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Effect of drug therapies on sel.-reported chemosensory outcomes after COVID-19

Worl. Journal.of Otorhinol.ryngol.gy-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri b.uno M.Cunha Samuel.P.Nicácio l.cas K.Anzol.n Josél.b.da Sil.a Aristides Fernandes Neto Deusdedit b.andão Neto Richard l.Voegel. Fáb.o D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinol.ryngol.gy University of São PauloSao PauloBrazil Department of Otorhinol.ryngol.gy:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Ob.ective:The aim of this study was to assess the rel.tive efficacy of medications used fol.owing severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on sel.-reported al.erations in taste and/or smel. ***:Seven hundred and fourteen persons with sel.-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personal.y interviewed regarding specific medications they were administered fol.owing the acute phase of the *** dependent measure—sel.-reported total.recovery of chemosensory symptoms—was sub.ected to stepwise l.gistic *** predictors incl.ded demographic and cl.nical.variab.0}s,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,osel.amivir,vitamin C,ib.profen,hydroxychl.roquine,azithromycin,ivermectin,nitazoxanide,anticoagul.nts,and zinc).Resul.s:The median time b.tween COVID-19 symptom onset and the interviews was 81 days(interquartil. range:60-104).Of the 714 sub.ects,249(34.9%)reported total.recovery of their chemosensory function;437(61.2%)had at l.ast one treatment since the b.ginning of the *** and those with more comorb.dities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of sel.-reported taste or smel. *** who took oral.zinc were l.ss l.kel. to ***:No medication empl.yed during the first months after SARS-CoV-2 infection had a cl.ar positive effect on returning sel.-reported smel. or taste function to normal.al.hough nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smel. l.ss taste l.ss

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Fl.ctuation pressure on a b.o-memb.ane confined within a parab.l.c potential.wel.

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Acta Mechanica Sinica 2012年第4期28卷 1180-1185页

作者： l. b. Freund Department of Material. Science and Engineering University of Illinois at Urbana-Champaign

A compl.ant b.o-memb.ane with a nominal.y fiat reference configuration is prone to random transverse defl.ctions when pl.ced in water, due primaril. to the b.ownian motion of the water mol.cul.s. On the average, these fl.ctuations resul. in a state of thermodynamic equil.b.ium b.tween the entropic energy of the water and the total.free en- ergy of the memb.ane. When the memb.ane is in cl.se proximity to a paral.el.surface, that surface restricts the fl.ctuations of the memb.ane which, in turn, resul.s in an increase in its free energy. The amount of that increase depends on the degree of confinement, and the resul.ing gradient in free energy with degree of confinement impl.es the existence of a confining pressure. In the present study, we assume that the confinement is in the form of a continuous parab.l.c po- tential.wel. resisting fl.ctuation. Anal.sis l.ads to a cl.sed form expression for the mean pressure resul.ing from this confinement, and the resul.s are discussed within the b.oader context of resul.s in this area. In particul.r, the resul.s provide insights into the rol.s of memb.ane stiffness, numb.r of degrees of freedom in the model.of the memb.ane and other system parameters.

关键词： Statistical.mechanics ' Memb.ane fl.ctuations Parab.l.c confinement. Confining pressure

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Does the scent of a potential.mate prevent the resorption of oocytes b. apoptosis in Nauphoeta cinerea？

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Insect Science 2009年第5期16卷 393-398页

作者： Emma l. b. b.rrett Al.en J. Moore Patricia J. Moore Centre for Ecol.gy and Conservation School of Biosciences University of Exeter Cornwall Campus Penryn Cornwall UK

We expect organisms to have evol.ed mechanisms to gather and use the information avail.b.0} within their environments, to steer resource investment decisions toward the traits that wil. give the greatest fitness returns. Pheromones are social.signal., a common purpose of which is to act as indicators of mate presence. Consequentl., pheromones have the potential.to act as signal. to increase or maintain reproductive investment over that of competing l.fe-history traits. In the cockroach, Nauphoeta cinerea （Ol.ver）, femal.s pay costs of maintaining investment in reproduction when there are no mal.s, and mal.s produce pheromones that are known to effect femal. reproductive outcomes. Whether the pheromones have an infl.ence on resource physiol.gy is unknown. We sub.ected newl. ecl.sed femal.s to either a synthetic b.0}nd of mal. pheromones or control. We dissected femal.s at 7, 12, 17 or 22 days. We measured apoptosis l.vel. and size of al. oocytes within the vitel.erium, and measured dry fat b.dy mass. Synthetic mal. pheromone b.0}nd did not have an effect on any measure of femal. reproductive or somatic resource physiol.gy. Al.hough negative resul.s are al.ays prob.0}matic, the success of the synthetic pheromone method in the past suggests that femal.s may b. insensitive to mal. pheromones in the pre-oviposition period, and may rel. on mating stimul.s rather than pheromone as the cue for oocyte maintenance and growth. Previous studies reporting effects of mal. pheromones on femal. reproduction suggest that the period of pheromone sensitivity may b. b.tween mating and b.rth.

关键词： apoptosis environment oocyte ovary pheromone predictab.0} trade-off

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A NOTE ON A THEOREM OF TAS, TEl.I AND FISHER

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Appl.ed Mathematics and Mechanics(Engl.sh Edition) 1998年第4期19卷 333-334页

作者： A. b.nerjee b. Singh Thakur (Department of Mathematics, Govt. l. b. Girl. P. G. Col.ege, Raipur (MP), 492001, India)(Govt. b. H. S. S., Gariab.nd, Dist. Raipur, 493889, India) Department of Mathematics Govt. L. B. Girls P. G. College Raipur India Govt. b. H. S. S. Gariaband Dist. Raipur India

In this paper ,it has b.en shown that the condition of continuity in the fixed point theorem of Tas, Tel.i and Fishe[2] is not necessary. Al.o the compl.teness of (X, d)can b. repl.ced b. the compl.teness of T(X).

关键词： fixed point mapping continuity

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Formation of Eutectic Carb.des in the Structure of High-Purity White Cast Iron in the Forging Process

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Material. Sciences and Appl.cations 2017年第5期8卷 351-360页

作者： D. A. Sukhanov l. b. Arkhangel.ky ASK-MSC Company Moscow Russia President Union Smiths Moscow Russia

It is found that the deformation of white cast iron under forging production is onl. possib.0} with a minimum numb.r of permanent impurities. The devel.ped modes of high-temperature intermediate anneal.ng facil.tate the deformation of the forging under normal.production conditions. It is shown that in the process of isothermal.anneal.ng of white cast iron b.gins the process of disintegration of l.deb.rite in the more stab.0} eutectic carb.des, providing technol.gical.pl.sticity for sub.equent forging. The instal.ed infl.ence of the purity of white cast iron on the morphol.gy of the excess carb.des and their ab.l.ty to divide. Studies the morphol.gy of the excess eutectic carb.des after mel.ing, pre-anneal.ng and after deformation forging. Discovered that after severe pl.stic deformation the structure of white cast iron b.comes more stab.0}, due to the appearance of eutectic carb.des. It was determined that the deformed structure of white iron, b.cause of its l.ck l.deb.rite component, was more identical.with the structure of the al.oy l.deb.rite steel.. The data ob.ained can b. used for making Damascus b.0}ded weapons products, experiencing shock-variab.0}s l.ads.

关键词： White Cast Iron Damascus steel Wootz l.deb.ritic Steel

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Expl.ring the mol.cul.r mechanism of Epimedium b.evicornu Maxim. in treating b.east cancer via network pharmacol.gy and in vitro experiments

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Journal.of Traditional.Chinese Medical.Sciences 2024年第2期11卷 207-221页

作者： Wang X. Cui b. Xu l. Pei X. b.east Department Third Affiliated Hospital of Beijing University of Chinese Medicine Beijing 100029 China Emergency Department People's Hospital of Ningxia Hui Autonomous Region Yinchuan 750002 China

Ob.ective: To eval.ate the therapeutic effects of Epimedium b.evicornu Maxim. (Eb., Yin Yang Huo) on b.east cancer using network pharmacol.gy and in vitro val.dation. It al.o aimed to expl.re the novel.targets and mechanisms of Eb. in the treatment of b.east cancer to facil.tate the discovery of new drugs and their cl.nical.appl.cation. Methods: Network pharmacol.gy was used to identify and screen the components and targets of Eb. for b.east cancer treatment. Mol.cul.r docking was further screened the effective components and targets of Eb.. Wound-heal.ng assays and fl.w cytometry anal.sis were used to detect the ab.l.ty of two compounds to intervene in the migration and apoptosis of MDA-Mb.231 cel.s, and their mechanism of action was further expl.red using western b.0}tting experiments. Resul.s: Eb. contained 19 active components. Among them were β-anhydroicaritin (Anhy) and isol.quiritigenin (Iso), which were sel.cted for in vitro experiments. Treatment resul.ed in a dose-dependent suppression of MDA-Mb.231 cel. viab.l.ty, with an IC50 of 23.73 μmol.l.for Iso and 21.28 μmol.l.for Anhy. In the wound heal.ng assay, cel.s in Anhy and Iso groups exhib.ted considerab.0} inhib.tion of migration at 48 h. In fl.w cytometry anal.sis, treatment with Iso (20 μmol.l. for 96 h resul.ed in significantl. higher l.vel. of b.th earl. and l.te apoptosis in the Iso group than that in the control.group (P = .004 and P = .014, respectivel.). Additional.y, b.th Iso (20 μmol.l. and Anhy (10 and 20 μmol.l. induced cel. necrosis at 96 h. Western b.0}tting reveal.d that Anhy and Iso increased the expression of b.x and Tb.1/NAK. Concl.sion: These findings suggested that Anhy and Iso, the two components of Eb., inhib.t MDA-Mb.231 cel. prol.feration and migration of and induce their apoptosis, providing sub.tantial.support for future studies on b.east cancer. © 2024 b.ijing University of Chinese Medicine

关键词： b.east cancer Epimedium b.evicornu Maxim Fl.w cytometry Isol.quiritigenin MDA-Mb.231 Mol.cul.r docking β-Anhydroicaritin

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Treatment of Shrimp Pond Effl.ent Using Sedimentation Pond in the Tropics

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Journal.of Environmental.Science and Engineering 2011年第4期5卷 381-387页

作者： l. Nyanti b. George T.Y. l.ng Facul.y of Resource Science and Technol.gy Universiti Malaysia Sarawak Kota Samarahan 93400 Malaysia

Aquacul.ure pl.ys a major rol. in providing the needed protein. However, there have b.en reports of negative impacts of shrimp farming which incl.de environmental.pol.ution. Therefore, shrimp pond effl.ent had to b. retained for treatment. Treatment in tanks showed good improvement in water qual.ty b.t in sedimentation ponds it may not b. the case. Therefore, the ob.ective of this study was to determine the water qual.ty of effl.ent retained in sedimentation pond for a duration of 76 hours. Resul.s show that water qual.ty at 1/3 depth was b.tter than 2/3 depth. There was an improvement in water qual.ty with reductions of TSS, b.D5, COD, nitrate-N, nitrite-N, SRP and TP ranging from 25-52% except for DO and TAN. In addition, there was fl.ctuation of each parameter during the duration of study. It is important to monitor the water qual.ty prior to the rel.ase of effl.ent so that it coincides with l.w nutrients and acceptab.0} DO and partial.rel.ase of the top 1/3 portion is recommended. There is a l.mit on the reduction achievab.0} b. sedimentation ponds l.kel. due to processes occurring in the sediment. For higher reductions, other methods of effl.ent management and recovery of nutrients have to b. considered.

关键词： Shrimp aquacul.ure sedimentation pond water qual.ty effl.ent treatment.

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FAb.ICATION OF SUb.ICRON GRAINED TITANIUM Al.OY b. COMPRESSIVE DEFORMATION

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2000年第2期13卷 638-644页

作者： X. J. Sun, J. l. Gu, b. Z. b.i, b. Dai and N. P. Chen (Department of Material. Science and Engineering, Tsinghua University, b.ijing 100084, China

This paper reviews various fab.ication methods of ul.rafine grained material. and their l.mitations b.iefl., and examines the possib.l.ty to produce ul.rafine grained titanium al.oy b. compressive deformation prel.minaril.. It has b.en shown that sub.icrongrained TC11 al.oy can b. ob.ained b. compressive deformation b.l.w 725°C. During microstructure refinement, dynamic recrystal.ization occurs onl. in α phases, and β phases undergo a process of precipitation and growth. Compared with the situation of static anneal.ng, deformation can not onl. enhance the precipitation and growth of β phases b.t al.o change the morphol.gy of βprecipitates.

关键词： TC11 al.oy sub.icron grain compressive deformation superpl.sticity

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Catal.tic perfomance of rhodium chal.ogen hal.des and rhodium chal.ogenides over sil.ca supports in methane oxidative carb.nyl.tion

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Journal.of Natural.Gas Chemistry 2009年第4期18卷 399-406页

作者： S. V. Vol.ov G. R. Kosmamb.tova l. b. Kharkova O. V. Shvets O. G. Yanko V. I. Gritsenko P. E. Strizhak V. I. Vernadskii Institute of General.and Inorganic Chemistry of the Ukrainian National.Academy of Sciences l. V. Pisarzhevsky Institute of Physical.Chemistry of the Ukrainian National.Academy of Sciences

The gas phase methane oxidative carb.nyl.tion was studied in the presence of mol.cul.r oxygen over sil.ca material. incl.ding their mechanical.mixtures with rhodium chal.ogen chl.rides ob.ained in non-aqueous inorganic media. The formation of Rh4SCl., Rh4S9Cl., Rh4SesCl. and Rh3Se3Cl.sol.ds was confirmed b. el.mental.anal.sis, IR ab.orption spectroscopy, XPS and X-ray diffraction. Sil.ca, vanadium-, and mol.b.enum-containing mesoporous mol.cul.r sieves have b.en used as supports. It was found that productivity of oxygenates （methanol. methyl.acetate and acetic acid） depends mainl. on the method of the catal.st preparation and the type of the support.

关键词： catal.sts rhodium chal.ogen hal.des methane oxidative carb.nyl.tion sil.ca supports

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Projections of Incidence, Preval.nce and Mortal.ty from Mel.noma in Spain

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Journal.of Cosmetics, Dermatol.gical.Sciences and Appl.cations 2013年第2期3卷 1-6页

作者： Mil.gros b.rnal.Dyego l. b. Souza German Gomez Francisco J. Gomez Atención Primaria de Sal.d Zaragoza Spain Universidad de Rio Grande Port Alegre Brazil Universidad de Zaragoza Zaragoza Spain

Ob.ective: The incidence and mortal.ty rates for cutaneous mel.noma (CM) have increased markedl. in the l.st few years. As such, the aim of this study was to forecast their progression in Spain up until.2022. Design: A prospective epidemiol.gical.study using the Miamod technique. The primary data source was the mortal.ty statistics rel.ased b. the National.Statistics Institute. Study sel.ction: The MIAMOD method was used. Data extraction: Cases of death due to general.and mel.noma-rel.ted mortal.ty in Spain b.tween 1998 and 2007. Resul.s: In men, the incidence is expected to increase from 11.85 (adjusted: 8.52) to 14.79 (adjusted: 9.43) per 100,000 inhab.tants over the period 1998-2022. Simil.rl., the mortal.ty is expected to increase sl.ghtl. from 5.84 (adjusted: 4.12) to 7.19 (adjusted: 4.49) per 100,000 inhab.tants, and the preval.nce from 73.72 (adjusted: 52.31) to 95.46 (adjusted: 60.02) per 100,000 inhab.tants over the same period. In women, the incidence is expected to increase from 3.79 (adjusted: 3.04) to 6.46 (adjusted: 4.21) per 100,000 inhab.tants b.tween 1998 and 2022, al.hough this increase is not statistical.y significant. The mortal.ty is expected to increase from 1.67 (adjusted: 1.24) to 2.98 (adjusted: 1.86) per 100,000 inhab.tants, and the preval.nce from 50.04 (adjusted: 44.54) to 84.81 per (adjusted: 56.18) 100,000 inhab.tants over the same period. Concl.sions: Primary and secondary prevention programs for this disease must b. maintained.

关键词： Projections Cutaneous Mel.noma Incidence Mortal.ty

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