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Oxbow lakes as Geological Archives of Historical Changes in Channel Substrate, Swan Creek, Toledo, Ohio (USA)

Open Journal of Modern Hydrology 2022年第2期12卷 32-54页

作者： Jocelyn l. hicks James E. Evans Department of Geology School of Earth Environment and Society Bowling Green State University Bowling Green OH USA

Efforts to restore urban rivers require an understanding of human-influenced changes in channel substrates. This study uses three naturally-occurring oxbows in a 3.5 km reach of Swan Creek, flowing through the City of Toledo, Ohio (USA) to reconstruct historical changes in channel substrate. Human impacts in the watershed were: 1) land clearance for agriculture (peaking in 1900-1920) and for suburban housing tracts (peaking in 1945-1970), followed by 2) the post-1940 creation of more efficient urban run-off systems from streets, parking lots, housing developments, and shopping centers. Historical aerial photographs and maps from 1935, 1940, 1950, 1963, 1974, and 1994 were georeferenced using ground control points, input to ArcGIS, and have root mean square error (RMSE) ranging from 0.19 - 0.77 m (average RMSE = 0.47 ± 0.20 m) when compared to the 2006 digital ortho quarter-quadrangle (DOQQ) image used as the basis for comparison. Results showed that channel sinuosity continually increased from 1.88 (1935) to 1.99 (2006). Two oxbows probably formed in 1913, and the third formed in 1940. Sediment cores and trenches were used to recognize historical channel substrates. Age control was provided by 14C geochronology and labels on food packaging materials found in flood layers. Grain-size analysis of channel substrates shows a historical coarsening-upward trend: the largest clast size interval (f5) changes from +0.78f in pre-1935 channels, to -1.15f in pre-1940 channels, to -1.69f in the 2006 channel. These results indicate recent urban runoff created fluvial pavements and increasing channel mobility as the stream removes legacy sediment from intrabasinal sediment storage.

关键词： Oxbows Channel Substrate legacy Sediment Anthropogenic Change Sediment Budget

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If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease

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Asian Journal of Urology 2019年第1期6卷 10-25页

作者： Karen S.Sfanos Srinivasan Yegnasubramanian William G.Nelson Tamara l.lotan Ibrahim Kulac Jessica l.hicks Qizhi Zheng Charles J.Bieberich Michael C.Haffner Angelo M.De Marzo Department of Pathology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Oncology The Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Pathology Koc Universitesi Tip FakultesiIstanbulTurkey Department of Biological Sciences University of Maryland Baltimore CountyBaltimoreMDUSA

Antibodies are employed ubiquitously in biomedical sciences,including for diagnostics and *** of the most important uses is for immunohistochemical(IHC)staining,a process that has been improving and evolving over *** is useful when properly employed,yet misuse of the method is widespread and contributes to the“reproducibility crisis”in *** report some of the common problems encountered with IHC assays,and direct readers to a wealth of literature documenting and providing some solutions to this *** also describe a series of vignettes that include our approach to analytical validation of antibodies and IHC assays that have facilitated a number of biological insights into prostate cancer and the refutation of a controversial association of a viral etiology in *** postulate that a great deal of the problem with lack of accuracy in IHC assays stems from the lack of awareness by researchers for the critical necessity for end-users to validate IHC antibodies and assays in their laboratories,regardless of manufacturer claims or past *** suggest that one reason for the pervasive lack of end-user validation for research antibodies is that researchers fail to realize that there are two general classes of antibodies employed in ***,there are antibodies that are“clinical grade”reagents used by pathologists to help render diagnoses that influence patient *** diagnostic antibodies,which tend to be highly validated prior to clinical implementation,are in the vast minority(e.g.lass of antibodies are“research grade”antibodies(now numbering>3800000),which are often not extensively validated prior to *** increased awareness of the problem,both the United States,National Institutes of Health and some journals are requiring investigators to provide evidence of specificity of their antibody-based assays.

关键词： Prostate cancer Antibodies Immunohistochemistry

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厄瓜多尔的土壤保护

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水土保持应用技术 1983年第4期 38-40页

作者： Sam Portch Jesse l.hicks ,张天义

近些年来,厄瓜多尔的土壤学家及其农业部门的官员已经开始关注境内的土壤侵蚀问题.政府农业部设立了土壤保护机构.但其工作性质和其它部门不尽相同,由于缺乏农民的支持和政治、经济方面原因,开展工作比较困难.1952年,M.阿克斯达·索利... 详细信息

近些年来,厄瓜多尔的土壤学家及其农业部门的官员已经开始关注境内的土壤侵蚀问题.政府农业部设立了土壤保护机构.但其工作性质和其它部门不尽相同,由于缺乏农民的支持和政治、经济方面原因,开展工作比较困难.1952年,M.阿克斯达·索利斯编写了一本关于水土保护方面的专著.内容是论述厄瓜多尔的严重的土壤侵蚀问题,并

关键词：厄瓜多尔美国南美洲美利坚合众国北美洲土壤保护土地保护希克斯农民劳动者土壤保持

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2003年10月至2004年2月与马里兰州大洋城一家旅馆饮用水相关的军团菌病

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美国医学会杂志（中文版） 2006年第5期25卷 319-320页

作者： D Goeller D Blythe M Davenport M Blackburn B Flannery C lucas B Fields M Moore AD Castel l hicks 肖燕（译）崔德健（校） Worcester County Health Dept Snow Hill Maryland Dept of Health and Mental Hygiene Div of Bacterial and Mycotic Diseases National Center for Infectious Diseases EIS officers CDC. 不详

2003年10月至2004年2月，在马里兰州大洋城一家旅馆住过的旅客中诊断出8例军团菌病（7例确诊，1例疑似）。本报告对伍斯特县卫生局（WCHD）、马里兰州健康及心理卫生署（DHMH）和疾病预防与控制中心（CDC）随后进行的一项联合调查进行... 详细信息

2003年10月至2004年2月，在马里兰州大洋城一家旅馆住过的旅客中诊断出8例军团菌病（7例确诊，1例疑似）。本报告对伍斯特县卫生局（WCHD）、马里兰州健康及心理卫生署（DHMH）和疾病预防与控制中心（CDC）随后进行的一项联合调查进行了总结。调查指出，该旅馆的饮用热水系统极有可能是传染源。这次爆发强调了加强以州为基础的监控对及时诊断和控制旅游相关军团菌病的重要性。

关键词：军团菌病旅馆兰州马里饮用疾病预防与控制中心水相县卫生局

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Remembering,Forgetting,and Absencing Disasters in the Post-disaster Recovery Process

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International Journal of Disaster Risk Science 2020年第3期11卷 287-299页

作者： Charlotte Monteil Jenni Barclay Anna hicks lancaster Environment Center Lancaster UniversityBailrigg LAI 4YWUK School of Environmental Sciences University of East AngliaNorwich NR47TJUK Edinburgh Office British Geological SurveyEdinburgh EH 144BAUK

Sustainable post-disaster recovery implies learning from past experience in order to prevent recreating forms of *** construction supports both the healing process and redevelopment ***,memory of disaster results from the balance between remembering,forgetting,and absencing elements of the disaster,and can be both a tool and an obstacle to sustainable *** explore here how collective memory is built in a post-disaster context to respond to the needs of this critical period,and how it shapes *** ethnographic study,conducted between 2015 and 2017,explores the recovery processes in Montserrat,a small Caribbean island affected by an extended volcanic crisis from 1995 to *** this study does not give tangible solutions for disaster risk reduction in a post-disaster context,it highlights potential obstacles for learning from a disaster and how they may be *** argue that it is crucial to acknowledge evolving collective memory in order to implement effective measures for preserving and sharing a shared understanding of disaster across generations and social groups in a way that supports disaster risk *** also maintain that acknowledging the dilemma faced by authorities and disaster management agencies during a period of conflicting needs may encourage the reconsideration of risk framing,and hence reveal how to improve implementation of disaster risk reduction measures.

关键词： Absencing risk information Disaster remembering Forgetting processes Montserrat Post-disaster recovery

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lOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma

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Genes & Diseases 2023年第1期10卷 254-266页

作者： Xiang Chen Margaret Clement MJohn hicks Poonam Sarkar MWaleed Gaber Tsz-Kwong Man Department of Pediatrics Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Department of Pathology Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Dan l.Duncan Comprehensive Cancer Center 7200 Cambridge StreetHoustonTX 77054USA Texas Children's Cancer and Hematology Centers 1102 Bates StHoustonTX 77030USA

Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric *** the use of chemotherapy and surgery,metastasis remains to be the leading cause of death in patients with *** have previously reported that cytoplasmic mislocalization of p27 is associated with a poor outcome in *** this study,we further show that lysyl oxidase(lOx)expression was associated with p27 *** is an enigmatic molecule that acts as a tumor suppressor or a metastatic promoter;however,its role in osteosarcoma is still ***,we performed both in vitro and in vivo analyses to dissect the role of lox in *** result of our survival analysis indicated that lox expression significantly correlated with a poor outcome in osteosarcoma with or without controlling for the initial metastasis status(Plly,we found that higher loX expression promoted osteosarcoma cell proliferation,migration,and invasiveness in vitro and produced a higher number of mice with pulmonary metastases in an orthotopic xenograft mouse ***,phospho-FAK was increased in osteosarcoma cells with high lOX *** results further showed that FAK inhibition significantly reduced tumor cell proliferation and migration in vitro as well as loX-mediated metastasis in ***,our findings suggest that there is a novel link between p27 mislocalization and lOX *** plays a pivotal role in osteosarcoma metastasis by upregulating FAK *** inhibition may constitute a promising therapeutic strategy to reduce the development of metastasis in osteosarcoma with lox overexpression.

关键词： Focal adhesion kinase lysyl oxidase Metastasis Osteosarcoma

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SlP-2: a potential new target for improving mitochondrial function in Parkinson's disease

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Neural Regeneration Research 2017年第9期12卷 1435-1436页

作者： Alessandra Zanon Andrew A.hicks Peter P.Pramstaller Irene Pichler Institute for Biomedicine Eurac Research Affiliated Institute of the University of Lübeck

Parkinson＇s disease （PD） is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases are idiopathic, in about 10% of the patients a genetic cause can be detected, ascribable to mutations in more than a dozen genes. PD is characterized clinically by tremor, rigidity, reduced mo- tor activity （bradykinesia）, and postural instability and pathological- ly by loss of dopaminergic （DA） neurons in the substantia nigra pars compacta, loss of DA innervation in the striatum, and the presence of a-synuclein positive aggregates in the form of lewy bodies. The symptomatic treatment of PD with levodopa, which aims at replac- ing dopamine, remains the gold standard, and no neuroprotective or disease-modifying therapy is available. During treatment, the disease continues to progress, and long-term use of levodopa has import- ant limitations including motor complications termed dyskinesias. Therefore, a pharmacological therapy able to prevent or halt the neu- rodegenerative process is urgently required.

关键词： SlP-2 a potential new target for improving mitochondrial function in Parkinson’s disease

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The Critical Significance of Middle Class America for a Collective U.S. Prosperity and Socioeconomic Sustainability

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Management Studies 2017年第5期5卷 394-407页

作者： Reza G. Hamzaee lexy hicks Micah Burrow Missouri Westem State University Missouri USA

The shrinking size of middle class in the U.S. has motivated this research work. The focus of this research has been on sustainability of society through middle-class promoting public policy. We have estimated three various regression equations to test the significance of several socio-economic variables on what would define some desirable indices of healthier nations such as mean years of schooling, human development, and quality of life. Quality of life in certain countries such as Norway, Denmark, etc., is highlighted as best, compared to many other nations of the world. We have introduced a better measure of quality of life and estimated the empirical impacts of some explanatory variables, such as healthcare, property price to income ratio, and pollution on that index of life quality. An implication of this study for public policy would be revealed in clear needs for reducing pollution, more income creating innovative objectives, while healthcare accessibility and the corresponding costs to citizens must be brought down.

关键词： socio-economic policy middle class income inequality human development

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改善门诊抗生素使用利用数据的力量

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英国医学杂志中文版 2019年第6期22卷 311-312页

作者： lauri A hicks laura M King Katherine E Fleming-Dutra 于东豪(译) 曹彬(校) Office of Antibiotic Stewardship Division of Healthcare Quality PromotionNational Center for Emerging and Zoonotic Infectious DiseasesCenters for Disease Control and Prevention1600 Clifton Road NEMailstop A-31 AtlantaGA 30329USA 首都医科大学附属北京潞河医院呼吸与危重症医学科中日友好医院呼吸与危重症医学科

据估算,门诊处方占据了85%~95%的抗生素使用,而在门诊背景下,抗生素常常被滥用或误用1-3.人们越来越多的意识到优化门诊环境下的抗生素使用是提高患者安全的潜在机会4。THE BMJ的两项研究描述了如何利用门诊抗生素处方数据的力量来提高... 详细信息

据估算,门诊处方占据了85%~95%的抗生素使用,而在门诊背景下,抗生素常常被滥用或误用1-3.人们越来越多的意识到优化门诊环境下的抗生素使用是提高患者安全的潜在机会4。THE BMJ的两项研究描述了如何利用门诊抗生素处方数据的力量来提高管理质量5-6.数据对于确定改进的机会以采取通报行动,追溯和上报抗生素的使用,并评估干预措施的影响十分重要4。

关键词：门诊处方抗生素力量数管理质量 BMJ

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Shade-Inducible Gene Expression Change in Arabidopsis thaliana at Different Temperatures

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American Journal of Plant Sciences 2016年第2期7卷 352-423页

作者： ByungHoon B. Kim Kaiesa l. Peets Jamekia S. Grant Joshua S. hicks Dominique C. Zellous Duane R. Anderson Department of Natural and Forensic Sciences Albany State University Albany GA USA

We tested whether the plant response to an environmental factor could be affected by the context of another factor by using shade avoidance response at different temperatures. Depleting the red light (R;λmax = 660 nm) and/or enriching the far-red light (FR;λmax = 730 nm) results in a low R:FR ratio in the environment, which induces shade avoidance response such as elongation of petioles and reduction of plant pigments. On the other hand, warmer environmental temperature is known to mimic shade avoidance response under normal light condition, suggesting a potential crosstalk between the temperature and the light quality signals. Therefore, we investigated the patterns of gene expression responses to low R:FR ratio in different temperature contexts (22°C and 26°C) through microarray analyses. Similar, yet distinct patterns between the two responses were implicated by the levels of correlation in the commonly affected MapMan bins. However, the induction levels of typical shade genes such as ATHB2, IAA29, IAA19, HFR1, YUC8, and FT were very similar at both temperatures. Moreover, petiole length, chlorophylls, carotenoids, and anthocyanins contents did not support any statistically significant interaction between the light quality and the high temperature responses despite the obvious independent effect of each signal, which suggests cumulative effects of two independent responses. Nevertheless, other types of low R: FR-responsive genes with differential expression patterns at different temperatures were identified. They are overrepresented in secondary metabolism, lipid transport, oxidative stress, jasmonic acid, ethylene, light, pathogen defense responses, and extracellular region.

关键词： Shade Avoidance Temperature Microarray Crosstalk Gene Expression

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