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Changes in cellular proliferation and plasma products are associated with liver failure

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World Journal of Hepatology 2016年第32期8卷 1370-1383页

作者： Juliana Gil Melgaco Frederico Marianetti Soriani Pedro Henrique Ferreira Sucupira leonardo Assaf Pinheiro Yasmine Rangel Vieira Jaqueline Mendes de Oliveira lia laura lewis-Ximenez Cristina Carvalho Vianna Araújo lúcio filgueiras pacheco-moreira Gustavo Batista Menezes Oswaldo Goncalves Cruz Claudia lamarca Vitral Marcelo Alves Pinto Departamento de Microbiologia e Parasitologia Universidade Federal Fluminense Instituto Oswaldo Cruz/Fiocruz Laboratório de Desenvolvimento Tecnológico em Virologia Departamento de Biologia Geral Instituto de Ciencias BiologicasUniversidade Federal de Minas Gerais Instituto Oswaldo Cruz/Fiocruz Ambulatório de Hepatites Virais Hospital Federal de Bonsucesso laboratório de Imunofarmacologia Departamento de Bioquímica e ImunologiaInstituto de Ciencias BiológicasUniversidade Federal de Minas Gerais Fundacao Oswaldo Cruz Programa de Computacao Científica

AIM To study the differences in immune response and cytokine profile between acute liver failure and selflimited acute *** Forty-six patients with self-limited acute hepatitis(AH), sixteen patients with acute liver failure(AlF), and twenty-two healthy subjects were involved in this study. The inflammatory and anti-inflammatory products in plasma samples were quantified using commercial enzyme-linked immunoassays and quantitative real-time PCR. The cellular immune responses were measured by proliferation assay using flow cytometry. The groups were divided into viral- and non-viral-induced selflimited AH and AlF. Thus, we worked with five groups: Hepatitis A virus(HAV)-induced self-limited acute hepatitis(HAV-AH), HAV-induced AlF(HAV-AlF), nonviral-induced self-limited acute hepatitis(non-viral AH), non-viral-induced acute liver failure(non-viral AlF), and healthy subjects(HC). Comparisons among HAV and non-viral-induced AH and AlF were *** The levels of mitochondrial DNA(mt DNA) and the cytokines investigated [interleukin(Il)-6, Il-8, Il-10, interferon gamma, and tumor necrosis factor] were significantly increased in AlF patients, independently of etiology(P lasma mt DNA and Il-10 were the best markers associated with AlF [mt DNA: OR = 320.5(95%CI: 14.42-7123.33), P l-10: OR = 18.8(95%CI: 1.38-257.94), P = 0.028] and death [mt DNA: OR = 12.1(95%CI: 2.57-57.07), P = 0.002; and Il-10: OR = 8.01(95%CI: 1.26-50.97), P = 0.027]. In the cellular proliferation assay, NK^(bright), NKT and regulatory T cells(TReg) predominated in virusspecific stimulation in HAV-induced AlF patients with an anergic behavior in the cellular response to mitotic stimulation. Therefore, in non-viral-induced AlF, anergic behavior of activated T cells was not observed after mitotic stimulation, as expected and as described by the literature. CONClUSION mt DNA and Il-10 may be predictors of AlF and death. TReg cells are involved in immunologi

关键词： Acute liver failure Cytokines Mitochondrial DNA Cellular immune response Hepatitis A virus

On the Singular Effects in the Relativistic landau levels in Graphene with a Disclination

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Communications in Theoretical Physics 2018年第12期69卷 817-822页

作者： Rosinildo F.do Nascimento Diego Cogollo Edilberto O.Silva Moisés Rojas Cleverson filgueiras Instituto de Fisica Universidade Federal de UberlandiaUberlandiaMGBrasil Unidade Academica de Fisica Universidade Federal de Campina GrandePOB 1007158109-970Campina Grande-PB Brazil Departamento de Fisica Universidade Federal do Maranhao65085-580Sao Luis-MABrazil Departamento de Fisica Universidade Federal de LavrasCaixa Postal 303737200-000Lavras-MGBrazil

The effect of a pseudo Aharonov-Bohm(AB) magnetic field generated by a disclination on a two-dimensional electron gas in graphene is addressed in the continuum limit within the geometric approach. The influence of the coupling between the spinor fields and the singular conical curvature is investigated, which shows that singularities have pronounced impact in the Hall conductivity. Moreover, the degeneracy related to the Dirac valleys is broken for negative values of the angular momentum quantum numbers, ?, including ? ≡ 0. In this case, a Hall plateau develops at the null filling factor. Obtaining the Hall conductivity by summing over the positive and the negative ?′s, the null landau level is recovered and the plateau at the null filling factor disappears. In any case, the standard plateaus, which are seen in a flat graphene are not obtained with these curvature and singular effects.

关键词： landau levels Hall conductivity Graphene Elastic deformations

Physicochemical Properties of Rhamnolipid Biosurfactant from <i>Pseudomonas aeruginosa</i>PA1 to Applications in Microemulsions

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Journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 64-79页

作者： Anderson Nogueira Mendes lívia Alves filgueiras José Carlos Pinto Marcio Nele Departamento de Biofisica e Fisiologia Universidade Federal do Piauí Teresina Brazil Programa de Engenharia Química Instituto de Tecnologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Departamento de Engenharia Química Escola de Química Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

Interfacial properties rhamnolipids from an extract produced by a strain of Pseudomonas aeruginosa were analyzed in this study. The extract of rhamnolipid was characterized by surface tension in different conditions;interfacial tension with different hydrocarbons;critical micelle concentration under different pH and temperatures;particle size and emulsification capacity using laser light profiling. It was observed that the rhamnolipids extract are sensitive to variations in pH, thermostable and function as good emulsificant for emulsification of methyl methacrylate. The emulsion stability order in function of the oil phase was methyl methacrylate > emulsions of castor oil > emulsion n-heptane > emulsion toluene > emulsion hexadecane > octane emulsion. The data presented show that rhamnolipid extracts may be used to formulate stable emulsions of methyl methacrylate. This process can be used to do nano/microsphere of polymethyl methacrylate.

关键词： Rhamnolipids Surface Tension Emulsion Stability Microemulsions

Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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World Journal of Stem Cells 2020年第5期12卷 381-405页

作者： Mariana Penteado Nucci Igor Salerno filgueiras Joao Matias Ferreira Fernando Anselmo de Oliveira leopoldo Penteado Nucci Javier Bustamante Mamani Gabriel Nery Albuquerque Rego lionel Fernel Gamarra lIM44 Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05529-060Brazil Hospital Israelita Albert Einstein Sao Paulo 05529-060Brazil Centro Universitário do Planalto Central BrasíliaDFBrazil

BACKGROUND Stroke is the second leading cause of death *** is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors,and stem cell(SC)therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy ***,the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of ***,tracking SCs from their niche to the target tissues is a complex *** To evaluate SC migration homing,tracking and therapeutic efficacy in the treatment of stroke using nanoparticles METHODS A systematic literature search was performed to identify articles published prior to November 2019 that were indexed in PubMed and *** following inclusion criteria were used:(1)Studies that used in vivo models of stroke or ischemic brain lesions;(2)Studies of SCs labeled with some type of contrast agent for cell migration detection;and(3)Studies that involved in vivo cellular homing and tracking *** A total of 82 articles were identified by indexing in Scopus and Pub *** inclusion criteria were applied,35 studies were selected,and the articles were assessed for eligibility;ultimately,only 25 studies were *** of the selected studies used SCs from human and mouse bone marrow labeled with magnetic nanoparticles alone or combined with fluorophore *** cells were administered in the stroke model(to treat middle cerebral artery occlusion in 74%of studies and for photothrombotic induction in 26%of studies).Fiftythree percent of studies used xenogeneic grafts for cell therapy,and the migration homing and tracking evaluation was performed by magnetic resonance imaging as well as other techniques,such as near-infrared fluorescence imaging(12%)or bioluminescence assays(12%).CONClUSION Our systematic review provided an up-to-date evaluation of SC migration hom

关键词： Stem cell Nanoparticles Homing Tracking Near-infrared fluorescence image Cellular therapy Magnetic resonance image Bioluminescence Stroke

Animal Models of Obsessive-Compulsive Disorder: Strain Differences

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World Journal of Neuroscience 2014年第3期4卷 240-246页

作者： Taimon P. Maio Guilherme B. filgueiras Daniel C. Cunha Celio Estanislau Department of General Psychology and Behavior Analysis State University of Londrina Londrina Brazil

Obsessive-compulsive disorder (OCD) is characterized by obsessions (intrusive thoughts, images etc.) and compulsions (repetitive, stereotyped and perseverant acts). Animal models of OCD are specifically devoted to simulating compulsive features of the disorder. In OCD, compulsive behaviors are recognized as repetitive and maladaptive and symptoms relief can be experienced due to treatment with selective serotonin reuptake inhibitors. Many animal models of OCD are provided with some degree of validity. Genetically based differences in behavior in animal models of OCD are of great value, given that human OCD is reported to involve genetic factors. Some animal models of OCD were already used in studies for the evaluation of strain differences. These works were explored in the present review.

关键词： Obsessive-Compulsive Disorder Animal Models Strain Differences Individual Differences

Acupuncture crossing method of treatment for joint pain and limitation of range of movement

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Acupuncture crossing method of treatment for joint pain and ...

Acinetobacter baumannii Isolated from Clinical Material of Patients from a University Hospital

第29届FIMS世界运动医学大会

作者： Silva Filho,R. C. filgueiras,D. Z. Centro Internacional de Estudos de Fisioterapia Acupuntura e Terapias OrientaisBrazil Centro Avanado de Pesquisas em Ciências Orientais Brazil

Introduction: Acupuncture therapy, commonly used in clinical practice in oriental cultures, has the potential to produce a positive effect with patients suffering of different kinds of pain. The acupuncture crossing m... 详细信息

关键词： acupuncture joint pain range of movement

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Open Journal of Medical Microbiology 2019年第4期9卷 230-237页

作者： Regina Paula Silva Joao Marcelo de Almeida Matozzo Rogério Cássio Fernandes Flávio Antonio de Melo Pedro Henrique Silva Belato Viviane Fajardo filgueiras Ana Beatriz Alkmim Teixeira loyola University of Vale do Sapucai-UNIVAS PousoAlegreBrasil Specializing in Microbiology Microbiology Sector at Samuel Libanio Hospital-HCSLPouso AlegreMGBrazil Faculty of Health Sciences University of Vale do Sapucai-UNIVASPousoAlegreBrasil Applied Health Sciences University of Vale do Sapucai-UNIVASPousoAlegreBrasil

Model Study: The genus Acinetobacter is composed of opportunistic pathogens that mainly affects immunocompromised and patients during a prolonged hospitalization period. A. baumannii can survive in the hospital setting at various locations such as mechanical ventilators, dialysis machines, ventilation systems, water sources, skin and mucous membranes of health professionals and patients, drug preparations and disinfectants among others. Antimicrobials are essential for the treatment of infections, so their use has become common, and often inappropriate and abusive. This pathogen has presented multi-resistance to several classes of antimicrobials and has become a major cause of death in hospitals. Objective: To evaluate the occurrence of Acinetobacter baumannii in clinical samples from the laboratory of Clinical Analyzes, HCSl of Pouso Alegre, MG. Methods: All the samples referring to the patients of the Samuel libanio Clinical Hospital including most of the specialties were evaluated. From the positive samples for Acinetobacter baumannii the medical records of hospitalized patients were evaluated. From the medical records, data were obtained as gender and age of the patient, place of hospitalization, together with month and year of the laboratory procedure. Result: A total of 14,859 samples of diverse materials were evaluated, being 80 (0.5%) samples positive for Acinetobacter baumannii. Of these positive samples, the largest occurrences were identified in male patients 59 (73.7%), aged over 60 years 37 (46.3%). The most affected hospital sector was Adult ICU with 44 (55.0%) of the cases. In May 2015, there were 5 (6.3%) cases registered and in May 2016, 16 (20.0%) cases. The clinical material with the highest occurrence of Acinetobacter baumannii was Mini Bal 29 (36.3%). Conclusion: Acinetobacter baumannii has been presenting a major increase in clinical samples from the lungs, mainly from male, elderly patients hospitalized in an intensive care unit and with resis

关键词： Acinetobacter baumannii Resistance Antimicrobial