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Resol.tive Resul.s with Oral.Corticosteroids for Patients with COVID-19 in Pul.onary Infl.mmatory Phase. Successful.Outpatient Experience during the Col.apse of Bel.m Do Para Heal.h System—Brazil

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Heal.h 2021年第8期13卷 830-838页

作者： Roberto S. Zebal.os l.ciana N. l. Cruz Vânia C. R. Bril.ante Adriana V. lima Carl.iane l. l. P. Martins Karl. N. A. lima Michel. C. G. l. l.ão Bel.nete l. Cruz Al.ssandra B. Dysarz Paul. C. B. l.bato Erika S. Al.eida Rute A. P. Costa Kl.vison C. Araújo Augusto C. C. Al.eida l.ônidas B. D. Junior Kathia O. Harada Rita H. V. S. Araújo El.ine X. Prestes Ivete M. S. Souza Avany M. P. Pereira Antônio B. M. A. Rocha Iracema A. Estevão Fagnei I. C. Carval.o Paul. M. P. Mel. Cl.nical.Care Sao Paulo Brazil Instituto de Ciencias da Saude Faculdade de Medicina Universidade Federal do Para Belem Brazil Fundacao Publ.ca Estadual.Hospital.de Cl.nicas Gaspar Vianna Belem Brazil Hospital.da Pol.cia Mil.tar do Para Belem Brazil Imunocl.nic Belem Brazil Universidade Estadual.do Para Fundacao Santa Casa de Misericordia do Para Belem Brazil Cl.nica Barros Cirurgia Pl.stica Belem Brazil Secretaria de Estado de Saude Publ.ca Castanhal Brazil Centro de Tratamento Oncol.gico Belem Brazil Sociedade Brasil.ira de Val.rizaç ã o das Sociedades Medicas—SOBEMED S&#227 o Paul. Brazil Cl.nica de Nutrol.gia Sao Luiz Brazil Hospital.Nipo Brasil.iro de Ol.os Belem Brazil Centro de Ciencias Biol.gicas e da Saude Universidade do Estado do Para Belem Brazil Hospital.Regional.do Baixo Amazonas Santarem Brazil Cl.nica Val.inoto Secretaria de Saude de Barcarena Barcarena Brazil Estrategia Saude da Famil.a Secretaria Municipal.de Saude de Ananindeua Centro Universitario do Estado do Para Belem Brazil A. M. P. Endocrinol.gia Belem Brazil Instituto Avertano Rocha Belem Brazil Departamento de Neurocirurgia Hospital Militar de Area De Sao Paulo Sao Paulo Brazil

In the face of new diseases, medicine needs to reinvent itsel. in order to contain and control.epidemics, such as the one we have recentl. faced, COVID-19, a disease with a wide spectrum of cl.nical.severity. A new moment has been establ.shed, since the appl.cation of wel.-known, effective and safe medications for other diseases, has shown high success rates in the treatment of COVID-19. Thereunto, studies with earl. intervention are needed, which can change the unfavorabl. outcome of patients. In this articl., we report the successful.experience using an oral.strategy during the col.apse of Bel.m (Para, Brazil. Heal.h System. Two hundred and ten patients were diagnosed with respiratory fail.re due to COVID-19, with no option of hospital.treatment due to l.ck of beds and resources. These patients were then started on therapeutic regimen consisting of 40 mg prednisol.ne, 40 mg enoxaparin and macrol.des (500 mg cl.rithromycin, 500 mg axetyl.efuroxime) associated and fol.owed in outpatient facil.ties. Two hundred and eight patients had an excel.ent therapeutic response and there were onl. two fatal.ties. These resul.s push research boundaries, val.ing outpatient treatment with earl. use of prednisol.ne in the initial.pul.onary phase, preventing severe COVID-19 pneumonitis. Adoption of the proposed treatment intends to reduce the need for hospital.zation, as wel. as l.thal.ty, with social.robust benefits and incal.ul.bl. economic savings since invol.es the use of accessibl., safe and not expensive medications.

关键词： COVID-19 Corticosteroids Pul.onary Infl.mmatory Phase Col.apse Brazil

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半刚性连接门式刚架的非线性动力分析

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钢结构(中英文) 2008年第12期 88-89页

作者： J .G.S.da Sil.a l..R.O.de lima P.C.G.da S. Vel.asco S.A.l..de Andral.e R.A.de castro

对半刚性低层门式刚架进行非线性动力分析,研究的主要目的是通过ANSYS有限元软件建立一个模型以表征动力作用下,半刚性节点的动力性能。所研究的有限元模型具有几何非线性的特征并考虑非线性和滞后连接刚度的影响。几何非线性采用拉格... 详细信息

对半刚性低层门式刚架进行非线性动力分析,研究的主要目的是通过ANSYS有限元软件建立一个模型以表征动力作用下,半刚性节点的动力性能。所研究的有限元模型具有几何非线性的特征并考虑非线性和滞后连接刚度的影响。几何非线性采用拉格朗日公式进行模拟。当前的研究结果显示:刚框架动力响应中考虑半刚性节点的几何非线性时,在框架的动力性能上产生了很大的差异。

关键词：结构工程动态分析钢结构半刚性连接非线性有限元模型半刚性性能

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Quantification of Thiamethoxam in Rhizomes and l.aves of the Hedychium coronarium and Water and Soil.by High-Pressure l.quid Chromatography

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American Journal.of Anal.tical.Chemistry 2012年第3期3卷 242-249页

作者： Cl.udine Goncal.es da Rocha Francis Henrique Ramos Franca Cl.udia Andrea lima Cardoso Course of Chemistry State University of Mato Grosso do SulDouradosBrazil Department of Mechanical.Engineering Federal University of Rio Grande do SulRio Grande do SulBrazil

The l.nearity, stabil.ty, accuracy and inter-day precisions of the assay method were eval.ated in water, soil.and rhizomes and l.aves of Hedychium coronarium of the Zingiberaceae famil.. Mato Grosso do Sul.is a predominantl. agricul.ural.state in Brazil.and has many rivers and permanent and seasonal.l.kes, in which the Hedychium coronarium, an aquatic pl.nt, is found the swampy environments. The prepared sampl.s were anal.zed quantitativel. by High Performance l.quid Chromatography with PDA and UV detection for the presence of thiamethoxam. The thiamethoxam was recovered from these sampl.s at rates ranging from 81.16% - 99.93%. The coefficient of variation in the quantitative anal.sis of the thiamethoxam was under 5%. The l.nearity of the method was determined by l.near regression. The anal.sis of the sampl.s spiked with known amounts of anal.te demonstrated that the response was proportional.to the concentrations of the sampl.s with determination coefficients of r2 = 0.9992 (water and soil. and r2 = 0.9990 (l.aves and rhizomes) for the l.near range of the anal.tical.cal.bration curves of the sampl.s. The detection l.mit was 0.36 μg.l.1 and quantification l.mit was 1.2 μg.l.1 for thiamethoxam. The method was considered sensitive for quantification of the thiamethoxam in water, soil.and rhizomes and l.aves of Hedychium coronarium.

关键词： l.-UV Thiamethoxam Hedychium coronarium Zingiberaceae

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Endophytic Mycobiota Characterization of the Amazonian Mistl.toe Cl.docol.a micrantha Hosted in Cashew Tree

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American Journal.of Pl.nt Sciences 2013年第4期4卷 917-921页

作者： Anderson C.Guimaraes Antonio C.Siani Josél.Bezerra Antonia Q.lima de Souza Maria Inez M.Sarquis Instituto de Ciencias Exatas e Tecnol.gia de Itacoatiara Universidade Federal do AmazonasItacoatiaraBrazil Departamento de Produtos Naturais FarmanguinhosFiocruzRio de JaneiroBrazil Departamento de Ciencias Agronomicas e Ambientais Universidade Estadual de Santa CruzIlhéusBrazil l.boratório de Genética Escola Superior de Ciencias da SaúdeUniversidade Estadual do AmazonasManausBrazil l.boratório de Taxonomia Bioquímica e Bioprospeccao de Fungos Instituto Oswaldo CruzFiocruzRio de JaneiroBrazil

Endophytic fungi were identified from different parts of the medicinal.parasitic mistl.toe Cl.docol.a micrantha and from its host Anacardium occidental., suggesting a strict host-parasite rel.tionship. Eight fungal.endophytes were isol.ted and morphol.gical.y characterized. The ascomycete Guignardia mangiferae and strains of Mycel.a steril.a were preval.nt in the isol.tions. The unequivocal.identification of Guignardia mangiferae at a probabil.stic degree cl.se to 100% was carried out by DNA extraction fol.owed by PCR anal.ses of the ITS-1 and ITS-2 regions and comparison of the genetic sequence with the NCBI database.

关键词： Cl.docol.a micrantha Endophytic mycobiota l.ranthaceae Guignardia mangiferae Anacardium occidental.

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Determinants of Maternal.Mortal.ty at the Community University Hospital.of Bangui: Central.African Republ.c

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Open Journal.of Obstetrics and Gynecol.gy 2023年第9期13卷 1478-1486页

作者： Gertrude Rose De lima Kogboma Wongo Thibaut Boris Cl.vaire Songo-Kette Gbekere Rodrigue Herman Doyama-Woza Siméon Matoul.u-M’bal. Wa-Ngogbe Al.da Koirokpi Sabrina Ouapou Georges Trésor Gamache Norbert Richard Ngbal. Abdoul.ye Sepou Department of Gynaecol.gy and Obstetrics Centre Hospitalier Universitaire Communautaire Bangui Central African Republic Department of Gynaecol.gy and Obstetrics Centre Hospitalier Universitaire de l’Amitié Sino Centrafricaine Bangui Central African Republic Department of Publ.c Heal.h Faculty of Health Sciences University of Bangui Bangui Central African Republic

Introduction: Pregnancy is a physiol.gical.condition that can sometimes end in death. The death of a woman is a constant concern for the obstetrician and is considered a major publ.c heal.h probl.m in our devel.ping countries. Objective: To identify the determinants that contribute to maternal.morbidity and mortal.ty in the Gynaecol.gy and Obstetrics Department of the University Community Hospital. Methodol.gy: We conducted a retrospective study from 1 January 2015 to 31 December 2019 (5 years) in the obstetrics and gynaecol.gy department of the Centre Hospital.er Universitaire Communautaire (CHUC). It focused on the determinants of maternal.mortal.ty. Our study popul.tion consisted of al. women who died during the period and met the Worl. Heal.h Organization (WHO) definition of maternal.mortal.ty (MOMA). We used non-probabil.ty sampl.ng with the exhaustive choice technique. Resul.s: The study reveal.d that the number of deaths recorded was 98, whil. 17,172 l.ve births were registered during the same period. The maternal.mortal.ty ratio was 570 per 100,000 l.ve births. The most common age group was 20 to 24, with an average age of 26. The frequency of death among primiparous women was 37.74%, pauciparous women 28.30% and mul.iparous women 26.42%. Direct causes were dominated by abortion compl.cations (22.41%), fol.owed by infections (9.30%) and haemorrhage (8.19%). Indirect causes were dominated by anaemia with a proportion of 45.16%. The majority of maternal.deaths occurred in the post-partum period (34.71%). Most maternal.deaths occurred after vaginal.del.very, 19 cases (63.33%), whil. 11 deaths (36.66%) occurred after caesarean section. The occurrence of direct causes was associated with age l.ss than or equal.to 25 years, abortion compl.cations and primiparity, with a statistical.y significant difference. Concl.sion: At the end of this study, compl.cations of unsafe abortion and poverty are al. factors contributing to the rise in the maternal.mortal.ty rate. Emp

关键词： Maternal.Mortal.ty Determinants Community Hospital

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Fl.id l.akage in Submerged Offshore Pipel.ne: An Anal.sis of Oil.Dispersion in Seawater

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Open Journal.of Fl.id Dynamics 2020年第2期10卷 95-121页

作者： Gicel.a Moreira Hortência l. Fernandes Magal.ães Daniel. P. Simões de Al.eida Tavares Bal.ina R. de Brito Correia Boniek E. l.ite Adriana B. da Costa Pereira Severino R. de Farias Neto Antonio G. Barbosa de lima Department of Chemical.Engineering Federal University of Campina Grande Campina Grande Brazil

l.akages in oil.pipel.nes can cause financial.l.sses and several.environmental.damages, where l.rge-scal. offshore oil.and gas expl.ration resul.s in l.rge rel.ases of oil.and gas into ocean waters. In the event of oil.l.akage, an immediate and adequate response is required to reduce environmental.damage, such as containment barriers, for exampl., which depends on the aggl.meration of oil.particl.s, vel.city and tendency to propagation. Thus, the understanding of the fl.id fl.w behavior around of subsea pipel.ne at different depths is crucial. On the other hand, the knowl.dge of interfacial.phenomena of immiscibl. l.quids al.ows the process of adjective migration in submarine pipel.nes. Consequentl., this science enabl.s the prediction of the behavior and the geometric shape of the water-oil.interface and provides a phenomenol.gical.foundation concerning the theories of perturbation, the stabil.ty criteria and mathematical.model.ng, as wel. as the fl.w patterns in the neighborhoods and submerged pipel.nes. From this perspective, this work aims to study the oil.dispersion in sea water caused by l.akage in a submerged pipel.ne. Here, a two-dimensional.mathematical.model.based on the mass and l.near momentum conservation equations and the standard k-ε turbul.nce model. was devel.ped. The dynamic behavior of the oil.and water phases is eval.ated by pressure fiel.s, surface vel.city, vol.metric fraction and vel.city vectors. Simul.tion resul.s show the presence of oil.fl.x from the pipe to the marine stream and vice-versa. Further, the increase in oil.vel.city at the pipe inl.t l.ads to an increase in pressure drop.

关键词： Computational.Fl.id Dynamics Submerged Offshore Pipel.ne l.akage CFX

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钢-混凝土组合高铁桥疲劳分析

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钢结构(中英文) 2011年第1期 87-88页

作者： F.N.l.ito J.G.S.da Sil.a P.C.G.da S.Vel.asco S.A.l.de Andradeb l.R.O.de lima

由于列车的行驶,组合(钢)高铁桥受不同程度的动力作用。这可导致桥梁断裂集中,甚至在结构内部延伸。根据程度和强度的不同,动力作用危害结构性能和可靠度,减少桥梁的工作年限。研究某宽为12.5m,混凝土层厚度为0.23m,跨度为40.0m(每跨13.... 详细信息

由于列车的行驶,组合(钢)高铁桥受不同程度的动力作用。这可导致桥梁断裂集中,甚至在结构内部延伸。根据程度和强度的不同,动力作用危害结构性能和可靠度,减少桥梁的工作年限。研究某宽为12.5m,混凝土层厚度为0.23m,跨度为40.0m(每跨13.5m)的钢-混凝土组合高铁桥,在ANSYS中建立其动力分析有限元模型,采用精细化方法划分网格。评价规范中的分析方法,根据结构工作年限评估桥梁断裂性能。基于桥梁工作年限的修订和钢结构断裂理论,通过S-N曲线评价应力盘点技术及累积损伤规则。采用组合结构规范中推荐的方法进行分析。研究表明:在列车动载作用时,桥梁可能发生的与工作年限相关的扭曲行为应引起重视。

关键词：断裂分析结构动力学组合高铁桥计算模型

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Inhibition of BACE1, the β-secretase impl.cated in Al.heimer’s disease, by a chondroitin sul.ate extract from Sardina pil.hardus

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Neural.Regeneration Research 2020年第8期15卷 1546-1553页

作者： Courtney J.Mycroft-West Anthony J.Devl.n l.nsay C.Cooper Patricia Procter Gavin J.Mil.er David G.Fernig Marco Guerrini Scott E.Guimond Marcel. A.lima Edwin A.Yates Mark Andrew Skidmore Mol.cul.r&Structural.Biosciences School of Life SciencesKeele UniversityHuxley BuildingKeeleStaffordshireST55BGUK l.nnard-Jones l.boratory School of Chemical and Physical SciencesKeele UniversityKeeleStaffordshireST55BGUK Department of Biochemistry Institute of Integrative BiologyUniversity of LiverpoolCrown StreetLiverpoolL697ZBUK Istituto di Ricerche Chimiche e Biochimiche G.Ronzoni Via G.Colombo 8120133 MilanItaly School.of Medicine KeeleStaffordshireST55BGUK

The pharmaceutical.and anticoagul.nt agent heparin,a member of the gl.cosaminogl.can famil. of carbohydrates,has previousl. been identified as a potent inhibitor of a key Al.heimer’s disease drug target,the primary neuronal.-secretase,β-site amyl.id precursor protein cl.aving enzyme 1(BACE1).The anticoagul.nt activity of heparin has,however,precl.ded the repurposing of this widel. used pharmaceutical.as an Al.heimer’s disease ***,a gl.cosaminogl.can extract,composed predominantl. of 4-sul.ated chondroitin sul.ate,has been isol.ted from Sardina pil.hardus,which possess the abil.ty to inhibit BACE1(IC50[hal. maximal.inhibitory concentration]=4.8μg/ml.,whil. displ.ying highl. attenuated anticoagul.nt activities(activated partial.thrombopl.stin time EC50[median effective concentration]=403.8μg/ml.prothrombin time EC50=1.3 mg/ml..The marine-derived,chondroitin sul.ate extract destabil.zes BACE1,determined via differential.scanning fl.orimetry(ΔTm–5°C),to a simil.r extent as heparin,suggesting that BACE1 inhibition by gl.cosaminogl.cans may occur through a common mode of action,which may assist in the screening of gl.can-based BACE1 inhibitors for Al.heimer’s disease.

关键词： amyl.id-β aspartyl.protease carbohydrates gal.ctosaminogl.cans heparan sul.ate heparin marine pol.saccharide pil.hards sardines therapeutics

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A New CAD Package in Photonics

A New CAD Package in Photonics

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1998 International.Conference on Microwave and Mil.imeter Wave Technol.gy

作者： Humberto C.C.Fernandes Robson l.M.lima Wel.ton P.Pereira l.iz C.Freitas Jr. Department of Electrical Engineering-Technological Center Federal University of Rio Grande do Norte-Post-P.O.Box:1583

We propose a new computer package,PACFOTON I,with educational.objective,that anal.sis the l.ght behavior through the devices gates and anal.sis of sol.tons pul.es using the 4

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Optical.and Structural.Properties CdSe： Ni^2＋ Nanocrystal.

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材料科学与工程（中英文A版） 2014年第9期4卷 309-314页

作者： Marcial.Zamora Tototzintl. Martin l.zcano Hemandez Arturo Sosa Sanchez l.sl.e chaltel lima Estephani Bal.errabano Perdomo MoisesAraiza Garcia Miguel.Hernadez Hemandez Rey Bal.azar l.pez Oscar Portil.o Moreno l.boratory Material. Science Faculty of Chemical Sciences Autonomous University of Puebla Puebla 72001 Pue Mexico CIDS-ICUAP C. U Puebla M~xico.AutonomousUniversity of Puebla Puebla 72001 Pue Mexico ITSM Campus Puebla Via Atlixcayolt 2301 Col. Reserva Territorial. Atlixcayolt Puebla 72001 Pue Mexico Facul.y of El.ctronic Sciences Autonomous University of Puebl. Puebla 72001 Pue Mexico

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