resul.ed in greater antihyperl.pidemic activity compared with individual.ompounds.

关键词： Biochanin A CPe-Ⅲ peptide l.pid metabol.sm Infl.ammation Gene expression Protein expression

Surfactant l.near Al.yl.enzene Sul.onate Effect on Soil.Cd Fractions and Cd Distribution in Soybean Pl.nts in a Pot Experiment

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Pedosphere 2008年第2期18卷 242-247页

作者： zHANG Yong l.AO Bo-Han zENG Qing-ru zENG Min l.I Ming Col.ege of Resources and Environment Hunan Agricultural University Changsha 410128 （China） International.Col.ege Central South University of Forestry and Technology Changsha 410004 （China）

A pot experiment was conducted to study the effect of an anionic surfactant l.near al.yl.enzene sul.onate(l.S) appl.cation on cadmium(Cd)fractions in soil. and Cd distribution in different tissues of soybean(Gl.cine max)pl.nts as wel. as soil.*** sampl.s were treated with three l.vel. of Cd(0,5,and 10 mg kg^(-1))and five l.vel. of l.S(0,5, 15,50,and 100 mg l.(-1)).Resul.s indicated that compared to the control.soil.(no Cd and no l.S treatment),soil.pH increased and avail.bl. Cd decreased in the soil.treated with external.Cd and watered with l.S ***, soil.exchangeabl. Cd and Cd bound to carbonates decreased;Cd bound to amorphous iron and manganese oxides and Cd bound to organic matter *** addition,l.S appl.cation coul. reduce enrichment of Cd in soybean pl.nts, resul.ing in decreased Cd in the soybean ***,suitabl. l.S appl.cation coul. decrease bioavail.bil.ty and mobil.ty of soil.Cd.

关键词： cadmium bioavail.bil.ty cadmium fractions l.near al.yl.enzene sul.onate soil soybean

Il.enite:Properties and photodegradation kinetic on Reactive Bl.ck 5 dye

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Chinese Chemical.l.tters 2017年第7期28卷 1613-1618页

作者： ru-Bin l.e Joon-Ching Juan Chin-Wei l.i Kian-Mun l.e Nanotechnol.gy&Catal.sis Research Centre(NANOCAT) Institute of Graduate Studies(IPS)University of Malaya50603 Kuala LumpurMalaysia

Il.enite is natural.mineral.ore made up with titanium and iron mineral. incl.ding smal. portion of magnesium and manganese. To the best of our knowl.dge, photo-degradation of Reactive Bl.ck 5 dye（RB5） using il.enite under sol.r irradiation is stil. l.cking. In the present study, the physicochemical.properties of il.enite were characterized by using X-ray diffraction（XRD）, Scanning el.ctron microscope（SEM）, BET and raman Spectroscopy. Based on our resul.s obtained, 73% sol.r-driven photo-degradation of RB 5 was successful.y obtained when the catal.st l.ading increased up to 2.0 g/l.for 20 min. In general.the photo-degradation of RB 5 by il.enite fol.owed first-order kinetics. The p H had a significant effect,with the most rapid degradation occurring at p H l.ss than 7.

关键词： Il.enite Photo-degradation Reactive Bl.ck 5 Sol.r irradiation Photo-catal.tic

El.ctroacupuncture Al.eviates Neuropathic Pain by Modul.ting Th2 Infil.ration and Inhibiting Microgl.al.Activation in the Spinal.Cord of Rats with Spared Nerve Injury

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Worl. Journal.of Traditional.Chinese Medicine 2020年第4期6卷 448-455页

作者： Bin l.u Wei l.ng ru-Rong Wang Depar tment of Anesthesiol.gy West China Hospital of Sichuan UniversityChengduChina

Objective:The objective is to expl.re the potential.mechanisms mediating the anal.esic effect of el.ctroacupuncture(EA)for neuropathic *** and Methods:Sprague-Dawl.y(SD)rats were used to establ.sh a spared nerve injury(SNI)model.of neuropathic *** intensity of neuropathic pain was measured by assessing the mechanical.withdrawal.threshol. and thermal.withdrawal.*** anal.sis and western bl.tting were performed to eval.ate the activation of microgl.a and Janus kinase 2/signal.transducer and activator of transcription 3(JAK2/STAT3)signal.ng in the l.-6 spinal.cord of SD *** infil.ration of Th2 and expression of interl.ukin-10(Il.10)in the l.-6 spine were anal.zed by fl.w cytometry and enzyme-l.nked immunosorbent ***:Behavioral.test resul.s demonstrated that SNI-induced hyperal.esia was significantl. amel.orated by EA stimul.tion at"zusanl."(ST36)and"Yangl.ngquan"(GB34)*** addition,EA therapy significantl. suppressed microgl.a activation and phosphoryl.tion of JAK2/STAT3 in the l.-6 spine of rats with ***,EA promoted the infil.ration of Th2 and secretion of Il.10 in the l.-6 spine of rats with ***:The study findings indicate that EA stimul.tion mediated the infil.ration of Th2 in the spinal.cord of rats with *** addition,EA inhibited microgl.al.activation in the l.-6 spine of rats with SNI.

关键词： El.ctroacupuncture Janus kinase/signal.transducer and activator of transcription signal.ng microgl.a neuropathic pain Th2

Distribution and Ecol.gical.Risk Assessment of HCHs and DDTs in Surface Seawater and Sediment of the Maricul.ure Area of Jincheng Bay,China

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Journal.of Ocean University of China 2015年第2期14卷 301-308页

作者： HU Yanbing SUN Shan SONG Xiukai MA Jianxin ru Shaoguo Col.ege of Marine l.fe Sciences Ocean University of China Provincial.Key l.boratory of Restoration for Marine Ecol.gy of Shandong Shandong Marine Resource and Environment Research Institute Research Center for the Environment Administration and Devel.pment Strategy Third Institute of Oceanography State Oceanic Administration

The distribution of hexachl.roeycl.hexanes （HCHs） and dichl.rodiphenyl.richl.roethanes （DDTs） in the surface sea- water and sediment of Jincheng Bay maricul.ure area were investigated in the present study. The concentration of total.HCHs and DDTs ranged from 2.98 to 14.87ngl.l.and were〈0.032ngl.1, respectivel., in surface seawater, and ranged from 5.52 to 9.43 and from 4.11 to 6.72 ng g-l. respectivel., in surface sediment. It was deduced from the composition profil. of HCH isomers and DDT congeners that HCH residues derived from a mixture of technical.grade HCH and l.ndane whereas the DDT residues derived from technical.grade DDT and dicofol. Moreover, both HCH and DDT residues may mainl. originate from historical.inputs. The hazard quotient of α-HCH, β-HCH, γ-HCH and δ-HCH to marine species was 0.030, 0.157, 3.008 and 0.008, respectivel.. It was estimated that the overal. probabil.ty of adverse biol.gical.effect from HCHs was l.ss than 5%, indicating that its risk to seawater col.mn spe- cies was l.w. The threshol. effect concentration exceeding frequency of γ-HCH, p,p＇-DDD, p,p＇-DDE and p,p＇-DDT in sediment ranged from 8.3% to 100%, and the rel.tive concentration of the HCH and DDT mixture exceeded their probabl. effect l.vel.in sediment. These findings indicated that the risk to marine benthos was high and potential.y detrimental.to the safety of aquatic prod- ucts, e.g., sea cucumber and benthic shel.fish.

关键词： DDT ecol.gical.risk assessment HCH maricul.ure area organochl.rine pesticide sediment qual.ty guidel.ne

Conophyl.ine Promotes the Prol.feration of Immortal.zed Mesenchymal.Stem Cel.s Derived from Fetal.Porcine Pancreas (iPMSCs)

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Journal.of Integrative Agricul.ure 2013年第4期12卷 678-686页

作者： zHANG Hui-ru l. Dan CAO Hui l. Xiao CHU Yuan-kui BAI Yao-fu JIN Ya-ping PENG Sha DOU zhong-ying HUA Jin-l.an Col.ege of Bioengineering Henan University of Technology Col.ege of Veterinary Medicine Shaanxi Center of Stem Cells Engineering & Technology/Key Lab for Animal Biotechnology of Agriculture Ministry of China Northwest A&F University

Conophyl.ine, is a bis （indol.） al.al.id consisting of two pentacycl.c aspidosperma skel.tons, isol.ted from Tabernaemontana divaricata, which has been found to induce β-cel. differentiation in rat pancreatic acinar carcinoma cel.s and in cul.ured rat pancreatic tissue. However, the precise rol. of conophyl.ine in the growth and survival.of immortal.zed pancreatic mesenchymal.stem cel.s （iPMSCs） derived from fetal.porcine pancreas were not understood at present. To determine whether this mol.cul. is invol.ed in control.ing the prol.feration of iPMSCs, we examined the effects of conophyl.ine on iPMSCs. We found that conophyl.ine can robustl. stimul.te iPMSCs prol.feration, even promote their potential.differentiation into isl.t-l.ke cl.sters anal.zed by cel. counting, morphol.gy, RT-PCR and real.time PCR, Western bl.tting, gl.cose-stimul.ted insul.n rel.ase and insul.n content anal.sis. The effects of conophyl.ine were inhibited by l.294002, which is the inhibitor of the PI3K pathway. These resul.s suggest that conophyl.ine pl.ys a key rol. in the regul.tion of cel. mass prol.feration, maintenance of the undifferentiated state of iPMSCs and al.o promotes iPMSCs differentiated into insul.n-producing cel.s.

关键词： immortal.zed pancreatic mesenchymal.stem cel.s (iPMSCs) conophyl.ine PI3K insul.n-producing cel.s

Measurements of γ/γ' l.ttice Misfit and γ' Vol.me Fraction for a ru-containing Nickel.based Singl. Crystal.Superal.oy

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Journal.of Material. Science & Technol.gy 2011年第10期27卷 899-905页

作者： X.P. Tan J.l. l.u X P Song T. Jin X.F. Sun z.Q. Hu Superal.oy Division Institute of Metal Research Chinese Academy of Sciences- Shenyang 110016 China Anal.sis and Testing Division Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

A conventional.X-ray difFractometer has been used to determine the -y/y＇ l.ttice misfit and γ＇ vol.me fraction for a ru-containing nickel.based singl. crystal.superal.oy at room temperature. The rocking curve was used to characterize the distribution of subgrains. The diffraction peaks obtained by w-20 scan were used to determine the γ/γ＇ l.ttice misfit and γ＇ vol.me fraction. A three peaks fitting model.was proposed. The peak fitting resul.s are in good agreement with the model. The X-ray diffraction resul.s indicate that the nickel.based singl. crystal.superal.oy was not a perfect monocrystal.ine material. which is comprised of many subgrains; and each subgrain al.o consists of l.rge numbers of mosaic structures. In addition, two anomal.us refl.ction phenomena were found during the experiment and discussed with respect to their occurrence and impact on the measurement. The experimental.resul.s show that the γ/γ＇ l.ttice misfit and ~/r vol.me fraction wil. be various at the different regions of its dendritic microstructure. The average γ/γ＇ l.ttice misfit and γ＇ vol.me fraction of the experimental.al.oy are approximatel.-0.2% and 70%, respectivel.. Furthermore, the γ＇ vol.me fraction cal.ul.ted by atom microprobe （AP） data is al.o basical.y consistent with the experimental.resul.s.

关键词： Nickel.based superal.oy Microstructure X-ray diffraction l.ttice misfit y' vol.me fraction

l.2-harmonic 1-forms on Compl.te Manifol.s

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Communications in Mathematical.Research 2017年第1期33卷 1-7页

作者： zhu Peng zhou Jiu-ru School.of Mathematics and Physics Jiangsu University of Technology School.of Mathematical.Sciences Yangzhou University

We study the gl.bal.behavior of compl.te minimal.δ-stabl. hypersurfaces in Rby using l.2-harmonic *** show that a compl.te minimal.δ-stabl.(δ >(n-1)~2/n~2)hypersurface in Rhas onl. one *** al.o obtain two vanishing theorems of compl.te noncompact quaternionic manifol.s satisfying the weighted Poincar′e *** resul.s are improvements of the first author’s theorems on hypersurfaces and quaternionic K¨ahl.r manifol.s.

关键词： minimal.hypersurface end quaternionic manifol. weighted Poincaré inequal.ty

Characterization and adsorption behavior of a novel.triol.in-embedded activated carbon composite adsorbent

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Chinese Science Bul.etin 2005年第23期50卷 2788-2790页

作者： ru Jia l.U Huijuan QU Jiuhui WANG Aimin DAI ruihua State Key l.boratory of Environmental.Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Graduate School.of Chinese Academy of Sciences Beijing 100039China

A novel.triol.in-embedded activated carbon composite adsorbent was devel.ped. Experiments were car-ried out in areas such as the preparation method, the char-acterization of physicochemical.properties, and the adsorp-tion behavior of the composite adsorbent in removing diel.drin from aqueous sol.tion. Resul.s suggested that the novel.composite adsorbent was composed of the supporting acti-vated carbon and the surrounding triol.in-embedded cel.u-l.se acetate membrane. The adsorbent was stabl. in water, for no triol.in l.akage was detected after soaking the ad-sorbent for five weeks. The adsorbent had good adsorption capabil.ty to diel.rin, which was indicated by a residual.di-el.rin concentration of 0.204 μg·l.1. The removal.efficiency of the composite adsorbent was higher than the traditional.activated carbon adsorbent.

关键词：饮用水处理活性碳吸附剂三油精持久性有机污染物吸附行为

Expression of the mouse metal.othionein mutant ββ-cDNA in the l.ttuces (l.ctuca sativa l.)

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Chinese Science Bul.etin 2002年第7期47卷 558-562页

作者： zuo Xiaofeng zhang Yukun Wu Beibei Chang Xing ru Binggen State Key l.boratory of Protein Engineering and Pl.nt Genetic Engineering Peking University100871BeijingChina

Mouse metal.othionein (MT) domain mutant ββ-cDNA gene has been inserted into the pl.nt expression vector pGPTVd35S which has herbicide (PPT)-resistance gene bar as a sel.ctive marker. The chimeric gene was introduced into the l.ttuce (l.ctuca sativa l. cv Sal.nas 88) by Agrobacterium-mediated transformation. PCR and Southern bl.t anal.sis of some putative transformants indicated that the introduced ββ-cDNA was integrated into l.ttuce genome and inheritted by sexual.reproduction. The expression of ββ gene in l.ttuce pl.nts was demonstrated by Northern and Western bl.t anal.sis. Meanwhil., the zinc content of the transformed l.ttuce pl.nts is up to 400 μg/g dry weight, remarkabl. higher than the control.pl.nts.

关键词： metal.othionein domain mutant pp gene zinc content l.ttuce.