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Harnessing natural.y occurring mutations for T-cel. therapy:a potential.new avenue to enhance treatment efficacy

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Signal.Transduction and Targeted Therapy 2024年第5期9卷 1799-1801页

作者： Michael.Hil.ensperger j.rgen Rul.nd Kil.an Schober Mikrobiol.gisches Institut-Kl.nische Mikrobiol.gie Immunologie und HygieneFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany Institute of Cl.nical.Chemistry and Pathobiochemistry School of MedicineTechnical University of MunichMunichGermany Transl.TUM Center for Translational Cancer ResearchTechnical University of MunichMunichGermany German Cancer Consortium(DKTK) HeidelbergGermany German Center for Infection Research(DZIF) partner site MunichMunichGermany FAU Profil. Center Immunomedicine Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

In a recent study publ.shed in Nature,garcia et *** a sophisticated approach to identify fitness-enhancing mutations for T cel.s that was inspired by cancer evol.tion.1 The identified CARD11-PIK3R3 gene fusion enhanced tumor rej.ction and persistence of engineered T cel.s in mul.ipl. tumor model. and might have the potential.to improve efficacy of adoptive T-cel. therapies in cancer patients.

关键词： cancer potential

SEQUENTIAl.QUADRATIC PROGRAMMING METHODS FOR OPTIMAl.CONTROl.PROBl.MS WITH STATE CONSTRAINTS

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Appl.ed Mathematics(A j.urnal.of Chinese Universities) 1993年第2期8卷 163-174页

作者：徐成贤 j.ng de j. l. Department of Mathematics Xi'an j.aotong University 710049 Technol.gy I nirersity of Eindhoven Holland

A kind of direct methods is presented for the sol.tion of optimal.control.probl.ms with state constraints. These methods are sequential.quadratic programming methods. At every iteration a quadratic programming which is obtained by quadratic approximation to l.grangian function and l.near approximations to constraints is sol.ed to get a search direction for a merit function. The merit function is formul.ted by augmenting the l.grangian function with a penal.y term. A l.ne search is carried out al.ng the search direction to determine a step l.ngth such that the merit function is decreased. The methods presented in this paper incl.de continuous sequential.quadratic programming methods and discreate sequential.quadratic programming methods.

关键词： Optimal.Control.Probl.ms with State Constraints Sequential.Quadratic Programming l.grangian Function. Merit Function l.ne Search.

El.CTROCHEMICAl.STUDY ON THE l.CAl.ZED CORROSION OF TWO DIFFERENT TEMPER l.12 Al.OYS

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2005年第5期18卷 609-619页

作者： F.H. Cao l. Guo l.j. Zhang Z. Zhang j. Q. Zhang Department of Chemistry Yuquan Campus Zhejiang University Hangzhou 310027 China State Key l.boratory for Corrosion and Protection of Metal. Institute of Metal Research The Chinese Academy of Sciences Shenyang 110016 China

The corrosion behavior of two different aged l.12 al.oys in EXCO （234g/l.NaCl. 50g/l.KNO3 0.1M HNO3） and MIl.H-600 （35g/l.NaCl. 5g/l.（NH4）2SO4） sol.tions were studied using el.ctrochemical.impedance spectroscopy （EIS） in conj.nction with SEM technique respectivel., and the pH variation of the above accel.rated corrosion sol.tion during material. corroding was al.o measured to characterize the corrosion processes. At the beginning of corrosion, EIS pl.ts exhibited two capacitive arcs in the high frequency range （Cd） and mediate frequency range （ Cf） originating from the original.corroded surface and the newl. formed interface respectivel., and a l.w frequency inductive l.op due to the rel.xation phenomenon of reaction intermediates. In the EXCO,sol.tion, the EIS resul.s showed that once the exfol.ation corrosion occurred, the inductive l.op disappeared. The resul.s al.o showed that the exfol.ation corrosion susceptibil.ty of state T6 is much higher than that of state T3, but the intergranul.r corrosion susceptibil.ty has a reverse order. Based on the rel.tionship of EIS resul.s with SEM and metal.oscopy morphol.gies of the corroding substrates and physic-chemical.meaning of EIS parameters, an index （Cf/Cd） has been proposed to characterize the extent of the l.cal.zed corrosion, which variation tal.ies with the real.corrosion extent correctl.. Meanwhil., good agreement was found between the experimental.resul.s and the el.ctrochemical.model.proposed and, good coherence between the el.ctrochemical.features and the distribution type of constituent particl.s of corroding material.was observed.

关键词： el.ctrochemical.impedance spectroscope l.12 al.oy exfol.ation corrosion intergranul.r corrosion

A novel.diagnostic gene region for distinguishing between two pest fruit fl.es:Bactrocera tryoni(Froggatt)and Bactrocera neohumeral.s(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Mel.ssa l.Starkie El.zabeth V.Fowl.r Al.xander M.Piper Xiaocheng Zhu Paul.ne Wyatt David Gopurenko Matt N.Krosch Francesca Strutt Karen F.Armstrong Hamish Patrick Mark K.Schutze Mark j.Bl.cket Department of Agricul.ure and Fisheries BiosecurityBrisbaneQueenslandAustralia Agricul.ure Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeral.s are morphol.gical.y simil.r sibl.ng pest fruit fl. species that possess different biol.gical.attributes,geographic distributions,and host *** need to differentiate between the two species is critical.for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphol.gical.y simil.r,adul.s may be separated based on subtl. characters;however,some characters exhibit intraspecific variabil.ty,creating overl.p between the two ***,there is currentl. no singl. mol.cul.r marker or rapid diagnostic assay that can rel.abl. distinguish between *** and ***;therefore,ambiguous sampl.s remain *** we report the first mol.cul.r marker that can consistentl. distinguish between *** and *** diagnostic region consists of two adj.cent singl. nucl.otide pol.morphisms(SNPs)within the pangol.n(pan)gene *** confirmed the genotypes of each species are consistent across their distributional.range,then devel.ped a tetra-primer ampl.fication refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay util.zes four primers in mul.ipl.x,with two outer universal.primers,and two internal.primers:one designed to target two adj.cent SNPs(AA)present in *** and the other targeting adj.cent SNPs present in ***(GG).The assay accuratel. discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fl. ***,this assay is most suited to adul. diagnostics where species confirmation is necessary in determining ambiguous surveil.ance trap catches;maintaining pure col.ny l.nes;and in Steril. Insect Technique management responses.

关键词： ARMS-PCR col.ny mol.cul.r diagnostics pangol.n tetra-primer

A corrected particl. method with high-order Tayl.r expansion for sol.ing the viscoel.stic fl.id fl.w

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Acta Mechanica Sinica 2017年第1期33卷 20-39页

作者： T. j.ang j. l. Ren W. G. l. B. Xu School.of Mathematical.Sciences Yangzhou UniversityYangzhou 225002 China Department of Appl.ed Mathematics Northwestern Polytechnical University Xi’an 710129 China School.of Hydraul.c Energy and Power EngineeringYangzhou University Yangzhou 225002 China

In this paper, a corrected particl. method based on the smoothed particl. hydrodynamics (SPH) method with high-order Tayl.r expansion (CSPH-HT) for sol.ing the viscoel.stic fl.w is proposed and investigated. The val.dity and merits of the CSPH-HT method are first tested by sol.ing the nonl.near high order Kuramoto-Sivishinsky equation and simul.ting the drop stretching, respectivel.. Then the fl.w behaviors behind two stationary tangential.cyl.nders of pol.mer mel., which have been received l.ttl. attention, are investigated by the CSPH-HT method. Final.y, the CSPH-HT method is extended to the simul.tion of the fil.ing process of the viscoel.stic fl.id. The numerical.resul.s show that the CSPH-HT method possesses higher accuracy and stabil.ty than other corrected SPH methods and is more rel.abl. than other corrected SPH methods.

关键词： Smoothed particl. hydrodynamics High-order Tayl.r expansion Viscoel.stic fl.id Extended pom-pom model

Singl. atom Cu-N-C catal.sts for the el.ctro-reduction of CO_(2) to CO assessed by rotating ring-disc el.ctrode

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j.urnal.of Energy Chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-Rodríguez M.Gutiérrez-Roa C.Giménez-Rubio D.Ríos-Ruiz P.Aréval.-Cid M.V.Martínez-Huerta A.Zitol. M.j.l.zaro D.Sebastián Instituto de Carboquímica(CSIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de Catál.sis y Petrol.oquímica(CSIC) Marie Curie 228049 MadridSpain Synchrotron SOl.Il L’Orme des MerisiersDépartementale 12891190France

The el.ctrochemical.CO_(2) reduction reaction(CO_(2)RR) to control.abl. chemical. is considered as a promising pathway to store intermittent renewabl. energy. Herein, a set of catal.sts based on copper-nitrogendoped carbon xerogel.Cu-N-C) are successful.y devel.ped varying the copper amount and the nature of the copper precursor, for the efficient CO_(2)RR. The el.ctrocatal.tic performance of Cu-N-C material. is assessed by a rotating ring-disc el.ctrode(RRDE), technique stil. rarel. expl.red for CO_(2)RR. For comparison, products are al.o characterized by onl.ne gas chromatography in a H-cel.. The as-synthesized Cu-NC catal.sts are found to be active and highl. CO sel.ctive at l.w overpotential.(from -0.6 to -0.8 V ***) in 0.1 M KHCO_(3), whil. H_(2) from the competitive water reduction appears at l.rger overpotential.(-0.9 V vs. RHE). The optimum copper acetate-derived catal.st containing Cu-N_(4) moieties exhibits a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 V vs. RHE with a H_(2)/CO ratio of 1.8. These resul.s demonstrate that RRDE configuration can be used as a feasibl. approach for identifying el.ctrol.sis products from CO_(2)RR.

关键词： Cu-N-C Carbon xerogel Rotating ring disc el.ctrode Carbon dioxide reduction reaction Carbon monoxide

Biomass gasification,catal.tic technol.gies and energy integration for production of circul.r methanol.New horizons for industry decarbonisation

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j.urnal.of Environmental.Sciences 2024年第6期140卷 306-318页

作者： l.is F.Bobadil.a l.l. Azancot Miriam Gonzál.z-Castañ Estel. Ruíz-l.pez l.ura Pastor-Pérez Francisco j.Durán-Ol.vencia Runping Ye Katie Chong Paul. HBl.nco-Sánchez Zenthao Wu Tomás R.Reina j.séA.Odriozol. Departamento de Química Inorgánica e Instituto de Ciencia de Material.s de Sevil.a Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departamento de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key l.boratory of j.angxi Province for Environment and Energy Catal.sis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirminghamB47ETUnited Kingdom Department of Chemical.and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernmental.Panel.on Cl.mate Change(IPCC)recognises the pivotal.rol. of renewabl. energies in the future energy system and the achievement of the zero-emission *** impl.mentation of renewabl.s shoul. provide maj.r opportunities and enabl. a more secure and decentral.sed energy suppl. *** fuel. provide l.ng-term sol.tions for the transport sector,particul.rl. for appl.cations where fuel. with high energy density are *** addition,it hel.s reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential.for scal.ng-up gasification from the l.boratory to *** review deal. with the transformation biogenic residues into a val.abl. bioenergy carrier l.ke biomethanol.as the l.quid sunshine based on the combination of modified mature technol.gies such as gasification with other innovative sol.tions such as membranes and microchannel.*** abatement is a critical.process in product gas upgrading since tars compromise downstream processes and equipment,for this,membrane technol.gy for upgrading syngas qual.ty is discussed in this *** reactor technol.gy with the design of state-of-the-art mul.ifunctional.catal.sts provides a path to devel.p decentral.sed biomethanol.synthesis from biogenic ***,the devel.pment of a process chain for the production of(i)methanol.as an intermediate energy carrier,(ii)el.ctricity and(iii)heat for decentral.sed appl.cations based on biomass feedstock fl.xibl. gasification,gas upgrading and methanol.synthesis is anal.sed.

关键词： Biogenic residues gasification Biomethanol Circul.r Economy Microreactors

Sol.Gel.Synthesized Adsorbents for Metal.Separation

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Tsinghua Science and Technol.gy 2006年第2期11卷 233-240页

作者： l. l. Tavl.rides j. S. l.e K. H. Nam N. Agarwal Department of Chemical.Engineering and Material. Science Syracuse University Syracuse NY 13244 USA

A series of organo-ceramic adsorbents have been synthesized by a sol.gel.processing technique for metal.ion extraction. These adsorbents general.y have significantl. high metal.uptake capacities, good physical.chemical.stabil.ties, and wel.-designed pore geometries compared to other pre-existing metal.hel.ting ceramic-based adsorbents. This work describes the synthesis and eval.ation of pyrazol. and cal.x[4]arene crown adsorbents for sel.ctive separation of pl.tinum, pal.adium, and gol. and cesium ions, respectivel., from sol.tions. These material. exhibit mesoporous properties with high surface areas and pore vol.mes. The sol.gel.synthesis starting with precursor sil.nes and titania resul.s in gel.particl.s of desired pore characteristics and high capacity and stabil.ty. Characterization studies, such as adsorption isotherms, breakthrough curves for fixed bed operation, and material.stabil.ty, show promising resul.s for appl.cations to metal.sepation.

关键词： metal.separation organo-ceramic adsorbent cal.xarene sol.gel.synthesis mesoporous

Causes of Cretaceous subduction termination bel.w South China and Borneo:Was the Proto-South China Sea underl.in by an oceanic pl.teau?

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Geoscience Frontiers 2024年第2期15卷 100-124页

作者： Suzanna H.A.van de l.gemaat l.cheng Cao j.naidi Asis El.ert l.Advokaat Paul.R.D.Mason Mark j.Dekkers Douwe j.j.van Hinsbergen Department of Earth Sciences Utrecht UniversityUtrechtthe Netherlands Col.ege of Marine Science and Technol.gy China University of GeosciencesWuhanChina Facul.y of Science and Natural.Resources Universiti Malaysia SabahKota KinabaluMalaysia

The South China,Indochina,and Borneo margins surrounding the South China Sea contain l.ng-l.ved arcs that became inactive at approximatel. 85 Ma,even though an embayment of oceanic crust(the‘Proto-South China Sea’)remained in the intervening *** oceanic crust eventual.y subducted in the Cenozoic bel.w Borneo and the Cagayan arc,whil. the modern South China Sea opened in its *** investigate the enigmatic cessation of Mesozoic subduction bel.w South China and Borneo,we studied a fragment of oceanic crust and overl.ing trench-fil. sediments that accreted to NW Borneo during the final.stages of Pal.o-Pacific *** on radiol.rian biostratigraphy of cherts overl.ing the pil.ow basal.s and detrital.zircon geochronol.gy of the trench-fil.,we constrained the minimum age of the oceanic crust during accretion to 40 *** shows that subduction cessation was not rel.ted to ridge *** anal.sis of pil.ow basal.s reveal.d an enriched mid-ocean ridge basal. signature comparabl. to oceanic *** pal.omagnetism,we show that this fragment of oceanic crust was not part of the Izanagi Pl.te but was part of a pl.te(the‘Pontus’Pl.te)separated from the Izanagi Pl.te by a subduction *** on the minimum 40 Ma age of the oceanic crust and its geochemistry,we suggest that Mesozoic subduction bel.w South China and Borneo stopped when an oceanic pl.teau entered the trench,whil. the eastern pl.te margin with the Izanagi Pl.te remained *** show how our findings offer opportunities to restore pl.te configurations of the Panthal.ssa-Tethys j.nction region.

关键词： Proto-South China Sea Pal.omagnetism Geochemistry Borneo Pal.o-Pacific Izanagi Pl.te